Clinical and Translational Science Institute of Southeast Wisconsin<\/a>, recently received five-year $24.4 million grant to continue its work of translating research discoveries into patient care. (Curtis is an adjunct professor in the CTSI at one of the institutions, the Medical College of Wisconsin).<\/p>\nResearch is a draw<\/h3>\n
The Blood Center\u2019s research focus was what originally attracted him there more than 30 years ago, Curtis said. Richard Aster, a researcher who was then CEO of the blood center, had increased and expanded the center\u2019s focus on research and had established a Blood Research Institute. He was looking for someone with a background in platelet immunology. Curtis, who has a master\u2019s degree in transfusion medicine from Marquette University, fit the bill.<\/p>\n
\u201cAster had a real good perspective on how important research was for any institution,\u201d said Curtis. He brought in researchers with expertise in blood clotting and bleeding disorders, molecular biology and other areas related to the study of blood.<\/p>\n
Curtis\u2019s own interest in research started when he was a child in Red Oak, Iowa, and took a book titled \u201cHow to Be a Scientist\u201d out of the local public library. \u201cI checked it out about 20 times. I was always curious about the environment and how things worked.\u201d After earning his bachelor\u2019s degree in biology at Iowa State University, and doing training at University of Iowa Hospital & Clinics, he decided the laboratory was where he wanted to be.<\/p>\n
Curtis came to 51ÁÔÆæ while he was working for the blood center because he realized that to become a laboratory director, he would need a doctorate. 51ÁÔÆæ had a strong reputation, and was close enough so that he could continue working while going to school. \u201cFor me, it was perfect.\u201d He worked out an arrangement with the dean and with his major professor that allowed him to use his own lab and include the research he was already doing as part of his doctoral program. \u201cIt was a great program, and I loved it,\u201d Curtis said.<\/p>\n
Curtis is now senior director of the diagnostic hematology group at Versiti, which includes three labs.<\/p>\n
His own research<\/h3>\n
He has also continued his own research with a focus on a blood-related condition called NAIT (neonatal alloimmune thrombocytopenia), which can cause babies to suffer increased risk of bleeding. Similar to the better-known Rh disease, it results from an incompatibility between a mother\u2019s blood \u2013 in this case the platelets \u2013 and the baby\u2019s blood.<\/p>\n
With this and other blood conditions studied at the diagnostic labs, the researchers work closely with doctors and other medical professionals to find ways to translate their work into tests and treatment. Developing testing for blood-related conditions is also an important part of the work. Curtis\u2019s lab, for example, recently helped develop a test called the P-selectin expression assay (PEA) that can help doctors who suspect patients may be having reactions causing large numbers of blood clots related to their immune system\u2019s response to\u00a0 heparin. The test can help detect this problem, called HIT (heparin-induced thrombocytopenia) faster.<\/p>\n
In the more than 30 years he\u2019s been at the blood center, Curtis said, he has seen remarkable advances in the technology that makes such research and treatment possible. DNA testing and the expensive equipment that allows for sequencing of genes in search of causes of diseases is one major advance. In past, he said, doctors would know something was wrong, but they didn\u2019t know why. Now causes of blood disorders can be tracked back to variants in specific genes.<\/p>\n
When new employees come to the blood center, they are amazed at the variety of work being done there, said Curtis. \u201cOne thing they say almost every single time is, \u2018I\u2019ve never worked with so many intelligent people at one place.\u2019\u201d<\/p>\n
His own view: \u201cI still feel the same after 30 years. It\u2019s a really fun place to be. It\u2019s not just a blood center, it\u2019s not just a research institute, it\u2019s not just a diagnostic place, it\u2019s all those things together.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
For Brian Curtis, blood is in his blood. Curtis, who earned his doctorate in health sciences and immunology from 51ÁÔÆæ, is a scientist who is senior director of diagnostic hematology laboratories for Versiti Blood Center of Wisconsin (formerly known as the BloodCenter of Wisconsin). <\/p>\n","protected":false},"author":835,"featured_media":84071,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174],"tags":[],"section":[125,122],"display_categories":[115,116],"related-coverage":[323,307],"uwmnews-feed":[154],"class_list":["post-84070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","section-alumni","section-campus-community","display_categories-top-story-secondary","display_categories-top-story-section","related-coverage-coronavirus","related-coverage-public-health","uwmnews-feed-health-sciences"],"yoast_head":"\n
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