  {"id":27285,"date":"2024-03-04T10:48:13","date_gmt":"2024-03-04T16:48:13","guid":{"rendered":"https:\/\/uwm.edu\/letters-science\/?p=27285"},"modified":"2024-03-05T10:41:44","modified_gmt":"2024-03-05T16:41:44","slug":"a-late-start-hasnt-slowed-this-undergrad-researcher-in-testing-novel-breast-cancer-drugs","status":"publish","type":"post","link":"https:\/\/uwm.edu\/letters-science\/in-focus\/research-news\/a-late-start-hasnt-slowed-this-undergrad-researcher-in-testing-novel-breast-cancer-drugs\/","title":{"rendered":"A late start hasn\u2019t slowed this undergrad researcher in testing novel breast cancer drugs"},"content":{"rendered":"\n<p>Amy Reyes got a late start on her research, but she\u2019s learned it\u2019s never too late to make a difference.<\/p>\n\n\n\n<p>Reyes is a senior on the pre-optometry track at 51ÁÔÆæ, set to graduate with a major in biology and a minor in chemistry this spring. She\u2019s also an undergraduate researcher working with the <a href=\"https:\/\/uwm.edu\/drug-discovery\/simmaron-research-locates-rd-to-uwm-and-collaborates-with-the-midd\/\">Simmaron Research Institute<\/a>, a nonprofit organization that collaborates with the <a href=\"https:\/\/uwm.edu\/drug-discovery\/\">Milwaukee Institute for Drug Discovery<\/a> at 51ÁÔÆæ.<\/p>\n\n\n\n<p>Under the guidance of her mentor, Dr. Avik Roy, Reyes is testing new drugs to treat a particularly aggressive form of breast cancer in hopes of finding the correct dosage to deliver to patients. The medicine is still in early testing phases, but someday, Reyes hopes that her research will improve the lives of cancer patients around the world.<\/p>\n\n\n\n<p><strong>A late start<\/strong><\/p>\n\n\n\n<p>Most 51ÁÔÆæ undergraduate researchers begin working with mentors in their sophomore or junior years, but undergraduate research wasn\u2019t even on Reyes\u2019 radar until this past summer. She followed in her brother\u2019s footsteps and attended a summer research camp at the Milwaukee School of Engineering. The 10-week program paired Reyes with a mentor and allowed her to run her own experiments.<\/p>\n\n\n\n<p>\u201cTruthfully, I was thrown into the deep end with research. I had to do a lot of it on my own and learn as I went,\u201d she said, \u201cbut because of that, I think I gained a lot of experience in that 10 weeks.\u201d<\/p>\n\n\n\n<p>She worked on creating components for a plant-based sunscreen by researching plants that had UV-absorbing properties and then extracting those compounds from the plant. It will be a long time before a commercial product might be available, \u201cBut maybe someday!\u201d Reyes hopes.<\/p>\n\n\n\n<figure class=\"alignright uwm-c-img--right\"><img loading=\"lazy\" decoding=\"async\" width=\"216\" height=\"288\" src=\"https:\/\/uwm.edu\/letters-science\/wp-content\/uploads\/sites\/255\/2024\/03\/Amy-Reyes-profile.webp\" alt=\"A young woman with dark hair in a purple shirt smiles in front of some laboratory equipment.\" class=\"wp-image-27352\" \/><figcaption>Undergraduate research Amy Reyes hopes her work will one day help cancer patients undergo treatment without harsh medication side effects. Photo courtesy of Amy Reyes.<\/figcaption><\/figure>\n\n\n\n<p>When the MSOE summer program ended and her senior year at 51ÁÔÆæ began, Reyes found she hadn\u2019t shaken the research bug. So, she reached out to Dr. Alexander Arnold, a 51ÁÔÆæ professor of chemistry and biochemistry and the director of Milwaukee\u2019s Institute for Drug Discovery. He paired Reyes with Dr. Roy.<\/p>\n\n\n\n<p>\u00a0\u201cI\u2019ve had a lot of one-on-one experience with my mentor. Because of that, I\u2019ve learned so much,\u201d Reyes said. \u201cHe\u2019s been teaching me a lot of new techniques, teaching me a lot of biostatistics. This is very new to me, but it\u2019s been a really great experience so far.\u201d<\/p>\n\n\n\n<p><strong>A personal connection<\/strong><\/p>\n\n\n\n<p>The Simmaron Research Institute is pursuing several lines of inquiry, including research into long COVID and <a href=\"https:\/\/uwm.edu\/letters-science\/in-focus\/undergraduate-researcher-works-to-pinpoint-the-cause-of-chronic-fatigue-syndrome\/\">chronic fatigue syndrome<\/a>, but Reyes is specifically working with Roy on the development of therapies to treat triple-negative breast cancer.<\/p>\n\n\n\n<p>Triple-negative breast cancer is a particularly aggressive form of cancer that accounts for 10-15% of all breast cancers, according to the American Cancer Society. The cancer cells lack estrogen and progesterone receptors, and make little to no HER2, a type of protein. Triple-negative breast cancer tends to be more common in patients who are younger than 40, who are Black, or who have the BRCA 1 gene.<\/p>\n\n\n\n<p>Working with MIDD, Dr. Roy created a novel drug called SIMMPYRA, which is now patent-pending.<\/p>\n\n\n\n<p>\u201cThese SIMMPYRAs are STAT3 inhibitors. STAT proteins are a family of proteins that are known to regulate gene expression. Previous research shows that STAT3 is highly active in several different forms of human cancer,\u201d Reyes explained. &#8220;Basically, SIMMPYRAs arrest cell proliferation, and cell proliferation can cause cancers. We\u2019ve been trying to find the optimal concentration of this drug that will work on triple-negative breast cancer.<\/p>\n\n\n\n<p>\u201cTreatments that currently exist use drugs that are at a very high concentration, so they have a lot more side effects,\u201d she added. \u201cWhat\u2019s great about the drugs that we\u2019re using is that we are able to see the same results, but at very low concentrations.\u201d<\/p>\n\n\n\n<p>She\u2019s zeroing in on the correct dosage by performing cytotoxicity assays. In essence, Reyes takes some triple-negative breast cancer cells and then treats them with different concentrations of the drug. Then, she examines the cells under a microscope to see which cells were apoptotic, meaning that they burst and died, and which cells remained healthy.<\/p>\n\n\n\n<p>\u201cI did the painstaking job of counting (the cells) individually to see how many died,\u201d Reyes said with a rueful smile.<\/p>\n\n\n\n<p>The research is important because SIMMPYRA, if it proves to successfully treat triple-negative breast cancer, may someday be used to help patients without having them suffer many of the major side effects of current chemotherapies, like hair loss, fatigue, and nausea. But Reyes has a personal stake in her work: Her mother is a breast cancer survivor.<\/p>\n\n\n\n<p>\u201cShe still talks to me about some of the trauma from getting diagnosed,\u201d Reyes confessed. \u201cShe doesn\u2019t know much about the research field, but she\u2019s super proud of me and she keeps telling me how lucky I am.\u201d<\/p>\n\n\n\n<p>Reyes\u2019 mother is planning to attend 51ÁÔÆæ\u2019s Undergraduate Research Symposium this spring to see her daughter present her work. Reyes plans to graduate in May and then take a gap year before attending optometry school. She\u2019s not sure if she\u2019ll continue performing research, but Reyes is glad that she took the chance to get involved. And someday, breast cancer patients may benefit from that chance she took.<\/p>\n\n\n\n<p><strong><em>By Sarah Vickery, College of Letters &amp; Science<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amy Reyes got a late start on her research, but she\u2019s learned it\u2019s never too late to make a difference. Reyes is a senior on the pre-optometry track at 51ÁÔÆæ, set to graduate with a major in biology and a &hellip;<\/p>\n","protected":false},"author":785,"featured_media":27351,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[1648,1945,1846],"tags":[1853],"class_list":["post-27285","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-focus","category-in-focus-2024","category-research-news","tag-march"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Letters &amp; Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/letters-science\/in-focus\/research-news\/a-late-start-hasnt-slowed-this-undergrad-researcher-in-testing-novel-breast-cancer-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A late start hasn\u2019t slowed this undergrad researcher in testing novel breast cancer drugs\" \/>\n<meta property=\"og:description\" content=\"Amy Reyes got a late start on her research, but she\u2019s learned it\u2019s never too late to make a difference. 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