51ÁÔÆæ

Chemical Tools for DNA-Protein Cross-Link Formation and Study DNA-protein cross-links (DPCs) are highly toxic lesions formed via a variety of chemical pathways and as intermediates in enzyme transformations. DPCs are potent blocks of helicases, as well as DNA and RNA …

Sometimes DNA Damage is Only the Beginning DNA damage is detrimental to genome integrity and can be mutagenic and/or cytotoxic. The latter lie at the etiology of disease but is also the goal of many anti-cancer therapeutics. Consequently, understanding this …