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DTSTART;TZID=America/Chicago:20250502T140000
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CREATED:20250429T195832Z
LAST-MODIFIED:20250429T200112Z
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SUMMARY:Colloquium: Prof. Yangjin Kim
DESCRIPTION:Cytokine Shield Formation in Tumor Growth by Blocking Chemotactic Migration of T Cells in Response to CXCL12 from Senescent Tumor Cells\nProf. Yangjin Kim\nProfessor\nBrown University \nCellular senescence can induce dual effects (promotion or inhibition) on cancer progression. While immune cells naturally respond and migrate toward various chemotactic sources from the tumor mass\, various factors including senescent tumor cells (STCs) in the tumor microenvironment (TME) may affect this chemotactic movement. In this work\, we investigate the mutual interactions between the tumor cells and the immune cells (T cells and macrophages) that either inhibit or facilitate tumor growth by developing a mathematical model that consists of taxis-reaction-diffusion equations and receptor kinetics for the key players in the interaction network. We first apply a mathematical model to a transwell Boyden chamber invasion assay used in the experiments to illustrate that STCs can play a pivotal role in negating immune attack through tight regulation of intra- and extra-cellular signaling molecules. The mathematical model consists of a system of parabolic-hyperbolic PDEs with two separate model domains based on experimental setting empirical data. Neuman B.C. on the outer boundary and Interface B.C. from homogenization of holes of various sizes on porous membrane are assigned. In particular\, we show that senescent tumor cells in cell cycle arrest can block intratumoral infiltration of CD8+ T cells by secreting a high level of CXCL12\, which leads to significant reduction its receptors\, CXCR4\, on T cells\, and thus impaired chemotaxis. Macrophages also play an important role in mediating or inhibiting given signaling pathways between different cells in TME. The predictions of nonlinear responses to CXCL12 were in good agreement with experimental data. We tested several hypotheses on immune-tumor interactions under various biophysical- and biochemical- conditions in the tumor microenvironment and developed new concepts for anti-tumor strategies targeting senescence induced immune impairment. \n 
URL:/math/event/colloquium-yaangjin-kim/
LOCATION:EMS Building\, E495\, 3200 N Cramer St\, Milwaukee\, WI\, United States
CATEGORIES:Colloquia
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CREATED:20250507T133644Z
LAST-MODIFIED:20250507T134001Z
UID:10016228-1747404000-1747407600@uwm.edu
SUMMARY:Colloquium: Prof. Christian Wolf
DESCRIPTION:  \nMeasures of Maximal Entropy on Coded Shift Spaces: Uniqueness and Computability\nProf. Christian Wolf\nExecutive Officer and Professor\nCUNY Graduate Center and City College \nIn this talk\, we present results about the uniqueness and computability of measures of maximal entropy on coded shift spaces. A coded shift space is defined as the closure of all bi-infinite concatenations of words from a fixed countable generating set. We derive sufficient conditions for the uniqueness of measures of maximal entropy based on the partition of the coded shift into its concatenation set (sequences that are concatenations of generating words) and its residual set (sequences added under the closure). We also discuss flexibility results for the entropy on the concatenation and residual sets. Next\, we present a local structure theorem for intrinsically ergodic coded shift spaces\, which shows that our results apply to a larger class of coded shift spaces compared to previous works by Climenhaga\, Climenhaga and Thompson\, and Pavlov. Finally\, if time permits\, we discuss the computability (in the sense of computable analysis) of measures of maximal entropy for coded shift spaces. The results presented in this talk are joint work with Tamara Kucherenko and Martin Schmoll. \n  \n 
URL:/math/event/colloquium-prof-christian-wolf/
LOCATION:EMS Building\, E495\, 3200 N Cramer St\, Milwaukee\, WI\, United States
CATEGORIES:Colloquia
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