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DTSTART;TZID=America/Chicago:20250207T140000
DTEND;TZID=America/Chicago:20250207T150000
DTSTAMP:20260419T003623
CREATED:20250113T152507Z
LAST-MODIFIED:20250127T142333Z
UID:10016196-1738936800-1738940400@uwm.edu
SUMMARY:Colloquium: Ning Wei
DESCRIPTION:The Impact of Ephaptic Coupling and Ionic Electrodiffusion on Arrhythmogenesis in the Heart\nNing Wei\nAssistant Professor\nPurdue University \nCardiac myocytes synchronize through electrical signaling to contract heart muscles\, facilitated by gap junctions (GJs) in the intercalated disc (ID). GJs provide low-resistance pathways for electrical impulse propagation between myocytes\, serving as the primary mechanism for electrical communication in the heart. However\, research indicates that conduction can persist without GJs. For instance\, GJ knockout mice still exhibit slow\, discontinuous electrical propagation\, suggesting alternative communication mechanisms. Ephaptic coupling (EpC) serves as an alternative way for cell communication\, relying on electrical fields within narrow clefts between neighboring myocytes. Studies show that EpC can enhance conduction velocity (CV) and reduce conduction block (CB)\, especially when GJs are compromised.  Reduced GJs and significant electrochemical gradients are prevalent in various heart diseases. However\, existing models often fail to capture their combined influence on cardiac conduction\, which limits our understanding of both the physiological and pathological aspects of the heart.  Our study aims to address this gap by developing a two-dimensional (2D) multidomain electrodiffusion model that incorporates EpC. This is the first model to capture the dynamics of all ions across multiple domains\, enabling us to reveal the impact of EpC in the heart. In particular\, we investigated the interplay between ionic electrodiffusion and EpC on action potential propagation\, morphology\, electrochemical properties and arrhythmogenesis in both healthy and ischemic hearts. Our findings indicate that ionic electrodiffusion enhances CV and reduces CB under strong EpC. Specifically\, the electrodiffusion of Ca2+ and K+ intensifies the effects of EpC on action potential morphology\, whereas Na+ diffusion mitigates these effects. Ionic electrodiffusion also facilitates action potential propagation into ischemic regions when EpC is substantial. Moreover\, strong EpC can effectively terminate reentry\, prevent its initiation\, and lower the maximum dominant frequency (max DF)\, irrespective of GJ functionality. However\, weak EpC may help counteract proarrhythmic effects when GJ coupling is slightly to moderately reduced\, contributing to the stabilization of conduction patterns.  Additionally\, strong EpC  notably alters ionic concentrations in the cleft\, significantly increasing [K+] and nearly depleting [Ca2+]\, while causing moderate changes in [Na+]. This multidomain electrodiffusion model sheds light on the mechanisms of EpC in the heart. 
URL:/math/event/colloquium-ning-wei/
LOCATION:EMS Building\, E495\, 3200 N Cramer St\, Milwaukee\, WI\, United States
CATEGORIES:Colloquia
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250214T140000
DTEND;TZID=America/Chicago:20250214T153000
DTSTAMP:20260419T003623
CREATED:20250205T144814Z
LAST-MODIFIED:20250205T144814Z
UID:10016206-1739541600-1739547000@uwm.edu
SUMMARY:Colloquium: Dr. Alexander Wilson
DESCRIPTION:Symmetries and Diagram Algebras\nDr. Alexander Wilson\nVisiting Assistant Professor of Mathematics\nOberlin College \nIn this talk I will introduce you to the world of symmetric group representations through diagram algebras\, which trace their origin to the Temperley-Lieb algebra with applications in integrable models\, knot theory\, and quantum groups. For representation theory\, these algebras offer a sneaky path toward solving difficult problems by understanding the ways that graph-theoretic diagrams combine. The only background I will assume is some familiarity with linear algebra\, so if you like (or at least tolerate) playing around with pretty combinatorial objects\, I hope you’ll attend!
URL:/math/event/colloquium-dr-alexander-wilson/
LOCATION:WI
CATEGORIES:Colloquia
X-TRIBE-STATUS:
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250221T140000
DTEND;TZID=America/Chicago:20250221T150000
DTSTAMP:20260419T003623
CREATED:20250113T152601Z
LAST-MODIFIED:20250205T152943Z
UID:10016197-1740146400-1740150000@uwm.edu
SUMMARY:Colloquium: Mr. Mike Clutterbuck
DESCRIPTION:Embeddings: The Language of AI\nMr. Mike Clutterbuck\nLead Data Scientist\nWantable Inc. \nEmbeddings are a core concept in machine learning that help AI understand and organize complex data. They take things like words\, images\, or user behavior and turn them into compact numerical representations\, making it easier for AI to spot patterns and relationships. This is how LLMs understand language and recommendation systems personalize content. \nMathematically\, embeddings work by placing similar items closer together in a structured space\, using techniques like matrix factorization\, neural networks\, and dimensionality reduction. This makes them essential for search\, personalization\, fraud detection\, next-word prediction\, and more. While they might seem abstract\, embeddings are working behind the scenes in many of the AI-powered products and tools we use today
URL:/math/event/colloquium-mike-clutterbuck/
LOCATION:EMS Building\, E495\, 3200 N Cramer St\, Milwaukee\, WI\, United States
CATEGORIES:Colloquia
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250228T140000
DTEND;TZID=America/Chicago:20250228T150000
DTSTAMP:20260419T003623
CREATED:20250114T154837Z
LAST-MODIFIED:20250210T190030Z
UID:10016201-1740751200-1740754800@uwm.edu
SUMMARY:Colloquium: Prof. Alastair Fletcher
DESCRIPTION:Infinitesimal Spaces of Quasiregular Mappings\nProf. Alastair Fletcher\nProfessor of Mathematical Sciences and Director of Undergraduate Studies\nNorthern Illinois University \nHow can we differentiate functions which are not differentiable? In the context of quasiregular mappings\, a generalization of holomorphic functions where now infinitesimal circles are mapped to infinitesimal ellipses\, there is a satisfactory answer to this question given by infinitesimal spaces. In this talk\, we will survey these objects and discuss some ongoing work with relevance to the Decomposition Problem for bi-Lipschitz maps.
URL:/math/event/alastair-fletcher/
LOCATION:EMS Building\, EMS E495\, 3200 Cramer St\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquia
ORGANIZER;CN="The Department of Mathematical Sciences":MAILTO:math-staff@uwm.edu
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