{"id":8542,"date":"2023-09-18T15:54:08","date_gmt":"2023-09-18T20:54:08","guid":{"rendered":"https:\/\/uwm.edu\/chemistry\/?p=8542"},"modified":"2023-10-16T21:14:28","modified_gmt":"2023-10-17T02:14:28","slug":"prof-xiaohua-peng-receives-nih-grant","status":"publish","type":"post","link":"https:\/\/uwm.edu\/chemistry\/prof-xiaohua-peng-receives-nih-grant\/","title":{"rendered":"Prof. Xiaohua Peng Receives NIH Grant"},"content":{"rendered":"<p>We congratulate Prof. <a href=\"https:\/\/uwm.edu\/chemistry\/our-people\/peng-xiaohua\/\">Xiaohua Peng<\/a> on receiving a National Institutes of Health award for $461,998.00. The grant is from the <a href=\"https:\/\/www.cancer.gov\">National Cancer Institute<\/a> to study <a href=\"https:\/\/reporter.nih.gov\/search\/DrBSBa3ZAEWwBkrgb4kRoQ\/project-details\/10730787#news\">Novel DNA cross-linking agents and combination strategies for tumor-specific activation.<\/a><\/p>\n<p>Dr. Peng&#8217;s research will be focusing on the development of novel ROS-activated anticancer prodrugs with improved tumor specificity and drug like property. They will also develop novel combination strategies of using selected pro-oxidants with ROS-activated prodrugs to achieve synergistic and durable antitumor effects while minimizing unwanted side-effects.<\/p>\n<p>Dr. Peng\u2019s group has already developed a H<sub>2<\/sub>O<sub>2<\/sub>-activated anticancer prodrug that showed\u00a0<i>in vivo<\/i>\u00a0efficacy and selectivity. Her group has demonstrated that\u00a0<b>vitamin C<\/b>\u00a0further enhanced the anticancer effect of the H<sub>2<\/sub>O<sub>2<\/sub>-activated prodrug by selectively intensifying H<sub>2<\/sub>O<sub>2<\/sub>\u00a0accumulation in cancer cells.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We congratulate Prof. Xiaohua Peng on receiving a National Institutes of Health award for $461,998.00. The grant is from the National Cancer Institute to study Novel DNA cross-linking agents and combination strategies for tumor-specific activation. Dr. Peng&#8217;s research will be &hellip;<\/p>\n","protected":false},"author":382,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"categories":[11],"tags":[],"class_list":["post-8542","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Chemistry &amp; Biochemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/chemistry\/prof-xiaohua-peng-receives-nih-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prof. Xiaohua Peng Receives NIH Grant\" \/>\n<meta property=\"og:description\" content=\"We congratulate Prof. Xiaohua Peng on receiving a National Institutes of Health award for $461,998.00. 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