{"id":62784,"date":"2018-09-24T10:00:55","date_gmt":"2018-09-24T15:00:55","guid":{"rendered":"https:\/\/uwm.edu\/news\/?p=62784"},"modified":"2018-10-02T09:29:46","modified_gmt":"2018-10-02T14:29:46","slug":"bioxfel-research-gets-renewed-funding","status":"publish","type":"post","link":"https:\/\/uwm.edu\/news\/bioxfel-research-gets-renewed-funding\/","title":{"rendered":"BioXFEL research gets renewed funding"},"content":{"rendered":"<p>How do proteins execute a task? How do they interact with one another? How do viruses and bacteria affect proteins to infect a cell? Until recently these questions went unanswered because scientists could not image most proteins.<\/p>\n<p>Then the National Science Foundation created a Science and Technology Center which includes researchers from nine institutions, including 51ÁÔÆæ, who use X-ray Free Electron Lasers (XFELs) to create slow-motion movies of molecular events happening at split-second timescales.<\/p>\n<figure id=\"attachment_62785\" aria-describedby=\"caption-attachment-62785\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-62785\" src=\"https:\/\/uwm.edu\/news\/wp-content\/uploads\/sites\/41\/2018\/09\/bioxfelPhysics.STC_.774-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" \/><figcaption id=\"caption-attachment-62785\" class=\"wp-caption-text\">51ÁÔÆæ faculty working in the BioXFEL Science and Technology Center are (clockwise from left) Abbas Ourmazd, Marius Schmidt, Dilano Saldin, Peter Schwander and senior scientist Russell Fung. Besides 51ÁÔÆæ, members include the University at Buffalo, its Hauptman-Woodward Medical Research Institute, Arizona State University, Stanford, Cornell, Rice, the University of California, San Francisco, and Miami University in Ohio. (51ÁÔÆæ Photo\/Troye Fox)<\/figcaption><\/figure>\n<p>Called BioXFEL, the center researchers are now capturing biology at the atomic level \u2013 processes that are difficult, if not impossible, to see with other methods. NSF <a href=\"https:\/\/www.bioxfel.org\/news\/331-nsf-awards-22-5-million-to-capture-biology-at-the-atomic-level-using-x-ray-lasers\" rel=\"noopener\" target=\"_blank\">has just renewed $22.5 million funding<\/a> forBioXFEL so members will continue work they began in 2013.<\/p>\n<p>The XFEL produces incredibly intense X-rays in extremely short pulses. It allows scientists to see essential processes, like how drugs bind or how proteins work, at rates as fast as a billionth of a billionth of a second.<\/p>\n<p>Here are two 51ÁÔÆæ accomplishments achieved using the XFEL at the SLAC National Accelerator Laboratory in California:<\/p>\n<p><strong>Abbas Ourmazd, distinguished professor of physics<\/strong><\/p>\n<p>Most viruses are too small to be photographed by light. The XFEL\u2019s intense X-ray flashes produce \u201csnapshots\u201d of particles at the nanoscale through diffraction. The X-rays hit the particle and scatter in a pattern that provides the data for mathematical reconstruction.<\/p>\n<p>Ourmazd and his lab members provide the data science necessary to transform the millions of still, two-dimensional images the XFEL equipment generates into clear, sequential, 3D movies through the BioXFEL collaboration.<\/p>\n<p>For example, Ourmazd\u2019s lab has made possible never-before-seen, 3D movies of a virus preparing to infect a healthy cell. \u201cOur approach is a powerful means of mining huge amounts of data to get information about specific, rare events,\u201d he said.<\/p>\n<p><strong>Marius Schmidt, professor of physics<\/strong><\/p>\n<p>The bacteria that causes tuberculosis are particularly difficult to treat because they are often antibiotic resistant. But in order to design drugs that foil resistance, scientists first have to know how the bacterium disables the antibiotic at the atomic level.<\/p>\n<p>In experiments led by Schmidt, a team of BioXFEL researchers mixed an antibiotic with an enzyme, a class of proteins that TB bacteria produce to protect themselves. Then they watched in real time as the enzyme attacked the antibiotic molecule and burst one of its chemical bonds.<\/p>\n<p>\u201cThis proof-of-concept study shows that we\u2019re able to see the shape and intermediate stages of the molecules during the process,\u201d said Schmidt, who recently participated in the first experiment at the European X-ray Free-Electron Laser which is an order of magnitude speedier than SLAC\u2019s.<\/p>\n<p>\u201cAfter decades of trying other techniques in the field of crystallography, the technology is now here.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>National Science Foundation&#8217;s Science and Technology Center includes researchers from nine institutions, including 51ÁÔÆæ. NSF has just renewed $22.5 million funding forBioXFEL so members will continue work they began in 2013.<\/p>\n","protected":false},"author":836,"featured_media":62785,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174,200,175],"tags":[],"section":[140,139],"display_categories":[],"related-coverage":[282],"uwmnews-feed":[158,161],"class_list":["post-62784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-news-in-brief","category-research","section-science","section-science-technology","related-coverage-physics","uwmnews-feed-letters-science","uwmnews-feed-hard-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>BioXFEL research gets renewed funding<\/title>\n<meta name=\"description\" content=\"National Science Foundation&#039;s Science and Technology Center includes researchers from nine institutions, including 51ÁÔÆæ. NSF has just renewed $22.5 million funding forBioXFEL so members will continue work they began in 2013.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/news\/bioxfel-research-gets-renewed-funding\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BioXFEL research gets renewed funding\" \/>\n<meta property=\"og:description\" content=\"National Science Foundation&#039;s Science and Technology Center includes researchers from nine institutions, including 51ÁÔÆæ. NSF has just renewed $22.5 million funding forBioXFEL so members will continue work they began in 2013.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/uwm.edu\/news\/bioxfel-research-gets-renewed-funding\/\" \/>\n<meta property=\"og:site_name\" content=\"51ÁÔÆæ REPORT\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-24T15:00:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-02T14:29:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uwm.edu\/news\/wp-content\/uploads\/sites\/41\/2018\/09\/bioxfelPhysics.STC_.774.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laura Otto\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@51ÁÔÆæNews\" \/>\n<meta name=\"twitter:site\" content=\"@51ÁÔÆæNews\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laura Otto\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/\"},\"author\":{\"name\":\"Laura Otto\",\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/#\\\/schema\\\/person\\\/2f360a26f3df4ff8f31b58e43d772565\"},\"headline\":\"BioXFEL research gets renewed funding\",\"datePublished\":\"2018-09-24T15:00:55+00:00\",\"dateModified\":\"2018-10-02T14:29:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/\"},\"wordCount\":516,\"publisher\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uwm.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/41\\\/2018\\\/09\\\/bioxfelPhysics.STC_.774.jpg\",\"articleSection\":[\"News\",\"News in Brief\",\"Research\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/\",\"url\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/\",\"name\":\"BioXFEL research gets renewed funding\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/uwm.edu\\\/news\\\/bioxfel-research-gets-renewed-funding\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uwm.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/41\\\/2018\\\/09\\\/bioxfelPhysics.STC_.774.jpg\",\"datePublished\":\"2018-09-24T15:00:55+00:00\",\"dateModified\":\"2018-10-02T14:29:46+00:00\",\"description\":\"National Science Foundation's Science and Technology Center includes researchers from nine institutions, including 51ÁÔÆæ. 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