  {"id":1138,"date":"2024-09-09T12:35:51","date_gmt":"2024-09-09T17:35:51","guid":{"rendered":"https:\/\/uwm.edu\/drug-discovery\/?p=1138"},"modified":"2026-02-27T08:56:22","modified_gmt":"2026-02-27T14:56:22","slug":"professor-shama-mirza-received-the-advancing-a-healthier-wisconsin-endowment-grant-in-collaboration-with-dr-mona-al-gizawiy-an-assistant-professor-of-biophysics-at-the-medical-college-of-wisconsin","status":"publish","type":"post","link":"https:\/\/uwm.edu\/drug-discovery\/professor-shama-mirza-received-the-advancing-a-healthier-wisconsin-endowment-grant-in-collaboration-with-dr-mona-al-gizawiy-an-assistant-professor-of-biophysics-at-the-medical-college-of-wisconsin\/","title":{"rendered":"Professor Shama Mirza received the Advancing a Healthier Wisconsin Endowment grant in collaboration with Dr. Mona Al-Gizawiy, an assistant professor of biophysics at the Medical College of Wisconsin."},"content":{"rendered":"\n<p>Glioblastoma (GBM) is an extremely aggressive cancer for which there are limited treatment options. Despite recent advances in therapy, the prognosis remains dismal and patient survival is short. After standard therapy, the recurrent tumors become resistant to therapy and render them extremely difficult to treat. The team of <a href=\"http:\/\/uwm.edu\/drug-discovery\/people\/mirza-shama\/\">Prof Mirza<\/a> from 51ÁÔÆæ (Chemistry &amp; Biochemistry Department) and<a href=\"https:\/\/www.mcw.edu\/departments\/biophysics\/people\/al-gizawiy-mona-phd\"> Prof. Mona Al-Gizawiy<\/a> from the Medical College of Wisconsin (Biophysics Department) are investigating if gallium, an iron mimetic, can be used to target cancer iron metabolism.<\/p>\n\n\n\n<figure class=\"alignleft uwm-c-img--left\"><img loading=\"lazy\" decoding=\"async\" width=\"294\" height=\"300\" src=\"https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/Ga-294x300.png\" alt=\"Image of Gallium in the style of the Periodic Table of Elements\" class=\"wp-image-1139\" srcset=\"https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/Ga-294x300.png 294w, https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/Ga.png 452w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/figure>\n\n\n\n<p>Iron plays a vital role in pathobiology of many cancers including brain cancer. In this proposal, a high-throughput characterization of iron regulating proteins will be carried out using mass spectrometry-based proteomics analyzing rat plasma from glioblastoma xenografts. The aim is to answer pressing questions regarding response to therapy and differentiating short-term vs long-term survivors. This work is supported by the <a href=\"http:\/\/ahwendowment.org\">Advancing a Healthier Wisconsin Endowment<\/a> grant, affiliated with the Medical College of Wisconsin.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glioblastoma (GBM) is an extremely aggressive cancer for which there are limited treatment options. Despite recent advances in therapy, the prognosis remains dismal and patient survival is short. After standard therapy, the recurrent tumors become resistant to therapy and render &hellip;<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","uwm_wg_additional_authors":[]},"categories":[8],"tags":[],"class_list":["post-1138","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Milwaukee Institute for Drug Discovery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/drug-discovery\/professor-shama-mirza-received-the-advancing-a-healthier-wisconsin-endowment-grant-in-collaboration-with-dr-mona-al-gizawiy-an-assistant-professor-of-biophysics-at-the-medical-college-of-wisconsin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Professor Shama Mirza received the Advancing a Healthier Wisconsin Endowment grant in collaboration with Dr. Mona Al-Gizawiy, an assistant professor of biophysics at the Medical College of Wisconsin.\" \/>\n<meta property=\"og:description\" content=\"Glioblastoma (GBM) is an extremely aggressive cancer for which there are limited treatment options. Despite recent advances in therapy, the prognosis remains dismal and patient survival is short. After standard therapy, the recurrent tumors become resistant to therapy and render &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/uwm.edu\/drug-discovery\/professor-shama-mirza-received-the-advancing-a-healthier-wisconsin-endowment-grant-in-collaboration-with-dr-mona-al-gizawiy-an-assistant-professor-of-biophysics-at-the-medical-college-of-wisconsin\/\" \/>\n<meta property=\"og:site_name\" content=\"Milwaukee Institute for Drug Discovery\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-09T17:35:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-27T14:56:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uwm.edu\/drug-discovery\/wp-content\/uploads\/sites\/390\/2024\/09\/Ga.png\" \/>\n\t<meta property=\"og:image:width\" content=\"452\" \/>\n\t<meta property=\"og:image:height\" content=\"462\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Alexander E Arnold\" 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