{"id":24589,"date":"2023-09-07T10:36:17","date_gmt":"2023-09-07T15:36:17","guid":{"rendered":"https:\/\/uwm.edu\/letters-science\/?p=24589"},"modified":"2024-09-23T16:07:31","modified_gmt":"2024-09-23T21:07:31","slug":"uwm-and-mcw-cancer-center-team-up-to-give-students-opportunities-in-pursuit-of-cancer-research","status":"publish","type":"post","link":"https:\/\/uwm.edu\/letters-science\/in-focus-2023\/uwm-and-mcw-cancer-center-team-up-to-give-students-opportunities-in-pursuit-of-cancer-research\/","title":{"rendered":"51ÁÔÆæ and MCW Cancer Center team up to give students opportunities in pursuit of cancer research"},"content":{"rendered":"\n

A new partnership between UW-Milwaukee and the Medical College of Wisconsin (MCW) Cancer Center is paving the way for undergraduate students to gain experience on the frontlines of cancer research.<\/p>\n\n\n\n

The\u00a0MCW Cancer Center and 51ÁÔÆæ Undergraduate Research Program<\/a>\u00a0is wrapping up its inaugural year as students in the program finish their summer research in the MCW Cancer Center labs. The collaboration is designed to train a new generation of researchers by pairing classroom training with hands-on experience as students work alongside mentors from the Cancer Center.<\/p>\n\n\n\n

\u201cWe want to identify and empower the next generation of career cancer researchers who will be the ones to make the next major breakthroughs in discoveries and therapeutics,\u201d said Michele Battle, PhD, one of the program\u2019s co-creators.<\/p>\n\n\n\n

In the beginning<\/h2>\n\n\n\n

The partnership grew out of a conversation between 51ÁÔÆæ Chancellor Mark Mone and Gustavo Leone, PhD, the director of the MCW Cancer Center<\/a>, as the two discussed ways the institutions could collaborate. For Mone, who was diagnosed with non-Hodgkins\u2019s lymphoma<\/a> in 2020, enabling students to engage in cancer research seemed like a natural fit.<\/p>\n\n\n\n

So, Mone approached Kyla Esguerra, the deputy director of undergraduate research at 51ÁÔÆæ, to set up the partnership on the university\u2019s side. Dr. Leone handed the same task to Dr. Battle, a professor of cell biology, neurobiology, and anatomy at MCW.<\/p>\n\n\n\n

Together, Dr. Battle and Esguerra built a program that is meant to provide students with a long-term research experience at the hands of accomplished mentors who can guide them on their career paths.<\/p>\n\n\n\n

\u201cOur goal is to provide them with a longitudinal experience so that they are integrated and working in cancer labs early during their time at 51ÁÔÆæ,\u201d Dr. Battle explained. \u201cWe want them to continue in those labs through the time that they graduate.\u201d<\/p>\n\n\n\n

That\u2019s important, she added, because while standalone research programs are enriching and give students valuable experience, they often focus on technical training, rather than allowing students to delve deeply into the work.<\/p>\n\n\n\n

\u201cWe encourage the students, from the start, to become very intellectually engaged in the research project,\u201d Dr. Battle said. \u201cWe want them to understand what the project is about, why it is important, how it is going to impact cancer research, and how it is going to impact how we care for patients or design new drugs.\u201d<\/p>\n\n\n\n

But to do that, Esguerra realized that the students needed to learn how to do research.<\/p>\n\n\n\n

In the classroom and the lab<\/h2>\n\n\n\n

So, the program is designed to start with a seminar class, co-taught by Dr. Battle and Esguerra, for any student interested in taking part in the program. They drew students from several disciplines across the university, including public health and psychology, though most are majors in the natural sciences or on the pre-med track. Research experience was a plus, Esguerra noted, but not required.<\/p>\n\n\n\n

The class focused on the basics of research: How to identify a line of inquiry, write a proposal, and apply for grant funding, among other skills. The students were paired with mentors at the MCW Cancer Center to work on existing projects so they could gain a deeper understanding of the skills and science behind various aspects of cancer research. At the end of the class, the students presented their research proposals before a committee of experts, including Chancellor Mone and Dr. Leone.<\/p>\n\n\n\n

\u201c(The students) just blew them away. It was really spectacular,\u201d Dr. Battle said with pride.<\/p>\n\n\n\n

Based on their submissions, 10 of the students were awarded a $10,000 scholarship to participate in a summer fellowship to advance their research projects alongside their mentors at the MCW Cancer Center.<\/p>\n\n\n\n

Florin Saitis and Suha Malik smiled with delight when they heard they were chosen for the summer fellowship.<\/p>\n\n\n\n

\u201cIt seemed daunting at first, since it involved research into something significant as cancer,\u201d Malik admitted. \u201cAlthough I had been involved in research at 51ÁÔÆæ, I felt that, as a pre-med student, and as someone who envisions herself in the healthcare field in the future, this MCW Cancer Center\/51ÁÔÆæ joint program would provide unparalleled opportunity to become involved in research centering around healthcare.\u201d<\/p>\n\n\n\n

Malik and Saitis, both biology majors, are two of the 10 students chosen to receive fellowships. Saitis worked under the guidance of Dr. Blake Hill and Malik was mentored by Dr. Leone.<\/p>\n\n\n\n

Both say the classroom seminar and the proposal presentation were intimidating, but rewarding.<\/p>\n\n\n\n

\u201cThe mentorship and the support that we received, not only from our MCW Cancer Center mentors but also Kyla and Dr. Battle, really guided us,\u201d Malik said. It also prepared them to present their work<\/a> at the 51ÁÔÆæ Undergraduate Research Symposium<\/a> in April.<\/p>\n\n\n\n

Saitis said that he appreciated the camaraderie that the cohort built, and the experience he gained. Spending time in the lab was a fun challenge, he added.<\/p>\n\n\n\n

\u201cLearning to work with PhD students and research scientists, learning a lot of different lab techniques, and seeing the variety of things that be accomplished at a research lab in a single day has really been incredible at a state-of-the-art facility,\u201d Saitis said. \u201cI\u2019ve also learned how to advocate for myself when I don\u2019t understand something, when there is my own knowledge gap that needs to be filled.\u201d<\/p>\n\n\n\n

In the future<\/h2>\n\n\n\n

The MCW Cancer Center and 51ÁÔÆæ Undergraduate Research Program is welcoming its second cohort of researchers this fall as last year\u2019s group continues their work. Dr. Battle and Esguerra hope that students will continue to participate throughout their years at 51ÁÔÆæ.<\/p>\n\n\n\n

The 10 students presented outcomes of their work at a poster session at MCW on Aug. 30.<\/p>\n\n\n\n

\u201cAs they continue their work, they will continue to present locally, or hopefully we\u2019ll send them to research conferences,\u201d Dr. Battle mused. \u201cMaybe they\u2019ll have first authorship on a paper. \u2026 With these research projects, they set themselves up nicely for whatever they want to do next.\u201d<\/p>\n\n\n\n

For Saitis and Malik, that will probably be medical school. Malik comes from a family of physicians and wants to follow in that tradition. She\u2019s also found her own love of medicine studying the human body. Saitis enjoys interacting with patients and volunteered at a local clinic when he was in high school.<\/p>\n\n\n\n

\u201cI\u2019m excited to be somewhere I can make a difference in the research load,\u201d Saitis added.<\/p>\n\n\n\n

Wherever they end up, Esguerra is pleased with how they started.<\/p>\n\n\n\n

\u201cIt\u2019s a steep learning curve, and we had students from many different starting points. We were thrilled that they all ended up submitting research proposals,\u201d Esguerra said. She\u2019s excited to find more students who want to contribute to cancer research, and from more disciplines \u2013 perhaps from social sciences like economics or political science.<\/p>\n\n\n\n

\u201cWe\u2019re looking for students who are curious and inquisitive, who have an interest in creating new knowledge,\u201d she said.<\/p>\n\n\n\n

If that sounds like you, check out the MCW Cancer Center and 51ÁÔÆæ Undergraduate Research program. You might just be needed on the frontlines of cancer research.<\/p>\n\n\n\n

By Sarah Vickery, College of Letters & Science<\/h5>\n\n\n\n

Suha Malik is conducting research under the guidance of her mentor, Gustavo Leone<\/a>, PhD, MCW Cancer Center director.<\/p>\n\n\n\n

Her research focuses on the cell cycle \u2013 specifically, the phase in the cycle where the cell stops growing and begins to replicate its chromosomes to prepare for division.<\/p>\n\n\n\n

\u201cThe Retinoblastoma-E2F axis regulates the checkpoint between G1, a growth phase in the cell, and S phase, when DNA replication occurs,\u201d Malik explained. \u201cRB is a protein called retinoblastoma. It acts a tumor-suppressor protein. E2Fs are a family of transcription factors, and many of these promote the expression of genes that are vital for DNA replication.\u201d<\/p>\n\n\n\n

RB binds to E2Fs to inactivate them, preventing the progression of the cell cycle. When RB is not bound to E2Fs, the cell cycle can continue.<\/p>\n\n\n\n

\u201cIn terms of cancer, if something goes wrong in this Rb\/ E2F axis, the cell may be dividing when it\u2019s not supposed to. That can cause this proliferation of cells, which can cause tumors and eventually cancer,\u201d Malik said.<\/p>\n\n\n\n

She and Dr. Leone are examining what happens if either the Rb or E2F is \u201cknocked out\u201d of cells in mice. They hope their research will allow them to identify particular genes affected by the axis, which could potentially be targets in cancer treatment.<\/p>\n\n\n\n

Florin Saitis is working with his mentor, Dr. Blake Hill<\/a>, to understand the role of mitochondria in pancreatic cancer.<\/p>\n\n\n\n

Pancreatic cancer is notoriously difficult to diagnose and treat. It has a 5-year survival rate of around 10%.<\/p>\n\n\n\n

\u201cIn pancreatic cancer, it has been shown that there is an increase in mitochondrial fission. Some preliminary studies have said that, if you\u2019re able to prevent this mitochondrial fission, it will impair the cancer cells\u2019 travel,\u201d Saitis said.<\/p>\n\n\n\n

Mitochondria are organelles that live within the body\u2019s cells. As many may remember from high school biology classes, mitochondria are the \u201cpowerhouses\u201d of the cell. They take energy from food and convert it into a molecule called ATP, which is the energy \u201ccurrency\u201d that cells use to function. Mitochondria are also constantly dividing in a process called \u201cfission\u201d before they fuse back togetehr.<\/p>\n\n\n\n

Saitis and Dr. Hill are examining a specific protein that binds to the outer membrane of the mitochondria and recruits the enzyme that performs mitochondrial fission.<\/p>\n\n\n\n

\u201cWe\u2019re looking at inhibiting mitochondrial fission and its impact on pancreatic cancer cells. Hopefully in the future, this will become a novel treatment for pancreatic cancer,\u201d Saitis explained. \u201cBased on early results, I found that inhibiting Fis1 (the recruiter protein) with a novel peptide inhibitor reduced mouse pancreatic cancer cell proliferation by up to 75%!\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

A new partnership between UW-Milwaukee and the Medical College of Wisconsin (MCW) Cancer Center is paving the way for undergraduate students to gain experience on the frontlines of cancer research. The\u00a0MCW Cancer Center and 51ÁÔÆæ Undergraduate Research Program\u00a0is wrapping up …<\/p>\n","protected":false},"author":1483,"featured_media":24594,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[1756],"tags":[1859],"class_list":["post-24589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-focus-2023","tag-september"],"yoast_head":"\nLetters & Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/letters-science\/in-focus-2023\/uwm-and-mcw-cancer-center-team-up-to-give-students-opportunities-in-pursuit-of-cancer-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"51ÁÔÆæ and MCW Cancer Center team up to give students opportunities in pursuit of cancer research\" \/>\n<meta property=\"og:description\" content=\"A new partnership between UW-Milwaukee and the Medical College of Wisconsin (MCW) Cancer Center is paving the way for undergraduate students to gain experience on the frontlines of cancer research. 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