{"id":14986,"date":"2025-05-05T11:19:27","date_gmt":"2025-05-05T16:19:27","guid":{"rendered":"https:\/\/uwm.edu\/math\/?post_type=tribe_events&p=14986"},"modified":"2025-05-05T11:19:27","modified_gmt":"2025-05-05T16:19:27","slug":"ms-thesis-defense-mr-micah-hesketh","status":"publish","type":"tribe_events","link":"https:\/\/uwm.edu\/math\/event\/ms-thesis-defense-mr-micah-hesketh\/","title":{"rendered":"MS Thesis Defense: Mr. Micah Hesketh"},"content":{"rendered":"

\"\"Compartmental Ordinary Differential Equation Model of the Amyloid-beta Cascade Hypothesis in Transgenic TgF-344AD Rats<\/h1>\n

Mr. Micah Hesketh
\nGraduate Student<\/em>
\nUniversity of Wisconsin-Milwaukee<\/p>\n

Alzheimer\u2019s disease is a devastating neurodegenerative disease whose etiology is poorly understood and for which current treatments provide modest control of symptoms. There are many different hypotheses which seek to explain the cause of this disease, one of which is the Amyloid-beta cascade hypothesis. To better investigate the causes and progression of the disease, animal models have been developed, notably the transgenic TgF344-AD rat. We combine observations on the accumulation of amyloid-beta, changes in neuronal density, and a decline in cognitive performance in rats with a simple compartmental ordinary differential equation model based on the Amyloid-beta cascade hypothesis.<\/p>\n

Advisor:
\nPeter Hinow<\/p>\n

Committee Members:
\nDr. Peter Hinow, Dr. Gabriella Pinter, and Dr. Lijing Sun<\/p>\n","protected":false},"excerpt":{"rendered":"

Compartmental Ordinary Differential Equation Model of the Amyloid-beta Cascade Hypothesis in Transgenic TgF-344AD Rats Mr. Micah Hesketh Graduate Student University of Wisconsin-Milwaukee Alzheimer\u2019s disease is a devastating neurodegenerative disease whose etiology is poorly understood and for which current treatments provide …<\/p>\n","protected":false},"author":4217,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","uwm_wg_additional_authors":[]},"tags":[],"tribe_events_cat":[64],"class_list":["post-14986","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-graduate-student-defenses","cat_graduate-student-defenses"],"yoast_head":"\nMathematical Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/math\/event\/ms-thesis-defense-mr-micah-hesketh\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MS Thesis Defense: Mr. Micah Hesketh\" \/>\n<meta property=\"og:description\" content=\"Compartmental Ordinary Differential Equation Model of the Amyloid-beta Cascade Hypothesis in Transgenic TgF-344AD Rats Mr. Micah Hesketh Graduate Student University of Wisconsin-Milwaukee Alzheimer\u2019s disease is a devastating neurodegenerative disease whose etiology is poorly understood and for which current treatments provide …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/uwm.edu\/math\/event\/ms-thesis-defense-mr-micah-hesketh\/\" \/>\n<meta property=\"og:site_name\" content=\"Mathematical Sciences\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uwm.edu\/math\/wp-content\/uploads\/sites\/112\/2025\/05\/BANNER-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"984\" \/>\n\t<meta property=\"og:image:height\" content=\"504\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/uwm.edu\\\/math\\\/event\\\/ms-thesis-defense-mr-micah-hesketh\\\/\",\"url\":\"https:\\\/\\\/uwm.edu\\\/math\\\/event\\\/ms-thesis-defense-mr-micah-hesketh\\\/\",\"name\":\"MS Thesis Defense: Mr. Micah Hesketh - 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