a. “Synthesis of Propellanes with Large and Medium-sized Rings from Cyclic \uf061-Diketones and
\nDimethyl \u00df-Ketoglutarate,” J. Cook and D. Yang, presented at the 7th Central Regional Meeting of
\nthe American Chemical Society, West Virginia University, Morgantown, WV, May 28-30, 1975,
\nAbstract No. 122.
\nb. “Chemistry of 1,2- and 1,3-Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate: Synthesis of
\nMethyl-2,3,5,6,7,8 – Hexahydro – 2, 5 – dioxo – 4 H- 1-benzopyran-4′ -Acetate,” J. Cook, D. Yang, J.
\nOehldrich, and U. Weiss, presented at the 6th Natural Products Symposium of the West Indies,
\nMona, Jamaica, January 4-10, 1976.
\nc. “Synthesis of Beta Carbolines: Pictet-Spengler Condensations in Refluxing Benzene,” J. Sandrin,
\nD. Soerens, L. Hutchins, E. Richfield, F. Ungemach, and J. Cook, presented at the 10th Middle
\nAtlantic Regional Meeting of the American Chemical Society, Temple University, Philadelphia,
\nPA, February 24, 1976, Abstract No. K-25.
\nd. “Reactions of 1,2 and 1,3-Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate: Preparation of
\n1:1 Adducts,” D. Yang, J. Oehldrich, and J.M. Cook, presented at the 10th Middle Atlantic Regional
\nMeeting of the American Chemical Society, Temple University, Philadalphia, PA, February 25,
\n1976, Abstract No. K-41.
\ne. “Facile Entry into Biologically Important Ring Systems by Reaction of Dimethyl \u00df-Ketoglutarate
\nwith Alicyclic 1,3-Dicarbonyl Compounds or with \uf061-Halo Ketones,” J. Oehldrich, O. Campos, D.
\nFoerst, and J.M. Cook, presented at the 10th American Chemical Society Great Lakes Regional
\nMeeting, Northwestern University, Evanston, IL, June 18, 1976, Abstract No. 179.
\nf. “13C-NMR Studies of 1,3-Disubstituted-1,2,3,4-Tetrahydro-\u00df-Carbolines,” J. Sandrin, D. Soerens
\nand J.M. Cook, presented at the 10th American Chemical Society Great Lakes Regional Meeting,
\nNorthwestern University, Evanston, IL, June 1, 1976, Abstract No. 280.
\ng. “Synthesis and Stereochemistry of 1,3-Disubstituted-1,2,3,4-Tetrahydro \u00df-Carbolines,” J. Sandrin,
\nD. Soerens and J.M. Cook, presented at the 17th Annual Meeting of the American Society of
\nPharmacognosy, Telemark Lodge, Cable, WI, July 11-16, 1976, Abstract No. 23.
\nh. “Reaction of Dimethyl \u00df-Ketoglutarate with Carbonyl Compounds: Synthesis of Coumarin,
\nCarbostyril, and Furan Derivatives,” J. Oehldrich, O. Campos, D. Foerst and J.M. Cook, presented
\nat the 17th Annual Meeting of the American Society of Pharmacognosy, Telemark Lodge, Cable,
\nWI, July 11-16, 1976, Abstract No. 41.
\ni. “Synthesis of Oxo-substituted Heterocycles from Cyclohexane-1,3-dione,” R. Mitschka, P. Mokry
\nand J.M. Cook, presented at the 28th Southeastern Regional Meeting of the American Chemical
\nSociety,” Gatlinburg, TN, October 27-28, 1976, Abstract No. 372.
\nj. “Studies in the Indole Alkaloid Area: C-13 NMR of 1,3-Disubstituted-1,2,3,4- Tetrahydro
\n\u00df-Carbolines,” J. Sandrin, G.S. Wu, F. Ungemach, and J.M. Cook, presented at the 11th Great Lakes
\nRegional Meeting of the American Chemical Society, Stevens Point, WI, June 6-8, 1977, Abstract
\nNo. 180.
\nk. “Studies in the Indole Alkaloid Area: Pictet-Spengler Reactions in Refluxing Benzene,” D. Soerens,
\nO. Campos, E. Yamanaka and J.M. Cook, presented at the 11th Great Lakes Regional Meeting of
\nthe American Chemical Society, Stevens, Point, WI, June 6-9, 1977, Abstract No. 181.
\nl. “Reactions of Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate: Synthesis of Cyclopentanoid
\nDerivatives,” J.M. Cook, J. Oehldrich, and R. Weber, presented at the 11th Great Lakes Regional
\nMeeting of the American Chemical Society, Stevens Point, WI June 6-8, 1977, Abstract No. 182.
\nm. “Studies in the Indole Alkaloid Area: Pictet-Spengler Reactions in Aprotic Media,” D. Soerens, J.
\nSandrin and J.M. Cook, presented at the 174th National Meeting of the American Chemical Society,
\nChicago, IL, August 29-September 2, 1977, Abstract No. 118.
\nn. “Synthesis of the Antibiotic, Pyridindolol, a \u00df-Galactosidase Inhibitor from Streptomyces
\nalboverticillatus,” E. Yamanaka, G.S. Wu, and J.M. Cook, presented at the 7th Natural Products
\nSymposium, University of the West Indies, Mona, Jamaica, January 9-13, 1978.
\no. “Pictet-Spengler Reactions in Aprotic Media: Synthesis of Pyridindolol, a \u00df-Galactosidase Inhibitor
\nfrom Streptomyces alboverticillatus,” D. Soerens, G.S. Wu, E. Yamanaka and J.M. Cook, presented
\nat the 175th American Chemical Society National Meeting, Anaheim, CA, March 12-17, 1978.
\np. “Reactions of Dimethyl \u00df-Ketoglutarate with 1,2-Dicarbonyl Compounds: General Approach to the
\nSynthesis of Cyclopentanoid Compounds,” R. Mitschka, U. Weiss and J.M. Cook, presented at the
\nJoint Central-Great Lakes Regional Meeting of the American Chemical Society, Butler University,
\nIndianapolis, IN, May 24-26, 1978, Abstract No. 81.
\nq. “Studies Directed toward the Synthesis of 3-Acylindole Bases,” O. Campos and J.M. Cook,
\npresented at the Joint Central-Great Lakes Regional Meeting of the American Chemical Society,
\nButler University, Indianapolis, IN, May 24-26, 1978, Abstract No. 30.
\nr. “Studies Directed Toward the Synthesis of Indole Alkaloid, Suaveoline,” D. Soerens and J.M. Cook,
\npresented at the Joint Central-Great Lakes Regional Meeting of the American Chemical Society,
\nButler University, Indianapolis, IN, May 24-26, 1978, Abstract No. 31.
\ns. “Reactions of Dimethyl 3-Ketoglutarate with 1,2-Dicarbonyl Compounds: General Approach to the
\nSynthesis of Cyclopentanoid Compounds,” R. Mitschka, A. Gawish, C. Wieringa and J.M. Cook,
\n178th American Chemical Society National Meeting, Washington, DC, September 10-14, 1979,
\nAbstract No. ORGN-146.
\nt. “Synthesis of 1,6-Diazaphenalene, a Vinylogous Imidazole,” M.I. El-Sheikh, J.-C. Chang, R. Weber
\nand J.M. Cook, American Chemical Society Great Lakes Regional Meeting, Rockford College,
\nRockford, IL, June 4-5, 1979, Abstract No. 206.
\nu. “Stereoselective Synthesis of trans-1-Substituted-3-Methoxycarbonyl-1,2,3,4- tetra-hydro
\n\u00df-Carbolines,” R. Weber, F. Ungemach, M. DiPierro, D. Soerens, J.V. Silverton and J.M. Cook,
\nAmerican Chemical Society Great Lakes Regional Meeting, Rockford College, Rockford, IL, June
\n4-6, 1979, Abstract No. 207.
\nv. “Stereoselective Synthesis of trans-1-Substituted-3-methoxycarbonyl-1,2,3,4- tetrahydro
\n\u00df-Carbolines,” R. Weber, F. Ungemach, M. DiPierro, D. Soerens, J.V. Silverton and J.M. Cook,
\n11th Central Regional Meeting, Ohio State University, Columbus, OH, May 7-9, 1979, Abstract
\nNo. 23.
\nw. “General Approach to the Synthesis of Cyclopentanoid Compounds: Studies Directed Toward the
\nPreparation of Staurane and Modhephene,” J.M. Cook, 8th Natural Products Symposium, University
\nof the West Indies, Mona, Jamaica, January 7-11, 1980.
\nx. “In Vitro Inhibition of [3H] Diazepam Binding to Benzodiazepine Receptors by \u00df-Carbolines,” K.C.
\nRice, P. Skolnick, S.M. Paul, S. Barker, J.M. Cook, R. Weber, and M. Cain, presented at the 2nd
\nChemical Congress of the North American Continent, August 24-29, 1980, Las Vegas, NV, Abstract
\nNo. MEDI-069.
\ny. “General Approach Toward the Synthesis of Polyquinanes,” J.M. Cook, A. Gawish, J. Wrobel, K.
\nTakahashi, and U. Weiss, presented at the 2nd Chemical Congress of the North American Continent,
\nAugust 24-29, 1980, Las Vegas, NV, Abstract No. ORGN-247.
\nz. “Selenium Dioxide and DDQ Oxidations in the Indole Area,” J.M. Cook, R. Mantei, M. Cain, and
\nM. DiPierro, presented at the 2nd Chemical Congress of the North American Continent, August
\n24-29, 1980, Las Vegas, NV, Abstract No. ORGN-341.
\naa. “An Anomalous Semmler-Wolff Aromatization Reaction,” M.I. El-Sheikh and J.M. Cook, 14th
\nGreat Lakes Regional Meeting, June 4-6, 1980, Western Illinois University, Macomb, IL, Abstract
\nNo. 110.
\nbb. “General Method for the Synthesis of Polycyclopentanoid Compounds. Recent Progress Directed
\ntoward the Preparation of Staurane and Modhephene,” A. Gawish, J. Wrobel, K. Takahashi, U.
\nWeiss and J.M. Cook, 14th Great Lakes Regional Meeting, June 4-6, 1980, Western Illinois
\nUniversity, Macomb, IL, Abstract No. 127.
\ncc. “Studies Directed toward the Synthesis of Potential Antimalarial Agents. Synthesis of 9-Methoxy
\nand 9-Amino-1,6-diazaphenalene Derivatives,” R. Weber, J. Chang, M.I. El-Sheikh and J.M. Cook,
\n14th Great Lakes Regional Meeting, June 4-6, 1980, Western Illinois University, Macomb, IL,
\nAbstract No. 140.
\ndd. “Selenium Dioxide and DDQ Oxidations in the Indole Area. The Synthesis of \u00df-Carboline
\nAlkaloids, 1-Acetyl-\u00df-Carboline, 1-Acetyl-3-Methoxycarbonyl-\u00df- Carbo-line and Desmethoxy
\nCrenatine,” R. Mantei, M. Cain, M. DiPierro and J.M. Cook, 14th Great Lakes Regional Meeting,
\nJune 4-6, 1980, Western Illinois University, Macomb, IL, Abstract No. 151.
\nee. “\u00df-Carbolines: Synthesis, Neurochemical, and Pharmacological Actions on Brain Benzodiazepine
\nReceptors,” M. Cain, R. Weber, F. Guzman, J.M. Cook, K.C. Rice, and P. Skolnick, 9th Natural
\nProducts Symposium, University of the West Indies, Mona, Jamaica, January 4-8, 1982.
\nff. “Synthesis of 3-Hydroxymethyl-\u00df-Carboline, a Diazepam Antagonist,” P. Skolnick, S. Paul, J.
\nCrawley, K. Rice, S. Barker, R. Weber, M. Cain, and J.M. Cook, 1981 Joint Meeting of the
\nCentral-Great Lakes American Chemical Society, Dayton, OH, May 20-22, 1981, Abstract No.
\nMEDI-220.
\ngg. “Studies Directed Toward the Synthesis of Potential Antimalarial Agents, Chemistry of
\n1,6-Diazaphenalene and its Derivatives,” R.W. Weber, K. Avasthi, S.J. Lee and J.M. Cook, Joint
\nMeeting of the Central-Great Lakes American Chemical Society, Dayton, OH, May 20-22, 1981,
\nAbstract No. ORGN-283.
\nhh. “Synthesis of 3-Hydroxymethyl \u00df-Carboline, a Diazepam Antagonist,” M. Cain, R. Weber, J.M.
\nCook, K. Rice, J.W. Crawley, and P. Skolnick, 28th International Union of Pure and Applied
\nChemistry Meeting, University of British Columbia, Vancouver, BC, August 24-28, 1981.
\nii. “Anomalous Action of Benzodiazepine Antagonists in Preventing 3-Carbomethoxy-\u00df- Carboline
\n(BCCM)-Induced Convulsions,” M. Schwei, M. Cain, J. Cook, S. Paul, and P. Skolnick, ASPET
\nMeeting, Louisville, KY, August, 1982.
\njj. “Reaction of 1,6-Diazaphenalene with Electrophiles. Theoretical and Experimental Results,” R.
\nWeber, S.J. Lee, J.M. Cook, and W. England, 16th Annual Meeting of Great Lakes American
\nChemical Society Region, Illinois State University, Normal, IL, June 7-9, 1982, Abstract No. 184.
\nkk. “\u00df-Carbolines: Synthesis, Neurochemical and Pharmacological Actions on Brain Benzodiazepine
\nReceptors,” M. Cain, F. Guzman, R. Weber, J.M. Cook, K.C. Rice, and P. Skolnick, 16th Annual
\nMeeting of Great Lakes American Chemical Society Region, Illinois State University, Normal, IL,
\nJune 7-9, 1982, Abstract No. 185.
\nll. “General Approach Toward the Synthesis of Polyquinanes. Entry into the Triquinacene Ring
\nSystem,” G. Lannoye, V. Honkan, U. Weiss, S. Bertz, and J.M. Cook, 16th Annual Meeting Great
\nLakes American Chemical Society Region, Illinois State University, Normal, IL, June 7-9, 1982,
\nAbstract No. 201.
\nmm. “Reaction of Dicarbonyl Compounds with Dimethyl 3-Ketoglutarate, Influence of Steric
\nEffects on Success of the Condensation,” M.N. Deshpande, G. Kubiak, W.C. Han, U. Weiss and
\nJ.M. Cook, 16th Annual Meeting Great Lakes American Chemical Society Region, Illinois State
\nUniversity, Normal, IL, June 7-9, 1982, Abstract No. 206.
\nnn. “General Approach for the Synthesis of Polyquinanes. Synthesis of Modhephane and Triquinacene
\nvia the Weiss Reaction,” V. Honkan, G. Lannoye, J. Wrobel, S. Bertz, K. Takahashi and J.M. Cook,
\n184th American Chemical Society National Meeting, Kansas City, MO, September 12-17, 1982,
\nAbstract No. ORG-134.
\noo. “Selenium Dioxide and DDQ Oxidations in the Indole Area. Synthesis of the \u00df-Carboline Alkaloids
\nCanthine-6-one and Crenatine,” M. Cain and J.M. Cook, 184th American Chemical Society National
\nMeeting, Kansas City, MO, September 12-17, 1982, Abstract No. ORG-15.
\npp. “\u00df-Carbolines: Synthesis, Neurochemical and Pharmacological Actions on Brain Benzodiazepine
\nReceptors,” M. Cain, F. Guzman, P. Larscheid, J.M. Cook, M. Schweri, S. Paul, W. Mendelson, and
\nP. Skolnick, 184th American Chemical Society National Meeting, Kansas City, MO, September 12-
\n17, 1982.
\nqq. “Synthesis of \u00df-Carboline Alkaloids. Search for Valium Agonists and Antagonists,” F. Guzman, P.
\nLarscheid, M. Cain, P. Skolnick, M. Schweri and J.M. Cook, 17th Great Lakes Regional Meeting,
\nAmerican Chemical Society, College of St. Catherines, June 1-3, 1983, Abstract No. 211.
\nrr. “The Influence of Steric and Electronic Effects on Success of the Wiess Reaction,” G. Kubiak, M.
\nDeshpande and J.M. Cook, 17th Great Lakes Regional Meeting, American Chemical Society,
\nCollege of St. Catherines, June 1-3, 1983, Abstract No. 205.
\nss. “General Approach for the Synthesis of Polyquinanes via the Weiss Reaction,” G. Lannoye, G.
\nKubiak, V. Honkan and J.M. Cook, 17th Great Lakes Regional Meeting, American Chemical
\nSociety, College of St. Catherines, June 1-3, 1983, Abstract No. 206.
\ntt. “Synthesis of \u00df-Carbolines and Related Heterocycles, Search for Valium Agonists and Antagonists,”
\nF. Guzman, P. Larscheid, M. Cain, J.M. Cook, P. Skolnick, and M. Schweri, 186th National
\nAmerican Chemical Society Meeting, Washington. DC, August 27-September 2, 1983.
\nuu. “Characterization of Drug Epitomes Recognized by Antibodies in Quinidine and Quinine-Induced
\nThrombocytopenia,” D. Christies, R. Weber, J.M. Cook and R.H. Aster, Blood, 62, No. 5
\n(supplement 1, p. 243a) presented at 25th Am. Soc. of Hematology, San Francisco, CA, December
\n3-6, 1983, Abstract No. 875.
\nvv. “Benzodiazepine Receptor Mediation of Genetically-Determined Stereotype Abnormal Behavior of
\nTottering Mice,” P.J. Syapin, J.H. Schneider, P. Larscheid and J.M. Cook, Neurosciences Meeting,
\nBoston, MA, 1983.
\nww. “Reversal of Cerebrovascular and Metabolic Effects of Flurazepam with a Benzo-diazepine
\nAntagonist, 3-Hydroxymethyl \u00df-Carboline,” J. Feld, W.E. Hoffman, V. Baughman, J.M. Cook, D.J.
\nMiletich, and R. Albrecht, Anesthesiology, 59, A-332, 1983.
\nxx. “Synthesis of \u00df-Carbolines. Search for Chemical Anxiogenic and Anxiolytic Agents,” P. Larscheid,
\nF. Guzman, J.M. Cook, P. Skolnick, and S. Paul, 10th Natural Products and Medicinal Chemistry
\nSymposium, University of the West Indies, Mona, Jamaica, January 3-7, 1984.
\nyy. “Interactions of Central Benzodiazepine and Barbiturate Receptors,” N. Naughton, S.T. Anderson,
\nW.E. Hoffman, J.M. Cook, and P. Larscheid, FASEB, St. Louis, MO, April 1984, Abstract No.
\n3873.
\nzz. “Differential Antagonism of Diazepam-Induced Hypnosis,” J.M. Witkin, J.E. Barret, J.M. Cook,
\nand P. Larscheid, FASEB, St. Louis, MO, April 1984, Abstract No. 3774.
\naaa. “\u00df-Carbolines as Antagonists of the Anticonvulsant and Discriminative Effects of Diazepam,” H.E.
\nShannon, P. Larscheid and J.M. Cook, FASEB, St. Louis, MO, April 1984, Abstract No. 3776.
\nbbb. “Midazolam-Alcohol Interactions and Reversal with a New Benzodiazepine Antag-onist,” P. Van
\nGorder, C. Perkezas, F. Guzman, J.M. Cook, D.J. Miletich, R.F. Albrecht, and W.E. Hoffman,
\nAnnual Meeting of the Neuroscience Society, Anaheim, CA, November 13, 1984.
\nccc. “SAR of \u00df-Carbolines as Regards Binding Affinity to Benzodiazepine Receptors,” B. Johnson, R.
\nCraig, P. Larscheid, F. Guzman, and J.M. Cook, Joint Great Lakes- Central Regional Meeting,
\nWestern Michigan University, Kalamazoo, MI, May 23-25, 1984, Abstract No. 228.
\nddd. “Synthesis of \u00df-Carbolines: Preparation of “Active” Antagonists of the Benzo-diazepines,” F.
\nGuzman, P. Larscheid, T. Hagen, C. Schultz, and J.M. Cook, Joint Great Lakes-Central Regional
\nMeeting, Western Michigan University, Kalamazoo, MI, May 23-25, 1984, Abstract No. 229.
\neee. “Preparation of 2,6-Disubstituted cis-Bicyclo[3.3.0]octane-3,7-Diones,” G. Lannoye, G. Kubiak and
\nJ.M. Cook, Joint Great Lakes-Central Regional Meeting, Western Michigan University, Kalamazoo,
\nMI, May 23-25, 1984, Abstract No. 307.
\nfff. “Reaction of 1,2-Dicarbonyl Compounds 1 with Dimethyl \u00df-Ketoglutarate 2. Approach Toward
\nHighly Strained [5.5.m.n.] Fenestranes,” G. Kubiak, M.N. Deshpande, M. Jawdosiuk, U. Weiss and
\nJ.M. Cook, Joint Great Lakes-Central Regional Meeting, Western Michigan University, Kalamazoo,
\nMI, May 23-25, 1984, Abstract No. 365.
\nggg. “Synthesis of \u00df-Carbolines: Search for New and More Stable Valium Antagonists,” T. Hagen, F.
\nGuzman, P. Skolnick, W. Hoffman, and J.M. Cook, 19th Great Lakes Regional Meeting of the
\nAmerican Chemical Society, Purdue University, West Lafayette, IN, June 10-12, 1985, Abstract
\nNo. 238.
\nhhh. “Simple Synthesis of 3,4-Indolosubstituted \u00df-Carbolines. A New Class of Benzo-diazepine
\nAntagonists,” M. Trudell, R. Craig, P. Skolnick, and J.M. Cook, 19th Great Lakes Regional Meeting
\nof the American Chemical Society, Purdue University, West Lafayette, IN, June 10-12, 1985,
\nAbstract No. 239.
\niii. “General Approach for the Synthesis of Polyquinenes. Synthesis of Staurane- 5,8,11- Tetraene,” M.
\nDeshpande, G. Kubiak, M. Jawdosiuk, U. Weiss, and J.M. Cook, 19th Great Lakes Regional
\nMeeting of the American Chemical Society, Purdue University, West Lafayette, IN, June 10-12,
\n1985, Abstract No. 315.
\njjj. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Synthesis of
\nTetracyclo[6.6.0.0.1,5O.8,12] tetradecane-3,6,10,13-tetraene,” M. Venkatachalam, M. Jawdosiuk, and
\nJ.M. Cook, 19th Great Lakes Regional Meeting of the American Chemical Society, Purdue
\nUniversity, West Lafayette, IN, June 10-12, 1985, Abstract No. 316.
\nkkk. “Selective Entry into Mono or Dialkylated cis-Bicyclo[3.3.0]octane-3,7-dione Systems,” G. Kubiak,
\nG. Lannoye, and J.M. Cook, 19th Great Lakes Regional Meeting of the American Chemical Society,
\nPurdue University, West Lafayette, IN, June 10-12, 1985, Abstract No. 317.
\nlll. “Simple Synthesis of 3,4-Indolosubstituted \u00df-Carbolines. A New Class of Benzo-diazepine
\nAntagonists,” M. Trudell, R. Craig, P. Skolnick, and J.M. Cook, 190th National American Chemical
\nSociety Meeting, Chicago, IL, September 8-13, 1985, Abstract No. MEDI-87.
\nmmm. “Synthesis of \u00df-Carbolines: Search for New and More Stable Valium Antagonists,” T.
\nHagen, F. Guzman, P. Larscheid, P. Skolnick, W. Hoffman, and J.M. Cook, 190th National
\nAmerican Chemical Society Meeting, Chicago, IL, September 8-13, 1985, Abstract No. ORGN-82.
\nnnn. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Synthesis of
\nTetracyclo[6.6.0.01,5O.8,12] tetradecane-3,6,10,13-tetraene,” M. Venkatachalam, M. Jawdosiuk, and
\nJ.M. Cook, 190th National American Chemical Society Meeting, Chicago, IL, September 8-13,
\nl985, Abstract No. ORGN-50.
\nooo. “Regiospecific Entry into Mono or Dialkylated cis-Biocyclo[3.3.0]-octane-3,7-dione Systems,” G.
\nKubiak, G. Lannoye, and J.M. Cook, 190th National American Chemical Society Meeting, Chicago,
\nIL, September 8-13, 1985, Abstract No. ORGN-49.
\nppp. “General Approach for the Synthesis of Polyquinenes,” J.M. Cook, National Science Foundation
\nWorkshop in Organic Synthesis, Pingree Park, CO, July 10-14, 1985.
\nqqq. “Synthesis of the Anticonvulsant 3-Chloro-1H,8H-Pyrido[2,3-b:4,5-b’]diindole. A Selective
\nBenzodiazepine Receptor Agonist with No Sedative Properties,” M. Trudell, J.M. Cook, P.
\nSkolnick, and H. Shannon, Eleventh Mona Symposium, on Natural Products and Medicinal
\nChemistry, UWI, January 6-10, 1986.
\nrrr. “General Approach for the Synthesis of Polyquinenes,” G. Kubiak, G. Lannoye, M. Ventakachalam,
\nU. Weiss, and J.M. Cook, 191st ACS National Meeting, New York, N.Y., April 13-18, 1986.
\nAbstract No. MEDI-47.
\nsss. “Synthesis of 3,6-Disubstituted \u00df-Carbolines Which Possess Either Benzodiazepine Antagonist or
\nAgonist Activity,” H.E. Shannon, P. Skolnick, T.J. Hagen, F. Guzman, and J.M. Cook, 191st ACS
\nNational Meeting, New York, N.Y., April 13-18, 1986.
\nttt. “Synthesis of the Anticonvulsant 2-Chloro-7,12-Dihydropyrido[3,2-b:5,4-b’]- diindole. A Selective
\nBenzodiazepine Receptor Agonist with No Sedative Activity,” M. Trudell, H. Shannon, P. Skolnick
\nand J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette University, Milwaukee, WI,
\nJune 2-4, 1986, Abstract No. 261.
\nuuu. “A New Class of Norharman Derivatives Which Potently Bind to Benzodiazepine Receptors:
\n6-Substituted Derivatives of Norharman That Bind at 100 nM,” T. Hagen, P. Skolnick, H.E.
\nShannon, and J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette University,
\nMilwaukee, WI, June 2-4, 1986, Abstract No. 262.
\nvvv. “Synthetic Studies in the \u00df-Carboline Area. A Simple One-Pot Oxidation- Amination Reaction,”
\nM.L. Trudell, N. Fukada, and J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette
\nUniversity, Milwaukee, WI, June 2-4, 1986, Abstract No. 303.
\nwww. “Dialkylation of cis-Bicyclo[3.3.0]octane-3,7-dione Derivatives,” G. Lannoye, G. Kubiak,
\nand J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette University, Milwaukee, WI,
\nJune 2-4, 1986, Abstract 304.
\nxxx. “General Approach for the Synthesis of Polyquinenes,” G. Lannoye, M. Venkatachalam, G. Kubiak,
\nU. Weiss, and J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette University,
\nMilwaukee, WI, June 2-4, 1986, Abstract No. 305.
\nyyy. “General Approach for the Synthesis of Polyquinanes. Synthesis of cis-cis-Tetracyclo[
\n9.3.0.01,5.07,11]tetradeca-4, 8-diacetoxy-6-one via the Aldol Approach,” M. Venkatachalam,
\nU. Weiss, and J.M. Cook, 20th Great Lakes Regional ACS Meeting, Marquette University,
\nMilwaukee, WI, June 2-4, 1986, Abstract No. 306.
\nzzz. “General Approach for the Synthesis of Polyquinenes,” G. Lannoye, M. Venkatachalam, G. Kubiak,
\nU. Weiss, and J.M. Cook, 8th Rocky Mountain Regional ACS Meeting, Denver, CO, June 8-12,
\n1986, Abstract No. ORSY-383.
\naaaa. “Synthesis of the Anticonvulsant 2-Chloro-7,12-Dihydropyrido[3,2-b:5,4-b’] diindole. A
\nSelective Benzodiazepine Receptor Agonist with No Sedative Activity,” M. Trudell, H. Shannon,
\nP. Skolnick, and J.M. Cook, 8th Rocky Mountain Regional ACS Meeting, Denver, CO, June 8-12,
\n1986, Abstract No. RSY-384.
\nbbbb. “Behavorial Effects of Benzodiazepine (BZ) Agonist, Antagonist and Inverse Agonists in
\nthe Baboon,” C.A. Sannerud, S. Tantiraksachai, J.M. Cook, and R.R. Griffiths, Federation
\nProceedings, 46(4), 1301 (1987) #5746.
\ncccc. “Alterations of the Behavorial Effects of Benzodiazepine Receptor Ligands During
\nChronic Diazepam Administration,” C.A. Sannerud, J.M. Cook, and R.R. Griffiths, Society of
\nNeuroscience Abstracts, 1987, 13, 966.
\ndddd. “Synthesis of 6-Substituted \u00df-Carbolines Which Behave as Benzodiazepine Receptor
\nAntagonists or Inverse Agonists,” T.J. Hagen, P. Skolnick, and J.M. Cook, 193rd National ACS
\nMeeting, Denver, CO, April 5-10, 1987, Abstract MED-035.
\neeee. “Pyridodiindoles. Synthesis of Rigid, Planar Ligands of Benzodiazepine Receptors,” M.L.
\nTrudell, S. Lifer, and J.M. Cook, 193rd National ACS Meeting, Denver, CO, April 5-10, 1987,
\nAbstract No. MED-036.
\nffff. “General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. Studies Directed
\nToward the Preparation of Dicyclopenta[a,d]pentalene, Dicyclopenta-[cd,gh]pentalene and
\nDicyclopenta[a,e]pentalene,” G. Lannoye and J.M. Cook, 193rd National ACS Meeting, Denver,
\nCO, April 5-10, 1987, Abstract ORGN-100.
\ngggg. “Hydrazine-Mediated One Pot Amination-Oxidation Reaction,” M.L. Trudell and J.M.
\nCook, 193rd National ACS Meeting, Denver, CO, April 5-10, 1987, Abstract ORGN-253.
\nhhhh. “Synthesis of Pyrido[3,2-b:5,4-b’]diindoles and \u00df-Carbolines. The Pharmacophore for the
\nBenzodiazepine Receptor Inverse Agonist Site,” T.J. Hagen, M.L. Trudell, S. Lifer, Y.-C. Tan, M.S.
\nAllen, P. Skolnick, P.W. Codding, and J.M. Cook, presented at the 43rd Southwest Regional
\nMeeting of the American Chemical Society, Little Rock, AR, December 2-4, 1987, Abstract No.
\n214.
\niiii. “Repeated Administration of Behavioral Receptor Ligands in the Baboon,” C.A.Sannerud, J.M.
\nCook and R.R. Griffiths, Society of Neuroscience Abstracts, 14(1), 345, 1988.
\njjjj. “Pictet-Spengler Reactions in Aprotic Media. Synthesis of the Indole Alkaloids 1-Methoxy
\nCanthine-6-one and Suaveoline,” J.M. Cook, T.J. Hagen, and M.L. Trudell, presented at the 12th
\nMona Symposium, Natural Products and Medicinal Chemistry, University of the West Indies,
\nMona, Jamaica, January 4-8, 1988.
\nkkkk. “General Approach to the Synthesis of Polyquinenes via the Weiss Reaction,” G. Lannoye,
\nK. Sambasivarao, and J.M. Cook, 9th Rocky Mountain Regional Meeting of the American Chemical
\nSociety, Las Vegas, NV, March 27-30, 1988, Abstract No. 49.
\nllll. “Studies on the Pharmacophore for the Benzodiazepine Inverse Agonist Site. Synthesis of a Potent
\nLong-Lived Inverse Agonist,” M.S. Allen, T.J. Hagen, M.L. Trudell, S. Lifer, Y.-C. Tan, and J.M.
\nCook, 9th Rocky Mountain Regional Meeting of the American Chemical Society, Las Vegas, NV,
\nMarch 27-30, 1988, Abstract No. 64.
\nmmmm. “Pictet-Spengler Reactions in Aprotic Media. Studies Directed Toward the Synthesis of
\nthe Indole Alkaloids Suaveoline and 1-Methoxy Canthine-6-one,” M.L. Trudell, T.J. Hagen, and
\nJ.M. Cook, 9th Rocky Mountain Regional Meeting of the American Chemical Society, Las Vegas,
\nNV, March 27-30, 1988, Abstract No. 191.
\nnnnn. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Synthesis
\nof 1,10-Disubstituted Triquinacenes Including the First Propellane Triquinacene,” A.K. Gupta, U.
\nWeiss, and J.M. Cook, 20th Central Regional Meeting of the American Chemical Society, West
\nVirginia University, Morgantown, WV, June 1-3, 1988, Abstract No. 113.
\noooo. “Synthesis of Water Soluble Pyridodiindole Ligands with Potent Affinity for
\nBenzodiazepine Receptors,” Y.-C. Tan, M.L. Trudell, and J.M. Cook, 20th Central Regional
\nMeeting of the American Chemical Society, West Virginia University, Morgantown, WV, June 1-3,
\n1988, Abstract No. 114.
\npppp. “Pictet-Spengler Reactions in Aprotic Media. Synthesis of the Cytotoxic Alkaloid
\n1-Methoxy Canthine-6-one,” T.J. Hagen and J.M. Cook, 20th Central Regional Meeting of the
\nAmerican Chemical Society, West Virginia University, Morgantown, WV, June 1-3, 1988, Abstract
\nNo. 137.
\nqqqq. “Studies Directed Toward the Synthesis of the Indole Alkaloid Suaveoline,” M.L. Trudell
\nand J.M. Cook, 20th Central Regional Meeting of the American Chemical Society, West Virginia
\nUniversity, Morgantown, WV, June 1-3, 1988, Abstract No. 139.
\nrrrr. “Facile Alteration of the Symmetry of the cis-Bicyclo[3.3.0]octane-3,7-dione Union for the
\nSynthesis of Polyquinenes,” K. Sambasivarao, G. Kubiak, and J.M. Cook, 20th Central Regional
\nMeeting of the American Chemical Society, West Virginia University, Morgantown, WV, June 1-3,
\n1988, Abstract No. 144.
\nssss. “Sterochemical Control in the Pictet-Spengler Reaction. Chirally-controlled Synthesis of
\nOptically Active 1,3-Disubstituted-1,2,3,4-Tetrahydro-\u00df-Carbolines,” L.H. Zhang and J.M. Cook,
\n20th Central Regional Meeting of the American Chemical Society, West Virginia University,
\nMorgantown, WV, June 1-3, 1988, Abstract No. 145.
\ntttt. “Synthesis of 3-Substituted-\u00df-Carbolines as Benzodiazepine Receptor Ligands: Probing the
\nBenzodiazepine Receptor Inverse Agonist Site via the Template Approach,” M.S. Allen, T.J. Hagen,
\nP. Skolnick, and J.M. Cook, 20th Central Regional Meeting of the American Chemical Society,
\nWest Virginia University, Morgantown, WV, June 1-3, 1988, Abstract No. 168.
\nuuuu. “Defining the Pharmacophore of the Benzodiazepine Inverse Agonist Site,” K. Narayanan,
\nP. Skolnick, and J.M. Cook, 20th Central Regional Meeting of the American Chemical Society,
\nWest Virginia University, Morgantown, WV, June 1-3, 1988, Abstract No. 169.
\nvvvv. “Synthesis and 2 D-Cosy Characterization of Quinine and Quinidine Metabolites.
\nAntibody-Mediated Platelet Destruction by Quinine, Quinidine, and Their Metabolites,” H.
\nDiaz-Arauzo, D.J. Christie, and J.M. Cook, 20th Central Regional Meeting of the American
\nChemical Society, West Virginia University, Morgantown, WV, June 1-3, 1988, Abstract No. 170.
\nwwww. “Studies on the Pharmacophore for the Benzodiazepine Receptor Inverse Agonist Site:
\nSynthesis of a Potent Long-lived Inverse Agonist and an Irreversible Inhibitor,” M.S. Allen, T.J.
\nHagen, M.L. Trudell, P. Skolnick, J.M. Cook, 40th ACS Southwest Regional Meeting, Radisson
\nHotel Atlanta, Atlanta, Georgia, Nov. 9-11, 1988, Abstract No. 446.
\nxxxx. “Synthesis of Higher Homologs of 7,12-Dihydropyrido-[3,4-b:5,4,-b’]diindole. Probing the
\nDimensions of the Benzodiazepine Receptor Inverse Agonist Site,” K. Narayanan, P. Skolnick, J.M.
\nCook, 197th ACS National Meeting, Dallas, Texas, April 9-14, 1989, MEDI-0036.
\nyyyy. “The Template Approach to the Pharmacophore of the Benzodiazepine Receptor Inverse
\nAgonist Site,” M.S. Allen, P. Skolnick, T.J. Hagen, K. Koehler, J.M. Cook, 197th ACS National
\nMeeting, Dallas, Texas, April 8-14, 1989, MEDI-0055.
\nzzzz. “Antibody-Mediated Platelet Destruction by Quinine, Quinidine and Their Metabolites.
\nSynthesis and Conformation of the Metabolites of Quinine and Quinidine,” H. Diaz-Arauzo, D.J.
\nChristie, J.M. Cook, 197th ACS National Meeting, Dallas, Texas, April 9-14, 1989, MEDI-0081.
\naaaaa. “Pictet-Spengler Reactions in Aprotic Media, Studies Directed Toward the Synthesis of the
\nMacroline Alkaloids Suaveloline and Macroline,” M.L. Trudell, L.-H. Zhang, J.M. Cook, 197th
\nACS National Meeting, Dallas, Texas, April 9-14, 1989, ORGN-0035.
\nbbbbb. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Synthesis
\nof 1,10-Disubstituted Triquinacenes Including ‘Propellane’ Triquinancene,” A.K. Gupta, X. Fu, J.M.
\nCook, 197th National ACS Meeting, Dallas, Texas, April 9-14, 1989, ORGN-0159.
\nccccc. “Functionalization of the cis-Bicyclo[3.3.0]octane-3,7-dione Unit and its Application to
\nthe Synthesis of Polyquinenes,” K. Sambasivarao, J.M. Cook, 197th National ACS Meeting, Dallas,
\nTexas, April 9-14, 1989, ORGN-0194.
\nddddd. “Computer-assisted Approach to the Pharmacophore of the Benzodiazepine Receptor
\nInverse Agonist Site, M.S. Allen, P. Skolnick, L. Schindler, J.M. Cook, 22nd ACS Great Lakes
\nRegional Meeting, University of Minnesota-Duluth, Duluth, MN, May 31-June 2, 1989, Abstract
\nNO. 28.
\neeeee. “Molecular Yardsticks: Probing the Dimensions of the Benzodiazepine Receptor Inverse
\nAgonist Site with Rigid, Planar Ligands,” K. Narayanan, P. Skolnick, J.M. Cook, 22nd ACS Great
\nLakes Regional Meeting, University of Minnesota-Duluth, Duluth, MN, May 31-June 2, 1989,
\nAbstract No. 29.
\nfffff. “Antibody-Mediated Platelet Destruction by Quinine, Quinidine and Their Metabolites.
\nSynthesis and Conformation of the Metabolites of Quinine and Quinidine,” H. Diaz-Arauzo, D.J.
\nChristie, J.M. Cook, 22nd ACS Great Lakes Regional Meeting, University of Minnesota-Duluth,
\nDuluth, MN, May 31-June 2, 1989, Abstract No. 30.
\nggggg. “Pictet-Spengler Reactions in Aprotic Media. Stereocontrolled Approach to the Synthesis
\nof Macroline Alkaloids,” L.-H. Zhang, J.M. Cook, 22nd ACS Great Lakes Regional Meeting,
\nUniversity of Minnesota-Duluth, Duluth, MN, May 31- June 2, 1989, Abstract No. 76.
\nhhhhh. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction, Progress
\nToward the Synthesis of Dicyclopenta[cd,gh]pentalene,” A.K. Gupta, J.M. Cook, 22nd ACS Great
\nLakes Regional Meeting, University of Minnesota- Duluth, Duluth, MN, May 31-June 2, 1989,
\nAbstract No. 86.
\niiiii. “Synthesis of Polyquinenes via the Weiss Reaction. Studies Directed Toward the Preparation of
\nDicyclopenta[a,d]pentalene and Dicyclopenta[a,e]pentalene,” K. Sambasivarao, J.M. Cook, 22nd
\nACS Great Lakes Regional Meeting, University of Minnesota-Duluth, Duluth, MN, May 31-June
\n2, 1989, Abstract No. 87.
\njjjjj. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Synthesis of
\nCentro-substituted Triquinacenes Including 1,10-Cyclododecyl-triquinacene,” X. Fu, A.K. Gupta,
\nJ.M. Cook, 22nd ACS Great Lakes Regional Meeting, University of Minnesota-Duluth, Duluth,
\nMN, May 31-June 2, 1989, Abstract No. 88.
\nkkkkk. “Studies Directed Toward the Synthesis of Diazapentalenes,” S.P. Hollinshead, K.
\nSambasivarao, J.M. Cook, 22nd ACS Great Lakes Regional Meeting, University of
\nMinnesota-Duluth, Duluth, MN, May 31-June 2, 1989, Abstract No. 97.
\nlllll. “The Total Synthesis of the Macroline-Related Alkaloid Suaveoline,” L.H. Zhang, M.L. Trudell,
\nS.P. Hollinshead, J.M. Cook, 198th National Meeting of the ACS, Miami Beach, FL, September
\n10-15, 1989, Abstract No. ORGN-113.
\nmmmmm. “Chiral Control in the Pictet-Spengler Reaction. Synthesis of Macroline-Related
\nAlkaloids,” J.M. Cook, L.H. Zhang, M. Trudell, and S.P. Hollinshead, The Mona Symposium
\n(1990), National Products and Medicinal Chemistry, University of West Indies, Kingston, Jamaica,
\nJanuary 8-12, 1990.
\nnnnnn. “Synthetic Studies on the Pharmacophore for the Benzodiazepine Inverse Agonist Site,”
\nJ.A. Laloggia, M.S. Allen and J.M. Cook, 20th Annual Undergraduate Research Symposium in
\nChemistry, Carthage College, April 25-26, 1990.
\nooooo. “Chiral Control in the Pictet-Spengler Reaction. Synthesis of Macroline-Related
\nAlkaloids,” J.M. Cook, L.H. Zhang, and M. Trudell, 23rd Great Lakes Regional Meeting of the
\nACS, NIU, DeKalb, Illinois, May 30 – June 1, 1990, Abstract #167.
\nppppp. “Studies Directed Toward the Synthesis of Polyquinenes via the Weiss Reaction,” X. Fu,
\nA.K. Gupta, K.S. Rao and J.M. Cook, 23rd Great Lakes Regional Meeting of the ACS, NIU,
\nDeKalb, Illinois, May 30 – June 1, 1990, Abstract #163.
\nqqqqq. “A Synthetic and Computer Assisted Investigation of the Topography of the
\nBenzodiazepine Receptor Inverse Agonist Site, M. S. Allen, P. Skolnick, T.J. Hagen, K. Koehler
\nand J.M. Cook, 23rd Great Lakes Regional Meeting of the ACS, NIU, DeKalb, Illinois, May
\n30 – June 1, 1990, Abstract #179.
\nrrrrr. “Molecular Modelling of the Benzodiazepine Receptor (BzR) Agonist Site. Structural
\nRequirements for \u00df-Carbolines,” H. Diaz-Arauzo, M.S. Allen, P. Skolnick and J.M. Cook, 23rd
\nGreat Lakes Regional Meeting of the ACS, NIU, DeKalb, Illinois, May 30 – June 1, 1990, Abstract
\n#180.
\nsssss. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids. Studies Directed
\nToward the Enantiospecific Preparation of Na-Methylsarpagine, The Nonmacroline Portion of
\nMacralstonidine,” 23rd Great Lakes Regional Meeting of the ACS, NIU, DeKalb, Illinois, May
\n30 – June 1, 1990, Abstract #182.
\nttttt. “Molecular Yardsticks. Probing the Dimensions of the Benzodiazepine Receptor Inverse Agonist
\nSite with Rigid, Planar Ligands,” K. Narayanan, M. Martin, P. Skolnick and J.M. Cook, 23rd Great
\nLakes Regional Meeting of the ACS, NIU, DeKalb, Illinois, May 30 – June 1, 1990, Abstract #183.
\nuuuuu. “Carboxyl-Mediated Pictet-Spengler Reaction. Synthetic Approach to Cytotoxic,
\nAntileukemic Indole Alkaloids,” K. Narayanan, L. Schindler and J. M. Cook, 23rd Great Lakes
\nRegional Meeting of the ACS, NIU, DeKalb, Illinois, May 30 – June 1, 1990, Abstract #184.
\nvvvvv. “Inverse Agonists. Probes to Study the Structure, Topology and Function of the
\nBenzodiazepine Receptor,” J. M. Cook, H. Diaz-Arauzo and M.S. Allen, 52nd Annual Scientific
\nMeeting of the Committee on Problems of Drug Dependence, Richmond, Virginia, June 10 – 14,
\n1990.
\nwwwww. “The Total Synthesis of Suaveoline, Macroline and Alstonerine,” J. M. Cook, Y. Bi and
\nM. Trudell, 200th National Meeting of the ACS, Washington, D.C., August 26 – September 1, 1990,
\nAbstract #208.
\nxxxxx. “Mechanistic Study of the Acid-Catalyzed Epimerization of Reserpine to Isoreserpine,”
\nA.K. Gupta, L.H. Zhang and J.M. Cook, 200th National Meeting of the ACS, Washington, D.C.,
\nAugust 26 – September 1, 1990.
\nyyyyy. “CoMFA Approach to Long-lived Inverse Agonists at Benzodiazepine Receptors,” M.S.
\nAllen, T.J. Hagen, K. Koehler and J.M. Cook, 200th National Meeting of the ACS, Washington,
\nD.C., August 26 – September 1, 1990.
\nzzzzz. “Structural Requirements for Agonist Actions of \u00df-Carbolines at the Benzodiazepine
\nReceptor (BzR). Alignment Rule and Pharmacophore for Full and Partial Agonists at the BzR,” H.
\nDiaz-Arauzo, P. Skolnick and J.M. Cook, 200th National Meeting of the ACS, Washington, D.C.,
\nAugust 26 – September 1, 1990.
\naaaaaa. “Carboxyl-Mediated Pictet-Spengler Reaction. Synthetic Approach to Cytotoxic
\nAntileukemic Alkaloids,” K. Narayanan and J.M. Cook, The 4th Symposium on the Latest Trends
\nin Organic Synthesis, Blacksburg, Virginia, October 14-17, 1990.
\nbbbbbb. “\u00df-Carbolines Alter Pentobarbital Withdrawal,” G.J.Yutrzenka, J. Cook, T. Stone, S.
\nAnderson, ASPET 1991 Meeting, San Diego, CA, 1991.
\ncccccc. “The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective
\nAnticonvulsant\/Anxiolytic,” 53rd Annual Scientific Meeting of the Committee on Problems of Drug
\nDependence, the Breakers, Palm Beach, FL, Section on Medicinal Chemistry-Novel Compounds,
\nJune 16-20, 1991.
\ndddddd. “CoMFA Approach to the Benzodiazepine Receptor Inverse Agonist Site,” M.S. Allen,
\nT.J. Hagen, K. Koehler and J.M. Cook, 1991 Joint Central-Great Lakes Regional Meeting of The
\nAmerican Chemical Society, Indiana University-Purdue University at Indianapolis, Indiana, May
\n29-31, 1991, Abstract No. 194.
\neeeeee. “The Agonist Pharmacophore of the Benzodiazepine Receptor,” H. Diaz-Arauzo, P.
\nSkolnick and J.M. Cook, 1991 Joint Central-Great Lakes Regional Meeting of The American
\nChemical Society, Indiana University-Purdue University at Indianapolis, Indiana, May 29-31, 1991,
\nAbstract No. 195.
\nffffff. “Synthesis of Rigid Planar Ligands to Probe the Topography of the Benzodiazepine
\nReceptor Site,” L. Dorn, M. Martin and J.M. Cook, 1991 Joint Central-Great Lakes Regional
\nMeeting of The American Chemical Society, Indiana University-Purdue University at Indianapolis,
\nIndiana, May 29-31, 1991, Abstract No. 339.
\ngggggg. “Benzosubstituted Benzodiazepine Probes With Which to Study the Topography of the
\nAgonist Pharmacophore of the BzR,” Weijiang Zhang, H. Diaz-Arauzo and J.M. Cook, 1991 Joint
\nCentral-Great Lakes Regional Meeting of The American Chemical Society, Indiana
\nUniversity-Purdue University at Indianapolis, Indiana, May 29-31, 1991, Abstract No. 340.
\nhhhhhh. “Stereospecificity of the Pictet-Spengler Reaction. Kinetic versus Thermodynamic
\nControl,” K. Czerwinski, L. Deng and J.M. Cook, 1991 Joint Central-Great Lakes Regional Meeting
\nof The American Chemical Society, Indiana University-Purdue University at Indianapolis, Indiana,
\nMay 29-31, 1991, Abstract No. 356.
\niiiiii. “Studies Directed Toward the Enantiospecific Synthesis of the Suaveoline Alkaloids.
\nApplication of the Oxy-Cope Rearrangement to the Construction of the Pyridine E-Ring,” F.Yu, X.
\nFu and J.M. Cook, 1991 Joint Central-Great Lakes Regional Meeting of The American Chemical
\nSociety, Indiana University-Purdue University at Indianapolis, Indiana, May 29-31, 1991, Abstract
\nNo. 403.
\njjjjjj. “Carboxyl-Mediated Pictet-Spengler Reaction. Synthesis of Antileukemic Cytotoxic
\nCanthine-6-one Alkaloids,” K. Narayanan and J.M. Cook, 1991 Joint Central-Great Lakes Regional
\nMeeting of The American Chemical Society, Indiana University-Purdue University at Indianapolis,
\nIndiana, May 29-31, 1991, Abstract No. 404.
\nkkkkkk. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids. Recent Progress
\nDirected Toward the Synthesis of Na-Methylsarpagine, Talpinine, Talcarpine, and Other Alstonia
\nAlkaloids,” L.K. Hamaker, Y. Bi and J.M. Cook, 1991 Joint Central-Great Lakes Regional Meeting
\nof The American Chemical Society, Indiana University-Purdue University at Indianapolis, IN, May
\n29-31, 1991, Abs. No. 405.
\nllllll. “Studies on the Pictet-Spengler Reaction. New Strategies for the Synthesis of Ring-A
\nMethoxylated Indole Alkaloids,” M.S. Allen, K. Narayanan and J.M. Cook, 32nd Meeting of the
\nAmerican Society of Pharmacognosy: International Research Congress on Natural Products,
\nChicago, IL, July 21-26, 1991, Abstract No. O-42.
\nmmmmmm. “Recent Progress Toward the Synthesis of Macroline\/Sarpagine Alkaloids,” L.K. Hamaker,
\nY. Bi, F. Yu, X. Fu and J.M. Cook, 32nd Annual Meeting of the American Society of
\nPharmacognosy: International Research Congress on Natural Products, Chicago, IL, July 21-26,
\n1991, Abstract No. O-43.
\nnnnnnn. “Probes to Study the Structure and Function of the Benzodiazepine (Valium) Receptor.
\nThe Synthesis of a New Selective Anxiolytic\/Anticonvulsant Agent,” M. Allen, H. Diaz and J.M.
\nCook, MONA Symposium 1992, Natural Products & Medicinal Chemistry, University of the West
\nIndies, Mona, Jamaica, January 6-10, 1992.
\noooooo. “Molecular Yardsticks. Probing the Dimensions of the Benzodiazepine Receptor
\nAgonist\/Inverse Agonist Binding Site With Rigid Planar Ligands,” W. Zhang, H. Diaz-Arauzo, L.
\nDorn, M. Martin, P. Skolnick and J.M. Cook, 203rd ACS National Meeting, San Francisco, April
\n5-10, 1992, MED 184.
\npppppp. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids. Total Synthesis of
\nRaumacline, Suaveoline, and 19,20-Dehydrotalcarpine,” X. Fu, Y. Bi, L.K. Hamaker, F. Y. and J.M.
\nCook, 203rd ACS National Meeting, San Francisco, April 5-10, 1992, ORG-490.
\nqqqqqq. “Receptor Mapping of the Benzodiazepine Binding Site,” K.F. Koehler, T.J. Hagen, H.
\nDiaz-Arauzo, M.S. Allen, G. Constantino, P. Skolnick and J.M. Cook, 25th Great Lakes Regional
\nACS Meeting, Milwaukee, WI, June 1-3, 1992, ORG-153.
\nrrrrrr. “Study of the Topography of the Agonist Pharmacophore at the Benzodiazepine Receptor
\nBinding Site,” W. Zhang and J.M. Cook, 25th Great Lakes Regional ACS Meeting, Milwaukee, WI,
\nJune 1-3, 1992, ORG-180.
\nssssss. “Predictive Binding of \u00df-Carboline Inverse Agonists and Antagonists via the CoMFA
\nApproach,” A.J. LaLoggia, M.S. Allen, K. Koehler, (G.D. Searle), P. Skolnick and J.M. Cook, 25th
\nGreat Lakes Regional ACS Meeting, Milwaukee, WI, June 1-3, 1992, ORG-181.
\ntttttt. “Stereospecificity in the Pictet-Spengler Reaction,” K.M. Czerwinski, L. Deng and J.M.
\nCook, 25th Great Lakes Regional ACS Meeting, Milwaukee, WI, June 1-3, 1992, ORG-184.
\nuuuuuu. “Studies Directed Toward the Enantiospecific Preparation of Macroline, Affinisine and
\nNa-Methylsarpagine,” Y. Bi and J.M. Cook, 25th Great Lakes Regional ACS Meeting, Milwaukee,
\nWI, June 1-3, 1992, ORG-193.
\nvvvvvv. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids. Recent Progress
\nDirected Toward the Synthesis of Alstophylline, Talpinine, Talcarpine, and Other Alstonia
\nAlkaloids,” L.K. Hamaker, M.S. Allen and J.M. Cook, 25th Great Lakes Regional ACS Meeting,
\nMilwaukee, WI, June 1-3, 1992, ORG-195.
\nwwwwww. “Studies Directed Toward the Enantiospecific Synthesis of the Suaveoline Alkaloids.
\nApplication of the Anionic Oxy-Cope Rearrangement to the Construction of the Pyridine E-Ring,”
\nF. Yu and J.M. Cook, 25th Great Lakes Regional ACS Meeting, Milwaukee, WI, June 1-3, 1992,
\nORG-197.
\nxxxxxx. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids. Total Synthesis of
\nRaumacline, Nb-Methyl Raumacline, and Suaveoline,” X. Fu and J.M. Cook, 25th Great Lakes
\nRegional ACS Meeting, June 1-3, 1992, ORG-198.
\nyyyyyy. “Molecular Yardsticks. Rigid Benzodiazepine Receptor Ligands to Probe the Spatial
\nDimensions of the Binding Site,” M.J. Martin, L.J. Dorn, K.F. Koehler, P. Skolnick and J.M. Cook,
\n25th Great Lakes Regional ACS Meeting, Milwaukee, WI, June 1-3, 1992, ORG-263.
\nzzzzzz. “Molecular Yardsticks: Studying the Topopgraphy of the Agonist Pharmacophore at the
\nBenzodiazepine Receptor Binding Site,” W. Zhang, P. Skolnick and J.M. Cook, 204th ACS National
\nMeeting, August 23-28th, 1992, MED-71.
\naaaaaaa. “General Approach to the Enantiospecific Synthesis of the Suaveoline\/Ajmaline Alkaloids:
\nApplication of the Anionic Oxy-Cope Rearrangement to the Construction of the Pyridine E-Ring,”
\nF. Yu, X. Fu and J.M. Cook, 204th ACS National Meeting, August 23-28th, 1992, ORG-27.
\nbbbbbbb. “Mechanism-Driven Trans-Stereospecificity in the Pictet-Spengler Reaction,” K.M.
\nCzerwinski, L. Deng and J.M. Cook, 204th ACS National Meeting, August 23-28th, 1992, ORG-80.
\nccccccc. “General Approach to the Synthesis of Macroline\/Sarpagine Alkaloids: The
\nEnantiospecific Preparation of Macroline and Related Alkaloids,” Y. Bi and J.M. Cook, 204th ACS
\nNational Meeting, August 23-28th, 1992, ORG-99.
\nddddddd. “Enantiospecific Approach Toward the Synthesis of Alstonerine, Alstophylline, and
\n10,20-Dehydrotalcarpine,” L.K. Hamaker, M.S. Allen and J.M. Cook, 204th ACS National Meeting,
\nAugust 23-28th, 1992, ORG-100.
\neeeeeee. “Molecular Yardsticks. Rigid Probes to Study the Topography of the Benzodiaz-epine
\nReceptor Site,” NIMH Workshop, Keystone, Colorado, September, 1992.
\nfffffff. “Beta Carbolines: The Design of Pharmacologic Probes for the Study of Anterior
\nHypothalamic Function,” M.J. Martin, K. Koehler and J.M. Cook, Cellular Consequences of Sleep,
\nMaui, Hawaii, March 13-17, 1993.
\nggggggg. “The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective
\nAnticonvulsant\/Anxiolytic,” E.D. Cox, M.S. Reddy and J.M. Cook, 33rd National Organic
\nSymposium, Bozeman, Montana, June 13-17, 1993, Abs. A-50.
\nhhhhhhh. “Complete Trans Stereoselectivity in the Aprotic Pictet-Spengler Reaction,” K.M.
\nCzerwinski and J.M. Cook, 33rd National Organic Symposium, Bozeman, Montana, June 13-17,
\n1993, Abs. A-54.
\niiiiiii. “Enantiospecific Approach Towards the Synthesis of Macroline\/Sarpagine\/Ajmaline
\nAlkaloids,” L.K. Hamaker, Y. Bi, F. Yu and J.M. Cook, 33rd National Organic Symposium,
\nBozeman, Montana, June 13-17, 1993, Abs. A-93.
\njjjjjjj. “Synthetic and Computer Assisted Analysis of the Structural Requirements for Selective
\nHigh Affinity Ligand Binding to ‘Diazepam-Insensitive’ Benzodiazepine Receptors,” K. Koehler, P.
\nSkolnick, R. Liu, Q. Huang, Z-Q Gu and J.M. Cook, 33rd National Organic Symposium, Bozeman,
\nMontana, June 13-17, 1993, Abs. B-3.
\nkkkkkkk. “Design, Synthesis and Evaluation of Indoleamine-2,3-Dioxygenase Inhibitors to Combat
\nAberant Tryptophan Metabolism,” A.C. Peterson, M.T. Migawa, J.M. Cook, R.R. Brown and J.A.
\nWill, 33rd National Organic Symposium, Bozeman, Montana, June 13-17, 1993, Abs. B-48.
\nlllllll. “A Study of the Topography of the Agonist Pharmacophore at the Benzodiazepine
\nReceptor Binding Site and Its Effect on Activity,” W. Zhang, P. Skolnick and J.M. Cook, 33rd
\nNational Organic Symposium, Bozeman, Montana, June 13-17, 1993, Abs. B-135.
\nmmmmmmm. “Synthesis and Evaluation of Inhibitors to Combat Aberrant Tryptophan
\nMetabolism Catalyzed by Indoleamine 2,3-Dioxygenase,” A.C. Peterson, M.T. Migawa, J.M. Cook,
\nR.R. Brown and J.A. Will, 206th ACS National Meeting, Chicago, Illinois, August 22-27, 1993,
\nMEDI-242.
\nnnnnnnn. “Study of the Agonist Pharmacophore of the Benzodiazepine Receptor. The Synthesis of
\nAnxioselective Anxiolytics,” W. Zhang, P. Skolnick and J.M. Cook, 206th ACS National Meeting,
\nChicago, Illinois, August 22-27, 1993, MEDI-196.
\nooooooo. “Studies Directed Toward the Enantiospecific Preparation of the Bisindole Alkaloid
\nMacralstonidine. The Total Synthesis of (+)-Macroline and (+)-Affinisine,” Y. Bi, and J.M. Cook,
\n206th ACS National Meeting, Chicago, Illinois, August 22-27, 1993, ORGN-67.
\nppppppp. “Approach to the Enantiospecific Synthesis of Norsuaveoline, Macrophylline, and the
\nRelated Desmethylmacrophylline,” F. Yu and J.M. Cook, 206th ACS National Meeting, Chicago,
\nIllinois, August 22-27, 1993, ORGN-68.
\nqqqqqqq. “Enantiospecific Approach Towards the Synthesis of Macroline\/Sarpagine Alkaloids,”
\nL.K. Hamaker, M.S. Allen and J.M. Cook, 206th ACS National Meeting, Chicago, Illinois, August
\n22-27, 1993, ORGN-69.
\nrrrrrrr. “Stereochemical Control of the Pictet-Spengler Reaction,” K. Czerwinski, K. Koehler and
\nJ.M. Cook, 206th ACS National Meeting, Chicago, Illinois, August 22-27, 1993, ORGN-70.
\nsssssss. “Effect of Novel \u00df-Carboline Compounds on Pentobarbital Induced Sleep,” C. LeBeaux,
\nK. Campbell-Prue, J. Cook and G. Yutrzenka, American Indian Research Opportunities Conference,
\nBozeman, Montana, August 12-13, 1993.
\nttttttt. “Effect of Novel \u00df-Carboline Compounds on Pentobarbital Induced Incoordination,” K.
\nCampbell-Prue, C. LeBeaux, J. Cook and G. Yutrzenka, American Indian Research Opportunities
\nConference, Bozeman, Montana, August 12-13, 1993.
\nuuuuuuu. “Enantiospecific Approach Towards the Synthesis of Macroline\/Sarpagine\/Ajmaline
\nAlkaloids,” J.M. Cook, Y. Bi, L.K. Hamaker and M.S. Allen, Fifteenth Mona Symposium in Natural
\nProducts and Medicinal Chemistry, Mona, Jamaica, January 3-7, 1994.
\nvvvvvvv. “Synthesis and SAR Study of Selective High-Affinity Ligands That Bind to
\nDiazepam- Insensitive Benzodiazepine Receptors,” presented at the 207th ACS National Meeting,
\nSan Diego, CA, March 13-17, 1994, MEDI-187.
\nwwwwwww. “Chemical and Computer-Assisted Study of the Agonist Pharmacophore of the
\nBenzodiazepine Receptor,” W. Zhang, P. Skolnick and J.M. Cook, presented at the 207th ACS
\nNational Meeting, San Diego, CA, March 13-17, 1994, MEDI-188.
\nxxxxxxx. “Stereoselective Pictet-Spengler Reactions: Application to the Synthesis of Optically
\nActive Tetrahydro \u00df-Carbolines,” M.S. Reddy and J.M. Cook, presented at the 207th ACS National
\nMeeting, San Diego, CA, March 13-17, 1994, ORGN-312.
\nyyyyyyy. “General Approach for the Synthesis of Macroline-Sarpagine Alkaloids: Enantiospecific
\nSynthesis of (+)Macroline and a Partial Synthesis of (+)Villalstonine,” Y. Bi, L. Hamaker and J.M.
\nCook, presented at the 207th ACS National Meeting, San Diego, CA, March 13-17, 1994, ORGN-
\n444.
\nzzzzzzz. “Effect of 3-Substituted \u00df-Carbolines on Pentobarbital (PB) Induced Sleep,” G.J.
\nYutrzenka, C. LeBeaux, K. Campbell-Prue and J.M. Cook, XII International Congress of
\nPharmacology, Montreal, Quebec, July 24-29, 1994.
\naaaaaaaa. “Mode of Action of \u00df-Carboline Convulsants on the Insect Nervous System and Their
\nPotential as Insectides,” J.R. Bloomquist, A.J. LaLoggia, M.S. Reddy and J.M. Cook, presented in
\nthe summer of 1994.
\nbbbbbbbb. “Chemical and Computer-Assisted Development of the Inclusive Pharmacophore for the
\nBenzodiazepine Receptor,” James Cook, presented at the 28th Middle Atlantic Regional Meeting of
\nthe ACS, University of Maryland, Baltimore County, Baltimore, MD, May 25-27, 1994, ABS 112.
\ncccccccc. “Synthesis and SAR Study of Selective High Affinity Ligands Which Bind to
\nBenzodiazepine Receptor Subtypes,” R. Liu, P. Zhang, P. Skolnick and J.M. Cook, presented at the
\nJoint Great Lakes, Central Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June
\n1-3, 1994, ABS 314.
\ndddddddd. “Synthesis and SAR Study of Novel Imidazobenzodiazepines Which Bind to
\nDiazepam- Insensitive Benzodiazepine Receptors,” P. Zhang, R. Liu, P. Skolnick and J.M. Cook,
\npresented at the Joint Great Lakes, Central Regional ACS Meeting, University of Michigan, Ann
\nArbor, MI, June 1-3, 1994, ABS 315.
\neeeeeeee. “Synthesis of 3,4,6-Trisubstituted \u00df-Carbolines. Probing the Dimensions of the Lipophilic
\nPockets in the BzR Site(s),” E. Cox and J.M. Cook, presented at the Joint Great Lakes, Central
\nRegional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 316.
\nffffffff. “Evaluation of Competitive and Non-competitive Inhibitors of Indoleamine
\n2,3-Dioxygenase to Combat Aberrant Tryptophan Metabolism in Immunological Disease States,”
\nA.C. Peterson, E. Cox, J.M. Cook, R.A. Arend and R.R. Brown, presented at the Joint Great Lakes,
\nCentral Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 319.
\ngggggggg. “A Chemical and Computer Assisted Study of the Inclusive Pharmacophore of the
\nBenzodiazepine Receptor,” W. Zhang and J.M. Cook, presented at the Joint Great Lakes, Central
\nRegional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 320.
\nhhhhhhhh. “Enantiospecific Synthesis of Macrolin\/Sarpagine\/Ajmaline-Related Alkaloids via the
\nPictet-Spengler Reaction,” Y. Bi, L. Hamaker and J.M. Cook, presented at the Joint Great Lakes,
\nCentral Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 358.
\niiiiiiii. “Enantiospecific Approach Towards the Synthesis of the Macroline-Related Alkaloids
\nAlstophylline and Macralstonine,” L. Hamaker, M.S. Allen and J.M. Cook, presented at the Joint
\nGreat Lakes, Central Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3,
\n1994, ABS 381.
\njjjjjjjj. “The Aza-Wittig Approach to the Enantiospecific Synthesis of Norsuaveoline,
\nMacrophylline, and the Related Desmethylmacrophylline,” F. Yu and J.M. Cook, presented at the
\nJoint Great Lakes, Central Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June
\n1-3, 1994, ABS 396.
\nkkkkkkkk. “Studies Directed Toward the Enantiospecific Synthesis of Alstonia, Gardneria, and
\nVoacanga Oxindole Alkaloids,” A.C. Peterson and J.M. Cook, presented at the Joint Great Lakes,
\nCentral Regional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 399.
\nllllllll. “Synthetic Approach to Angular Tetraquinanes Related to 14\u03c0 Cyclo pentapentalenes,”
\nM.S. Reddy and J.M. Cook, presented at the Joint Great Lakes, Central Regional ACS Meeting,
\nUniversity of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 402.
\nmmmmmmmm. “Stereochemical Control of the Pictet-Spengler Reaction,” K. Czwerinski, K.
\nKoehler and J.M. Cook, presented at the Joint Great Lakes, Central Regional ACS Meeting,
\nUniversity of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 403.
\nnnnnnnnn. “The Total Synthesis of Roeharmine, (+)Norroecarboline, and (-)-1,2,3,4- Tetrahydroroeharmine,”
\nM. Sreenivasa Reddy and J.M. Cook, presented at the Joint Great Lakes, Central
\nRegional ACS Meeting, University of Michigan, Ann Arbor, MI, June 1-3, 1994, ABS 428.
\noooooooo. “Search for \u03b15 Benzodiazeping Receptor Subtype Specific Ligands Based on the Structure
\nof Sarmazenil (Ro 15-4513),” R.Y. Liu, N.P. Gillard, Z-Q. Gu, K. Rice, R. McKernan and J.M.
\nCook. Presented at the 56th Annual Scientific Meeting of the College on Problems of Drug
\nDependence, The Breakers, West Palm Beach, June 18-23, 1994, Oral Communications VI.
\npppppppp. “Chemical and Computer-Assisted Study of the Inclusive Pharmacophore\/Receptor Model
\nof the Benzodiazepine Receptor Binding Site,” W. Zhang, R. Liu, Q. Huang, P. Zhang, K.F. Koehler
\nand J.M. Cook, presented at the 208th National ACS Meeting, Washington, D.C., August 21-25,
\n1994, MED-191.
\nqqqqqqqq. “Use of \u00df-Carbolines to Further Differentiate the Agonist\/Inverse Agonist Pharmacophore
\nat the BzR,” E.D. Cox and J.M. Cook, presented at the 208th National ACS Meeting, Washington,
\nD.C., August 21-25, 1994, MED-192.
\nrrrrrrrr. “Synthesis and SAR Study of Novel Imidazobenzodiazepines at Diazepam- Insensitive and
\nDiazepam-Sensitive Benzodiazepine Receptors,” P. Zhang, W. Zhang, R. Liu and J.M. Cook,
\npresented at the 208th National ACS Meeting, Washington, D.C., August 21-25, 1994, MED-195.
\nssssssss. “Total Synthesis of Roemeria Alkaloids. A Study of the Racemization in
\n(-)-1,2,3,4- Tetrahydroroeharmine,” M.S. Reddy and J.M. Cook, presented at the 208th National
\nACS Meeting, Washington, D.C., August 21-25, 1994, ORG 259.
\ntttttttt. “Enantiospecific Approach Toward the Synthesis of the Alstonia Alkaloid Alstophylline
\nand the Bisindole Macralstonine,” L.K. Hamaker and J.M Cook, presented at the 208th National
\nACS Meeting, Washington, D.C., August 21-25, 1994, ORG 269.
\nuuuuuuuu. “Studies Toward the Enantiospecific Synthesis of Suaveoline Alkaloids. Aza-Wittig
\nApproach to the Construction of the Pyridine E-Ring Systems,” F. Yu and J.M. Cook, presented at
\nthe 208th National ACS Meeting, Washington, D.C., August 21-25, 1994, ORG 270.
\nvvvvvvvv. “Studies Directed Toward the Diastereoselective Synthesis of Alstonia Oxindole
\nAlkaloids,” A.C. Peterson and J.M. Cook, presented at the 208th National ACS Meeting,
\nWashington, D.C., August 21-25, 1994, ORG 271.
\nwwwwwwww. “Recent Advances in GABAA\/Benzodiazepine Receptor Subtype Selectivity,”
\nJ.M. Cook, 27th Annual Mardi Gras Symposium on Chemistry in Drugs of Abuse: Recent
\nAdvances in Chemistry and Pharmacology, University of New Orleans, February 24, 1995.
\nxxxxxxxx. “Synthesis of Ligands Selective for the \u03b15 Benzodiazepine Receptor (BzR) Subtype,” R.Y.
\nLiu, P.W. Zhang, N.P. Gillard, R. McKernan and J.M. Cook, presented at the 209th National ACS
\nMeeting, Anaheim, CA, April 2-6, 1995, MED 1.
\nyyyyyyyy. “Evidence for Cleavage Across the C(1)N(2) Bond in the Epimerization of 1,2,3,4-
\nTetrahydro-\u00df-Carbolines,” E.D. Cox, L.K. Hamaker, M.S. Reddy, P. Zhang, K. Czerwinski and J.M.
\nCook, presented at the 209th National ACS Meeting, Anaheim, CA, April 2-6, 1995. ORG 356.
\nzzzzzzzz. “Stereospecific Approach to 19,20-Dehydro-10-methoxytalcarpine. The Enantio-specific
\nSynthesis of 5-Methoxy-D-(+)-or L(-)-tryptophan,” P.W. Zhang and J.M. Cook, presented at the
\n28th Great Lakes Regional Meeting of the ACS, La Crosse, WI, June 5-8, 1995, #142.
\naaaaaaaaa. “A Chemical and Computer Assisted Study of the Inclusive Pharmacophore of the
\nBenzodiazepine Receptor,” Q. Huang, W. Zhang and J.M. Cook, presented at the 28th Great Lakes
\nRegional Meeting of the ACS, La Crosse, WI, June 5-8, 1995, #169.
\nbbbbbbbbb. “Scission of the C(1)-N(2) Bond in the Epimerization of 1,2,3,4-Tetrahydro \u00df-Carbolines,”
\nE.D. Cox, M. S. Reddy and J.M. Cook, presented at the 28th Great Lakes Regional Meeting of the
\nACS, La Crosse, WI, June 5-8, 1995, #183.
\nccccccccc. “Synthesis and SAR Study of Novel Imidazobenzodiazepines Which Bind to ‘Diazepam-
\nInsensitive’ GABAA Receptors,” P. Zhang, R. Liu, B. Harris, P. Skolnick and J.M. Cook, presented
\nat the 28th Great Lakes Regional Meeting of the ACS, La Crosse, WI, June 5-8, 1995, #199.
\nddddddddd. “Synthesis and Study of Ligands Selective for the \u03b15\u03b22\u03b32 BzR Subtype,” R.Y. Liu, P.W.
\nZhang, N.P. Gillard, R. McKernan and J.M. Cook, presented at the 28th Great Lakes Regional
\nMeeting of the ACS, La Crosse, WI, June 5-8, 1995, #200.
\neeeeeeeee. “Studies Directed Toward the Rapid Construction of Angular Tetraquinanes Related to 14\u03c0
\nCyclopentapentalenes,” S. Van Ornum, M.S. Reddy and J.M. Cook, presented at the 28th Great
\nLakes Regional Meeting of the ACS, La Crosse, WI, June 5-8, 1995, #210.
\nfffffffff. “Pharmacophore Mapping: Synthesis of Ligands Selective for the \u03b15\u03b22\u03b32 BzR Site,” R.Y.
\nLiu, P.W. Zhang, Q. Huang, N.P. Gillard, R. McKernan and J.M. Cook, presented at the 57th Annual
\nScientific Meeting of the College on Problems of Drug Dependence, Scottsdale, Arizona, June 10-
\n15, 1995, P.S. II #35.
\nggggggggg. “Synthesis of Novel Imidazobenzodiazepines: The Selective Ligands for the GABAA
\nReceptor Subtype,” P. Zhang, R. Liu, P. Skolnick and J.M. Cook, presented at the 210th ACS
\nNational Meeting, Chicago, Illinois, August 20-24, 1995, MEDI-0148.
\nhhhhhhhhh. “Chemical and Computer-Assisted Study of the Inclusive Pharmacophore of the
\nBenzodiazepine Receptor,” Q. Huang, W. Zhang and J.M. Cook, presented at the 210th ACS
\nNational Meeting, Chicago, Illinois, August 20-24, 1995, MEDI -159.
\niiiiiiiii. “Synthesis of Ligands Selective for the \u03b1-5 Benzodiazepine Receptor (BzR) Subtype,”
\nR.Y. Liu, P.W. Zhang, N.P. Gillard, R. McKernan and J.M. Cook, presented at the 210th ACS
\nNational Meeting, Chicago, Illinois, August 20-24, 1995, MEDI-160.
\njjjjjjjjj. “Enantiospecific Synthesis of Macroline\/Sarpagine\/Ajmaline-related Indole Alkaloids via
\nthe Pictet-Spengler Reaction,” J. Li, L. Hamaker, K. Czerwinski, P. Zhang and J.M. Cook, presented
\nat the 210th ACS National Meeting, Chicago, Illinois, August 20-24, 1995, ORGN-212.
\nkkkkkkkkk. “Studies Toward the Synthesis of the Antiamoebic Bisindole Alkaloid
\n(-)-Macrocarpamine: The Partial Synthesis of (-)-Anhydromacrosalhine-methine,” T. Gan and J.M.
\nCook, presented at the 210th ACS National Meeting, Chicago, Illinois, August 20-24, 1995, ORGN-
\n213.
\nlllllllll. “Stereospecific Approach to 19,20-Dehydro-10-methoxytalcarpamine: The Enantiospecific
\nSynthesis of 5-Methoxy-D(+)- or L(-)-Tryptophan,” P. Zhang, T. Gan and J.M. Cook,
\npresented at the 210th ACS National Meeting, Chicago, Illinois, August 20-24, 1995, ORGN-214.
\nmmmmmmmmm. “Studies Directed Toward the Diastereoselective Synthesis of Alstonia Oxindole
\nAlkaloids,” A.C. Peterson, P. Yu and J.M. Cook, presented at the 210th ACS National Meeting,
\nChicago, Illinois, August 20-24, 1995, ORGN-215.
\nnnnnnnnnn. “Scission of the C(1)-N(2) Bond in the Epimerization of 1,2,3,4-Tetrahydro-\u00df-Carbolines,”
\nE.D. Cox, L.K. Hamaker, M.S. Reddy, P. Zhang, K.M. Czerwinski and J.M. Cook, presented at the
\n210th ACS National Meeting, Chicago, Illinois, August 20-24, 1995, ORGN-216.
\nooooooooo. “Studies Directed Toward the Construction of Angular Tetraquinanes Related to 14\u03c0
\nCyclopentapentalenes,” S.G. van Ornum, M.S. Reddy and J.M. Cook, presented at the 210th ACS
\nNational Meeting, Chicago, Illinois, August 20-24, 1995, ORGN-217.
\nppppppppp. “Studies Directed Toward Enantiospecific Synthesis of the Antiamoebic Alkaloid
\nMacrocarpanine and 10-Methoxymacrocarpamine,” J.M. Cook and T. Gan, presented at the
\nSixteenth Mona Symposium on Natural Products and Medicinal Chemistry, Mona, Jamaica, January
\n8-12, 1996.
\nqqqqqqqqq. \u201cPartial Synthesis of the Antiamoebic Alkaloid Macrocarpamine via the Asymmetric
\nPictet-Spengler Reaction,” J.M. Cook and T. Gan, presented at the 211th ACS National Meeting,
\nNew Orleans, March 23-28, 1996, ORGN-116.
\nrrrrrrrrr. “The Partial Synthesis of the Antiamoebic Alkaloid Macrocarpamine via The Asymmetric
\nPictet-Spengler Reaction,\u201d T. Gan and J.M. Cook presented at the 29th Great Lakes Regional ACS
\nMeeting, Illinois State University, Normal, IL, May 19-22, 1996, Abstract No. 130.
\nsssssssss. “Studies Directed Toward the Construction of Angular Tetraquinanes Related to 14\u03c0
\nCyclopentapentalenes,\u201d S. van Ornum, M.S. Reddy and J.M. Cook, presented at the 29th Great
\nLakes Regional ACS Meeting, Illinois State University, IL, May 19-22, 1996, Abstract No. 251.
\nttttttttt. “Synthesis of Ligands Selective for the \u03b15 Benzodiazepine Receptor (BzR) Subtype,” R.
\nLiu, P.W. Zhang, N.P. Gillard, R. McKernan and J.M. Cook, presented at the 29th Great Lakes
\nRegional ACS Meeting, Illinois State University, Normal, IL., May 19-22, 1996, Abstract No. 255.
\nuuuuuuuuu. “Enantiospecific Synthesis of Macroline\/Sarpagine\/Ajmaline-Related Indole Alkaloids via
\nThe Pictet-Spengler Reaction,\u201d J. Li, L. Hamaker, K. Czerwinski, P. Zhang and J.M. Cook,
\npresented at the 29th Great Lakes Regional ACS Meeting, Illinois State University, Normal, IL,
\nMay 19-22, 1996, Abstract No. 256.
\nvvvvvvvvv. \u201cScission of The C(1)-N(2) Bond in the Epimerization of 1,2,3,4-Tetrahydro \u03b2-
\nCarbolines,\u201d E. Cox, L.K. Hamaker, M.S. Reddy, P. Zhang, K. Czerwinski and J.M. Cook, presented
\nat the 29th Great Lakes Regional ACS Meeting, Illinois State University, Normal, IL, May 19-22,
\n1996, Abstract No. 257.
\nwwwwwwwww. \u201cGeneral Approach to The Diasteroselective Synthesis of Alstonia Oxindole
\nAlkaloids,\u201d P. Yu, A. Peterson and J.M. Cook, presented at the 29th Great Lakes Regional ACS
\nMeeting, Illinois State University, Normal, IL, May 19-22, 1996, Abstract No. 258.
\nxxxxxxxxx. \u201cStudies of the Pharmacophore-Receptor Models for Benzodiazepine Receptor Subtypes:
\nBinding Affinities of Substituted \u03b2-Carbolines for \u03b1x\u03b23\u03b32(X=1,2,3,5 or 6) Subtypes and a
\nComparative Molecular Field Analysis,\u201d Q. Huang, E.D. Cox, T. Gan, D.W. Bennett and J.M. Cook,
\npresented at the 212th ACS National Meeting, Orlando, Florida, August, 25-29, 1996, MEDI-0157.
\nyyyyyyyyy. \u201cPartial Synthesis of The Antiamoebic Alkaloid Macrocarpamine via the Asymmetric
\nPictet-Spengler Reaction,\u201d T. Gan and J.M. Cook, presented at the 212th ACS National Meeting,
\nOrlando, Florida, August 25-29, 1996, ORGN-0042.
\nzzzzzzzzz. \u201cThe cis the trans Epimerization 1,2,3,4-Tetrahydo \u03b2-carbolines Employed in the Total
\nSynthesis of Indole Alkaloids: Further Evidence for Cleavage Across the C(l) – N(2) Bond,\u201d E. Cox,
\nJ. Li, P. Yu, and J.M. Cook, presented at the 212th ACS National Meeting, Orlando, Florida, August,
\n25-29, 1996, ORGN-0044.
\naaaaaaaaaa. \u201cStudies Directed Toward the Construction of Angular Tetraquinanes Related to 14\u03c0-
\nCyclopentapentalenes,\u201d S. Van Ornum, M. Reddy and J.M. Cook, presented at the 212th ACS
\nNational Meeting, Orlando, Florida, August 25-29, 1996, ORGN-0068.
\nbbbbbbbbbb. \u201cGeneration of Four Five-membered Rings in a One-pot process: Studies Toward the
\nSynthesis of Dicyclopenta[a,e]pentalene via the Tandem Pauson-Khand Reaction,\u201d S.G. Van
\nOrnum, M. S. Reddy, and J.M. Cook, presented at the 213th ACS National Meeting, San Francisco,
\nCA, April 13-17, 1997, ORGN-0498.
\ncccccccccc. \u201cEnantiospecific Total Synthesis of Tryprostatin A,\u201d T. Gan and J.M. Cook, presented at
\nthe 213th ACS National Meeting, San Francisco, CA, April 13-17, 1997, ORGN-0595.
\ndddddddddd. \u201cEnantiospecific Total Synthesis of (+)-Ajmaline and Alkaloid G via the Asymmetric
\nPictet-Spengler Reaction,\u201d J. Li, and J.M. Cook, presented at the 213th ACS National Meeting, San
\nFrancisco, CA, April 13-17, 1997, ORGN-0455.
\neeeeeeeeee. \u201cEvidence for the Conservation of Conformational Topography at Five Major
\nGABAA\/Benzodiazepine Receptor Subsites: Potent Affinities of the S-Enantiomers of Frameworkconstrained
\n4,5-Substituted Pyrroloimidazobenzodiazepines,\u201d Q. Huang, R. Liu, J.M. Cook and
\nR.M. McKernan, presented at the 213th ACS National Meeting, San Francisco, CA, April 13-17,
\n1997, MEDI-0175.
\nffffffffff. \u201cA Study of Pharmacophore\/Receptor Models for Benzodiazepine Receptor Subtypes and
\nSAR Study via a Ligand-mapping Approach,\u201d Q. Huang, E.D. Cox, T. Gan, X. He, C. Ma, and J.M.
\nCook, presented at the 213th ACS National Meeting, San Francisco, CA, April 13-17, 1997, MEDI-
\n0040.
\ngggggggggg. \u201cSynthesis of Polyquinanes via the Tandem Pauson-Khand Reaction. Studies Directed
\nToward the Preparation of Dicyclopenta[a,d]pentalene and Dicyclopenta-[a,e]pentalene,\u201d S.G. Van
\nOrnum, and J.M. Cook, presented at the 30th Great Lakes Regional ACS Meeting, Loyola
\nUniversity, Chicago, IL., May 28-30, 1997, Org 97.
\nhhhhhhhhhh. \u201cEnantiospecific Total Synthesis of Tryprostatin A,\u201d Tong Gan and James M. Cook,
\npresented at the 30th Great Lakes Regional ACS Meeting, Loyola University, Chicago, IL., May
\n28-30, 1997, Org 132.
\niiiiiiiiii. \u201cConservation of Conformational Topography at Five GABAA\/Benzodiazepine Receptor
\nSubtypes,\u201d Xiaohui He, Qi Huang, Tong Gan, and James M. Cook, presented at the 30th Great
\nLakes Regional ACS Meeting, Loyola University, Chicago, IL., May 28-30, 1997, Org 203.
\njjjjjjjjjj. \u201cSearch for New Antianxiety Agents: Subtype Selectivity at \u03b11\u03b23\u03b32 and \u03b15\u03b23\u03b32 Receptor
\nSubtypes,\u201d Chunrong Ma, E.D. Cox, R. McKernan and J.M. Cook, presented at the 30th Great Lakes
\nRegional ACS Meeting, Loyola University, Chicago, IL., May 28-30, 1997, Org 204.
\nkkkkkkkkkk. \u201cGeneral Approach to the Enantiospecific Synthesis of Alstonia Oxindole Alkaloids,\u201d Peng
\nYu, F. Yu, T. Wang, A.C. Peterson and J.M. Cook, presented at the 30th Great Lakes Regional ACS
\nMeeting, Loyola University, Chicago, IL., May 28-30, 1997, Org 216.
\nllllllllll. \u201cEnantiospecific Total Synthesis of (+)-Ajmaline via the Asymmetric Pictet-Spengler
\nReaction,\u201d Jin Li and J.M. Cook, presented at the 30th Great Lakes Regional ACS Meeting, Loyola
\nUniversity, Chicago, IL., May 28-30, 1997, Org 217.
\nmmmmmmmmmm. \u201cApproach to the Enantiospecific Total Synthesis of Quebrachidine and
\nVincamajine,\u201d Tao Wang, P. Yu, J. Li and J.M. Cook, presented at the 30th Great Lakes Regional
\nACS Meeting, Loyola University, Chicago, IL., May 28-30, 1997, Org 218.
\nnnnnnnnnnn. \u201cApproach to Sarpagine Indole Alkaloids. Stereospecific Synthesis of (6S, 10S)-2-
\nMethoxy-9-OXO-12-benzyl-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooct [b]indole via the
\nAsymmetric Pictet-Spengler Reaction,\u201d S. Zhao, Q. Huang, R. Liu, P. Zhang and J.M. Cook,
\npresented at the 30th Great Lakes Regional ACS Meeting, Loyola University, Chicago, IL., May
\n28-30, 1997, Org 219.
\noooooooooo. \u201cGeneration of Four Five-Membered Rings in a One Pot Process. Studies Directed Toward
\nthe Synthesis of Dicyclopenta[a,e]pentalene via the Tandem Pauson-Khand Reaction,\u201d S.G. Van
\nOrnum and J.M. Cook, presented at the 30th Great Lakes Regional ACS Meeting, Loyola
\nUniversity, Chicago, IL., May 28-30, 1997, Org 231.
\npppppppppp. \u201cConservation of Conformational Topography at Five GABAA\/Benzodiazepine Receptor
\nSubtypes,\u201d Q. Huang, X. He, T. Gan and J.M. Cook, presented at the 59th Annual Scientific Meeting
\nof the College on Problems of Drug Dependence, Nashville, TN, June 14-19, 1997, Oral
\nCommunications III.
\nqqqqqqqqqq. \u201cPharmacophore – receptor Models for Five Major Benzodiazepine Receptor Subtypes,\u201d
\nJ.M. Cook, Q. Huang, E.D. Cox R. Liu, T. Gan, X. He and C. Ma, presented at the 214th ACS
\nNational Meeting, Las Vegas, Nevada, September 6-11, 1997, MEDI-124.
\nrrrrrrrrrr. \u201cEnantiospecific Total Synthesis of (+)-Ajmaline,\u201d J. Li and J.M. Cook, presented at the
\n214th ACS National Meeting, Las Vegas, Nevada, September 6-11, 1997, ORGN-190.
\nssssssssss. \u201cDiastereospecific Synthesis of Ketooxindoles: Potential Intermediates for the Synthesis
\nof Alstonisine as well as Voacanga-related Oxindole Alkaloids,\u201d P. Yu and J.M. Cook, presented at
\nthe 214th ACS National Meeting, Las Vegas, Nevada, September 6-11, 1997, ORGN-340.
\ntttttttttt. \u201cStudies Directed Toward the Synthesis of Dicyclopenta[a,e]pentalene and Dicyclopenta
\n[a,d]pentalene via the Tandem Pauson-Khand Reaction,\u201d S. Van Ornum and J.M. Cook, presented
\nat the 214th ACS National Meeting, Las Vegas, Nevada, September 6-11, 1997, ORGN-356.
\nuuuuuuuuuu. \u201cEnantiospecific Synthesis of Ajmaline, Alkaloid G, Talpinine and Talcarpine via the
\nAsymmetric Pictet-Spengler Reaction,\u201d J. Li, P. Yu, and J.M. Cook, presented at the Seventeenth
\nMona Symposium, 1998 in Mona, Jamaica, January 5-9, 1998.
\nvvvvvvvvvv. \u201cGABAERGIC Regulation of the Reinforcing Properties of Alcohol in Wistar rats,\u201d C. R.
\nCason, H. L. June, M. Fredericks, G. Cheatham, A. Chen, J. Cook, T. Gan and J. M. Murphy, 27th
\nAnnual Meeting of Society for Neuroscience, New Orleans, October 25-30, 1997, abstract 381.5.
\nwwwwwwwwww. \u201cExploration of the L2 Region of Pharmacophore\/Receptor Models for
\nBenzodiazepine Receptor Subtypes via Preparation of Rigidly Substituted Pyrazoloquinolinones
\n(CGS-Series),\u201d Qi Huang, X. He, C. Ma and J.M. Cook, 215th ACS National Meeting, Dallas Texas,
\nMarch 29-April 2, 1998, abstract MEDI-136.
\nxxxxxxxxxx. \u201cSearch for Selective Ligands for Benzodiazepine Receptor Subtypes by Probing the
\nPharmacophore\/Receptor Models of GABAA\/BzR Subtypes via Optically Active BzR Ligands,\u201d S.
\nYu, X. He, C. Ma, X. Liu and J.M. Cook, 215th ACS National Meeting, Dallas, Texas, March 29-
\nApril 2, 1998, abstract MEDI-137.
\nyyyyyyyyyy. \u201cFirst Enantiospecific Total Synthesis of Talcarpine and Talpinine from D-(+)-Tryptophan
\nvia the Asymmetric Pictet-Spengler Reaction,\u201d P. Yu and J.M. Cook 215th ACS National Meeting,
\nDallas, Texas, March 29-April 2, 1998, abstract ORGN-175.
\nzzzzzzzzzz. \u201cEnantiospecific Total Synthesis of (+)-Ajmaline via the Asymmetric Pictet Spengler
\nReaction,\u201d J. Li and J.M. Cook, 215th ACS National Meeting, Dallas, Texas, March 29-April 2,
\n1998, abstract ORGN-176.
\naaaaaaaaaaa. \u201cSynthetic Approach Toward The Synthesis of Dicyclopenta[a,d]pentalene and
\nDicyclopenta[a,e]pentalene via The Tandem Pauson-Khand Reaction,\u201d S.G. Van Ornum and J.M.
\nCook, 215th ACS National Meeting, Dallas, Texas, March 29-April 2, 1998, abstract ORGN-275.
\nbbbbbbbbbbb. \u201cEnantiospecific Total Synthesis of (+)-Ajmaline via the Asymmetric Pictet-
\nSpengler Reaction,\u201d Jin Li and J.M. Cook, 31st Great Lakes Regional Meeting of the ACS,
\nUniversity of Wisconsin-Milwaukee, Milwaukee, WI, June 1-3, 1998, abst. 185.
\nccccccccccc. \u201cExploration of Region L2 of Pharmacophore\/Receptor Models for GABAA\/BzR
\nSubtypes,\u201d J.M. Cook, Q. Huang, C. Ma, X. He and S. Yu, presented at The College on Problems
\nof Drug Dependence, Sixtieth Annual Scientific Meeting, Scottsdale, AZ, June 13-18, 1998, poster
\nsession III, #124.
\nddddddddddd. \u201cEnantiospecific Total Synthesis of Talcarpine 1 and Talpinine 2 via the
\nAsymmetric Pictet-Spengler Reaction,\u201d Peng Yu and J.M. Cook, 31st Great Lakes Regional
\nMeeting of the ACS, University of Wisconsin-Milwaukee, Milwaukee, WI, June 1-3, 1998, abst.
\n186.
\neeeeeeeeeee. \u201cThe Enantiospecific Total Synthesis of Norsuaveoline via The Pictet-Spengler Reaction,\u201d
\nTao Wang and J.M. Cook, 31st Great Lakes Regional Meeting of the ACS, University of Wisconsin-
\nMilwaukee, Milwaukee, WI, June 1-3, 1998, abst. 187.
\nfffffffffff. \u201cUtility of The Tandem Pauson-Khand Reaction Directed Toward The Synthesis of
\nDicyclopenta[a,d]pentalene and Dicyclopenta[a,e]pentalene,\u201d M.M. Bruendl, S.G. Van Ornum and
\nJ.M. Cook, 31st Great Lakes Regional Meeting of the ACS, University of Wisconsin-Milwaukee,
\nMilwaukee, WI, June 1-3, 1998, abst. 200.
\nggggggggggg. \u201cSynthesis and Evaluation of Functionalized Tryptophan Derivatives and
\nSubstituted \u03b2-Carbolines As Inhibitors of Indoleamine 2,3-Dioxygenase,\u201d Xiaoxiang Liu, Chunrong
\nMa, Andrew C. Peterson and J.M. Cook, 31st Great Lakes Regional Meeting of the ACS, University
\nof Wisconsin-Milwaukee, Milwaukee, WI, June 1-3, 1998, abst. 206.
\nhhhhhhhhhhh. \u201cEnatiospecific Total Synthesis of Tryprostatin A,\u201d Shuo Zhao, Tong Gan, Peng
\nYu and J.M. Cook, 31st Great Lakes Regional Meeting of the ACS, University of Wisconsin-
\nMilwaukee, Milwaukee, WI, June 1-3, 1998, abst. 227.
\niiiiiiiiiii. \u201cSynthetic Approach Directed Toward The Synthesis of Dicyclopenta[a,d]pentalene and
\nDicyclopenta[a,e]pentalene via the Tandem Pauson-Khand Reaction,\u201d S.G. Van Ornum and J.M.
\nCook, 31st Great Lakes Regional Meeting of the ACS, University of Wisconsin-Milwaukee,
\nMilwaukee, WI, June 1-3, 1998, abst 235.
\njjjjjjjjjjj. \u201cSearch for Selective Ligands for \u03b15-Benzodiazepine Receptor Subtypes By Probing The
\nPharmacophore\/Receptor Models of GABAA\/BZR Subtypes via Chiral BzR Ligands,\u201d Xiaoxiang
\nLiu and J.M. Cook, 31st Great Lakes Regional Meeting of the ACS, University of Wisconsin-
\nMilwaukee, Milwaukee, WI, June 1-3, 1998, abst 245.
\nkkkkkkkkkkk. \u201cThe Agonist Pharmacophore of The Benzodiazepine Receptor. Synthesis of A
\nSelective Anticonvulsant\/anxiolytic,\u201d Chunrong Ma, E.D. Cox, R. McKernan and J.M. Cook, 31st
\nGreat Lakes Regional Meeting of the ACS, University of Wisconsin-Milwaukee, Milwaukee, WI,
\nJune 1-3, 1998, abst 246.
\nlllllllllll. \u201cEvidence of Conservation of Conformational Topography at Five GABAA\/BzR
\nSubtypes,\u201dXiaohui He, Qi Huang, Tong Gan and J.M. Cook, 31st Great Lakes Regional Meeting of
\nthe ACS, University of Wisconsin-Milwaukee, Milwaukee, WI, June 1-3, 1998, abst 248.
\nmmmmmmmmmmm. \u201cExploration of the L2 Region of Pharmacophore\/Receptor Models For
\nBenzodiazepine Receptor Subtypes via Preparation of Rigidly Substituted Pyrazoloquinolinones
\n(CGS Series),\u201d Qi Huang, Xiaohui He, Chunrong Ma and J.M. Cook, 31st Great Lakes Regional
\nMeeting of the ACS, University of Wisconsin-Milwaukee, Milwaukee, WI, June 1-3, 1998, abst
\n249.
\nnnnnnnnnnnn. \u201cStudy of Pharmacophore\/Receptor Models for Benzodiazepine Receptor
\nSubtypes via Preparation of Rigidly Substituted Pyrazoloquinolinones,\u201d Q. Huang, X. He, S. Yu, C.
\nMa and J. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27, 1998, abst MEDI-
\n96.
\nooooooooooo. \u201cDevelopment of Selective Ligands for Benzodiazephine Receptor Subtypes By
\nManipulating the Stereochemistry of Optically Active BzR Ligands,\u201d S. Yu, X. He, C. Ma, X. Liu
\nand J. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27, 1998, abst MEDI-97.
\nppppppppppp. \u201cSynthesis and Study of Bz1 Receptor Subtype Specific Ligands,\u201d C. Ma, X. He,
\nS. Yu, R. McKernan and J. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27,
\n1998, abst MEDI-98.
\nqqqqqqqqqqq. \u201cIn Search of Inhibitors for the Indoleamine 2,3-dioxygenase (IDO) Enzyme
\nSystem, X. Liu, C. Ma, A. C. Peterson and J. M. Cook, 216th National ACS Meeting, Boston, MA,
\nAugust 23-27, 1998, abst ORG-105.
\nrrrrrrrrrrr. \u201cPhotochemical Tandem Pauson-Khand Reaction: Studies Directed Toward The Synthesis
\nof Dicyclpenta[a,f]pentalene and Dicyclopenta[a,e]pentalene,\u201d M. M. Bruendl, S. G. Van Ornum,
\nJ. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27, 1998, abst ORG-117.
\nsssssssssss. \u201cGeneral Approach to The Diastereospecific Synthesis of Indole Alkaloids: Total
\nSynthesis of Talcarpine, Talpinine, Alstonerine, and Anhydromacrosalhine-Methine via the
\nAsymmetric Pictet-Spengler Reaction,\u201d P. Yu, J. Li, T. Wang and J. M. Cook, 216th National ACS
\nMeeting, Boston, MA, August 23-27, 1998, abst. ORG-554.
\nttttttttttt. \u201cGeneral Approach to the Synthesis of Sarpagine\/Ajmaline Alkaloids: Enantiospecific
\nTotal Synthesis of (+)-Ajmaline via the Asymmetric Pictet-Spengler Reaction,\u201d J. Li and J. M.
\nCook, 216th National ACS Meeting, Boston, MA, August 23-27, 1998, abst. ORG-555.
\nuuuuuuuuuuu. \u201cTotal Synthesis of Norsuaveoline From D-(+)-Tryptophan via an Asymmetric
\nPictet-Spengler Reaction and Regioselective Oxyanion Cope Rearrangement,\u201d T. Wang, P. Yu, J.
\nLi and J. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27, 1998, abst. ORG-
\n556.
\nvvvvvvvvvvv. \u201cEnantiospecific Total Synthesis of the Enantiomers of Tryprostatin A and B,\u201d S.
\nZhao, T. Gan, P. Yu and J. M. Cook, 216th National ACS Meeting, Boston, MA, August 23-27,
\n1998, abst. ORG-557.
\nwwwwwwwwwww. \u201cStudy of Pharmacophore\/Receptor Models for GABAA\/BzR Subtypes via QSAR
\nAnalysis of Symmetrically Substituted Pyrazoloquinolinones,\u201d X. He, S. Yu, C. Ma, Q. Huang, R.
\nMcKernan, and J.M. Cook, 217th National ACS Meeting, Anaheim, CA, March 21-25, 1999, abst.
\nMEDI-095.
\nxxxxxxxxxxx. \u201cStudies in Search of Memory-enhancing Agents that Act via GABAA\/Bz
\nReceptors: Part 1. Evidence for the Conservation of Pharmacophoric Descriptors at all DS Subtypes,\u201d
\nS. Yu, X. He, C. Ma, J.M. Cook, 217th National ACS Meeting, Anaheim, CA, March 21-
\n25, 1999, abst. MEDI-096.
\nyyyyyyyyyyy. \u201cManipulation of Stereochemistry of Optically Active BzR Ligands:
\nDevelopment of Selective Ligands for Benzodiazepine Receptor Subtypes,\u201d M.M. Bruendl, X. He,
\nC. Ma, J.M. Cook, 217th National ACS Meeting, Anaheim, CA, March 21-25, 1999, abst. MEDI-
\n097.
\nzzzzzzzzzzz. \u201cSynthesis of [5.5.5.5]- and [5.6.6.5]Tetracycles via the Tandem Pauson-Khand Reaction,\u201d
\nM.M. Bruendl, H. Cao, J.M. Cook, 217th National ACS Meeting, Anaheim, CA, March 21-25,
\n1999, abst. ORG-271.
\naaaaaaaaaaaa. \u201cStudies Toward the Enantiospecific Total Synthesis of Pleiocarpamine via a
\nNovel Pictet-Spengler Reaction,\u201d S. Yu, E.D. Cox, J.M. Cook, 217th National ACS Meeting,
\nAnaheim, CA, March 21-25, 1999, abst. ORG-405.
\nbbbbbbbbbbbb. \u201cNovel Synthesis of Optically Active Tryptophan Derivatives,\u201d C. Ma, X. Liu, S.
\nYu, S. Zhao, J.M. Cook, 217th National ACS Meeting, Anaheim, CA, March 21- 25, 1999, abst.
\nORG-416.
\ncccccccccccc. \u201cSynthesis of Chiral Imidazobenzodiazepines Employed in the Development of
\nSelective Ligands for Benzodiazepine Receptor Subtypes,\u201d M.M. Bruendl, X. He, C. Ma, and J.M.
\nCook, 36th National Organic Chemistry Symposium, University of Wisconsin-Madison, Madison,
\nWI, June 13-17, 1999, abst. 29.
\ndddddddddddd. \u201cStudy of Pharmacophore\/Receptor Models for GABAA\/BzR Subtypes By
\nSynthesis of Rigidly Substituted Imidazobenzodiazepines and Pyrazoloquinolinones,\u201d X. He, S. Yu,
\nC. Ma, M. Bruendl, and J.M. Cook, 36th National Organic Symposium, University of Wisconsin-
\nMadison, Madison, WI, June 13-17, 1999, abst. 102.
\neeeeeeeeeeee. \u201cApproach to the Total Synthesis of Indole Alkaloid Alstophylline,\u201d X. Liu, C.
\nMa, L. Hamaker, and J.M. Cook, 36th National Organic Symposium, University of Wisconsin-
\nMadison, Madison, WI, June 13-17, 1999, abst. 160.
\nffffffffffff. \u201cEfficient Synthesis of Optically Active Tryptophan and Isotryptophan Derivatives,\u201d C.
\nMa, X. Liu, S. Yu, X. He, and J.M. Cook, 36th National Organic Symposium, University of
\nWisconsin-Madison, Madison, WI, June 13-17, 1999, abst. 169.
\ngggggggggggg. \u201cEnantiospecfic Total Synthesis of Norsuaveoline via Asymmetric Pictet-
\nSpengler Reaction and Regioselective Oxyanion Cope Rearrangement,\u201d T. Wang and J.M. Cook,
\n36th National Organic Symposium, University of Wisconsin-Madison, Madison, WI, June 13-17,
\n1999, abst. 279.
\nhhhhhhhhhhhh. \u201cStudies Directed Toward the Enantiospecific Total Synthesis of Indole Alkaloid
\nPleiocarpamine via a Novel Pictet-Spengler Reaction,\u201d S. Yu, E.D. Cox, and J.M. Cook, 36th
\nNational Organic Symposium, University of Wisconsin- Madison, Madison, WI, June 13-17, 1999,
\nabst. 302.
\niiiiiiiiiiii. \u201cSarpagine Indole Alkaloids. Stereospecific Synthesis of (6s, 10s)-2-Methoxy-9-oxo-12-
\nbenzyl-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooct[b]indole via Asymmetric Pictet-Spengler
\nReaction,\u201d S. Zhao and J.M. Cook, 36th National Organic Symposium, University of Wisconsin-
\nMadison, Madison, WI, June 13-17, 1999, abst.310.
\njjjjjjjjjjjj. \u201cDevelopment of Selective Ligands for Benzodiazepine Receptor Subtypes by
\nManipulating the Stereochemistry of Optically Active BzR Ligands,\u201d M.M. Bruendl, X. He, C. Ma,
\nand J.M. Cook, 218th National ACS Meeting, New Orleans, LA, August 22-26, 1999, abst. MEDI-
\n127.
\nkkkkkkkkkkkk. \u201cSearch for Selective Ligands for GABAA\/BZR Subtypes and Their Role as
\nInverse Agonists\/Antagonists in Alteration of Alcohol Dependence,\u201d X. He, C. Ma, M. Bruendl, S.
\nYu, H. June, R. McKernan, and J.M. Cook, 218th National ACS Meeting, New Orleans, LA, August
\n22-26, 1999, abst. MEDI-128.
\nllllllllllll. \u201cSearch for Bz1 Selective Ligands For GABAA\/Benzodiazepine Receptor Subtypes,\u201d C.
\nMa, X. He, M. Bruendl, R. McMcKernan, and J.M. Cook, 218th National ACS Meeting, New
\nOrleans, LA, August 22-26, 1999, abst. MEDI-129.
\nmmmmmmmmmmmm. \u201cTotal Synthesis of Tryprostatin A and B, and Enantiomers,\u201d S. Zhao, T.
\nGan, P. Yu and J.M. Cook, 218th National ACS Meeting, New Orleans, LA, August 22-26, 1999,
\nabst. ORGN-155.
\nnnnnnnnnnnnn. \u201cGeneral Approach for the Synthesis of Ajmaline and Sarpagine Indole Alkaloids:
\nEnantiospecific Total Synthesis of Norsuaveoline via Asymmetric Pictet-Spengler Reaction,\u201d T.
\nWang and J.M. Cook, 218th National ACS Meeting, New Orleans, LA, August 22-26, 1999, abst.
\nORGN-156
\noooooooooooo. \u201cEnantiospecfic Synthesis of Tryptophans and Tryprostatins via the Sch\u00f6llkopf
\nChiral Auxillary,\u201d S. Zhao, C. Ma, and J.M. Cook, MONA Symposium-2000, Mona, Jamaica,
\nJanuary 2-7, 2000.
\npppppppppppp. \u201cEnantiospecific Synthesis of Tryprostatins via the Sch\u00f6llkopf Chiral Auxiliary,\u201d
\nS. Zhao, C. Ma, X. Liu, and J.M. Cook, 219th National ACS Meeting, San Francisco, CA, March
\n26-30,2000, abst. ORGN- 749.
\nqqqqqqqqqqqq. \u201cGeneral Approach for the Synthesis of Suaveoline and Sarpagine Indole
\nAlkaloids. Enantiospecific Total Synthesis of Norsuaveoline and Vellosimine,\u201d T. Wang and J.M.
\nCook, 219th National ACS Meeting, San Francisco, CA, March 26-30, 2000, abst. ORGN- 752.
\nrrrrrrrrrrrr. \u201cSearch for Selective Ligands for GABAA\/BzR Subtypes and Their Role in Alteration of
\nAlcohol Dependence,\u201d J.M. Cook, X. He, C. Ma, S. Yu, H. June, and R. McKernan, 219th National
\nACS Meeting, San Francisco, CA, March 26-30, 2000, abst. MEDI-101.
\nssssssssssss. \u201cDevelopment of Selective Ligands for Benzodiazipine Receptor Subtypes,\u201d J.M. Cook,
\nC. Ma, X. He, and M.M. Bruendl, 219th National ACS Meeting, San Francisco, CA, March 26-30,
\n2000, abst. MEDI-105.
\ntttttttttttt. \u201cComparison of the Behavioral Effects of Beta-CCt and Flumazenil in Rhesus
\nMonkeys,\u201dC.P. France, L.R. Gerak, C. Ma, and J.M. Cook, 62nd Meeting of theCollege on Problems
\nof Drug Dependence, Oral Communications XVIII, Puerto Rico, June 17-22, 2000.
\nuuuuuuuuuuuu. \u201cSearch for Benzodiazepine\/GABAA Subtype Selective Ligands and Implications
\nin Alcohol Self-Administration,\u201d X. He, C. Ma, H. June, and J.M. Cook, 62nd Meeting of the
\nCollege on Problems of Drug Dependence, Poster Session IV (85), Puerto Rico, June 17-22, 2000.
\nvvvvvvvvvvvv. \u201cGeneral Approach for the Synthesis of Sarpagine\/Ajmaline\/Corynanthe
\nAlkaloids via the Asymmetric Pictet-Spengler Reaction. Enantiospecific Synthesis of Ajmaline,
\nVellosimine, Geissoschizine and Corynantheidine,\u201d T. Wang, S. Yu, and J.M. Cook, (Planery
\nLecture), 32nd Great Lakes 2000 Regional Meeting of the ACS, Fargo, North Dakota, June 4-6,
\n2000, abst.74.
\nwwwwwwwwwwww. \u201cApproach to the Total Synthesis of the Indole Alkaloid Na-Methylsarpagine and
\nthe Bisindole Alkaloid Macralstonine,\u201d S. Zhao and J.M. Cook, 32nd Great Lakes 2000 Regional
\nMeeting of the ACS, Fargo, North Dakota, June 4-6, 2000, abst.93.
\nxxxxxxxxxxxx. \u201cProgress Towards the Total Synthesis of 10-Methoxyanhydromacrosalhinemethine
\nvia the Asymmetric Pictet-Spengler Reaction, X. Liao, S. Zhao, and J.M. Cook, 32nd Great
\nLakes 2000 Regional Meeting of the ACS, Fargo, North Dakota, June 4-6, 2000, abst. 145.
\nyyyyyyyyyyyy. \u201cStudies Towards the Total Synthesis of the Bisindole Alkaloid Macralstonine,\u201d
\nX. Liu, C. Ma, and J.M. Cook, 32nd Great Lakes 2000 Regional Meeting of the ACS, Fargo, North
\nDakota, June 4-6, 2000, abst. 146.
\nzzzzzzzzzzzz. \u201cEnantiospecific Synthesis of Vellosimine and Norsuaveoline as well as an
\nApproach Toward Quebrachidine,\u201d T. Wang and J.M. Cook, 32nd Great Lakes 2000 Regional
\nMeeting of the ACS, Fargo, North Dakota, June 4-6, 2000, abst.150.
\naaaaaaaaaaaaa. \u201cEnantiospecfic Approach Towards the Total Synthesis of the Enantiomer of (+)
\nAjmaline,\u201d Q. Xu, T. Wang, and J.M. Cook, 32nd Great Lakes 2000 Regional Meeting of the ACS,
\nFargo, North Dakota, June 4-6, 2000, abst. 152.
\nbbbbbbbbbbbbb. \u201cConstruction of [5.5.5.5] Tetracycles via the Tandem Pauson-Khand Reaction
\nand New Entry into [5.8.5] Ring Systems,\u201d H. Cao, S. Van Ornum, M. Bruendl, and J.M. Cook,
\n32nd Great Lakes 2000 Regional Meeting of the ACS, Fargo, North Dakota, June 4-6, 2000, abst.
\n158.
\nccccccccccccc. \u201cGeneral Approach to the Corynanthe Alkaloids: Enantiospecific Total Synthesis
\nof (-) Corynantheidol and (+)-Geissoschizine,\u201d M. Berner, S. Yu, and J.M. Cook, 32nd Great Lakes
\n2000 Regional Meeting of the ACS, Fargo, North Dakota, June 4-6, 2000, abst.173.
\nddddddddddddd. \u201cTotal Synthesis of the Enantiomer of the Indole Alkaloid Affinisine and
\nApproach to the Total Synthesis of Alstophylline and Macralstonine,\u201d X. Liu, T. Wang, C. Ma, Q,
\nXu, and J.M. Cook, 220th National ACS Meeting, Washington, D.C., August 20-24, 2000, abst.
\nORG -122.
\neeeeeeeeeeeee. \u201cGeneral Approach for the Synthesis of (-)Corynantheidine, (-)Corynantheidol,
\n(+)-Geissoschizine, and (-)-Geissoschizol from a Common Intermediate,\u201d M. Berner, S. Yu, and
\nJ.M. Cook, 220th National ACS Meeting, Washington, D.C., August 20-24, 2000, abst. ORG – 131.
\nfffffffffffff. \u201cApproach to the Total Synthesis of the Bisindole Alkaloid Macralstonidine,\u201d S. Zhao and
\nJ.M. Cook, 220th National ACS Meeting, Washington, D.C., August 20-24, 2000, abst. ORG – 137.
\nggggggggggggg. \u201cEnantiospecific Total Synthesis of the Sarpagine Indole Alkaloid (+)-
\nVellosimine as well as a Study Toward the Total Synthesis of the Bisindole Alstonisidine,\u201d T. Wang
\nand J.M. Cook, 220th National ACS Meeting, Washington, D.C., August 20-24, 2000, abst. ORG –
\n140.
\nhhhhhhhhhhhhh. \u201cEnantiospecific Synthesis of Sarpagine, Ajmaline, and Corynanthe Indole
\nAlkaloids via the Asymmetric Pictet-Spengler Reaction,\u201d (planery lecture), The Twenty-third Gulf
\nCoast Chemistry Conference, Pensacola, Florida, September 14-16, 2000 (Thursday Lecture 2:40).
\niiiiiiiiiiiii. \u201cDiscriminative Stimulus Effects of the Novel 1,4-Benzodiazpine QHII-66 in Ethanol-and
\nTriazolam-Trained Squirrel Monkeys,\u201d S. Lelas, D.M. Platt, J.K. Rowlett, R.D. Spealman, J. Cook,
\nand C. Ma, 30th Annual Meeting of the Society for Neuroscience, New Orleans, LA, November 4-
\n9, 2000, Soci. Neurosci. Abst., 26, Part 1, 280 (abst. 103.2).
\njjjjjjjjjjjjj. \u201cSelective GABAA \u03b11 Subunit Ligands (BCCt, 3PBC) Attenuate Responding Maintained
\nby Ethanol Following Microinjection into the Ventral Pallidum,\u201d M.R. Carroll, K.L. Foster, S.
\nHarvey, P.F. McKay, J.M. Cook and H. June, Alcoholism: Clin. Exp. 24: 47A (abst. 24).
\nkkkkkkkkkkkkk. \u201cDevelopment of Selective Ligands for GABAA\/BzR Subtypes and Their Role in
\nAlteration of Alcohol Dependence,\u201d X. Li, X. He, C. Ma, S. Harvey, and J.M. Cook, 221st National
\nACS Meeting, San Diego, CA, April 1-5, 2001, abst. MEDI-83.
\nlllllllllllll. \u201cHigh-yield Generation of the [5.5.5.5]Tetracyclic Systems via Molybdenum Carbonyl
\nMediated Tandem Pauson-Khand Reaction,\u201d H. Cao and J.M. Cook, 221st National ACS Meeting,
\nSan Diego, CA, April 1-5, 2001, abst. ORGN-420.
\nmmmmmmmmmmmmm. \u201cApproach to the Total Synthesis of 10-Methoxyanhydromacrosalhinemethine
\nvia the Asymmetric Pictet-Spengler Reaction,\u201d X. Liao, S. Zhao, and J.M. Cook, 221st
\nNational ACS Meeting, San Diego, CA, April 1-5, 2001, abst. ORGN-586.
\nnnnnnnnnnnnnn. \u201cGeneral Approach to the Total Synthesis of Macroline\/Sarpagine Indole
\nAlkaloids as well as Their Enantiomers,\u201d X. Liu and J.M. Cook, 221st National ACS Meeting, San
\nDiego, CA, April 1-5, 2001, abst. ORGN-591
\nooooooooooooo. \u201cGeneral Approach for the Synthesis of Sarpagine Ajmaline and Corynanthe
\nAlkaloids via the Asymmetric Pictet-Spengler Reaction,\u201d (planery lecture) Royal Society of
\nChemistry, Perkin Division, 15th Lakeland Symposium: Grasmere, Grasmere Village, UK, May 10-
\n14, 2001, (Friday morning lecture).
\nppppppppppppp. \u201cAlcohols Euphoric Properties are Regulated by the GABAA Receptor \u03b11
\nSubtype,\u201d W. Yin, M. Carroll, H. June, and J.M. Cook, College on Problems of Drug Dependence,
\n63rd Annual Scientific Meeting, Scottsdale, AZ, June 16-21, 2001, Oral Communications IX (1:45
\np.m.).
\nqqqqqqqqqqqqq. \u201cApproach to Cyclopentapentalenes. Regiospecific Synthesis of the Highly
\nFunctionalized [5.5.5.5]Tetracycles via the Molybdenum Carbonyl-Mediated Tandem Pauson-
\nKhand Reaction,\u201d H. Cao, J.M. Cook, and J. Flippen-Anderson, 37th National Organic Chemistry
\nSymposium, Montana State University, Bozeman, MT, June 10-14, 2001, abst. 58.
\nrrrrrrrrrrrrr. \u201cResearch in Search of Selective Ligands for GABAA\/BZR Subtypes and Their Role in
\nAlteration of Alcohol Dependence,\u201d X. Li, X. He, C. Ma, S. Harvey, and J.M. Cook, 37th National
\nOrganic Chemistry Symposium, Montana State University, Bozeman, MT, June 10-14, 2001, abst.-
\n122.
\nsssssssssssss. \u201cStudies Directed Toward the Antimalarial Bisindole Alkaloid Macralstonine O-Methyl
\nEther as well as Macralstonine,\u201d X. Liu and J.M. Cook, 37th National Organic Chemistry
\nSymposium, Montana State University, Bozeman, MT, June 10-14, 2001, abst.-126.
\nttttttttttttt. \u201cStudies Directed Toward the Total Synthesis of the Bisindole Villalstonine,\u201d J. Ma, S.
\nYu, O.M. Berner, and J.M. Cook, 37th National Organic Chemistry Symposium, Montana State
\nUniversity, Bozeman, MT, June 10-14, 2001, abst.-132.
\nuuuuuuuuuuuuu. \u201cStudies Directed Toward the Enantiospecific Total Synthesis of Oxindole
\nAlkaloids: Approach to the Total Synthesis of Alstonisine,\u201d X. Wearing, P. Yu, and J.M. Cook, 37th
\nNational Organic Chemistry Symposium, Montana State University, Bozeman, MT, June 10-14,
\n2001, abst.-219.
\nvvvvvvvvvvvvv. \u201cSearch for Benzodiazpine\/GABAA Subtype Selective Ligands that Reverse
\nAlcohol Self-Administration,\u201d W. Yin, C. Zhang, M. Carroll, H. June, and J,M, Cook, 37th National
\nOrganic Chemistry Symposium, Montana State University, Bozeman, MT, June 10-14, 2001, abst.-
\n234.
\nwwwwwwwwwwwww. \u201cStudy of Pharmacophore\/Receptor Models for GABAA\/BzR Subtypes,\u201d
\nChunchun Zhang and J.M. Cook, 37th National Organic Chemistry Symposium, Montana State
\nUniversity, Bozeman, MT, June 10-14, 2001, abst.-238.
\nxxxxxxxxxxxxx. \u201cThe Enantiospecific Total Synthesis of the Alstonia Bisindole Alkaloid,
\nMacralstonidine,\u201d X. Liao, S. Zhao, and J.M. Cook, 37th National Organic Chemistry Symposium,
\nMontana State University, Bozeman, MT, June 10-14, 2001, abst.-239.
\nyyyyyyyyyyyyy. \u201cEnantiospecific Synthesis of a Very Potent Tryprostatin Diastereomer, Active
\nAgainst Human Cancer Cell Lines,\u201d S. Zhao, X. Liu, C. Zhang, A. Morin, K. Smith, T. McDonald,
\nand J.M. Cook, 37th National Organic Chemistry Symposium, Montana State University, Bozeman,
\nMT, June 10-14, 2001, abst. 240.
\nzzzzzzzzzzzzz. \u201cSearch for Benzodiazepine\/GABA(A) Subtype Selective Ligands that Reverse
\nAlcohol Self-Administration,\u201d J. Cook, W. Yin, C. Zhang, X. Li, and H. June, (plenary lecture), 53rd
\nSoutheastern Regional Meeting of the ACS, Savannah, GA, September 23-26, 2001, plenary lecture,
\nabst. 379.
\naaaaaaaaaaaaaa. \u201cThe Enantiospecfic Synthesis of Sarpagine, Ajmaline, and Corynanthe Indole
\nAlkaloids Via the Asymmetric Pictet-Spengler Reaction,\u201d T. Wang, S. Zhao, X. Liu, and J.M. Cook,
\n19th Meeting of the Northeast Chapter of the International Isotope Society, Pearl River, N.Y.,
\nOctober 26, 2001 (plenary lecture).
\nbbbbbbbbbbbbbb. \u201cThe Role of the GABA(A) \u03b11 Subtype in Mediating the Sedative and Anxiolytic
\nProperties of Benzodiazepines,\u201d M.R. Carroll, J. Woods, R.Y. Seyoum, and H. June, presented at
\nthe RCM Meeting, 2001.
\ncccccccccccccc. \u201cInvolvement of GABA(A) Receptors Containing the \u03b15 Subunit in Nitrous
\nOxide Withdrawal,\u201d L. Vaughn, R. Lindau, W. Yin, and J.M. Cook, presented at the Neuroscience
\nMeeting, San Diego, CA, 2001.
\ndddddddddddddd. \u201cThe Role of BZ\/\u03b11 and BZ\/\u03b15 Receptors in Discriminative Stimulus Effects of
\nTriazolam in Squirrel Monkeys,\u201d S. Lelas, J.K. Rowlett, R.D. Spealman, J.M. Cook, X. Li, and W.
\nYin, presented at the Neuroscience Meeting, San Diego, CA, 2001.
\neeeeeeeeeeeeee. \u201cRole of GABA(A)\/\u03b11 Receptor Mechanisms in the Discriminative Stimulus
\nEffects of Ethanol in Squirrel Monkeys,\u201d D.M. Platt, J.K. Rowlett, R.D. Spealman, J.M. Cook, and
\nW. Yin, FASEB Summer Reasearch Conference, Arizona, August 2001.
\nffffffffffffff. \u201cSearch for Benzodiazepine\/GABA(A) Subtype Selective Ligands that Reverse Alcohol
\nSelf-Administration,\u201d W. Yin, C. Zhang, M. Carrol, H. June, and J.M. Cook, 21st Symposium on
\nMedicinal Chemistry, 10th Annual Meeting of the Division of Medicinal Chemistry, Kyoto, Japan,
\nNovember 28-30th, 2001, (plenary lecture).
\ngggggggggggggg. \u201cEnantiospecific Synthesis of Sarpagine, Ajmaline and Corynanthe Alkaloids via
\nthe Asymmetric Pictet-Spengler Reaction,\u201d T. Wang, S. Zhao, X. Liu, and J.M. Cook, Mini-
\nSymposium of the Society of Synthetic Organic Chemistry(Japan), Chiba, Japan, November 30,
\n2001 (plenary lecture).
\nhhhhhhhhhhhhhh. \u201cThe Enantiospecific, Stereospecific Total Synthesis of the Alstonia Bisindole,
\nMacralstonidine,\u201d S. Zhao, X. Liao, and J.M. Cook, The Mona Symposium 2002, Natural Products
\nand Medicinal Chemistry, University of the West Indies, Mona Jamaica, Jan. 7-10, 2002, p.21.
\niiiiiiiiiiiiii. \u201cSearch for Benzodiazepine\/GABAA Subtype Selective Ligands to Treat Alcohol Abuse,\u201d
\nW. Yin, C. Zhang, H. June, and J.M. Cook, 28th National Medicinal Chemistry Symposium, San
\nDiego, CA, June 8-12, 2002 (plenary lecture).
\njjjjjjjjjjjjjj. \u201cApproach to Cyclopentapentalenes: Regiospecific Synthesis of the Highly Functionalized
\n[5.5.5.5]Tetracycles via the Molybdenum Carbonyl-Mediated Tandem Pauson-Khand Reaction,\u201d
\nH. Cao, J.M. Cook, and J. Flippen-Anderson, 223rd National Meeting of the ACS, Orlando, FL,
\nApril 7-11, 2002, abst. ORGN 301.
\nkkkkkkkkkkkkkk. \u201cProgress Towards The Synthesis of Antimalarial Bisindole Alkaloids,\u201d X. Liao
\nand J.M. Cook, 223rd National Meeting of the ACS, Orlando, FL, April 7-11, 2002, abst. ORGN
\n104.
\nllllllllllllll. \u201cGeneral Approach for the Synthesis of Indole Alkaloids via the Asymmetric Pictet-
\nSpengler Reaction,\u201d J. Cook, 2002 Gordon Research Conference on Heterocyclic Compounds,
\nSalve Regina University, Newport, RI, 2002 (plenary lecture)
\nmmmmmmmmmmmmmm. \u201cSearch for Benzodiazepine\/GABAA Subtype Selective Ligands that
\nReverse Alcohol Self-Administration,\u201d W.Yin, J. Cook, and H. June, 34th Great Lakes Regional
\nMeeting of the ACS, Minneapolis, MN, June 2-4, 2002, abst. 85.
\nnnnnnnnnnnnnnn. \u201cEnantiospecific Synthesis of a Very Potent Tryprostatin Diastereomer Active
\nAgainst Human Cancer Cell Lines,\u201d C. Zhang, S. Zhao, and J.M. Cook, 34th Great Lakes Regional
\nMeeting of the ACS, Minneapolis, MN, June 2002, abst. 92.
\noooooooooooooo. \u201cRegiospecific Synthesis of the Highly Functionalized [5.5.5.5]Tetracycles,\u201d Hui
\nCao and J.M. Cook, 34th Great Lakes Regional Meeting of the ACS, Minneapolis, MN, June 2-4,
\n2002, abst. 110.
\npppppppppppppp. \u201cThe First Enantiospecific Total Synthesis of Alstonisine from D-(+)-Tryptophan
\nvia the Asymmetric Pictet-Spengler Reaction,\u201d X. Wearing, P.Yu, and J.M. Cook, 34th Great Lakes
\nRegional Meeting of the ACS, Minneapolis, MN June 2-4, 2002, abst. 203.
\nqqqqqqqqqqqqqq. \u201cStudy of Selective Ligands for GABA\/BzR Subtypes and their Role in Alteration
\nof Alcohol Dependence,\u201d X. Li, W. Yin, S. Harvey, and J.M. Cook, 34th Great Lakes Regional
\nMeeting of the ACS, Minneapolis, MN, June 2-4, 2002, abst. 78.
\nrrrrrrrrrrrrrr. \u201cApproach Toward the Total Synthesis of the Antimalarial Alkaloid Villalstonine,\u201d J. Ma,
\nS. Yu, O. Mathias, and J.M. Cook, 34th Great Lakes Regional Meeting of the ACS, Minneapolis,
\nMN, June 2-4, 2002, abst. 90.
\nssssssssssssss. \u201cThe Total Synthesis of Bisindole Dispegatrine,\u201d X. Liao and J.M. Cook, 34th
\nGreat Lakes Regional Meeting of the ACS, Minneapolis, MN, June 2-4, 2002, abst. 105.
\ntttttttttttttt. \u201cSearch for Benzodiazepine\/GABA(A) Subtype Selective Ligands that Reverse Alcohol
\nSelf-Administration,\u201d W. Yin, X. Liao, H. June, and J. Cook, 224th ACS National Meeting, Boston,
\nMA, August 18-22, 2002, abst. MEDI-244.
\nuuuuuuuuuuuuuu. \u201cStudies in Search of Memory Enhancing Agents Which Act via GABA(A)\/BzR
\nReceptors,\u201d X. Li, C. Cook, F.J. Helmstetter, and J.M. Cook, 224th ACS National Meeting, Boston,
\nMA, August 18-22, 2002, abst. MEDI-245.
\nvvvvvvvvvvvvvv. \u201cEnantiospecific Stereospecific Total Synthesis of Alstonisine,\u201d X. Wearing, J.M.
\nCook, and J.L Flippen-Anderson, 224th ACS National Meeting, Boston, MA, August 18-22, 2002,
\nabst. O361.
\nwwwwwwwwwwwwww. \u201cApproach to Cyclopentapentalenes, Regiospecific Synthesis of the
\nHighly Functionalized [5.5.5.5]tetracycles via the Molybdenum Carbonyl-mediated Tandem
\nPauson-Khand Reaction,\u201d H. Cao, J.M. Cook, and J. Flippen-Anderson, 224th ACS National
\nMeeting, Boston, MA, August 18-22, 2002, abst. O835.
\nxxxxxxxxxxxxxx. \u201cThe GABA(A) Receptor \u03b11 Subtype in the Ventral Pallidum Regulates AlcoholSeeking
\nBehaviors,\u201d W. Yin, C. Zhang, H. June, and J.M. Cook, The 12th Neuropharmacology
\nConference, GABA(A) Receptors in Cellular and Network Excitability, Sheraton World Resort,
\nOrlando, FL, October 31-November 2, 2002, poster P-D05.
\nyyyyyyyyyyyyyy. \u201cGABA(A)\/\u03b11, 5HT1A, Alcohol and Agression in Rats,\u201d S.L. Gourley, J.F.
\nDebold, J.M. Cook and K.A. Miczek, Society for Neuroscience 32nd Annual Meeting, Orlando, FL,
\nNovember 2-7, 2002, abstract 607.9.
\nzzzzzzzzzzzzzz. \u201cRole of GABAA\/\u03b15 Receptor Mechanisms in the Discriminative Stimulus
\nEffects of Ethanol in Squirrel Monkeys,\u201d D.M. Platt, J.K. Rowlett, R.D. Spealman, J.M. Cook, and
\nW. Yin, Alcohol Society Meeting, June, 2003.
\naaaaaaaaaaaaaaa. \u201cBiological Activity of the Tryprostatins and their Diastereomers on Human
\nCarcinoma Cell Lines,\u201d C.C. Zhang, S. Zhao, and J.M. Cook, 225th ACS National Meeting, New
\nOrleans, LA, March 23-27, 2003 (abst MEDI-87).
\nbbbbbbbbbbbbbbb. \u201cStudies of Memory Enhancing Agents which act via GABAA\/BzR Receptors,\u201d
\nX. Li, H. Cao, C. Cook, F. Helmstetter, and J.M. Cook, 225th ACS National Meeting, New Orleans,
\nLA, March 23-27, 2003 (abst MEDI-221).
\nccccccccccccccc. \u201cEnantiospecific, Sterospecific Total Synthesis of Alstonisine and Approach to
\nthe Total Synthesis of Nb-Demethylalstophylline Oxindole,\u201d Xiangyu Z. Wearing and J.M. Cook,
\n225th ACS National Meeting, New Orleans, LA, March 23-27, 2003 (abst ORG-412).
\nddddddddddddddd. \u201cSterospecific, Enantiospecific Total Synthesis of the Sarpagine Indole Alkaloids
\n(E)16-Epiaffinisine, (E)16-Epinormacusine B and Dehydro-16-epiaffinisine,\u201d Jianming Yu and
\nJames M. Cook, 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003, Organic
\nSection (March 25th).
\neeeeeeeeeeeeeee. \u201c\u03b11 Subunit Containing GABAA Receptor Antagonism and Alcohol Heightened
\nAggressive Behavior in Male Rats,\u201d D.L. Zitzman, J.F. DeBold, S.L. Gourley, J.M. Cook, and K.A.
\nMiczek, Neuroscience Meeting, New Orleans, LA, November 12-17, 2003, #852.5.
\nfffffffffffffff. \u201cThe Reinforcing Effects of Amphetamine in the Selectivity Bred High Alcohol Drinking
\n(HAD-1) and Low Alcohol Drinking (LAD-1) Rat Lines,\u201d J.E. Woods, J.Cook, And H.L. June,
\nNeuroscience Meeting, New Orleans, LA, November 12-17, 2003, #852.12.
\nggggggggggggggg. \u201cRational Design of Indoleamine 2,3-Dioxygenase Inhibitors,\u201d A. Martin, C.
\nAustin, J. Mizdrak, V. MacFarlane, C. Zhang, W. Yin, X. Li, J. Jamie, R. Truscott, J. Cook, and R.
\nGriffith, 19th Royal Australian Chemical Institute Conference, Lorne, Victoria, Australia, July 6-11,
\n2003.
\nhhhhhhhhhhhhhhh. \u201cElucidating Benzodiazepine Receptor Subtype Mechanisms Using Zolpidem
\nand the Putative GABAA\/\u03b15 Selective Agonist QH-ii-066,\u201d A.N. Duke, D. Platt, R. Spealman, J.M.
\nCook, X. Li, and J. Rowlett, Sixty-fifth Annual Scientific Meeting of the College on Problems of
\nDrug Dependence, Bal harbour, FL, June 14-19, 2003.
\niiiiiiiiiiiiiii. \u201cThe SAR and Possible Treatment of Alcohol Abuse with \u03b11 Selective Benzodiazepine\/
\nGABAA Receptor Antagonists,\u201d James Cook, Sixty-fifth Annual Scientific Meeting on the College
\non Problems of Drug Dependence, Bal Harbour, FL, June 14-19, 2003. Invited Lecture-Workshop
\n(30 min).
\njjjjjjjjjjjjjjj. \u201cSearch of Benzodiazepine\/GABA(A) Subtype Selective Ligands that Reverse Alcohol
\nSelf-Administration,\u201d W. Yin, C. Zhang, X. Li, H. June, and J.M. Cook, Sixty-fifth Annual
\nScientific Meeting of the College on Problems of Drug Dependence, Bal Harbour, FL, June 14-19,
\n2003.
\nkkkkkkkkkkkkkkk. \u201cApproach Towards the Total Synthesis of Villalstonine,\u201d J. Ma and J.M. Cook,
\n38th National Organic Symposium, Indiana University, Bloomington, IN, June 8-12, 2003, Abstract
\nNumber: B64
\nlllllllllllllll. \u201cStudy of the Conformation of GABAA-Benzodiazepine Receptor Bivalent Ligands by
\nLow Temperature NMR,\u201d D. Han, F. Holger, X. Li, J.R. Deschamps, H. Cao, J. Ma, W. Yin, and
\nJ.M. Cook, 38th National Organic Symposium, Indiana University, Bloomington, IN, June 8-12,
\n2003, Abstract Number: A76.
\nmmmmmmmmmmmmmmm. \u201cGeneral Approach for the Synthesis of Natural and Non-natural
\nProducts via the Tandem Pauson-Khand Reaction: Synthesis of 14\u03c0 Annulenes and [5.8.5]
\nSystems,\u201d H. Cao, J. Flippen-Anderson and J. M. Cook, 228th ACS National Meeting, Philadelphia,
\nPA, August 22-26, 2004 (abst. ORG-390).
\nnnnnnnnnnnnnnnn. \u201cStereocontrolled Total Synthesis of (-)-11-Methoxy-17-Epivincamajine and (-)-
\nVincamajinine,\u201d X. Z. Wearing, Y. Yu, F. Rivas and J. M. Cook, Philadelphia, PA, August 22-26,
\n2004 (abst. ORG-391)
\nooooooooooooooo. \u201cGABAA\/\u03b11 Receptor Involvement in the Hyperphagic Effect of
\nBenzodiazepines in Squirrel Monkeys,\u201dA. Duke, D. Platt, J. M. Cook, W. Yin and J. K. Rowlett,
\n66th Annual Meeting of the College on Probems of Drug Dependence, San Juan, Puerto Rico, June
\n12-17, 2004, Poster Session III, Poster 32.
\nppppppppppppppp. \u201cGABA-A Receptor Mechanisms Underlying Motor Effects of Benzodiazepines
\nin Monkeys,\u201d S. C. Licata, D. M. Platt, A. N. Duke, J. M. Cook, P. V. V. S. Sarma, and J. K. Rowlett,
\nNeuroscience Meeting, San Diego, CA October 22-28 (2004).
\nqqqqqqqqqqqqqqq. \u201cThe GABA(A)\/\u03b11 Receptor-Preferring Antagonist BCCt Does Not Attenuate
\nBenzodiazepine-Induced Suppression of Locomotor Activity,\u201d A. N. Duke, D. M. Platt, W. Yin, J.
\nM. Cook and J. Rowlett, Neuroscience Meeting, San Diego, October 22-28 (2004).
\nrrrrrrrrrrrrrrr. \u201cSearch for Benzodiazepine\/GABA(A) Subtype Selective Bivalent Ligands That Reverse
\nAlcohol Self-Administration,\u201d W. Yin, C. Zhang, S. S. V. V. Pullela, H. June and J. M. Cook, 227th
\nACS National Meeting, Anaheim, CA March 28 \u2013 April 1, 2004 (abst. MEDI 0286).
\nsssssssssssssss. \u201cSynthesis, in vitro Affinity and Efficacy of the First Bivalent \u03b15 Subtype
\nSelective BzR\/GABA(A) Antagonist,\u201d X. Li, W. Sieghart, G. R. Wenger and J. M. Cook. 227th ACS
\nNational Meeting, Anaheim, CA March 28 \u2013 April 1, 2004 (abst. MEDI 0348).
\nttttttttttttttt. \u201cPreparation of Analogs of the Cytotoxic Tryprostatins A and B. Study of Structure
\nActivity Relationships as well as Irreversible Inhibitors for Mechanistic Work,\u201d C. Zhang, J. Ma
\nand J. M. Cook, 227th ACS National Meeting, Anaheim, CA March 28 \u2013 April 1, 2004 (abst. MEDI
\n0115).
\nuuuuuuuuuuuuuuu. \u201cStudy of the Structure-Activity Relationships of GABA(A)-Benzodiazepine
\nReceptor Bivalent Ligands by Low Temperature NMR Spectoscopy and X-ray Analysis,\u201d D. Han,
\nF. H. Forsterling, X. Li, J. R. Deschamps, H. Cao, and J. M. Cook, 227th ACS National Meeting,
\nAnaheim, CA March 28 \u2013 April 1, 2004 (abst. MEDI 0285).
\nvvvvvvvvvvvvvvv. \u201cDevelopment of Selective Ligands for Benzodiazepine Receptor Subtypes by
\nManipulating the Stereochemistry of Optically Active BzR Ligands,\u201d X. Li, J. R. Atack, and J. M.
\nCook, 227th ACS National Meeting, Anaheim, CA March 28 \u2013 April 1, 2004 (abst. MEDI 0287).
\nwwwwwwwwwwwwwww. \u201cMEDI-0285 Also Chosen for Sci-Mix (represented).\u201d
\nxxxxxxxxxxxxxxx. \u201cMEDI-0287 Also Chosen for Sci-Mix (represented).\u201d
\nyyyyyyyyyyyyyyy. Regiospecific, Enantiospecific Total Synthesis of the 12-Alkoxy-substitutal
\nSarpagine Alkaloids, (+)-12-Methoxy-Na-Methylvellosimine, (+)-12 Methoxyaffinisine and (-)-
\nFuchsiaefoline,\u201d H. Zhou, W. Yin and J. M. Cook, 227th ACS National Meeting, Anaheim, CA
\nMarch 28 \u2013 April 1, 2004 (abst. ORGN 0444).
\nzzzzzzzzzzzzzzz. \u201cUse of the Molybdenum Hexacarbonyl-Mediated Tandem Allenic Pauson-
\nKhand Reaction for the Synthesis of a Dicyclo[a,e]pentalene,\u201d H. Cao, J. L. Flippen-Anderson, J.
\nL. Chen and J. M. Cook, 227th ACS National Meeting, Anaheim, CA March 28 \u2013 April 1, 2004
\n(abst. ORGN 0083).
\naaaaaaaaaaaaaaaa. \u201cMechanistic Study on the Asymmetric Pictet-Spengler Reaction. Evidence
\nSupporting the Carbocationic Pathway,\u201d D. Han, X. Liu, and J. M. Cook, 227th ACS National
\nMeeting, Anaheim, CA March 28 \u2013 April 1, 2004 (abst. ORGN 0485).
\nbbbbbbbbbbbbbbbb. \u201cFirst Enantiospecific Total Synthesis of a Quaternary Voachalotine Alkaloid,
\n(+)-Dehydrovoachalotine,\u201d J. Yu, J. Ma, X. Wearing and J. M. Cook, 227th ACS National Meeting,
\nAnaheim, CA March 28 \u2013 April 1, 2004 (abst. ORGN 0439).
\ncccccccccccccccc. \u201cProgress Toward the Total Synthesis of the Antimalarial Bisindole Alkaloid
\nVillastonine,\u201d J. Ma, C. Zhang, J. Yu, and J. M. Cook, 227th ACS National Meeting, Anaheim, CA
\nMarch 28 \u2013 April 1, 2004 (abst. ORGN 0443).
\ndddddddddddddddd. \u201cProgress Toward the Enantiospecific Stereospecific Total Synthesis of Nb-
\nDemethylalstophylline Oxindole,\u201d X. Z. Wearing and J. M. Cook, 227th ACS National Meeting,
\nAnaheim, CA March 28 \u2013 April 1, 2004 (abst. ORGN 0483).
\neeeeeeeeeeeeeeee. \u201cGeneral Approach to the Synthesis of Sarpagine\/Macroline Bisindole
\nAlkaloids,\u201d X. Liao, H. Zhou and J. M. Cook, 227th ACS National Meeting, Anaheim, CA Mar. 28
\n\u2013 Apr. 1, 2004 (abst. ORGN 0442).
\nffffffffffffffff. \u201cStereoselective Total Synthesis of (-)-Vincamajinine and (-)-11-Methoxy-17-
\nepivincamijine,\u201d X. Z. Wearing, J. Yu and J. M. Cook, 227th ACS National Meeting, Anaheim, CA
\nMarch 28 \u2013 April 1, 2004 (abst. ORGN 0484)
\ngggggggggggggggg. \u201cORGN-0483 Also chosen for Sci-mix (represented).\u201d
\nhhhhhhhhhhhhhhhh. \u201cGeneral Approach for the Synthesis of Natural and Non-natural Products via the
\nTandem Pauson-Khand Reaction. Synthesis of 14\u03c0 Annulenes and [5.8.5] Systems,\u201d H. Cao, J.
\nFlippen-Anderson and J. M. Cook, 36th Great Lakes Regional ACS Meeting, Peoria, IL, October
\n17-20 (2004), abstract 294.
\niiiiiiiiiiiiiiii. \u201cSynthesis, In Vitro Affinity and Efficacy of the First Bivalent Alpha 5 Subtype Selective
\nBzR\/GABA(A) Antagonist,\u201d W. Yin, F. Rivas, R. Furtmueller, X. Li, W. Sieghart, G. Wenger and
\nJ. M. Cook, Neuroscience 2004, San Diego, CA, October 23-27 (2004), Tue, Posterboard MM31.
\njjjjjjjjjjjjjjjj. \u201cAlcohol Drinking in Baboons: Effects of 3-Propyloxy Beta-Carboline,\u201d E. M. Weerts, B.
\nJ. Kaminski, W. Yin, P.V.V.S. Sarma and J. M. Cook, College on Problems of Drug Dependence,
\nJune 19-25, Orlando, FL (2005).
\nkkkkkkkkkkkkkkkk. \u201cNeurochemical and Behavioral Effects of Novel 8-Acetylenyl Analogs of
\nTriazolam,\u201d S. Licata, D. M. Platt, J. M. Cook, H. Zhou, P.V.V.S. Sarma, R. F\u00fcrtmueller, W.
\nSieghart, S. Huck and J. K. Rowlett, 2005 Neuroscience Meeting, November 12-17, Washington,
\nDC (2005).
\nllllllllllllllll. \u201cGeneral Approach to the Synthesis of Ring-A Alkoxy Substituted Indole Alkaloids via
\nthe Asymmetric Pictet-Spengler Reaction,\u201d H. Zhou, X. Liao, J. Ma, A. Wearing and J. M. Cook,
\nThe 21st Mona Symposium on Natural Products and Medicinal Chemistry, Mona Jamaica, January
\n3-6 (2006).
\nmmmmmmmmmmmmmmmm. \u201cGeneral Approach to the Synthesis of Ring-A Alkoxy
\nSubstituted Indole Alkaloids via the Asymmetric Pictet-Spengler Reaction,\u201d J. M. Cook,H. Zhou,
\nX. Liao, J. Ma, and P.V.V.S. Sarma, Abstracts, 37th Great Lakes Regional Meeting of the American
\nChemical Society, Milwaukee, WI, May 31-June 2, 2006, GLRM-307.
\nnnnnnnnnnnnnnnnn. \u201cElectronic Effects On the Cis to Trans Epimerization of Pictet-Spengler
\nProduced 1,2,3,4-Tetrahydro-\uf062-Carbolines,\u201d M. L. Van Linn, D. Han, H. J. Kumpaty, F. H.
\nForsterling, J.R. Deschamps, J. M. Cook, Abstraccts of Papers, 232nd ACS National Meeting, San
\nFrancisco, CA, Sept. 10-14, 2006, ORGN-832.
\noooooooooooooooo. \u201cSynthesis of Optically Active Subtype Selective BZR Ligands,\u201d S. Huang, T.
\nClayton, M. Dai, R. Edwankar, C. Sawant, J. M. Cook, Abstracts of Papers, 232nd ACS National
\nMeeting, San Francisco, CA, Sept. 10-14, 2006, MEDI-502.
\npppppppppppppppp. \u201cSearch For Benzodiazepine\/GABA(A) Subtype Selective Ligands That Reverse
\nAlcohol Self-Administration\u201d M. L. Van Linn, E. Weerts, D. Platt, W. Yin, P.V.V.S. Sarma, J. M.
\nCook, Abstracts, 37th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee,
\nWI, May 31-June 2 2006, GLRM-156.
\nqqqqqqqqqqqqqqqq. \u201cThe SAR Study of Benzodiazepine Receptor Bivalent Ligands by Low
\nTemperature NMR Spectroscopy and X-Ray Analysis,\u201d S. Huang, T. Clayton, M. Dai, W. Yin, J.
\nMa, R. Edwankar, C. Sawant, M. Van Linn, Y. Teng, M. Johnson, H. F. Forsterling, and J. M. Cook,
\nAbstracts, 37th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI
\nMay 31 \u2013 June 2, 2006, GLRM-155.
\nrrrrrrrrrrrrrrrr. \u201cEnantiospecific Synthesis of (+)-Na-Methyl-pericyclivine, (-)-Na-
\nMethylakuammidine, (+)-10-Methoxy-Na-Methylpericyclivine and 10-Hydroxy-Na-
\nMethylpericyclivine,\u201d P.V.V.S. Sarma, R. V. Edwankar, C. R. Edwankar, S. Huang, J. M. Cook,
\nAbstracts, 37th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI
\nMay 31-June 2, 2006, GLRM-143.
\nssssssssssssssss. \u201cGeneral Approach to the Synthesis of Oxygenated Bisindole Alkaloids,\u201d M. Dai,
\nS. Huang, J. M. Cook, Abstracts, 37th Great Lakes Regional Meeting of the American Chemical
\nSociety, Milwaukee, WI, May 31-June 2, 2006, GLRM-142.
\ntttttttttttttttt. \u201cGeneral Approach Towards the Total Synthesis of 9-Methoxy Indole Alkaloids: 9-
\nMethoxygeissoschizol, 9-Methoxy-Nb-Methyl-geissoschizol and the Opioid Analgesic Active
\nMitragynine,\u201d J. Ma, J. M. Cook, Abstracts, 37th Great Lakes Regional Meeting of the American
\nChemical Society, Milwaukee, WI, May 31-June 2, 2006, GLRM-141.
\nuuuuuuuuuuuuuuuu. \u201cProgress Towards the Total Synthesis of the Opioid Analgesic Indole Alkaloids
\nMitragynine and 7-Hydroxymitragynine as well as the Antimalarial Bisindole 10-
\nHydroxysambaresine,\u201d J. Ma, W. Yin, J. M. Cook, Abstracts of Papers, 231st ACS National
\nMeeting, Atlanta, GA, March 26-30, 2006, ORGN-174.
\nvvvvvvvvvvvvvvvv. \u201cGeneral Approach for the Synthesis of 12-Methoxy Substituted Sarpagine Indole
\nAlkaloids Including 12-Methoxy-Nb-Methyl-voachalotine and Fuschsiaefoline,\u201d H. Zhou, J. M.
\nCook, Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006, ORGN-
\n173.
\nwwwwwwwwwwwwwwww. \u201cTotal Synthesis of Antileishmanial and Antibacterial Alkaloids (+)-Na-
\nMethylpericyclivine and (-)-Na-Methylakuammidine as well as the Ring A-Oxygenated Natural
\nProducts, (+)-10-Methoxy Na-Methylpericyclivine and 10-Hydroxy Na-
\nMethylpericyclivine,\u201dP.V.V.S. Sarma, J. M. Cook, Abstracts of Papers, 231st ACS National
\nMeeting, Atlanta, GA, March 26-30, 2006, ORGN-172.
\nxxxxxxxxxxxxxxxx. \u201cModulation of Alcohol-heightened Aggression in Mice by \uf061-5-Containing
\nGABA(A) Receptors,\u201d S. Faccidomo, J. G. Maggin, S. Melief, T. Clayton, J. M. Cook, K. A.
\nMiczek, Society for Neuroscience, October, 2006, Atlanta, GA.
\nyyyyyyyyyyyyyyyy. \u201cDifferential Sedative and Motor Effects of GABA(A) Subtype Selective
\nCompounds in Rhesus Monkeys,\u201d A. Duke, D. Platt, S. Licatta, R. Edwankar, S. Huang, J. M. Cook,
\nR. Furtmueller, W. Sieghart, and J. K. Rowlett, Society for Neuroscience, October, 2006, Atlanta,
\nGA.
\nzzzzzzzzzzzzzzzz. \u201cAttenuation of Motor and Sedative-like Effects of Alparzolam by Flumazenil
\nand BCCt in Rhesus Monkeys,\u201d A. Duke, D. M. Platt, J. M. Cook, W. Yin and J. K. Rowlett, CPDD
\n68th Annual Meeting, June 17-22, 2006, Scottsdale, AZ.
\naaaaaaaaaaaaaaaaa. \u201cSynthesis, Pharmacological Studies, and Molecular Modeling of Novel 1,3-
\nDiazipinium Chlorides,\u201d J. A. Grant, Y. A. Jackson, M. Gossel-Williams, T. Clayton, J. M. Cook,
\nLatest Trends in Organic Synthesis, Brock University, St.Catherines, Ontario, CA, 2006.
\nbbbbbbbbbbbbbbbbb. \u201cGeneral Approach to the Synthesis of Indole Alkaloids via the Asymmetric
\nPictet-Spengler Reaction,\u201d J.M. Cook, (Plenary Lecture,) presented at the New Horizons in
\nCatalysis (Synthetic Heterocyclic Chemistry), at the Palau de Congressos de Catalunya, Barcelona,
\nApril 12-13 (2007).
\nccccccccccccccccc. \u201cSynthesis of Subtype Selective Ligands for Alpha -5 Containing GABA (A) \/ Bz
\nReceptors to Treat Memory Deficits,\u201d T. Clayton, M.Ernst, L. Richter, S. Sankar, T. Delorey, W.
\nSieghart, R. Furtm\u00fceller, G. Ecker, and J.M. Cook, 233rd ACS National Meeting, March 25-29,
\nChicago, Ill., 2007, MED – 299.
\nddddddddddddddddd. \u201cDesign and Synthesis of Stereoenantiomeric Benzodiazepine Receptor Ligands,\u201d
\nS.Huang, M. Savic, R. Furtmueller, A.Duke, T.Clayton, W. Sieghart, J.K. Rowlett and J.M. Cook,
\n233rd ACS National Meeting, March 25-29, Chicago, Ill., 2007, MED \u2013 302.
\neeeeeeeeeeeeeeeee. \u201cEpimerization Kinetics of Electronically Altered 1-Phenyl-1,2,3,4 \u2013 Tetrahydro
\n\u03b2-carbolines,\u201d M. Van Linn, F.H. Forsterling, H.J. Kumpathy, J. Deshamps and J.M. Cook, 233rd
\nACS National Meeting, March 25-29, Chicago, Ill., 2007, Org-86.
\nfffffffffffffffff. \u201cProgress Toward the Total Synthesis of the Bisindole Alkaloid Angusticraline:
\nEmphasis on the Northern Hemisphere as well as the Total Synthesis of Other Monomeric Indole
\nAlkaloids,\u201d C.R. Edwanker, R. Edwanker and J.M. Cook, 233rd ACS National Meeting, March 25-
\n29, Chicago, Ill., 2007 ORG-418.
\nggggggggggggggggg. \u201cThe First Enantiospecific Total Synthesis of the Important Biogenetic
\nIntermediates, (+) – Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-epi-Vellosimine
\nand Macusine A,\u201d W. Yin, J. Ma, J.M. Cook, Abstracts of Papers, 233rd ACS National Meeting,
\nChicago, IL, United States, March 25-29, 2007.
\nhhhhhhhhhhhhhhhhh. \u201cGABA-A\/alpha 5 Receptor Mechanisms in the Discriminative Stimulus Effects
\nof GABA-A Modulators\u201d D. Platt, M. Van Linn, T. Clayton, J.M. Cook, J. Rowlett, 69th Annual
\nMeeting of the College on Problems of Drug Dependence, June 16-21, Hilton, Quebec, Canada,
\nPoster Session III (2007).
\niiiiiiiiiiiiiiiii. \u201cDifferential Antagonism of the Sedative and Motor Effects of Zolpidem and Alprazolam
\nby BCCt,\u201d A.N. Duke, D.M. Platt, J.M. Cook, M. Van Linn, J. Rowlett, 69th Annual Meeting of the
\nCollege on Problems of Drug Dependence, June 16-21, Hilton, Quebec, Canada (2007).
\njjjjjjjjjjjjjjjjj. \u201cGeneral Approach to the Synthesis of Alkoxy Substituted Indole Alkaloids,\u201d J.M. Cook,
\nScientific Update Meeting, August 28-31, San Diego, CA (2007), (Plenary Lecture.)
\nkkkkkkkkkkkkkkkkk. \u201cLinear Free Energy Relationship of the cis to trans Epimerization of Substituted
\n1-Phenyl-1,2,3,4-Tetrahydro-\u03b2-Carbolines,\u201d M.L. Van Linn, F.H. Forsterling, M.P. Ver Haag, J.R.
\nDeschamps, J.M. Cook, Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United
\nStates, August 19-23, 2007.
\nlllllllllllllllll. \u201cSerendipity Rediscovered – An Oxymoron or Rational Drug Design: Studies on Subtype
\nSelective BzR\/GABAergic Ligands,\u201d J.M. Cook, H. June, E. Weerts, M.L. Van Linn, D. Platt, T.
\nDeLorey, M. Savic, T. Clayton, Abstracts of Papers, 234th ACS National Meeting, Boston, MA,
\nUnited States, August 19-23, 2007 (Plenary Lecture.)
\nmmmmmmmmmmmmmmmmm. \u201cActivity of Phenoxysytrene and Stilbene Analogs Against
\nClinically Important Gram-positive Bacteria,\u201d K. Engelbrecht, M.S. Kabir, J.M. Cook, A. Monte,
\nM. Rott, W.R. Schwan, Abstracts of Papers, 47th Interscience Conference on Antimicrobial Agents
\nand Chemotherapy (ICAAC), Chicago, IL, September 17-21, 2007.
\nnnnnnnnnnnnnnnnnn. \u201cAntibacterial Activity of (E)-3-Methoxy-5-Hydroxy-Stilbene and Analogs
\nAgainst Clinically Significant Gram\/positive Bacteria,\u201d E. Kathleen, M.S. Kabir, J.M. Cook, A.
\nMonte, M. Rott, W.R. Schwan, Abstracts of Papers, North Central Branch Meeting of the American
\nSociety for Microbiology, Marshfield, WI, October 5, 2007.
\nooooooooooooooooo. \u201cRole of GABA(A) Receptors in Diazepam-induced Attenuation of the
\nAnxiogenic Effects of Acute Citalopram Treatment in BALB\/c Mice,\u201d M. Birkett, A. Duke, J.
\nMeyer, J.M. Cook, S. Huang, M. Van Linn, J.K. Rowlett, Society for Neuroscience, November, San
\nDiego, CA (2007).
\nppppppppppppppppp. \u201cDifferential Precipitated Withdrawal by Flumazenil and BCCt Following
\nChronic Alprazolam Administration,\u201d A.N. Duke, D. Platt, M. Van Linn, P.V.V.S. Sarma, J.M.
\nCook, J.K. Rowlett, Society for Neuroscience, November, San Diego, CA (2007).
\nqqqqqqqqqqqqqqqqq. \u201cAntagonism of the Reinforcing Effects of Triazolam by Selective Antagonists in
\nRhesus Monkeys,\u201d K.M. Bano, D.M. Platt, J.M. Cook, M.L. Van Linn, J.K. Rowlett, Society for
\nNeuroscience, November, San Diego, CA (2007).
\nrrrrrrrrrrrrrrrrr. \u201cRy-023, a Selective Inverse Agonist at the Benzodiazepine Binding Site on the
\nGABA-A \u03b15 Receptor, Improves Performance in a Delayed-Match-to-Sample Task in Rhesus
\nMonkeys,\u201d M. Weed, T. Clayton, J.M. Cook, 46th American College of
\nNeuropsychopharmacology, December 9-13, Boca Raton, FL, Abst. #158 (2007).
\nsssssssssssssssss. \u201cRole of Alpha-5\/GABA(A) Receptor Mechanisms in the Reinforcing Effects of
\nEthanol in Rhesus Monkeys,\u201d D.M. Platt, D. R\u00fcedi-Bettschen, S. Rallapalli, J.M. Cook, Meeting
\nof the European Behavioral Pharmacology Society (2007).
\nttttttttttttttttt. \u201cProgress Toward the Total Synthesis of the Alpha-Adrenergic Blocking Agent
\nDispegatrine, as well as the Total Synthesis of Other Monomeric Indole Alkaloids,\u201d Edwanker,
\nC.R., Edwanker, R.V., and Cook, J.M. In Abstracts of Papers, 235th ACS National Meeting, New
\nOrleans, LA, United States, April 6-10, 2008; pp ORGN-649.
\nuuuuuuuuuuuuuuuuu. \u201cProgress Toward the Total Synthesis of the Bisindole Alkaloid Macrospegatrine:
\nEmphasis on the Northern Hemisphere as well as the Total Synthesis of Other Monomeric Indole
\nAlkaloids,\u201d Edwanker, R.V., Edwanker, C.R., and Cook, J.M., Abstracts of Papers, 235th ACS
\nNational Meeting, New Orleans, LA, United States, April 6-10, 2008, ORGN-652.
\nvvvvvvvvvvvvvvvvv. \u201cProgress Toward the Enantiospecific Total Synthesis of 18-Hydroxyaffinisine
\nand Voacoline,\u201d Jain, H.; and Cook, J.M.; Abstacts of Papers, 235th ACS National Meeting, New
\nOrleans, LA, United States, April 6-10, 2008, ORGN-651.
\nwwwwwwwwwwwwwwwww. \u201cNew Classes of Gram-Positive Antibacterials: Inhibitors of MRSA and
\nSurrogates of the Causative Agents of Anthrax and Tuberculosis,\u201d Kabir, M.S.; Engelbrecht, K.;
\nMonte, A.P.; Rott, M.A.; Schwan, W.R.; Cook, J.M., Abstracts of Papers, 235th ACS National
\nMeeting, New Orleans, LA, United States, April 6-10, 2008, MEDI-031.
\nxxxxxxxxxxxxxxxxx. \u201cStraightforward and Efficient Cu-Catalyzed Cross-Coupling Reaction of
\nArylvinyl Iodides and Phenols as well as Thiophenols: Facile Regioselective Synthesis of E-
\n[Phenoxystryrenes and (E)-1-Phenyl-2-(arylthio)ethylenes [(E)-phenyl(styrl) sulfanes],\u201d Kabir,
\nM.S.; Monte, A.P.; Cook, J.M., Abstracts of Papers, 235th ACS National Meeting, New Orleans,
\nLA, United States, April 6-10, 2008, ORGN-650.
\nyyyyyyyyyyyyyyyyy. \u201cInsight into the Mechanism of the Pictet-Spengler Reaction for the Synthesis of
\nNatural Products,\u201d Van Linn, M.L.; Forsterling, F.H.; Cook, J.M., Abstracts of Papers, 235th ACS
\nNational Meeting, New Orleans, LA, United States, April 6-10, 2008, ORGN-163
\nzzzzzzzzzzzzzzzzz. \u201cProgress Toward the Enantiospecific Total Synthesis of Accedinisine and N\u2019-
\nDemethylaccedinisine,\u201d Yang, J.; Sarma, P.V.V.S.; Cook, J.M., Abstracts of Papers, 235th ACS
\nNational Meeting, New Orleans, LA, United States, April 6-10, 2008, ORGN-648.
\naaaaaaaaaaaaaaaaaa. \u201cPharmacokinetics Interaction Between Ritonavir and Quinine,\u201d Soyinka, J.O.;
\nOnyeji, C.O.; Owolabi, A.R.; Sarma, P.; Cook, J.M., 48th Annual ICAAC\/IDSA Meeting,
\nWashington, D.C., October 25-28, 2008.
\nbbbbbbbbbbbbbbbbbb. \u201cHypolocomotor Activity of Diazepam in Wistar Rats is Mediated by
\nGABA(A) Receptors Containing the \u03b11, but not the \u03b15 Subunit,\u201d Savic, M. Rallapalli, S.; Milinkovi,
\nM.; Samard, J.; Van Linn, M.; and Cook, J.M., CINP Congress, Munich, Germany, July 2008.
\ncccccccccccccccccc. \u201cEvaluation of Novel Gram Positive Specific Antimicrobials Derived From (E)-
\n3-Hydroxy-5-Methoxystilbene,\u201d Polanowski, R.; Engelbrecht, K.; Schwan, W.; Monte, A.; Kabir,
\nM.; Cook, J.; Stemper, M.; and Rott, M.A.; American Society for Microbiology, St. Cloud, MN,
\nOctober 17, 18 (2008).
\ndddddddddddddddddd. \u201cThe Selective \u03b15 GABA(A) Receptor Antagonist Xli-093 Reverses
\nDiazepam Induced Memory Deficits in the Holeboard Task,\u201d Shinday, N.; Rallapalli, S.; Cook,
\nJ.M.; Meyer, J.S.; and Rowlett, J.K., Neuroscience Meeting, Washington, DC, November (2008).
\neeeeeeeeeeeeeeeeee. \u201cIn Vitro and In Vivo Characterization of the Novel Benzodiazepine Analog NEP-
\n510,\u201d Fischer, B.D.; Bano, K.M.; Duke, A.; Platt, D.; He, X.; Huang, Q.; Johnson, E.M.;
\nFurtmueller, R.; Sieghart, W.; Cook, J.M.; Rowlett, J.K., Neuroscience Meeting, Washington, DC,
\nNovember (2008).
\nffffffffffffffffff. \u201cSerendipity Rediscovered, An Oxymoron or Rational Drug Design.\u201d Cook, J. M.
\nAbstracts of Papers, 38th Great Lakes Regional Meeting of the American Chemical Society,
\nChicago, IL, United States, May 13-16, 2009, GLRM-025, plenary lecture.
\ngggggggggggggggggg. \u201cProgress Toward the Total Synthesis of \uf061-Adrenergic Blocking Agent
\nDispegatrine as well as the First Enantiospecific Total Synthesis of Lochvinerine, (+)-16-
\nEpisarpagine and Lochnerine.\u201d Edwankar, C. R.; Edwankar, R. V.; Cook, J. M. Abstract of Papers,
\n238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009, ORGN-748.
\nhhhhhhhhhhhhhhhhhh. \u201cProgress Toward the Total Synthesis of \uf061-Adrenergic Blocking Agent
\nDispegatrine as well as the First Enantiospecific Total Synthesis of Lochvinerine, (+)-16-
\nEpisarpagine and Lochnerine.\u201d Edwankar, C. R.; Edwankar, R. V.; Liao, X.; Cook, J. M. Abstracts
\nof Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009,
\nORGN-514.
\niiiiiiiiiiiiiiiiii. \u201cNew Benzodiazepine-related Agents to Treat Neuropathic Pain.\u201d Edwankar, C. R.;
\nEdwankar, R.V.; Zeilhofer, H.; Stables, J. P.; Roth, B. L.; Furtmuller, R.; Sieghart, W.; Cook, J. M.
\nAbstract of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20,
\n2009, MEDI-169.
\njjjjjjjjjjjjjjjjjj. \u201cProgress Toward the Total Synthesis of Alstonia Indole Alkaloids Peraksine and
\nMacrosalhine Bromide as well as the Formal Total Synthesis of Secotalcarpine and Macrocarpine
\nB.\u201d Edwankar, R. V.; Edwankar, C. R.; Cook, J. M. Abstracts of Papers, 238th ACS National
\nMeeting, Washington, DC, United States, August 16-20, 2009, ORGN-743.
\nkkkkkkkkkkkkkkkkkk. \u201cThe First Enantiospecific Total Synthesis of Alstonia Indole Alkaloid
\nPeraksine as well as Progress Toward the Total Synthesis of Secotalcarpine and Macrocarpine B.\u201d
\nEdwankar, R. V.; Edwankar, C. R.; Cook, J. M. Abstracts of Papers, 238th ACS National Meeting,
\nSalt Lake City, UT, United States, March 22-26, 2009, ORGN-531.
\nllllllllllllllllll. \u201cNovel Nonsedative Agents to Treat Epilepsy. Benzodiazepine-related Ligands that do not
\nDevelop Tolerance.\u201d Edwankar, R. V.; Edwankar, C. R.; Stables, J. P.; Roth, B. L.; Furtmuller, R.;
\nSieghart, W.; Cook, J. M. Abstracts of Papers, 238th ACS National Meeting, Washington, DC,
\nUnited States, August 16-20, 2009, MEDI-099.
\nmmmmmmmmmmmmmmmmmm. \u201cProgress Toward the Total Synthesis of Nb-
\nDemethylalstophylline Oxindole Alkaloid.\u201d Fonseca, G. O.; Cook, J. M.; Abstracts of Papers, 237th
\nACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009, ORGN-516.
\nnnnnnnnnnnnnnnnnnn. \u201cProgress Toward the Total Synthesis of Dicyclopenat [a,f] pentalene.\u201d
\nFonseca, G. O.; Cook, J. M.; Abstracts of Papers, 237th ACS National Meeting, Salt Lake City, UT,
\nUnited States, March 22-26, 2009, ORGN-515.
\noooooooooooooooooo. \u201cNew Classes of Novel Gram-positive Specific Antimicrobials:
\nInhibitors of E. coli, S. aureus, and Surrogates of the Causative Agents of Methicillin-resistant
\nS.aureus, Tuberculosis and Anthrax.\u201d Kabir, M. S.; Ara, S.; Polanowski, R. L.; Engelbrecht, K.;
\nKrueger, S. M.; Stemper, M. E.; Rott, M. A.; Schwan, W. R.; Monte, A. P.; Cook, J. M.. Abstracts
\nof Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009,
\nMEDI-047.
\npppppppppppppppppp. \u201cNew Agents to Treat Drug-Resistant Gram-positive Antimicrobial
\nInfections as well as Anthrax and Drug Resistant Tuberculosis.\u201d Kabir, M. S.; Ara, S.; Polanowski,
\nR. L.; Engelbrecht, K.; Stemper, M. E.; Krueger, S. M.; Rott, M. A.; Schwan, W. R.; Monte, A. P.;
\nCook, J. M. Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States,
\nAugust 16-20, 2009, MEDI-343.
\nqqqqqqqqqqqqqqqqqq. \u201cEnolate Driven Copper-Mediated Intramolecular Cross-Coupling
\nStrategies for the Asymmetric Total Synthesis of Antimalarial, Antileishmanial and Antimicrobial
\nAlkaloids and Unnatural Agents.\u201d Kabir, M. S.; Edwankar, C. R.; Edwankar, R. V.; Yang, J.; Jain,
\nH. D.; Ara, S.; Monte, A. P.; Cook, J. M. Abstracts of Papers, 237th ACS National Meeting, Salt
\nLake City, UT, United States, March 22-26, 2009, ORGN-499.
\nrrrrrrrrrrrrrrrrrr. \u201cHighly Active Thio Ligated Cu-Catalyst: Easy Access to Stereo and
\nRegiospecific Vinyl Ethers.\u201d Kabir, M. S.; Van Linn, M. L.; Cook, J. M.. Abstracts of Papers, 238th
\nACS National Meeting, Washington, DC, United States, August 16-20, 2009, ORGN-465.
\nssssssssssssssssss. \u201cProgress Toward the Total Synthesis of the Sarpagine Related Alkaloids
\nAmervolfine and Ervincidine.\u201d Rallapalli, S. K.; Cook, J. M.\u201d Abstracts of Papers, 237th ACS
\nNational Meeting, Salt Lake City, UT, United States, March 22-26, 2009, ORGN-517.
\ntttttttttttttttttt. \u201cSynthesis of Bivalent Ligands Including the Subtype Selective Antagonist Xli-093 for \uf0615
\nBzR\/GABAAergic Receptors. Approach to Treatment of Cognitive Deficits.\u201d Rallapalli, S. K.;
\nMajumder, S.; Roth, B.; Shinday, N. M.; Rowlett, J. K.; Cook, J. M. Abstracts of Papers, 238th ACS
\nNational Meeting, Washington, DC, United States, August 16-20, 2009, MEDI-326.
\nuuuuuuuuuuuuuuuuuu. \u201cMechanistic Studies on the Asymmetric Picter-Spengler Reaction,\u201d
\nVan Linn, M. L.; Cook, J. M. Abstracts of Papers, 238th ACS National Meeting, Washington, DC,
\nUnited States, August 16-20, 2009, ORGN-470.
\nvvvvvvvvvvvvvvvvvv. \u201cInvestigation of the Kinetics of the Cis to Trans Isomerization of 1,2,3-
\nTrisubstituted Tetrahydro-\uf062-Carbolines: A Hammett Study,\u201d Van Linn, M. L.; Cook, J. M. Abstracts
\nof Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009,
\nORGN-394.
\nwwwwwwwwwwwwwwwwww. \u201cNew Agents to Treat Alcohol Abuse Effective Against
\nAnxiety and Anhedonia,\u201d Van Linn, M. L.; Yin, W.; Namjoshi, O.; Platt, D.; Weerts, E.M.; June,
\nH. L.; Roth, B.; Majumder, S.; Cook, J. M. Abstracts of Papers, 238th ACS National Meeting,
\nWashington, DC, United States, August 16-20, 2009, MEDI-321.
\nxxxxxxxxxxxxxxxxxx. \u201cDevelopment of GABA (A) Subtype Selective Agents for the
\nTreatment of Alcohol Abuse.\u201d Van Linn, M. L.; Yin, W.; Platt, D.; Weerts, E.M.; June, H. L.; Cook,
\nJ. M. Abstracts of Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March
\n22-26, 2009, MEDI-108.
\nyyyyyyyyyyyyyyyyyy. \u201cThe First Enantiospecific Total Synthesis of the 3-Oxygenated
\nSarpagine Indole Alkaloids Affinine and 16-Epiaffinine,\u201d Yang, J.; Rallapalli, S. K.; Cook, J. M.
\nAbstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20,
\n2009, ORGN-783.
\nzzzzzzzzzzzzzzzzzz. \u201cScreening Synthetic Stilbene Analogs for Antimicrobial Activity Against
\nMycobacterium smegmatis and Staphylococcus aureus\u201d, Krueger, S. M.; Polanowski, R.;
\nEngelbrecht, K.; Kabir, M. S.; Cook, J. M.; Monte, A. P.; Rott, M. A.; Schwan, W. R. 109th
\nAmerican Society for Microbiology, ASM, Philadelphia, PA. Date presented: May 20, 2009.
\naaaaaaaaaaaaaaaaaaa. \u201cAlpha-5\/GABA(A), but not alpha-1\/GABA(A), receptor mechanisms
\ncontribute to the reinforcing effects of ethanol in monkeys,\u201d D. M. Platt, D. Ruedi-Bettschen, S.
\nRallapalli, M. Van Linn, O. Namjoshi, and J. M. Cook, Behav Pharmcol 20:S69-70. 13th Biennial
\nMeeting of European Behavioural Pharmacology Society, Rome, Italy, 2009.
\nbbbbbbbbbbbbbbbbbbb. \u201cEvaluation of Novel Gram positive Specific Antimicrobials Derived
\nfrom (E)-3-Hydroxy-5-methoxystilbene\u201d, Polanowski, R.; Engelbrecht, K.; Schwan, W. R.; Monte,
\nA. P.; Kabir, M. S.; Cook, J. M.; Monte, A. P.; Rott, M. A.; Stemper, M. E.; Rott, M. A. American
\nSociety of Microbiology-North Central Branch, American Society of Microbiology, St.Cloud, MN.
\nAcademic, Regional, http:\/\/, Poster. Date presented: October 18, 2008.
\nccccccccccccccccccc. \u201cWYS-8, a Novel Ligand at GABA(A) Receptors: a Step Forward to Linking in
\nvitro with in vivo Selectivity? \u201c S. M. Joksimovic, M.M.Savic, M. M. Milinkovic, M. Van Linn , J.
\nRamerstorfer, S. Majumder, W. Yin, B.L. Roth, W. Sieghart, J. M. Cook. 22nd ECNP Congress,
\nSeptember 12-16, 2009, Istanbul, Turkey.
\nddddddddddddddddddd. \u201cBehavioral Characterization of JY-XHE-053, a Benzodiazepine Ligand
\nLess Efficacious at GABA(A) Receptors Containing \uf0611 and \uf0615 than \uf0612 and \uf0613 Subunits,\u201d M. M.
\nMilinkovic, M. M.Savic, S. Huang, R. Furtmuller, S. Majumder, J. Samardzic, J. M. Divljakovic,
\nB. L. Roth, W. Sieghart, J. M. Cook. 22nd ECNP Congress, September 12-16, 2009, Istanbul,
\nTurkey.
\neeeeeeeeeeeeeeeeeee. \u201cThe Alpha-5 GABA(A) Inverse Agonist PWZ-029 Attenuates Isolation Rearing-
\nInduced Context Fear Deficits,\u201d S. Powell, J. Perez, J. Gresack, J. Cook, M. Geyer and V.
\nRisbrough, ACNP meeting, December 7-12, Westin, Hollywood, Fla. 2009.
\nfffffffffffffffffff. \u201cRole of GABA(A) Receptor Subtypes in Benzodiazepine Self-administration by
\nRhesus Monkeys\u201d, B. Fischer, D. Platt, M. Van Linn, S. Rallapalli, T. Clayton, J. M. Cook and J.
\nK. Rowlett, 71st Annual Meeting of the College on the Problems of Drug Dependence, June 20-25,
\nReno, NV, 2009.
\nggggggggggggggggggg. \u201cGABA-A Receptor Subtype Mechanisms in the Discriminative
\nStimulus Effects of Ethanol in Monkeys\u201d, D. Platt, M. Van Linn, S. Rallapalli, T.Clayton and J. M.
\nCook, 71st Annual Meeting of the College on the Problems on Drug Dependence, June 20-25, Reno,
\nNV, 2009.
\nhhhhhhhhhhhhhhhhhhh. \u201cPWZ-029, An Inverse Agonist Selective for \uf0615 Subunit Containing
\nGABA(A) Receptors, Enhances Performance on an Executive Function Task in Monkeys\u201d, J. K.
\nRowlett, C. A. Moran, T. Clayton, S. Rallapalli, B. Roth and J. M. Cook, European Behavioral
\nPharmacology Society, Fall, Rome, Italy, 2009.
\niiiiiiiiiiiiiiiiiii. \u201cRat Genetic Models with Natural Deficits in Cognition for Drug Development,\u201d
\nS. Nye, B. Abroe, J. K. Rowlett, S. Rallapalli, A. Kerr, R. Swain and J. M. Cook, Society of
\nNeuroscience Meeting, Oct 19-23, Chicago, IL, 2009.
\njjjjjjjjjjjjjjjjjjj. \u201cAlpha 5\/GABA(A) But not Alpha 1\/GABA(A) Receptor Mechanisms
\nContribute to the Reinforcing Effects of Ethanol in Monkeys,\u201d D. Platt, D. Ruedi-Bettschen, S.
\nRallapalli, M. Van Linn and J. M. Cook, European Behavioral Pharmacological Society, Fall,
\nRome, Italy, 2009; Behav. Pharmacol, 20:S69-70.
\nkkkkkkkkkkkkkkkkkkk. \u201cPharmacokinetic Interaction Between Ritonavir and Quinine,\u201d J.
\nSoyinka, C. Onyejii, A. Owolobi, P. Sarma and J. M. Cook, 48th Annual ICAAC\/IDSA Meeting, Oct
\n25-28, Washington, DC, 2009.
\nlllllllllllllllllll. \u201cRole of Alpha 5 Containing GABA(A) Receptors in Mediating Benzodiazepine
\nActions in Neocortical Circuits\u201d J. Schweizer, U. Rudolph, J. M. Cook and B. Antkowiak, 2009.
\nmmmmmmmmmmmmmmmmmmm. \u201cHZ-166, A Novel GABA(A) Receptor Subtype Selective
\nBenzodiazepine Site Ligand , is Antihyperalgesic in Mouse Models of Inflammatory and
\nNeuropathic Pain,\u201d A. DiLio, Z. Wang, R. Edwankar, H. Zeilhofer, J. M. Cook, 66th Southwest and
\n62nd South Eastern Regional Meeting of the ACS, New Orleans, LA, Riverside Hilton, 11\/30\/2010-
\n12\/4\/2010.
\nnnnnnnnnnnnnnnnnnnn. \u201cSH-I 048A, A Novel Positive Modulator of GABA(A) Receptor: In
\nVitro and Behavioral Profile,\u201d S. Joksimovic, S. Huang, J. Rammerstorfer, M. Milinkovic, J. M.
\nDivljakovic, B. Roth, W. Sieghart, M.M. Savic, J. M. Cook, Congress of European College of
\nNeuropsychopharmacology, Amerstam, July (2010).
\nooooooooooooooooooo. \u201cContribution of \uf0611 Subunit-Containing GABA (A) Receptors to
\nDiazepam Motor Impairment,\u201d J. Divljakovic, M. VanLinn, M. M. Milinkovic, W.Yin, B. Batinic,
\nJ. Cook, M. Savic. Congress of European College of Neuropsychopharmacology, Amerstam, July
\n(2010).
\nppppppppppppppppppp. \u201cAcute Dependence in Squirrel Monkeys Following Zolpidem
\nAdministration: Role of \uf0611 GABA (A) Receptors,\u2019 L. Teixeira, B. Fischer, M. VanLinn, O.
\nNamjoshi, W. Yin, T. Clayton, J. Cook, J. Rowlett, Society for Neuroscience Meeting, San Diego,
\nFall 2010.
\nqqqqqqqqqqqqqqqqqqq. \u201cRole of \uf0611 and \uf0615 Subunit Containing Receptors in the Cognitive
\nImpairing Effects of Benzodiazepines,\u201d C. Moran, O. Namjoshi, S. Rallapalli, J. M. Cook, J.
\nRowlett, Society for Neuroscience Meeting, Fall 2010.
\nrrrrrrrrrrrrrrrrrrr. \u201cEvaluation of \uf0611 GABA (A) Receptor Mechanisms in the Reinforcing Effects
\nof Alcohol in Rhesus Monkeys,\u201d M. Szafir, M. VanLinn, O. Namjoshi, W. Yin, T. Clayton, J. Cook,
\nD. M. Platt, Society of Neuroscience Meeting, Fall, 2010.
\nsssssssssssssssssss. \u201cThe Role of \uf0615 GABA (A) Receptors in Tests of Learning and Memory in
\nRhesus Monkeys,\u201d P. Soto, S. Rallapalli, J. M. Cook, N. Ator, M. Weed, Society of Neuroscience
\nMeeting, Fall, 2010.
\nttttttttttttttttttt. \u201cAlpha5\/GABA-A Receptor Inverse Agonists Attenuate the Abuse Related
\nEffects of Ethanol in Monkeys,\u201d Platt D. M., Ruedi-Bettschen D., Rowlett J.K., Rallapalli S.,
\nClayton T., and Cook J.M., Alcohol Clin Exp Res 34:538. Research Society on Alcoholism 33rd
\nAnnual Meeting, San Antonio, TX, 2010.
\nuuuuuuuuuuuuuuuuuuu. \u201cHZ-166, A Nonsedating Anxiolytic Active Against Neuropathic Pain,\u201d
\nA. DiLio, R. Edwankar, U. Zeilhofer, J. M. Cook, ISHC Meeting, Glasgow, Scotland, July 31-
\nAugust 4, 2011
\nvvvvvvvvvvvvvvvvvvv. \u201cHZ-166, A Nonsedating Anxiolytic Active Against Neuropathic Pain,\u201d
\nJ. M. Cook, Medical College of Wisconsin, Pain Meeting, Summer 2011.
\nwwwwwwwwwwwwwwwwwww. \u201cThe Design and Synthesis of GABAergic Subtype Specific
\nLigands to Treat Diseases,\u201d J.M. Cook, CTSI Drug Development Workshop Meeting, Medical
\nCollege of Wisconsin, Spring 2012
\nxxxxxxxxxxxxxxxxxxx. \u201cWithdrawal from Repeated Haloperidol Reduces the Efficacy of
\nSubsequent Novel Antipsychotic Treatment in MAM Model of Schizophrenia\u201d, T. Grace, et al.,
\nM. Poe, J.M. Cook, Society for Neuroscience Meeting, San Diego, Fall, 2013.
\nyyyyyyyyyyyyyyyyyyy. \u201cReversal of Ketamine-Induced Cognitive Impairment by an \u03b12\/\u03b13
\nGABAA Receptor Modulator in Rhesus Monkeys\u201d, Z. Meng, M.M. Poe, Zhi-jian Wang, J.M.
\nCook, J.K. Rowlett, Society for Neuroscience Meeting, San Diego, Fall, 2013.
\nzzzzzzzzzzzzzzzzzzz. \u201cGeneral Approach Towards the Enantiospecific Synthesis of Macroline
\nOxindoles. Total Synthesis of Isoalstonisine, Affinisine Oxindole and an Improved Total
\nSynthesis of Alstonisine\u201d, G. Fonseca, J.M. Cook, 245th ACS National Meeting, New Orleans LA,
\nApril 7-11, (Abst. ORGN 180), 2013.
\naaaaaaaaaaaaaaaaaaaa. \u201cSynthesis of Biological Evaluation of \u03b15 GABAergic Subtype
\nSelective Ligand PWZ-029\u201d, P. Biawat, S. Rallapalli, C. Lauer, J. Rowlett, B. Curry, C.
\nKazerowski, J.M. Cook, 245th ACS National Meeting, New Orleans LA, April 7-11, (Abst. MEDI
\n147), 2013.
\nbbbbbbbbbbbbbbbbbbbb. \u201cSynthesis of Benzodiazepines Active Against Neuropathic Pain as
\nwell as Schizophrenia\u201d, M. Poe, Z. Wang, A. Di Lio, S. Rallapalli, R. Edwankar, J. Cook, H.U.
\nZeilhofer, 245th ACS National Meeting, New Orleans LA, April 7-11, (Abst. MEDI 371), 2013.
\ncccccccccccccccccccc. \u201cDesign and Synthesis of a New Class of Antibacterials with Activity
\nAgainst Mycobacteria and Gram-Positive Bacteria\u201d, C.M. Witzigmann, V.V. Tiruveedhula, J.M.
\nCook, A. Monte, W. Schwan, 245th ACS National Meeting, New Orleans LA, April 7-11, (Abst.
\nMEDI 391), 2013.
\ndddddddddddddddddddd. \u201cDesign and Synthesis and SAR Studies on a New Class of
\nAntimycobacterials\u201d, V.V. Tiruveedhula, M. Kabir, J.M. Cook, A. Monte, W. Schwan, M. Rott,
\nR. Polanowski, 245th ACS National Meeting, New Orleans LA, April 7-11, (Abst. MEDI 390),
\n2013.
\neeeeeeeeeeeeeeeeeeee. \u201cSynthesis of 2-Isopropoxy Beta Carboline; A Compound Active
\nAgainst Alcohol Self-Administration in P Rats with No Effect on Sucrose Responding\u201d, Jana Beth
\nPlotkin, Undergraduate Research Symposium, UW-Milwaukee, Milwaukee, Spring, 2013.
\nffffffffffffffffffff. \u201cMK-801-Induced Hyperlocomotion in Rats is Affected by Modulation of \u03b15-
\nContaining GABA Receptors\u201d, T. Timic, S. Joksimovic, M.M. Poe, J. Ramerstorfer, P. Biawat, T.
\nRadulovic, B. Roth, W. Sieghart, J.M. Cook, M. Savic, 26th ECNP Congress, Barcelona, Spain,
\nOct. 2013.
\ngggggggggggggggggggg. \u201cPWZ-029 Alleviates NMDA Receptor Antagonist-Induced Deficits in
\nWater Maze and Object Recognition Test in the Rat: Implications for the Treatment of Cognitive
\nImpairment in Schizophrenia\u201d, S. Joksimovic, A. Obradovic, T. Timic, T. Radulovic, P. Biawat, J.
\nKovacevic, M. Milic, B. Batinic, J. Cook, M. Savic, 26th ECNP Congress, Barcelona, Spain,, Oct.
\n2013.
\nhhhhhhhhhhhhhhhhhhhh. \u201cRole of Alpha 3 GABH\uf041\uf020\uf020Receptor Modulation in the Anti-Conflict
\nEffects of Benzodiazepine \u2013 Type Drugs in Monkeys,\u201d Sawyer, E.; Fischer, B.; Meng, Z.; Poe,
\nM.; Namjoshi,O.; Cook, J.; Rowlett, J., presented at The CPDD Meeting, San Diego, CA. Hilton
\nBayfront Hotel, June 17-21 (2013).
\niiiiiiiiiiiiiiiiiiii. \u201cLittle Role for Alpha1 GABA-A, Receptor Subtypes in the Reinforcing Effects
\nof Ethanol in Rhesus Monkeys,\u201d Platt D. M., Moran C., Sawyer E., Sirbu M., Van Linn M.,
\nNamjoshi O., Clayton T., and Cook J.M., Alcohol Clin Exp Res 37:247A. Research Society on
\nAlcoholism 65th Annual Meeting, Orlando, FL, 2013.
\njjjjjjjjjjjjjjjjjjjj. \u201cSynthesis of Natural Products and Related Heterocyclic Compounds. Search
\nFor Agents to Treat Neuropathic Pain Epilepsy and Anxiety Disorders as well as Simple
\nMolecules to Treat TB and MRSA Infections,\u201d Plenary Lecture, Cook, J.; Edwankar, C.; Poe, M.;
\nTiruveedhula, P.; Witzigmann, C., 25th Mona Symposium on Natural Products and Medicinal
\nChemistry, UWI, Mona Kingston Jamaica, Jan. 5-9, 2014.
\nkkkkkkkkkkkkkkkkkkkk. \u201cBehavioral Effects of the Novel, Benzodiazepine Positive Modulator
\nSH-053-2\u2019F-S-C H\uf033 in an Immune-Mediated Neurodevelopmental Disruption Model,\u201d Richetto,
\nJ.; Labouesse, M.; Poe, M.M.; Cook, J.; Graie, A.; Riva, M.; Meyer, U, presented at the SIRS
\nCongress (2014).
\nllllllllllllllllllll. \u201cChiral Subtype Selective Imidazobenzodizepines Important as Potential Agents
\nto Treat Schizophrenia,\u201d Poe, M.; Radditz, N.; Baker, D.; Cook, J., 247th ACS National Meeting,
\nDallas, TX, March 16-20 (Abst.MEDI 282), 2014.
\nmmmmmmmmmmmmmmmmmmmm. \u201cDesign and Synthesis of Novel Small Molecule Stilbenes
\nwith Activity Against Gram-Positive Bacteria and Mycobacterium,\u201d Witzigmann, C.;
\nTiruveedhula, V.; Monte, A.; Schwan, W.; Cook, J.M. 247th ACS National Meeting, Dallas, TX,
\nMarch 16-20 (Abst.MEDI 266), 2014.
\nnnnnnnnnnnnnnnnnnnnn. \u201cDesign and Synthesis of Novel Antimicrobials for the Treatment of
\nDrug Resistance Bacterial Infections, Including M. Tuberculosis,\u201d Tiruveedhula, V.; Witzigmann,
\nC.; Rott, M.; Schwan, W.; Monte, A.; Cook, J.M. 247th ACS National Meeting, Dallas, TX, March
\n16-20 (Abst.MEDI 263), 2014.
\noooooooooooooooooooo. \u201cSelective Pharmacologic Targeting of the GABAA\uf0614 Submit in
\nAirway Smooth Muscle to Alleviate Bronchospasm,\u201d Yucum, G.; Wakita, R.; Stephen, M.; Cook,
\nJ.; Emala, C.; Gallos, G.; Am. Physiol. Lung Meeting, 2015.
\npppppppppppppppppppp. \u201cReinforcing Effects of Ethanol Are Attenuated by Alpha%, GABA-A
\nReceptor Invase Againsts in Monkeys,\u201d Ruedi-Bettschen, D.; Rallapalli, S.; Clayton, T.; Cook, J.;
\nPlatt, D.M.; RSA Meeting 2015
\nqqqqqqqqqqqqqqqqqqqq. \u201cA Novel Trojan Horse for IN-vivo Sensitivity Testing of
\nMedulloblastoma Therapies,\u201d Sengupta, S.; Jones, O.; galligaris, Cook. J.; Peo, M.; Methuku, K.;
\nArcher, T.; Francois, J.j Tranghese, F.; Pomeroy, S.; Agar, N.; Langer, R.; 19th Society of Neurooncology
\nMetting, Miami, FIA, Nov. 13-16 (2015).
\nrrrrrrrrrrrrrrrrrrrr. \u201cDesign and Synthesis of Novel \u03b2-Carbolines as a GABAA Subtype Selective
\nAgent for the Treatment of Alcohol Abuse,\u201d Tiruveedhula, V.; Menthuka, K.; Warnock, K.; June,
\nH.; Cook, J.M., 248th ACS National Meeting, San Francisco, CA, August 10-14 (Abst. MEDI
\n0128), 2014.
\nssssssssssssssssssss. \u201cInducing Airway Smooth Muscle Relaxation by Targeting the Restricted \u03b1-
\nSubunit Repertoire of GABAA Receptors Using MD-45,\u201d Stephen, M.J.; Jahan, R.; Gallos, G.;
\nEmala, C.W.; Cook, J.M., 248th ACS National Meeting, San Francisco, CA, August 10-14 (Abst.
\nMEDI 057), 2014.
\ntttttttttttttttttttt. \u201cStereospecific Total Synthesis of the Indole Alkaloid Ervindidine:
\nEstablishment of the C-6 Hydroxyl Stereochemistry,\u201d Verma, R.S.; Rallapalli, S.K.; Verma, A.R.;
\nCook, J.M,, 248th ACS National Meeting, San Francisco, CA, August 10-14 (Abst. MEDI 433),
\n2014.
\nuuuuuuuuuuuuuuuuuuuu. \u201cEffects of Hz-166, a Novel \u03b12 and \u03b13 Subunit-Containing GABAA
\nReceptor Agonist, on Inflammatory Pain and Operant Behavior in Mice,\u201d Fischer, F.; Kroll, C.;
\nPoe, M.; Cook, J.M., Presented at The CPDD 76th Annual Scientific Meeting, June 14-19, 2014,
\nCaribe Hiltonm, San Juan, Puerto Rico.
\nvvvvvvvvvvvvvvvvvvvv. \u201cTonic Inhibition in the Central Amygdala Controls Anxiety
\nBehavior,\u201d Botta, P.; Kasugal, Y.; Demmou, L.; Xu, C.; Rudolph, U.; Ferraguti, F.; Luthi, A.; Poe,
\nM.M.; Cook, J.;, PhD Conference in Europe, 2014.
\nwwwwwwwwwwwwwwwwwwww. \u201cExamining the Effect of an \u03b15 Subunit-Containing GABAA
\nReceptor-Positivie Allosteric Modulator on UCMS-Induced Emotionality Behavior in the Mouse,\u201d
\nMeyer, U.; Poe, M.M.,; Cook, J.M.; et al. Presented at Conference in Europe, 2014.
\nxxxxxxxxxxxxxxxxxxxx. \u201cDesign and Characterization of a Novel System XC-Substrate,\u201d
\nRaddatz, A; Neary, M.; Hjelmhaug, J.; Edwarde, M.; Mueller, C.; Xie, X.; Cook, J.; Fucks-
\nLokensgard, R.; Mantsch, J.; Lobner, D.; Baker, D., Presented at the Fall Meeting of The Society
\nfor Neuroscience, 2014.<\/p>\n","protected":false},"excerpt":{"rendered":"
a. “Synthesis of Propellanes with Large and Medium-sized Rings from Cyclic \uf061-Diketones and Dimethyl \u00df-Ketoglutarate,” J. Cook and D. Yang, presented at the 7th Central Regional Meeting of the American Chemical Society, West Virginia University, Morgantown, WV, May 28-30, 1975, …<\/p>\n","protected":false},"author":382,"featured_media":0,"parent":0,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"class_list":["post-10349","page","type-page","status-publish","hentry"],"yoast_head":"\n