51猎奇

All People

Karyn Frick

  • Distinguished Professor, Associate Department Chair, Neuroscience Area Head, Neuroscience Major Director, Psychological & Brain Sciences

Education

  • PhD, The Johns Hopkins University
  • MA, The Johns Hopkins University

Courses Taught

  • PSYCH 101 - Introduction to Psychology
  • PSYCH 645 - Hormones and Behavior
  • PSYCH 682 - The Aging Brain
  • PSYCH 754 - Proseminar in Neuroscience

Research Interests

The primary focus of our research is to understand how sex-steroid hormones, aging, and environmental factors affect hippocampal function and hippocampal-dependent memory. This work is motivated by the rapidly expanding elderly population worldwide, which will greatly increase the prevalence of age-related cognitive decline and dementia. Our ultimate goal is to help mitigate the impact of cognitive aging on the individual and society by facilitating the development of treatments to reduce or prevent age-related memory decline in humans. To this end, we utilize rodents as research subjects because rodent species offer an unparalleled opportunity to examine systems-level and cellular-level questions about memory formation in a mammalian system where the effects of aging, hormones, and environmental stimulation are similar to those in humans. Our studies combine a variety of approaches including behavioral, biochemical, pharmacological, genetic, and anatomical methods in order to gain a more detailed picture of the molecular mechanisms underlying the effects of aging, estrogens, progestagens, and environmental enrichment on the hippocampus and hippocampal memory formation.

Selected Publications

Frick, K. M.(Ed). (2020) New York, NY: Oxford University Press.
Kim, J. , Schalk, J. C., Koss, W. A., Gremminger, R. L., Taxier, L. R., Gross, K. S., & Frick, K. M.(2019) The Journal of Neuroscience, 39(48), 9598-9610.
Taxier, L. R., Philippi, S. M., Fortress, A. M., & Frick, K. M.(2019) Hormones and Behavior, 114, 104545.
Koss, W. A., & Frick, K. M.(2019) Hormones and Behavior, 111, 96-104.
Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M.(2018) Neurobiology of Learning and Memory, 156, 103-116.
Koss, W. A., Haertel, J. M., Philippi, S. M., & Frick, K. M.(2018) eNeuro, 5(5).
Hanson, A. M., Sampathi Perera, K. L., Kim, J. , Pandey, R. K., Sweeney, N. K., Lu, X. , Imhoff, A. , Mackinnon, A. C., Frick, K. M., Donaldson, W. A., & Sem, D. S.(2018) Journal of Medicinal Chemistry, 61(11), 4720-4738.
Frick, K. M., & Kim, J. (2018) Hormones and Behavior.
Kim, J. , & Frick, K. M.(2017) Psychoneuroendocrinology, 85, 110-114.
Frick, K. M., Tuscher, J. J., Koss, W. A., Kim, J. , & Taxier, L. R.(2017) Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females.Saldanha, C. , & Robinson, T. (Eds). Physiology and Behavior, 187, 57-66.
Tuscher, J. J., Luine, V. N., Frankfurt, M. , & Frick, K. M.(2016) Estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on ERK and mTOR activation in the dorsal hippocampus.Journal of Neuroscience, 36(5), 1483-1489.
Koss, W. A., & Frick, K. M.(2016) Sex differences in hippocampal function.Journal of Neuroscience Research, 95(1-2), 539-562 (Invited review for Special issue entitled, 鈥淎n Issue Whose Time Has Come: Sex/Gender Influences on Nervous System Function鈥�).
Tuscher, J. J., Szinte, J. S., Starrett, J. R., Krentzel, A. A., Fortress, A. M., Remage-Healey, L. , & Frick, K. M.(2016) Inhibition of local estrogen synthesis in the hippocampus impairs memory consolidation in ovariectomized female mice.Hormones and Behavior, 83, 60-67.
Kim, J. , Szinte, J. S., Boulware, M. I., & Frick, K. M.(2016) 17尾-estradiol and agonism of G-protein-coupled estrogen receptor enhance hippocampal memory via different cell-signaling mechanisms.Journal of Neuroscience, 36(11), 3309-3321.
Frick, K. M.(2015) Molecular mechanisms underlying the memory-enhancing effects of estradiol.Hormones and Behavior, 74, 4-18 (Invited review for Special issue entitled, 鈥淓stradiol and Cognition鈥� for the 2015 Society for Neuroscience meeting).
Frick, K. M., Kim , J. , Tuscher, J. J., & Fortress, A. M.(2015) Learning and Memory, 22(9), 472-493 (Invited review for Special issue for the Molecular and Cellular Cognition Society meeting at the 2015 Society for Neuroscience meeting).
Fortress, A. M., Heisler, J. D., & Frick, K. M.(2015) Hippocampus, 25(5), 616-629.
Tuscher, J. J., Fortress, A. M., Kim, J. , & Frick, K. M.(2015) Behavioural Brain Research, 285, 140-157 (Invited review for Special issue entitled, 鈥淥bject Recognition Memory in Rats and Mice鈥�).
Fortress, A. M., & Frick, K. M.(2014) Frontiers in Neuroendocrinology, 35(4), 530-549 (Invited review paper).
Boulware, M. I., Heisler, J. D., & Frick, K. M.(2013) Journal of Neuroscience, 33(38), 15184-15194.