The inaugural Wisconsin took place at the Medical College of Wisconsin and was attended by nearly 500 scientists including undergraduate and graduate students from local educational institutions. The conference was a great success supported by an exceptional organizing team including MCW faculty . Randeep Pangli from UW-Whitewater was selected for the MIDD sponsored poster award for his contribution ” Boron Prodrugs of Niclosamides for the Treatment of Non-Alcoholic Steatohepatitis鈥�.
Nonalcoholic fatty liver disease (NAFLD) has emerged recently as the leading cause of chronic liver disease, affecting ~20% to 30% of the population in United States alone. Currently, there are no clinically approved drugs specifically indicated for the prevention and treatment of NASH. Repurposing of niclosamide might represent a new treatment strategy, which was evaluated by Mr. Pangli by synthesizing new analogs of niclosamide to improve water solubility, oral bioavailability, and metabolic stability.