{"id":146219,"date":"2026-01-26T10:41:23","date_gmt":"2026-01-26T16:41:23","guid":{"rendered":"https:\/\/uwm.edu\/news\/?p=146219"},"modified":"2026-01-30T10:50:28","modified_gmt":"2026-01-30T16:50:28","slug":"uwm-researcher-studies-zebrafish-to-better-understand-brain-development","status":"publish","type":"post","link":"https:\/\/uwm.edu\/news\/uwm-researcher-studies-zebrafish-to-better-understand-brain-development\/","title":{"rendered":"51ÁÔÆæ researcher studies zebrafish to better understand brain development"},"content":{"rendered":"

Gabby Voit has always been fascinated by biology. As a child, her brothers frequently brought home wild frogs and snakes. \u201cI would always make sure they were fed, had ample outdoor time, and that they were returned to the wild,\u201d she said.<\/p>\n

Today, Voit still works with animals \u2014 but with the goal of learning about human health. After graduating from high school in 2016, Voit studied genetics at UW-Madison. Her undergraduate studies focused on the early development of zebrafish, and how genetic mutations in the fish may explain genetic fertility issues in women.<\/p>\n

\u201cBecause zebrafish share many genetic traits with humans, they\u2019re a good model organism for understanding genetic activity during early human development,\u201d Voit said. Plus, because zebrafish are transparent, scientists can easily observe gestational changes in real time.<\/p>\n

Developing a research niche<\/h2>\n

Searching for PhD options, 51ÁÔÆæ was a natural choice. Voit grew up around the corner from 51ÁÔÆæ, and her dad taught in what is now the Lubar College of Business<\/a>. But it was the Gutzman Lab<\/a> \u2014 led by Professor Jennifer Gutzman,<\/a> who also studies the genetics of zebrafish \u2014 that ultimately convinced Voit to return to Milwaukee in 2021.<\/p>\n

\u201cI knew one of the most important things about picking a grad school is who your mentor is going to be, and I had heard from previous students that Dr. Gutzman was very hands-on and enthusiastic,\u201d Voit said.<\/p>\n

Her graduate studies at 51ÁÔÆæ explore the first full day of development (equivalent to about four weeks gestation in humans). In her first year, Voit and another researcher discovered a specific mutation that correlates to abnormal folding in the brain.<\/p>\n

\u201cIf one area doesn\u2019t structure correctly, it can lead to many implications later on in life, including developmental disabilities,\u201d she said.<\/p>\n

These genetic discoveries, Voit added, can help scientists better understand which genes are important for human development and which genetic mutations are linked to human conditions, from autism to cancer.<\/p>\n

Impacting human health<\/h2>\n

Now a third-year student, Voit has been awarded a Shaw Doctoral Fellowship and Advanced Opportunity Fellowship, two merit-based awards to help fund her research. She\u2019s currently leading research to understand physical forces that cause zebrafish\u2019s brain tissue to fold, a crucial step in healthy brain development.<\/p>\n

If something is awry in this process, the tissue may not fold correctly, which could lead to problems with brain function that contribute to disease in both zebrafish and people. \u201cMy goal is to discover genes that might be involved in this process so I can help lay groundwork that allows scientists to better help humans,\u201d she said.<\/p>\n

Voit is set to graduate from 51ÁÔÆæ with her PhD in Spring 2026. She\u2019s not quite sure what the future will hold \u2014 whether she\u2019ll apply the teaching skills she gained as a teaching assistant, lead a lab of her own, or combine her research interest with health care and work in clinical trials that help medical experts learn more about how to treat diseases.<\/p>\n

No matter where she ends up, she hopes the knowledge she gains will have a lasting impact. \u201cUnderstanding genetics, we\u2019re uncovering the blueprint of life itself,\u201d said Voit. \u201cThat can then lead to new breakthroughs in medicine, ultimately improving health outcomes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

51ÁÔÆæ PhD student Gabby Voit is leading research in the Gutzman Lab, where researchers study zebrafish to better understand brain function in humans. <\/p>\n","protected":false},"author":38221,"featured_media":146220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174,175,361],"tags":[],"section":[135],"display_categories":[352,116],"related-coverage":[284,362],"uwmnews-feed":[158,153,161],"class_list":["post-146219","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research","category-waves-stories","section-health","display_categories-top-story-tertiary","display_categories-top-story-section","related-coverage-health-wellness","related-coverage-make-new-waves","uwmnews-feed-letters-science","uwmnews-feed-graduate","uwmnews-feed-hard-science"],"yoast_head":"\n51ÁÔÆæ PhD student uses 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