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DTSTART;TZID=America/Chicago:20240308T140000
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DTSTAMP:20260421T161428
CREATED:20240213T184556Z
LAST-MODIFIED:20240229T211321Z
UID:10016138-1709906400-1709910000@uwm.edu
SUMMARY:Colloquium: Dr. Emmanuel Asante-Asamani
DESCRIPTION:A Mechanochemical Model of Cell Migration in Confined Environments\nDr. Emmanuel Asante-Asamani\nAssistant Professor of Mathematics\nClarkson University \nEukaryotic cells can move in confined environments by using pressure driven protrusions of their cell membrane\, a motility mechanism known as blebbing. Blebbing has been observed to facilitate the movement of tumor cells and some cancer cells during metastasis. Many questions remain unanswered about how cells translate mechanical cues from their environment into coordinated movement during blebbing. Of particular interest is how proteins that link the cell membrane to the cortex regulate the size and frequency of blebs under different levels of environmental confinement. In this talk\, I will present a multiscale model of bleb expansion that treats the cell as a viscous fluid encased by a viscoelastic boundary\, whose mechanical properties are regulated by dynamic structural and motor proteins. Numerical simulation of this model supports experimental data suggesting\, contrary to intuition\, that weakening the adhesion of the cell membrane to the cortex produces smaller and less frequent blebs.
URL:/math/event/colloquium-dr-emmanuel-asante-asamani/
LOCATION:EMS Building\, EMS E495\, 3200 Cramer St\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
ORGANIZER;CN="The Department of Mathematical Sciences":MAILTO:math-staff@uwm.edu
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