{"id":1145,"date":"2024-09-13T10:56:47","date_gmt":"2024-09-13T15:56:47","guid":{"rendered":"https:\/\/uwm.edu\/drug-discovery\/?p=1145"},"modified":"2026-02-27T08:55:31","modified_gmt":"2026-02-27T14:55:31","slug":"milwaukee-team-wins-nih-r01-to-develop-novel-anxiolytic-compounds-targeting-the-endocannabinoid-system","status":"publish","type":"post","link":"https:\/\/uwm.edu\/drug-discovery\/milwaukee-team-wins-nih-r01-to-develop-novel-anxiolytic-compounds-targeting-the-endocannabinoid-system\/","title":{"rendered":"Milwaukee Team Wins NIH R01 to Develop Novel Anxiolytic Compounds Targeting the Endocannabinoid System"},"content":{"rendered":"\n<p>Nearly 1\/3 of Americans will experience an anxiety disorder in their lifetime resulting in impaired social function and reduction of quality of life. Unfortunately, existing anxiety medications suffer from delayed or inadequate efficacy and sedative-hypnotic effects.&nbsp; Development of additional anxiolytics with different mechanisms of action could improve therapeutic outcomes.<\/p>\n\n\n\n<figure class=\"alignleft uwm-c-img--left\"><img loading=\"lazy\" decoding=\"async\" width=\"320\" height=\"240\" src=\"https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/SCP-2-reserach-team.jpg\" alt=\"Group photo outdoors of Chris Cunningham, Cecilia Hillard, and Elizabeth Liedhegner\" class=\"wp-image-1144\" srcset=\"https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/SCP-2-reserach-team.jpg 320w, https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/SCP-2-reserach-team-300x225.jpg 300w\" sizes=\"auto, (max-width: 320px) 100vw, 320px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>Professors <a href=\"https:\/\/cunninghamlab.wordpress.com\">Chris Cunningham<\/a> (Concordia University Wisconsin), <a href=\"http:\/\/mcw.edu\/departments\/pharmacology-and-toxicology\/people\/cecilia-hillard-phd\">Cecilia Hillard<\/a> (Medical College of Wisconsin), and <a href=\"https:\/\/uwm.edu\/biomedical-sciences-healthcare-administration\/directory\/liedhegner-elizabeth\/\">Elizabeth Liedhegner<\/a> (University of Wisconsin Milwaukee) have identified <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28750817\/\">Sterol Carrier Protein 2<\/a> (SCP-2), a non-specific lipid trafficking protein, as a novel therapeutic target for anxiety.&nbsp; In mice, inhibition or loss of SCP-2 leads to reduced anxiety-like behaviors and enhanced fear extinction via indirect activation of the endocannabinoid system.&nbsp; The team has been recently awarded an <a href=\"http:\/\/reporter.nih.gov\/search\/XYFmoCd0UUu2vycYAl0bLw\/project-details\/10998194\">R01 by the National Institute of Mental Health<\/a> to develop and evaluate inhibitors of SCP-2 as a novel class of anxiolytic therapy.&nbsp; The MIDD will support these studies through preclinical pharmacokinetic characterization of successful inhibitors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nearly 1\/3 of Americans will experience an anxiety disorder in their lifetime resulting in impaired social function and reduction of quality of life. Unfortunately, existing anxiety medications suffer from delayed or inadequate efficacy and sedative-hypnotic effects.&nbsp; Development of additional anxiolytics &hellip;<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","uwm_wg_additional_authors":[]},"categories":[8],"tags":[],"class_list":["post-1145","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Milwaukee Institute for Drug Discovery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/drug-discovery\/milwaukee-team-wins-nih-r01-to-develop-novel-anxiolytic-compounds-targeting-the-endocannabinoid-system\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Milwaukee Team Wins NIH R01 to Develop Novel Anxiolytic Compounds Targeting the Endocannabinoid System\" \/>\n<meta property=\"og:description\" content=\"Nearly 1\/3 of Americans will experience an anxiety disorder in their lifetime resulting in impaired social function and reduction of quality of life. 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