{"id":19401,"date":"2022-09-09T12:29:59","date_gmt":"2022-09-09T17:29:59","guid":{"rendered":"https:\/\/uwm.edu\/letters-science\/?p=19401"},"modified":"2023-12-04T14:50:58","modified_gmt":"2023-12-04T20:50:58","slug":"channeling-model-behavior-mathematics-prof-wins-nsf-grant","status":"publish","type":"post","link":"https:\/\/uwm.edu\/letters-science\/in-focus-2022\/channeling-model-behavior-mathematics-prof-wins-nsf-grant\/","title":{"rendered":"Channeling model behavior: Mathematics prof wins NSF grant"},"content":{"rendered":"
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Electrically charged ions like sodium, potassium, and calcium are essential for the body\u2019s cells to perform their functions. But, cells are surrounded by an impermeable barrier made of lipids, or fats. There are channels in the cell wall that ions may pass through to cross that barrier and make their way inside the cell.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

In the cell there is an organelle called a mitochondrion. If you think back to high school biology class, you may remember that mitochondria are the \u201cpower houses\u201d of the cell. Mitochondria produce a molecule known as ATP, which provides the body energy for functions like muscle contraction, cellular signaling, and protein synthesis.<\/p>\n

To do that, mitochondria need ions, and to get inside the mitochondria, the ions must pass through another ion channel. Known as VDAC (voltage-dependent anion channel), this channel is much different than regular ion channels in the cell membrane. A regular ion channel is specific to one kind of ion. In other words, only a sodium ion can pass through a sodium ion channel, and only a potassium ion can pass through a potassium ion channel. But the VDAC allows multiple ionic species to pass through \u2013 and even small molecules like ATP.<\/p>\n

\u201cYou also have to consider multiple ionic species that have different ionic sizes. How are you going to simulate these particles across the channel?\u201d mused Dexuan Xie<\/a>, a professor of mathematical sciences at 51ÁÔÆæ.<\/p>\n

That\u2019s the question that Professor Xie and his collaborator, Professor Ranjan Dash from the Medical College of Wisconsin, will answer with the help of a new, $600,000 grant from the National Science Foundation<\/a> (NSF) awarded on July 13, 2022.<\/p>\n

The grant is titled, \u201cDMS\/NIGMS 1: Collaborative Research: Advanced Ion Channel Modeling and Computational Tools with Application to Voltage- Dependent Anion Channel and Mitochondrial Model Development.\u201d Xie is collaborating with Dash to build computer models that will simulate how ions move through the VDAC and how the properties of those ions impact the function of the mitochondria.<\/p>\n

Solving this problem could result in solving a host of other problems. According to Xie and Dash\u2019s grant proposal, \u201cmitochondrial dysfunction \u2026 plays a critical role in the pathogenesis of numerous human maladies, including cardiac ischemia-reperfusion injury, heart disease, hypertension, diabetes, cancer, aging, and neurodegenerative diseases. Therefore, alleviating mitochondrial dysfunction through targeted interventions would curb the progression of these diseases and attenuate their severities.\u201d<\/p>\n

In other words, understanding how VDACs impact the mitochondria may help researchers discover treatments or even cures for diabetes, heart disease, cancer, and many other illnesses.<\/p>\n

Building a model<\/h3>\n

Constructing a computer model of a VDAC is a challenging feat because very little research has been done into this area. In addition, the current methods of computer modeling ion channels won\u2019t give an accurate picture of how a VDAC might function because they do not take into account \u201cany atomic charge, ionic charge, ion size, or membrane protein molecular structure,\u201d according to Xie and Dash\u2019s grant proposal.<\/p>\n

That\u2019s a problem because computer modeling relies on mathematical calculations for accuracy. Using the simulation data derived from specific equations, the computer can generate images of how a VDAC functions \u2013 impressive given that these functions are carried out on an atomic level.<\/p>\n

Over the past five years, Xie has developed increasingly efficient modeling methods to generate models of cellular ion channels. His work has been based on what is called either a Poisson-Nernst-Planck equation or a Poisson- Boltzmann equation, so named for the types of equations used to produce the data the computer needs to generate a vivid image of ion transport across a membrane via an ion channel.<\/p>\n

That works well in regular channels because ion channels have few variables. \u201cThese channels have a select function and only allow one kind of ionic species through and block others,\u201d Xie explained. He was actually halfway through a five-year, $42,000 grant awarded by the Simons Foundation to build ion channel models when he was awarded the NSF grant. He will continuously carry out this project in the coming three years under the support of a gift grant (a total of $8,400 per year) that he received from the Simons Foundation on Sept. 1.<\/p>\n

But modeling VDACs involves many more variables because a VDAC allows multiple types of ionic species and small molecules like ATP through the channel. So, Xie decided, he will have to develop more equations to account for those extra variables. The result will be a \u201cnonlocal Poisson-Nernst-Planck-Fermi\u201d model, or NPNPF for short.<\/p>\n

What does NPNPF mean?<\/h3>\n

\u2022 Poisson Equation: This equation calculates the potential field caused by electrical charges \u2013 important, as ions from a solution and atoms from a protein molecule are electrically charged particles.<\/p>\n

\u201cThat\u2019s a fundamental equation when you consider any electrostatic potential modeling,\u201d Xie said. \u201cThe Poisson-Boltzmann equation calculates the distribution of the ions in an equilibrium state,\u201d Because the ions are moving, they are unequal. That\u2019s widely described as the transporting movements of the ions, and they cause the electrical current. A Nernst-Planck equation is a powerful tool to model a non-equilibrium state of ions.\u201d<\/p>\n

\u2022 Nernst-Planck Equation: This equation is used to describe how charged ions move within water. It addresses the concentration of ions in water outside of an ion channel subject to an electric field.<\/p>\n

However, the Poisson-Boltzmann equation assumes that the water molecules outside of an ion channel are uniform.<\/p>\n

\u201cBut under an electrical field, water molecule distribution will be changed,\u201d Xie noted. Because an electrical field is not uniform, some areas are stronger and some areas are weaker. ou cannot use one constant to describe this dielectric property. That\u2019s why the equation must be\u2026<\/p>\n

\u2022 Nonlocal: \u201cIt means each water molecule is correlated to all other water molecules. That\u2019s nonlocal. Local means that you\u2019re only related to yourself. Nonlocal means that each one is related to others,\u201d Xie said.<\/p>\n

\u2022 Fermi: \u201cFermi is another kind of equation. (It) allows us to treat ionic size problems,\u201d Xie said. That will address the different sizes in sodium ions versus potassium ions versus ATP versus the other molecules that can be transported across a VDAC.<\/p>\n

\u201cWhen you combine that all together, we are going to develop new kinds of channel models that I consider nonlocal electric forces,\u201d Xie said.<\/p>\n

\u201cThe more equations, the higher the resolution of the computer model, and the more accurate the model will be,\u201d he added.<\/p>\n

Applications beyond mitochondria<\/h3>\n

This grant represents the fourth major NSF grant<\/a> Xie has been awarded during his tenure at 51ÁÔÆæ. His work tends to build; with each passing project, Xie discovers new ways to make computer modeling more efficient and more accurate.<\/p>\n

Like his other work, Xie anticipates that this grant project will lend itself to other useful applications. After all, he noted, \u201call of these techniques or numerical algorithms can be adapted to other situations. The models, the equations were the same; we just changed the meaning of the functions.\u201d<\/p>\n

For example, Xie and Dash anticipate that their work might have applications for scientists studying the transport of electrons in semiconductors and ion transports in lithium ion batteries and fuel cells.<\/p>\n

Or there might be applications in creating anti-viral drugs for diseases like COVID-19. Xie and Dash are hopeful that their work in electrostatics might shine light on exactly how the virus enters a cell, in hopes that they can identify parts of the virus that might be a good candidate to be targeted by new medicines.<\/p>\n

The NSF grant is funded through 2025.<\/p>\n

By Sarah Vickery, College of Letters & Science<\/strong><\/em><\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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