{"id":60056,"date":"2018-06-25T13:53:36","date_gmt":"2018-06-25T18:53:36","guid":{"rendered":"https:\/\/uwm.edu\/news\/?p=60056"},"modified":"2019-07-16T14:21:39","modified_gmt":"2019-07-16T19:21:39","slug":"uwm-researcher-helps-reveal-new-genes-associated-with-breast-cancer-risk","status":"publish","type":"post","link":"https:\/\/uwm.edu\/news\/uwm-researcher-helps-reveal-new-genes-associated-with-breast-cancer-risk\/","title":{"rendered":"51ÁÔÆæ researcher helps reveal new genes associated with breast cancer risk"},"content":{"rendered":"<p>Only a small percentage of breast cancer cases can be linked to heredity, and many of the genes with ties to the disease are unknown.<\/p>\n<p>But findings from a new study point to probable new genes for susceptibility.<\/p>\n<p>An international team of researchers, including Paul Auer at UW-Milwaukee, has recently identified 48 genes associated with a woman\u2019s predisposition to breast cancer \u2013 34 that were implicated in previous research and 14 new genes.<\/p>\n<figure id=\"attachment_60057\" aria-describedby=\"caption-attachment-60057\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-60057 size-medium\" src=\"https:\/\/uwm.edu\/news\/wp-content\/uploads\/sites\/41\/2018\/06\/Paul-Auer300x200-20180606_TCF_IMC_FH0A3697-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" \/><figcaption id=\"caption-attachment-60057\" class=\"wp-caption-text\">Paul Auer<\/figcaption><\/figure>\n<p>Led by Lang Wu at the Vanderbilt University School of Medicine and Wei Shi at the QIMR Berghofer Medical Research Institute in Australia, the work included nearly 200 researchers. It <a href=\"http:\/\/www.nature.com\/articles\/s41588-018-0132-x\" rel=\"noopener noreferrer\" target=\"_blank\">was published online<\/a>\u00a0in the journal Nature Genetics on June 18.<\/p>\n<p>Using data science models that predict gene expression in breast cancer tissue and data from The <a href=\"https:\/\/cancergenome.nih.gov\/\" rel=\"noopener noreferrer\" target=\"_blank\">Cancer Genome Atlas<\/a>, the researchers looked at 229,000 subjects of European ancestry, some with cancer and some without.<\/p>\n<p>Researchers further investigated the genetic pathways involved to uncover biological processes that may go awry during breast cancer development.\u00a0In laboratory experiments, they found that when some of the genes were \u201csilenced,\u201d breast cancer cells failed to grow.<\/p>\n<p>This big data statistical detective work is becoming an increasingly important part of health care as researchers comb through genetic information and large-scale, long-term compilations of medical records to establish links between genes and disease, said Auer, an associate professor of biostatistics at 51ÁÔÆæ\u2019s Zilber School of Public Health.<\/p>\n<p>\u201cThis paper demonstrates how a new statistical technique can be used to identify genes related to the genetic predisposition to breast cancer,\u201d he said. \u201cThe results from this study contribute to\u00a0a deeper understanding of the genetics and biology of breast cancer and could lead to\u00a0improved preventive and therapeutic strategies.\u201d<\/p>\n<p>Auer\u2019s data science expertise is often conducted in collaboration with larger teams of researchersto analyze millions of genes to try to isolate variations that are linked to disease. Besides breast cancer, he has applied mathematical tools to sort the ocean of human genomic information for links to heart disease, obesity and sickle cell anemia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international team of researchers, including Paul Auer at UW-Milwaukee, has recently identified 48 genes associated with a woman\u2019s predisposition to breast cancer \u2013 34 that were implicated in previous research and 14 new genes.<\/p>\n","protected":false},"author":40008,"featured_media":60057,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174,200,175],"tags":[],"section":[135,137],"display_categories":[],"related-coverage":[320,284],"uwmnews-feed":[167,166],"class_list":["post-60056","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-news-in-brief","category-research","section-health","section-public-health","related-coverage-data-science","related-coverage-health-wellness","uwmnews-feed-alumni-association","uwmnews-feed-public-health"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>51ÁÔÆæ researcher helps reveal new genes associated with breast cancer risk<\/title>\n<meta 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