  {"id":130321,"date":"2024-02-19T11:37:57","date_gmt":"2024-02-19T17:37:57","guid":{"rendered":"https:\/\/uwm.edu\/news\/?p=130321"},"modified":"2024-02-29T13:12:48","modified_gmt":"2024-02-29T19:12:48","slug":"inaugural-chancellor-chat-explores-uwm-scientists-groundbreaking-research","status":"publish","type":"post","link":"https:\/\/uwm.edu\/news\/inaugural-chancellor-chat-explores-uwm-scientists-groundbreaking-research\/","title":{"rendered":"Inaugural Chancellor Chat explores 51ÁÔÆæ scientist\u2019s groundbreaking research"},"content":{"rendered":"<p>51ÁÔÆæ research is making a difference, and 51ÁÔÆæ Chancellor Mark Mone is sharing what\u2019s happening in a series of Chancellor Chats.<\/p>\n<p>Karyn Frick, distinguished professor of psychology, <a href=\"https:\/\/www.youtube.com\/watch?v=s5S5TBuIOhQ\" rel=\"noopener\" target=\"_blank\">joined Mone for the inaugural chat<\/a> on Wednesday, Feb. 14. The two discussed Frick\u2019s groundbreaking research on the impact of estrogens in regulating memory formation and brain function. Future chats will include other researchers, scientists, alumni and partners.<\/p>\n<p>Mone and Frick talked about her work and offered the roomful of listeners, who gathered in the 51ÁÔÆæ Student Union\u2019s Alumni Fireside Lounge, the chance to ask questions about aging, brain function and dementia.<\/p>\n<p>\u201cOur memories make us who we are,\u201d Frick said. \u201cEveryone has different memories. That\u2019s what makes us all unique.\u201d<\/p>\n<p>Frick\u2019s Neuroendocrinology of Memory Lab focuses on understanding the brain mechanisms that underlie memory formation so that she can use this information to develop treatments that reduce age-related memory loss and dementia in Alzheimer\u2019s disease. She is primarily interested in how estrogens enhance memory formation and how estrogen loss at menopause leads to symptoms like memory loss and hot flashes.<\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/s5S5TBuIOhQ?si=c8gQhqIP-HtV7nog\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>This work led Frick to co-found Estrigenix Therapeutics Inc., a pharmaceutical company focused on developing treatments for menopausal women that provide the benefits of estrogens without the harmful side effects of traditional hormone therapies. Frick serves as chief scientific officer for Estrigenix, which was founded in 2018 with support from the 51ÁÔÆæ Lubar Entrepreneurship Center and the 51ÁÔÆæ Research Foundation.<\/p>\n<p>The lab\u2019s research has shown that estrogens can promote memory formation and reduce memory dysfunction in animal models of age-related memory loss and disease processes like dementia and Alzheimer\u2019s.<\/p>\n<p>\u201cMemory loss is not inevitable,\u201d she added. Senior moments are normal, and many people stay mentally sharp well into old age, she said. It becomes an issue when it begins to interfere with daily life.<\/p>\n<p>Although the lab\u2019s research focuses on women, both men and women produce estrogens as part of normal hormonal functions. The goal of the research is to understand the neurobiological mechanisms through which estrogens regulate memory so that this information can be used to develop estrogen-like compounds to alleviate memory loss.<\/p>\n<p>One challenge, Frick explained, is that traditional hormone therapies for women came under scrutiny in the early 2000s when clinical studies showed increased chances of breast and uterine cancers in some elderly women.<\/p>\n<p>Future treatments will need to overcome these issues. Frick and Estrigenix hope to do so by targeting a certain protein that binds estrogens and promotes memory without causing cancerous cell proliferation.<\/p>\n<p>The effort is complicated, requiring research from the fields of biology, chemistry, physics and other scientific fields, Frick said.<\/p>\n<p>She\u2019s quick to point out that she is not the only one doing the work at 51ÁÔÆæ. The lab includes research projects involving graduate students, postdoctoral students and undergraduates. She and others in the lab also collaborate with scientists from other universities on a variety of projects.<\/p>\n<p>\u201cScience is always evolving,\u201d Frick said, and these collaborative efforts are making a difference.<\/p>\n<p>All of this research makes Frick hopeful that new therapies will be developed for Alzheimer\u2019s and other progressive memory conditions within the next five to 10 years.<\/p>\n<p>\u201cIf we can identify the mechanisms, then we can develop better treatments,\u201d she said.<\/p>\n<p>Participants in the Chancellor\u2019s Chat asked Frick about everything from alleviating menopausal symptoms to the use of herbal remedies and phytoestrogens to federal funding for this type of research.<\/p>\n<p>One major question: \u201cWhat can people do to prevent memory loss as they age?\u201d<\/p>\n<p>The answer, according to Frick, is a healthy lifestyle. Improved diet and regular exercise can help with brain function as well as cardiovascular disease and other conditions that may affect the health of the blood vessels that feed the brain. Making changes at any time can help, she added. \u201cIt\u2019s never too late.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>51ÁÔÆæ Chancellor Mark Mone and Karyn Frick discussed her groundbreaking estrogen research at the inaugural Chancellor Chat.<\/p>\n","protected":false},"author":835,"featured_media":130322,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[174],"tags":[],"section":[135],"display_categories":[352,116],"related-coverage":[],"uwmnews-feed":[158],"class_list":["post-130321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","section-health","display_categories-top-story-tertiary","display_categories-top-story-section","uwmnews-feed-letters-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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