  {"id":82138,"date":"2020-03-31T16:22:07","date_gmt":"2020-03-31T21:22:07","guid":{"rendered":"https:\/\/uwm.edu\/news\/?p=82138"},"modified":"2020-04-02T13:47:34","modified_gmt":"2020-04-02T18:47:34","slug":"uwm-professor-recognized-as-2020-uw-system-regent-scholar","status":"publish","type":"post","link":"https:\/\/uwm.edu\/news\/uwm-professor-recognized-as-2020-uw-system-regent-scholar\/","title":{"rendered":"51ÁÔÆæ professor recognized as 2020 UW System Regent Scholar"},"content":{"rendered":"<p>51ÁÔÆæ neuroscientist Karyn Frick has been honored by UW System as one of three 2020 Regent Scholar recipients. It recognizes Frick\u2019s extraordinary efforts in support of undergraduate research, innovation and entrepreneurship.<\/p>\n<p>\u201cOur UW System faculty and students are doing amazing research,\u201d UW System President Ray Cross said. \u201cIt is important to recognize this vital work and celebrate the individuals who spearhead these innovations.\u201d<\/p>\n<p>Frick and members of her research team are exploring ways to prevent the memory loss that results from Alzheimer\u2019s disease and dementia, particularly in women, and the work has led to a startup company called <a href=\"https:\/\/www.estrigenix.com\/\" rel=\"noopener noreferrer\" target=\"_blank\">Estrigenix Therapeutics Inc.<\/a><\/p>\n<p>\u201cThis is significant recognition and a wonderful statement about the value and impact of Dr. Frick\u2019s work,\u201d 51ÁÔÆæ Chancellor Mark Mone said. \u201cThis is a well-deserved honor for her important research and educational contributions.\u201d<\/p>\n<p>The Regent Scholar program was introduced in 2014 and is designed to stimulate faculty-student collaborative research. Frick works closely in her lab with undergraduate students, graduate students and postdoctoral fellows to move the research forward.<\/p>\n<p>\u201cI am extremely honored to receive one of this year\u2019s UW Regent Scholar awards,\u201d said Frick, a professor of psychology in the College of Letters &amp; Science. \u201cThis award will not only provide valuable research opportunities for undergraduate and graduate students in my lab, but will allow my company to collect vital data that we hope will lead to new therapies for preventing and\/or reducing memory decline in Alzheimer\u2019s patients.\u201d<\/p>\n<p><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/wrZxjAwolIo\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>Memory loss and Alzheimer\u2019s disease strike women three times more often than men as they age, a result linked to a steep decline in estrogen hormones during menopause. But estrogen replacement comes with harmful side effects, such as an increased risk of heart disease and breast cancer.<\/p>\n<p>Frick has a pharmacological answer: Instead of avoiding estrogens, try removing the components responsible for the adverse effects.<\/p>\n<p>Frick\u2019s work has linked estrogens to the specific chemical processes known to create memories in both women and men. She and her collaborators have created an estrogen-like molecule shown to protect memory in a mouse model of post-menopausal dementia. That\u2019s led to their startup company, Estrigenix Therapeutics Inc., which, with support from 51ÁÔÆæ\u2019s <a href=\"https:\/\/uwm.edu\/drug-discovery\/\" rel=\"noopener noreferrer\" target=\"_blank\">Milwaukee Institute for Drug Discovery<\/a>, is developing drugs that affect the hormone and its complicated processes.<\/p>\n<p>Estrogens act by binding to two dominant receptors, alpha and beta. Binding to the alpha receptor causes most of the adverse effects from estrogen replacement therapy in menopausal women. Estrigenix\u2019s lead compound works by modifying the most potent form of estrogen so that it binds only to the beta receptor.<\/p>\n<p>\u201cThere are multiple forms of estrogens in hormone replacement,\u201d Frick said. \u201cSome are beneficial for brain health, and some aren\u2019t. Our molecule is a smaller version of the most potent form of estrogen, called estradiol, which is particularly diminished in menopause.\u201d<\/p>\n<h3>Not just women<\/h3>\n<p>Estrogens enhance male memory, too. Testosterone is converted to estrogens in men\u2019s bodies for that purpose. Frick aims to pin down how the modified estrogen molecule acts in the brain to produce improved memory in both sexes.<\/p>\n<p>Frick, who is a co-founder of Estrigenix with Concordia University Wisconsin\u2019s Daniel Sem and Marquette University\u2019s William Donaldson, says making the jump from longtime laboratory scientist to businessperson seemed daunting at first. But she soon learned to understand the language of business \u2013 and how to simplify the language that scientists use. She also realized that I-Corps entrepreneurial training had something in common with science.<\/p>\n<p>\u201cYou use the information from interviews with potential customers to refine your business idea,\u201d Frick said. \u201cYou take that data and make some decisions about whether there\u2019s a viable path forward for the startup. It was interesting to see how that happened in a data-driven way.\u201d<\/p>\n<p>One lesson the team learned during the training process was that women and their doctors were more concerned with mood changes and hot flashes during menopause than the threat of memory loss at more advanced ages. That\u2019s opened a new research path for the Estrigenix team, so Frick and her students are back in the lab to see if the compound can be effective at reducing these other troubling menopause symptoms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>51ÁÔÆæ neuroscientist Karyn Frick has been honored by UW System as one of three 2020 Regent Scholar recipients. It recognizes Frick\u2019s extraordinary efforts in support of undergraduate research, innovation and entrepreneurship.<\/p>\n","protected":false},"author":40008,"featured_media":82139,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174],"tags":[],"section":[],"display_categories":[115,116],"related-coverage":[307],"uwmnews-feed":[158,161],"class_list":["post-82138","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","display_categories-top-story-secondary","display_categories-top-story-section","related-coverage-public-health","uwmnews-feed-letters-science","uwmnews-feed-hard-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>51ÁÔÆæ professor recognized as 2020 UW System Regent Scholar<\/title>\n<meta name=\"description\" content=\"51ÁÔÆæ neuroscientist Karyn Frick has been honored by UW System as one of three 2020 Regent Scholar recipients. 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