BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Mathematical Sciences - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:/math
X-WR-CALDESC:Events for Mathematical Sciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20240310T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20241103T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20250309T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20251102T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20260308T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20261101T070000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250417T130000
DTEND;TZID=America/Chicago:20250417T140000
DTSTAMP:20260418T230855
CREATED:20250114T155559Z
LAST-MODIFIED:20250312T210355Z
UID:10016204-1744894800-1744898400@uwm.edu
SUMMARY:Marden Colloquium: Dr. Trachette Jackson
DESCRIPTION:Agent-based Modeling of Dysregulated Cell Signaling and the Tumor-Immune Landscape Predicts New Possibilities for Combination Therapy\nDr. Trachette Jackson\nProfessor of Mathematics and Associate Vice President for Research – Strategic Partnerships and Inclusive Excellence\nUniversity of Michigan \nMathematical models\, specifically agent-based models (ABMs)\, have shown recent successes in uncovering the multiscale dynamics that shape the trajectory of cancer. They have enabled the optimization of treatment methods and the identification of novel therapeutic strategies. To assess the combined effects on tumor growth and the immune response of monoclonal antibodies that boost the immune system (immunotherapy) and small molecule inhibitors (SMI) that counteract the effect of driver mutations\, we build and analyze an ABM that captures key facets of tumor heterogeneity and immune cell dynamics\, their spatial interactions\, and their response to therapeutic pressures. Our model predicts that under certain conditions\, immunotherapy alone is optimal; in others\, immunotherapy followed by mutation-targeted therapy is best. These results suggest that optimal treatment depends on the strength of cellular signaling pathways and highlight the need to quantify mutation-dependent cell signaling and the fitness advantage conferred on cancer cells harboring these mutations.
URL:/math/event/marden-colloquium-dr-trachette-jackson/
LOCATION:EMS Building\, EMS E495\, 3200 Cramer St\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
ORGANIZER;CN="The Department of Mathematical Sciences":MAILTO:math-staff@uwm.edu
X-TRIBE-STATUS:
END:VEVENT
END:VCALENDAR