{"id":10347,"date":"2025-07-22T11:22:56","date_gmt":"2025-07-22T16:22:56","guid":{"rendered":"https:\/\/uwm.edu\/chemistry\/?page_id=10347"},"modified":"2026-03-17T15:13:43","modified_gmt":"2026-03-17T20:13:43","slug":"cook-publications","status":"publish","type":"page","link":"https:\/\/uwm.edu\/chemistry\/cook-publications\/","title":{"rendered":"Cook Publications"},"content":{"rendered":"

A. Scholarly Publications
\n1. “Alstonerine, a New Indole Alkaloid from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, Chem. Commun., 1306-1307 (1969).
\n2. “The Structure of Alstonisidine: A Novel Dimeric Indole Alkaloid,” J.M. Cook and P.W. LeQuesne, J. Org. Chem., 36, 582-586 (1970).
\n3. “Some Aspects of Drug Usage, Trade and Plant Domestication Among the Yanomamo Indians of Venezuela and Brazil,” N. Chagnon, P.W. LeQuesne, and J.M. Cook, Acta Cient. Venezolana, 21, 186-193 (1970).
\n4. “Yanomamo Hallucinogens: Anthropological, Botanical and Chemical Findings,” N. Chagnon, P.W. LeQuesne, and J.M. Cook, Current Anthropology, 12, 72-74 (1971).
\n5. “Macralstonine from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, Phytochem., 10, 737-738 (1971).
\n6. “A Model Iron-Catalyzed Biomimetic Cyclization of a Cyclic Tryptamine N-Oxide,” G. Scherer, C. Dorschel, J.M. Cook, and P.W. LeQuesne, J. Org. Chem., 37, 1083-1085 (1971).
\n7. “Biomimetic Synthesis and Structure of the Bisindole Alkaloid Alstonisidine,” D.E. Burke, J.M.Cook, and P.W. LeQuesne, Chem. Commun., 697 (1972).
\n8. “Biomimetic Synthesis of the Bisindole Alkaloid Macralstonine,” D.E. Burke, J.M. Cook, C. DeMarkey, and P.W. LeQuesne, Chem. Commun., 1346-1347 (1972).
\n9. “Further Alkaloids of Alstonia muelleriana,” D.E. Burke, G.A. Cook, J.M. Cook, H. Lazar, K. Heller, and P.W. LeQuesne, Phytochem., 12, 1467-1474 (1973).
\n10. “Biomimetic Synthesis of Villalstonine and Alstonisidine,” D.E. Burke, J.M. Cook, and P.W. LeQuesne, J. Amer. Chem. Soc., 95, 546-553 (1973).
\n11. “Studies on Vinca Alkaloids. The Structure of Vincarodine,” J.P. Kutney, G. Cook. J. Cook, I. Itoh, J. Clardy, J. Fayos, P. Brown, and G. Svoboda, Heterocycles, 2, 73-78 (1974).
\n12. “11-Methoxyakuammicine from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, J. Org. Chem., 1367 (1975).
\n13. “Studies on the Synthesis of Bisindole Alkaloids. Structure and Absolute Configuration of 18′-Epi-4′-Epi-Vinblastine, 18′-Decarbometh-oxy-18′-Epi-4′-Epi- Vinblastine and 18′-Epi-3′,4′-Dehydrovinblastine,” J.P. Kutney, J. Cook, K. Fuji, A. Treasurywala, J. Clardy, J. Fayos, and H. Wright, Heterocycles, 3, 205-212 (1975).
\n14. “Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the Synthesis of Bisindole Alkaloids in the Vinblastine-Vincristine Series. The Chloro-indolenine Approach,” J.P. Kutney, J. Beck, F. Bylsma, J.M. Cook, W. Cretney, K. Fuji, R. Imhof, and A. Treasurywala, Helv. Chim. Acta, 58, 1690-1719 (1975).
\n15. “Reaction of 1,2 and 1,3 Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate. I. Synthesis of Methyl 5,6,7,8-Tetrahydro-5-oxocoumarin-\u00df(41H)-Acetate,” D. Yang, J. Oehldrich, D. Foerst, and J.M. Cook, J. Org. Chem., 41(4), 743 (1976).
\n16. “Reactions of Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate. II. Simple Synthesis of Compounds of the [10.3.3] and [6.3.3] Propellane Series,” J.M. Cook and D. Yang, J. Org. Chem., 41, 1903-1907 (1976).
\n17. “Pictet-Spengler Condensations in Refluxing Benzene,” J. Sandrin, D. Soerens, L. Hutchins, E. Richfield, F. Ungemach, and J.M. Cook, Heterocycles, 4, 1101-1105 (1976).
\n18. “13C-NMR of 1,3-Disubstituted 1,2,3,4-Tetrahydro-\u00df-Carbolines,” J. Sandrin, D. Soerens, and J.M. Cook, Heterocycles, 4, 1249-1255 (1976).
\n19. “Reactions of Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate. IV. Isolation of 1:1 Adducts,” J.
\nOehldrich, M. Mueller, D. Wichman, D. Yang, J.M. Cook, and U. Weiss, J. Org. Chem., 41, 4053-4058 (1976).
\n20. “Reactions of Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate. V. Simple Synthesis of Tricyclo [6.3.0.01,5]undecane-3,7,9-Trione: A Novel Cyclopentanoid Compound,” J. Oehldrich, J.M. Cook, and U. Weiss, Tetrahedron Lett., 4549- 4552 (1976).
\n21. “Reactions of Dicarbonyl Compounds with \u00df-Ketoglutaric Acid III: Synthesis of 4-Hydroxy-3,4-diphenylcyclopent-2-enone-2-carboxylic Acid,” J. Oehldrich and J.M. Cook, Can. J. Chem., 55, 82-84 (1977).
\n22. “Reactions of Dicarbonyl Compounds with Dimethyl \u00df-Ketoglutarate. VI. Revision of the Structure of the Reaction Product of Cyclohexane-1,3-dione and Dimethyl \u00df-Ketoglutarate and Conversion into 4-Substituted-5,6,7,9 -Tetrahydro-5-oxo-2- quinolones,” J. Oehldrich and J.M. Cook, J. Org. Chem., 42, 889-894 (1977).
\n23. “Synthesis of 1,2,3,4-Tetrahydro-\u00df-Carbolines,” J. Sandrin, D. Soerens, P. Mokry, and J.M. Cook, Heterocycles, 6, 1133-1139 (1977).
\n24. “Reaction of Carbonyl Compounds with Dimethyl \u00df-Ketoglutarate. Synthesis of Bicyclic Furan Derivatives,” O. Campos and J.M. Cook, J. Hetero. Chem., 14(5), 711-715 (1977).
\n25. “General Method for the Synthesis of [n.3.3]Propellanes, n > 3,” R. Weber and J.M. Cook, Can. J. Chem., 56, 198-192 (1978).
\n26. “Synthesis of the Antibiotic (\u00b1)-Pyridindolol,” G.S. Wu, E. Yamanaka, and J.M. Cook, Heterocycles, 9, 175-183 (1978).
\n27. “Synthesis of a Tetraketone of the Tetracyclo[5.5.1.0.4,13O10,13]tridecane (“Staurane”) Series,” R. Mitschka, U. Weiss, and J.M. Cook, J. Am. Chem. Soc., 100, 2973-2974 (1978).
\n28. “The Spiroindolenine Intermediate: A Review,” F. Ungemach and J.M. Cook, Heterocycles, 9, 1089-1119 (1978).
\n29. “Simple Entry into the 1,6-Diazaphenalene Ring System,” M.I. El-Sheikh, J.-C. Chang, and J.M. Cook, Heterocycles, 9, 1561-1570 (1978).
\n30. “Study of the Pictet-Spengler Reaction in Aprotic Media: Synthesis of the \u00df-Galactosidase Inhibitor, Pyridindolol,” D. Soerens, J. Sandrin, F. Ungemach, P. Mokry, G.S. Wu, E. Yamanaka, L. Hutchins, M. DiPierro, and J.M. Cook, J. Org. Chem., 44, 535-545 (1979).
\n31. “Selenium Dioxide Entry into 3-Acylindoles,” O. Campos and J.M. Cook, Tetrahedron Lett., 1025-1028 (1979).
\n32. “Synthesis of 1,6-Diazaphenalene, a Vinylogous Imidazole,” J.-C. Chang, M.I. El- Sheikh, and J.M. Cook, Heterocycles, 12, 903-907 (1979).
\n33. “Stereospecific Synthesis of Trans-1,3-Disubstituted-1,2,3,4-Tetrahydro \u00df-Carbo-lines,” F. Ungemach, M. DiPierro, R. Weber, and J.M. Cook, Tetrahedron Lett., 3225-3228 (1979).
\n34. “A Convenient Preparation of Cyclopentane-1,2-dione,” J. Wrobel and J.M. Cook, Synthetic Commun., 10, 333-337 (1980).
\n35. “General Method for the Assignment of Stereochemistry of 1,3-Disubstituted-1,2,3,4- Tetrahydro-\u00df-Carbolines by Carbon-13 Spectroscopy,” F. Ungemach, D. Soerens, R. Weber, M. DiPierro, O. Campos, P. Mokry, J.V. Silverton, and J.M. Cook, J. Am. Chem. Soc., 102, 6976-6984 (1980).
\n36. “Selenium Dioxide Oxidations in the \u00df-Carboline Area,” O. Campos, M. DiPierro, M. Cain, R. Mantei, A. Gawish, and J.M. Cook, Heterocycles, 14, 975-984 (1980).
\n37. “New Perspectives on the Semmler-Wolff Aromatization Reaction,” M.I. El-Sheikh and J.M. Cook, J. Org. Chem., 45, 2585-2587 (1980).
\n38. “Stereospecific Synthesis of 1,3-Disubstituted-1,2,3,4-Tetrahydro \u00df-Carbolines,” F. Ungemach, M.
\nDiPierro, R. Weber, and J.M. Cook, J. Org. Chem., 46, 164-168 (1981).
\n39. “General Approach for the Synthesis of Polyquinanes: Stereospecific, Regiospecific Entry into the Tetracyclo[6.6.0.01,5.O8,12]tetradecane System,” A. Gawish and J.M. Cook, Tetrahedron Lett., 22, 211-214 (1981).
\n40. “3-Hydroxymethyl \u00df-Carboline Antagonizes Some Pharmacologic Actions of Diazepam,” P. Skolnick, S.M. Paul, K.C. Rice, S. Barker, J.M. Cook, R. Weber, and M. Cain, Eur. J. Pharmacol., 69, 525-527 (1981).
\n41. “Reaction of Dicarbonyl Compounds with Dimethyl 3-ketoglutarate. Influence of Steric Effects on Success of the Condensation,” K. Avasthi, M.N. Deshpande, W.-C. Han, U. Weiss, and J.M. Cook, Tetrahedron Lett., 22, 3475-3478 (1981).
\n42. “The Chemistry of 1,6-Diazaphenalene. Electrophilic Substitution and Reaction with Singlet Oxygen,” K. Avasthi, S.-J. Lee, J.M. Cook, J.E. Pickett, and H.H. Wasserman, Heterocycles, 16, 1453-1461 (1981).
\n43. “General Approach for the Synthesis of Polyquinanes, Facile Generation of Molecular Complexity via Reaction of 1,2-Dicarbonyl Compounds with Dimethyl 3-keto-glutarate,” R. Mitschka, J. Oehldrich, K. Takahashi, J.M. Cook, U. Weiss, and J.V. Silverton, Tetrahedron (Symposium in Print, ed. by L.A. Paquette), 37, 4521-4542 (1981).
\n44. “Synthesis of 1,6-Diazaphenalene,” M.I. El-Sheikh, J.C. Chang, A. Harmon, K. Avasthi, and J.M. Cook, J. Org. Chem., 46, 4188-4193 (1981).
\n45. “Chemistry of 1,6-Diazaphenalene, Halogenation,” S.-J. Lee and J.M. Cook, Heterocycles, 16, 2125-2131 (1981).
\n46. “Regiospecific Cleavage of Strained Tri- and Tetraquinane \u00df-Diketones via a Retro- Claisen Reaction,” W.C. Han, K. Takahashi, J.M. Cook, U. Weiss, and J.V. Silverton, J. Am. Chem. Soc., 104, 318-321 (1982).
\n47. “Do Benzodiazepine Receptors Play a Role in Sleep Regulation? Studies with the Benzodiazepine Antagonist, 3-Hydroxymethyl-\u00df-Carboline,” W. Mendelson, M. Cain, J.M. Cook, S.M. Paul, and P. Skolnick, in “Beta-Carbolines and Isoquinolines,” ed. by Earl Usdin, A.R. Liss, Inc., New York, 233-252 (1982).
\n48. “\u00df-Carbolines and Benzodiazepine Receptors: Structure-Activity Relationships and Pharmacologic Activity,” P. Skolnick, E.F. Williams, J.M. Cook, M. Cain, K.C. Rice, J.M. Crawley, and S.M. Paul, in “Beta-Carbolines and Isoquinolines,” ed. by Earl Usdin, A.R. Liss, Inc., New York, 253-262 (1982).
\n49. “\u00df-Carbolines: Synthesis, Neurochemical and Pharmacological Actions on Brain Benzodiazepine Receptors,” M. Cain, R. Weber, F. Guzman, J.M. Cook, S.A. Barker, K.C. Rice, and P. Skolnick, J. Med. Chem., 25, 1081-1091 (1982).
\n50. “Synthesis of 9-Methoxy-1,6-Diazaphenalene,” R.W. Weber and J.M. Cook, Heterocycles, 19, 2089-2095 (1982).
\n51. “Benzodiazepine Receptor-Mediated Experimental ‘Anxiety’ in Primates,” P.T. Ninan, T.M. Insel, R.M. Cohen, J.M. Cook, P. Skolnick, and S.M. Paul, Science, 218, 1332-1334 (1982).
\n52. “Chemistry of 1,6-Diazaphenalene. Reaction with Alkylating and Acylating Agents,” K. Avasthi and J.M. Cook, J. Heterocyclic Chem., 19, 1415-1419 (1982).
\n53. “Biomimetic Approach to Potential Benzodiazepine Agonists and Antagonists,” M. Cain, F. Guzman, J.M. Cook, K.C. Rice, and P. Skolnick, Heterocycles, 19, 1003- 1007 (1982).
\n54. “Blockade of 3-Carbomethoxy \u00df-Carboline Induced Seizures by Diazepam and the Benzodiazepine Antagonists, Ro 15-1788 and CGS-8216,” M. Schweri, M. Cain, J. Cook, S. Paul, and P. Skolnick, Pharmac. Biochem. Behav., 17, 457-460 (1982).
\n55. “Halogenation of 1,6-Diazaphenalene. Theoretical and Experimental Results,” R.W. Weber, S.J. Lee, S. Milosevich, J.M. Cook, and W.B. England, Can. J. Chem., 60, 3049-3054 (1982).
\n56. “DDQ Oxidations in the Indole Area: Synthesis of Crenatine,” M. Cain, R. Mantei, and J.M. Cook, J. Org. Chem., 47, 4933-4936 (1982).
\n57. “Selenium Dioxide Oxidations in the Indole Area. Synthesis of \u00df-Carboline Alkaloids,” M. Cain, O. Campos, F. Guzman, and J.M. Cook, J. Am. Chem. Soc., 105, 907-913 (1983).
\n58. “Stereocontrolled Synthesis of (\u00b1) Modhephene via the Weiss Reaction,” J. Wrobel, K. Takahashi, V. Honkan, S. Bertz, G. Lannoye, and J.M. Cook, J. Org. Chem., 48, 139-141 (1983).
\n59. “Synthesis of Azaphenalenes,” S.J. Lee and J.M. Cook, Heterocycles, 20, 87-111 (1983).
\n60. “A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam,” W.B. Mendelson, M. Cain, J.M. Cook, S.M. Paul, and P. Skolnick, Science, 219, 414-416 (1983).
\n61. “Increased Wakefulness in Rats is Induced by 3-Hydroxymethyl \u00df-Carboline, a Benzodiazepine Antagonist,” W. Mendelson and J.M. Cook, Sleep 1982, 6th Eur. Congr. Sleep Res., Zurich 1982, Karger, Basel, 279-281 (1983).
\n62. “Pictet-Spengler Reactions in Aprotic Media,” M. Jawdosiuk and J.M. Cook, J. Org. Chem., 49, 2699-2701 (1984).
\n63. “Biomimetic Approach to Potential Benzodiazepine Receptor Agonists and Antagonists,” F. Guzman, M. Cain, P. Larscheid, T. Hagen, J. Cook, M. Schweri, P. Skolnick, and S. Paul, J. Med. Chem., 27, 564-570 (1984).
\n64. “Organocuprate Reactions with Cyclopropanes. Evidence for Three Types of Mechanisms and Against Direct Nucleophilic Displacement of \u00df-Cyclopropyl-\u03b1,\u00df-Unsaturated Ketones,” S.H. Bertz, G. Dabbagh, J.M. Cook, and V. Honkan, J. Org. Chem., 49, 1739-1843 (1984).
\n65. “Isolation of the Key Intermediate in the Formation of cis-Bicyclo[3.3.0]octane-3,7- diones from Dimethyl 3-ketoglutarate and 1,2-Dicarbonyl Compounds,” G. Kubiak, U. Weiss, and J.M. Cook, J. Org. Chem., 49, 561-564 (1984).
\n66. “Structural Features of the Quinidine and Quinine Molecule Necessary for Binding of Drug-Induced Antibodies to Human Platelets,” D.J. Christie, R. Weber, P. Mullen, J.M. Cook, and R. Aster, J. Laboratory and Clinical Medicine, 104, 730-740 (1984).
\n67. “\u00df-Carboline-3-Carboxylate-t-Butyl Ester: A Selective Bz-1 Receptor Antagonist,” H.E. Shannon, N.J. Katzman, F. Guzman, and J.M. Cook, Life Sci., 35, 2227- 2236 (1984).
\n68. “Interactions Between the Benzodiazepine Receptor Antagonist Ro 15-1788 (Flumazenil) and the Inverse Agonist BCCE: Behavioral Studies with Squirrel Monkeys,” J.E. Barrett, L.S. Brady, J.M. Witkin, J.M. Cook, and P. Larscheid, Life Sci., 36, 1407-1414 (1985).
\n69. “Midazolam-Ethanol Interactions and Reversal with a Benzodiazepine Antagonist,” P. Van Gorder, W. Hoffman, V. Baughman, R. Albrecht, D. Miletich, F. Guzman, and J.M. Cook, Anesth. Analg., 64, 129-135 (1985).
\n70. “Cerebrovascular and Cardiovascular Metabolic Effects of Flurazapam and a Benzodiazepine Antagonist 3-Hydroxymethyl \u00df-Carboline,” W. Hoffman, J.M. Feld, P. Larscheid, J.M. Cook, R.F. Albrecht, and D.J. Miletich, Eur. J. Pharmacol. 106, 585-591 (1985).
\n71. “A Benzodiazepine Antagonist Inhibits the Cerebral Metabolic and Respiratory Depressant Effects of Fentanyl,” N. Naughton, W.E. Hoffman, P. Larscheid, J.M. Cook, R.F. Albrecht, and D.J. Miletich, Life Sci., 36, (23) 2239-2245 (1985).
\n72. “Synthetic Studies in the \u00df-Carboline Area. New Entry into 4-Substituted and 3,4- Disubstituted \u00df-Carbolines,” N. Fukada, M.L. Trudell, B. Johnson, and J.M. Cook, Tetrahedron Lett., 26, 2139-2142 (1985).
\n73. “Evidence that a Benzodiazepine Receptor Mechanism Regulates the Secretion of Pituitary \u00df-Endorphin Levels in Rats,” S. Maiewski, P. Larscheid, J.M. Cook, and G. Mueller, Endocrinology, 117, 474-480 (1985).
\n74. “General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Preparation of the Chiral Tetracyclo[6.6.0.01,5O.8,12]tetradecane-3,6,10,13- tetraene,” M. Venkatachalam, M. Jawdosiuk, M. Deshpande, and J.M. Cook, Tetrahedron Lett., 26, 2275-2278 (1985).
\n75. “Studies on the Reaction of 1,2-Dicarbonyl Compounds with Dimethyl 3-Ketoglu-tarate. Steric and Electronic Effects,” G. Kubiak and J.M. Cook, Tetrahedron Lett., 26, 2163-2166 (1985).
\n76. “The Interaction Between Benzodiazepine Antagonists and Barbiturate-Induced Cerebrovascular and Cerebral Metabolic Depression,” R.F. Albrecht, J. Cook, W.E. Hoffman, P. Larscheid, D.J. Miletich, and N. Naughton, Neuropharmacology, 24, 957-963 (1985).
\n77. “General Approach for the Synthesis of Polyquinenes. II. Synthesis of Tetracyclo-[5.5.1.04,13.O10,13]tridecane-2,5,8,11 -tetraene,” M.N. Deshpande, M. Jawdosiuk, G. Kubiak, M. Venkatachalam, W. Weiss, and J.M. Cook, J. Am. Chem. Soc., 107, 4786-4788 (1985).
\n78. “General Approach for the Synthesis of Polyquinenes. III. Synthesis of Triquinacene via the Weiss Reaction,” S.H. Bertz, G. Lannoye, and J.M. Cook, Tetrahedron Lett., 26, 4695-4698 (1985).
\n79. “The Isolation and Characterization of a New Tetrahydroprotoberberine Alkaloid from Cordalis clarkei Prain,” M.A. Rothera, S. Wehrli, and J.M. Cook, J. Nat. Products., 48, 802-808 (1985).
\n80. “General Approach to the Synthesis of Polyquinanes,” M. Venkatachalam, G. Kubiak, J.M. Cook, and U. Weiss, Tetrahedron Lett., 26, 4863-4866 (1985).
\n81. \u201cCondensation of Dimethyl-1,3-Acetone dicarboxylate with 1,2\u2013Dicarbonyl Compounds; cis-Bicyclo[3.3.0]octane -3,7-diones,” S. Bertz, J.M. Cook, A. Gawish, and U. Weiss, Org. Syn., 64, 27-38 (1985).
\n82. “Formation of the Tetracyclo[5.4.2.O2,6.O2,9]tridecane Ring-system by a Novel Transannular Aldolization Reaction,” M.N. Deshpande, S. Wehrli, M. Jawdosiuk, J.T. Guy, Jr., D.W. Bennett, J.M. Cook, M.R. Depp, and U. Weiss, J. Org. Chem., 5l, 2436-2444 (l986).
\n83. “Cerebrovascular and Cerebral Metabolic Effects of Physostigmine, Midazolam and a Benzodiazepine Antagonist,” W.E. Hoffman, R.F. Albrecht, D.J. Miletich, T.J. Hagen, and J.M. Cook, Anesth. Analg., 65, 639-644 (1986).
\n84. “Differential Antagonism of Diazepam-Induced Loss of the Righting Response,” J. Witkin, J.E. Barrett, J.M. Cook, and P. Larscheid, Pharm. Biochem. and Behavior, 24, 963-965 (1986).
\n85. “General Approach to the Synthesis of Polyquinanes. Preparation of Trans-Trans- 4,8-Diacetoxy\u2013tetracyclo [9.3.0.01,5.p7,11]tetradeca-6-one via the Aldol Approach,” M. Venkatachalam, S. Wehrli, G. Kubiak, U. Weiss, and J.M. Cook, Tetrahedron. Lett., 27, 4111-4114 (1986).
\n86. “Discriminative and Aversive Stimulus Effects of \u00df-Carboline Ethyl Ester in Rhesus Monkeys,” K. Takada, G. Winger, J. Cook, P. Larscheid, and J.H. Woods, NIDA. Res. Mon. Ser., 67, 119-124 (1986).
\n87. “Discriminative and Aversive Properties of \u00df-Carboline-3-Carboxylic Acid Ethyl Ester, a Benzodiazepine Receptor Inverse Agonist, in Rhesus Monkeys,” K. Takada, G. Winger, J. Cook, P. Larscheid, and J.A. Woods, Life Sciences, 38, 1049-1056 (1986).
\n88. “General Approach for the Synthesis of Polyquinenes,” M. Venkatachalam, M.N. Deshpande, M. Jawdosiuk, G. Kubiak, S. Wehrli, U. Weiss, and J.M. Cook, Tetrahedron, “Symposium in Print,” 42, 1597-1605 (1986).
\n89. “Synthesis of 3,6-Disubstituted \u00df-Carbolines Which Possess Either Benzodiazepine Antagonist of Agonist Activity,” T.J. Hagen, F. Guzman, C. Schultz, J.M. Cook, P. Skolnick, and H. Shannon, Heterocycles, 24, 2845-2855 (l986).
\n90. “Synthesis of 7,12-Dihydropyrido[3,4-b:5,4-b’]diindoles. A Novel Class of Rigid, Planar Benzodiazepine Receptor Ligands,” M.L. Trudell, P. Skolnick, A.S. Basile, H.E. Shannon, and J.M. Cook, J. Med. Chem., 30, 456-458 (l987).
\n91. “The Synthesis of Novel 6-Substituted \u00df-Carbolines Which Behave as Benzodiazepine Receptor Antagonists or Inverse Agonists,” T.J. Hagen, P. Skolnick, and J.M. Cook, J. Med. Chem., 30, 750-753
\n(l987).
\n92. “Hydrazine Mediated One-Pot Amination-Oxidation Reaction: Facile Synthesis of 4-Amino \u00df-Carbolines and 4-Aminoisoquinolines,” M.L. Trudell, N. Fukada, and J.M. Cook, J. Org. Chem., 52, 4293-4296 (l987).
\n93. “General Approach to the Synthesis of Polyquinenes. IV. Studies Directed Toward the Preparation of Dicyclopenta[cd,gh]pentalene,” G. Lannoye and J.M. Cook, Tetrahedron Lett., 23, 4821-4824 (l987).
\n94. “General Approach to the Synthesis of Polyquinanes, Preparation of Trans-Trans- 4,8-Diacetoxy-tetracyclo [9.3.0.0l,5.07,11]tetradeca-6-one,” M. Venkatachalam, S. Wehrli, G. Kubiak, U. Weiss, and J.M. Cook, J. Org. Chem., 52, 4110-4115 (l987).
\n95. “Discriminative Stimulus Effects of Intraveous Nicotine in Squirrel Monkeys,” K. Takada, T.J. Hagen, J.M. Cook, S.A. Goldberg, and J.L. Katz, Pharmacol. Biochem. Behav., 30, 243-247 (1988).
\n96. “General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. V. Progress Toward the Synthesis of Dicyclopentapentalenes,” G. Lannoye and J.M. Cook, Tetrahedron Lett., 29, 171-174 (1988).
\n97. “Synthesis of 1-Methoxycanthine-6-one,” T.J. Hagen and J.M. Cook, Tetrahedron Lett., 24, 2421-2424 (1988).
\n98. “General Approach To The Synthesis of Polyquinenes via the Weiss Reaction. VI. Progress Toward the Synthesis of Dicyclopentapentalenes,” G. Lannoye, K. Sambasivarao, S. Wehrli, U. Weiss, and J.M. Cook, J. Org. Chem., 53, 2327-2340 (1988).
\n99. “\u00df-Carbolines as Antagonists of the Discriminative Stimulus Effects of Diazepam in Rats,” H.E. Shannon, T.J. Hagen, F. Guzman, and J.M. Cook, J. Pharm. Exp. Ther., 246, 275-281 (1988).
\n100.”General Approach to the Synthesis of Polyquinenes. VII. Synthesis of a Centro- substituted Triquinacene,” A.K. Gupta and J.M. Cook, Tetrahedron Lett., 24, 2535-2538 (1988).
\n101.”Regioselective Methylation of 7,12-Dihydropyrido[3,2-b:5,4-b’]diindole. Experi-mental and Computational Results,” M.L. Trudell, Y.-C. Tan, and J.M. Cook, J. Org. Chem., 53, 4873-4875 (1988).
\n102.”Antibody-Mediated Platelet Destruction by Quinine, Quinidine and Their Metabolites,” D.J. Christie, H. Diaz-Arauzo, and J.M. Cook, J. Laboratory and Clinical Medicine, 112, 92-98 (1988).
\n103.”Synthesis of Novel 3-Substituted \u00df-Carbolines as Benzodiazepine Receptor Ligands: Probing the Benzodiazepine Receptor Inverse Agonist Site,” M.S. Allen, T.J. Hagen, M.L. Trudell, P. Skolnick, and J.M. Cook, J. Med. Chem., 31, 1854-1861 (1988).
\n104.”General Approach to the Synthesis of Polyquinenes. IX. The Monofunctional-ization and Alteration of the Symmetry of the cis-Bicyclo[3.3.0]octane-3,7-dione Unit,” G. Lannoye, G. Kubiak, K. Sambasivarao, and J.M. Cook, J. Org. Chem., 53, 5173-5175 (1988).
\n105.”Pictet-Spengler Reactions in Aprotic Media. Nb-Benzyl Promoted Retention of Optical Activity in the Synthesis of an Indolo-substituted Aza-bicyclo[3.3.1]nonane. A Key Template for the Synthesis of Macroline Alkaloids,” L.H. Zhang and J.M. Cook, Heterocycles, 27, 2795-2803 (1988).
\n106.”Reactivity of 7,12-Dihyropyrido[3,2-b:5,4-6]diindoles with Electrophilic Reagents. Experimental and Computational Results,” M.L. Trudell, S.L. Lifer, Y.-C. Tan, W.B. England, and J.M. Cook, J. Org. Chem., 53, 4185-4190 (1988).
\n107.”Structure-activity Studies of \u00df-Carbolines, Crystal and Molecular Structures of t-Butyl-\u00df-Carboline-3-Carboxylate and 2-(Methoxycarbonyl) Canthine-6-one,” P.W. Codding, M.B. Szkaradzinska, A. Roszak, L.J. Aha, T.J. Hagen, and J.M. Cook, Can. J. Chem., 66, 2981-2986 (1988).
\n108.”Similarity of the Discriminative Stimulus Effects of N-Methyl-D-Aspartate and \u00df-Carboline Ethyl Ester in Pigeons,” J.H. Woods, C.P. France, J. Hartman, S. Baron, and J.M. Cook in “Frontiers in Excitatory Amino Acid Research,” E.A. Cavalheiro, J. Lehmann, and L. Turski (Ed.), A.R. Liss, New York, N.Y., 317-324 (1988).
\n109.”3-Ethoxy \u00df-Carboline: A High Affinity Benzodiazepine Receptor Ligand with Partial Inverse Agonist Properties,” R. Trullas, H. Ginter, B. Jackson, P. Skolnick, M. Allen, T. Hagen and J.M. Cook, Life Sci., 43, 1189-1197 (1988).
\n110.”Pictet-Spengler Reactions in Aprotic Media. Stereospecific Conversion of Optically Active cis-1,3-Disubstituted \u00df-Carbolines into Their Corresponding Trans Diastere-omers,” L.H. Zhang and J.M. Cook, Heterocycles, 27(6), 1357-1363 (1988).
\n111.”Synthesis of 7,12-Dihydropyridopyrroloindoles(Azapyridodiindoles) via the Fischer Indole Cyclization. A Search for Water Soluble Benzodiazepine Receptor Ligands,” Y.-C. Tan, M.L. Trudell and J.M. Cook, Heterocycles, 27(7), 1607-1614 (1988).
\n112.”Punishment of Behavior with Response-produced Injections of Drugs in Squirrel Monkeys,” J.L. Katz, K. Takada, J.E. Barrett and J.M. Cook, Psychopharmacol., 96, S30 (1988).
\n113.”General Approach to the Synthesis of Polyquinenes. VIII. Synthesis of Triquinacene, 1,10-Dimethyltriquinacene and 1,10-Cyclohexanotriquinacene,” A.K. Gupta, G. Lannoye, G. Kubiak, J. Schkeryantz, S. Wehrli and J.M. Cook, J. Am. Chem. Soc., 11, 2169-2179 (1989).
\n114.”Modeling the Benzodiazepine Receptor Using Structural and Theoretical Characterization of Novel \u00df-Carbolines,” P.W. Codding, A.W. Roszak, M.B. Szkaradzinska, J.M. Cook, and L.J. Aha, Trends in Medicinal Chemistry “88, H. Van der Goot, G. Domany, L. Pallos, and H. Timmerman (eds.), Budapest Hungary, August 1988, Pharmochemistry Library, Elsevier Science Publishers, Amsterdam, The Netherlands, 109-120 (1989).
\n115.”Drug Discrimination in Pentylenetetrazol-Trained Baboons: Generalization to Buspirone and \u00df-CCE But Not Lorazepam or Pentobarbital,” N.A. Ator, J.M. Cook, and R.R. Griffiths, Drug Dev. Res., 16, 257-267 (1989).
\n116.”Behavioral Effects of Benzodiazepine Antagonists in Chlordiazepoxide Tolerant and Non-Tolerant Rats,” K. Takada, T. Suzuki, T.J. Hagen, J.M. Cook, and J.L. Katz, Life Sci., 44, 289-299 (1989).
\n117.”DDQ Oxidations in the Indole Area. Synthesis of 4-Alkoxy \u00df-Carbolines Including the Natural Products Crenatine and 1-Methoxy Canthine-6-one,” T.J. Hagen, K. Narayanan, J. Names and J.M. Cook, J. Org. Chem., 54, 2170-2178 (1989).
\n118.”Studies on the Formation of Oxindoles From Their Azabicyclo[3.3.1]nonane Counterparts and the Implications for the Biogenesis of Alstonisine,” S.P. Hollinshead, D.S. Grubisha, D.W. Bennett and J.M. Cook, Heterocycles, 29, 529-537 (1989).
\n119.”Reinvestigation of the Mechanism of the Acid Catalyzed Epimerization of Reserpine to Isoreserpine,” L.-H. Zhang, A.K. Gupta and J.M. Cook, J. Org. Chem., 54, 4708-4712 (1989).
\n120.”Inhibition of Sleep and Benzodiazepine Receptor Binding by a \u00df-Carboline Derivative,” Joseph V. Martin, P. Skolnick, J.M. Cook and T.J. Hagen, and W.B. Mendelson, Pharm. Biochem. Behav., 34, 37-42 (1989).
\n121.”Behavioral Differentiation of Benzodiazepine Ligands After Repeated Administration in Baboons,” C.A. Sannerud, J.M. Cook and R.R. Griffiths, Eur. J. Pharmacol., 167, 333-343 (1989).
\n122.”Total Synthesis of (\u00b1) Suaveoline,” M.L. Trudell and J.M. Cook, J. Am. Chem. Soc., 111, 7504-7507 (1989).
\n123.”Pictet-Spengler Reactions in Aprotic Media. Stereospecificity in the Pictet-Spengler Reaction,” J. Sandrin, S.P. Hollinshead and J.M. Cook, J. Org. Chem., 54, 5636- 5640 (1989).
\n124.”[3,3,]Sigmatropic Rearrangements in Indoloazabicyclo[3,3,1]nonene Systems, Reversal of the Stereofacial Selectivity in the Claisen vs. Orthoester Claisen Rearrangement,” S.P. Hollinshead, L.-H. Zhang, M. Trudell and J.M. Cook, J. Am. Chem. Soc., 111, 8263-8265 (1989).
\n125.”Structural Requirements for Agonist Actions at the BzR: Studies with Analogs of ZK-93423,” S.P. Hollinshead, M.L. Trudell, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 1062-1069 (1990).
\n126.”Synthesis of 10,11-Dihydroxydihydroquinidine N-oxide, A New Metabolite of Quinidine. Preparation
\nand Proton NMR Spectroscopy of the Metabolites of Quinine and Quinidine and Conformational Analysis via 2-D COSY NMR Spectroscopy,” H. Diaz-Arauzo, D.J. Christie and J.M. Cook, J. Nat. Prod., 53, 112-124, (1990).
\n127.”Synthetic and Computer-Assisted Analyses of the Pharmacophore of the Benzodiazepine Receptor Inverse Agonist Site,” M.S. Allen, Y.-C. Tan, M.L. Trudell, K. Narayanan, L.R. Schindler, M. Martin, C. Schultz, T.J. Hagen, K.F. Koehler, P.W. Codding, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 2343-2357 (1990).
\n128.”Synthesis of 7,12-Dihydropyrido[3,2-b:5,4-b’]diindoles: Rigid Planar Templates of the Inverse Agonist\/Antagonist Benzodiazepine Receptor Binding Site,” M.L. Trudell, Sherry Lifer, Y.-C. Tan, M.J. Martin, Li Deng, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 2412-2420 (1990).
\n129.”Molecular Yardsticks: Synthesis of Higher Homologs of 7,12-Dihydropyrido-[3,4-b:5,4-b’]diindole. Probing the Dimensions of the Benzodiazepine Receptor Inverse Agonist Site,” K. Narayanan and J.M. Cook, Heterocycles, 31, (2), 203-209 (1990).
\n130.”General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. XI. Transient Formation of cis-Tetracyclo[7.2.1.04,11.06,10]dodeca-3,5,7,9-tetraene and Approach Toward 10,11-Dimethyl-cis-Tetracyclo [7.2.1.04,11.06,10] dodeca-3,5,7,9-tetraene,” A.K. Gupta, K. Sambasivarao, B. Opansky and J.M. Cook, J. Org. Chem., 55, 4480-4483 (1990).
\n131.”General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. II. Synthetic Approach to Pentaleno[2,1-b:5,4-b’]diindoles,” K. Sambasivarao, S.P. Hollinshead, D. Grubisha, F. Laib, D.W. Bennett, and J.M. Cook, J. Org. Chem., 55, 3858-3866 (1990).
\n132.”Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4-Tetrahydro \u00df-Carbolines from Tryptamine 2-Carboxylic Acids,” K. Narayanan and J.M. Cook, Tetrahedron Lett., 31, 3397-3400 (1990).
\n133.”General Approach to the Synthesis of Macroline-Related Alkaloids. Stereospecific Total Synthesis of (-)-Alstonerine,” L.-H. Zhang and J.M. Cook, J. Am. Chem. Soc., 112, 4088-4090 (1990).
\n134.”Improved Method for Bisallylation of cis-Bicyclo[3.3.0]octane-3,7-dione via the Claisen Rearrangement,” K. Sambasivarao and J.M. Cook, Org. Prep. and Procedures. International, 22(5), 630-632 (1990).
\n135.”General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. XII. The Chugaev Approach to Ellacene (1,10-Cyclododecanotriquinacene). X. Fu and J.M. Cook, Tetrahedron Lett., 31, 3409-3412 (1990).
\n136.”General Approach for the Synthesis of Polyquinenes via the Weiss Reaction XIII. Aldol Approach to Fenestranes,” G. Kubiak, X. Fu, A. Gupta and J.M. Cook, Tetrahedron Lett., 31, 4285-4288 (1990).
\n137.”Stereospecificity in the Pictet-Spengler Reaction. Kinetic vs. Thermodynamic Control,” L. Deng, K. Czerwinski and J.M. Cook, Tetrahedron Lett., 32, 175-178 (1991).
\n138.”Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4- Tetrahydro \u00df-carbolines From Tryptamine-2-carboxylic Acids,” K. Narayanan, L. Schindler and J.M. Cook, J. Org. Chem., 56, 359-365 (1991).
\n139.”Inverse Agonists. Probes to Study the Structure, Topology and Function of the Benzodiazepine Receptor,” J.M. Cook, H. Diaz-Arauzo, and M.S. Allen, presented at the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence, Inc., June 10-14, 1990, Richmond, Virginia. NIDA Research Monograph Series, 133-139 (1991).
\n140.”General Approach for the Synthesis of Polyquinenes via the Weiss Reaction,” A.K. Gupta, X. Fu, J.P. Snyder and J.M. Cook, Tetrahedron Report Number 291, Tetrahedron, 47, 3665-3720 (1991).
\n141.”Synthetic and Computer Assisted Analysis of the Pharmacophore for Agonists at Benzodiazepine Receptors,” H. Diaz-Arauzo, K. Koehler, T. Hagen and J.M. Cook, Life Sci., 49, 207-216 (1991).
\n142.”The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective Anticonvulsant\/Anxiolytic,” H. Diaz-Arauzo, G. Evoniuk, P. Skolnick and J.M. Cook, J. Med. Chem.,
\n34, 1754-1756 (1991).
\n143.”Structure of 2-Chloro-7,12-dihydropyrido[3,2-b:5,4-b’]diindole,” M.B. Szkaradzinska, A. Roszak, M.L. Trudell, J.M. Cook and P.W. Codding, Acta Crystallographica, C48, 382-384 (1991).
\n144.”Carboxy-Mediated Pictet-Spengler Reaction. Improved Synthesis of 2,3,5,6,11,11b- Hexahydro-3-OXO-1H-indolizino [8,7-b]indoles from Tryptamine-2-Carboxylic Acids,” K. Narayanan and J.M. Cook, J. Org. Chem., 56, 5733-5736 (1991).
\n145.”DDQ Oxidation of Ring-A Methoxylated 11b-Methoxycarbonyl-2,3,5,6,11,11b-Hexahydro-3-OXO-1H-indolizino [8,7-b]indoles,” K. Narayanan and J.M. Cook, Heterocycles, 32, 2005-2015 (1991).
\n146.”Behavioral Effects of Benzodiazepine Ligands in Non-Dependent, Diazepam Dependent and Diazepam Withdrawn Baboons,” C.A. Sannerud, M. Allen, J. M. Cook and R.R. Griffiths, Eur. J. Pharmacol., 202, 159-169 (1991).
\n147.”Pictet-Spengler Reactions in Aprotic Media. The Total Synthesis of (\u00b1) Suaveoline,” M.L. Trudell, D. Soerens, R. Weber, L. Hutchins, D. Grubisha, D. Bennett and J.M. Cook, Tetrahedron, 48, 1805-1822 (1992).
\n148.”Synthesis of Novel 2-Phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: Topological Comparisons with Analogues of 2-Phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)- ones at Benzodiazepine Receptors,” M.S. Allen, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 368-374 (1992).
\n149.”Stereospecificity in the Pictet-Spengler Reaction. Enantiospecific Synthesis of (6S,10S) (-)-5-Methyl-9-oxo-12-Benzyl -6,7,8,9,10,11-Hexahydro-6,10-Imino-5H-cyclooct[b]indole, A Template for the Preparation of Macroline\/Sarpagine Alkaloids,” L.-H. Zhang, Y. Bi, F. Yu, G. Menzia and J.M. Cook, Heterocycles, 34 (3), 517-547 (1992).
\n150.”Punishment of Schedule-Controlled Behavior with \u00df-Carboline Injections: Antagonism and Comparisons with Other Compounds,” K. Takada, J. Barrett, M.S. Allen, J.M. Cook and J.L. Katz, J. Pharmacol. and Exp. Thera., 261, 138-145 (1992).
\n151.”The Synthesis of Polyquinanes and Polyquinenes via the Weiss Reaction,” X. Fu and J.M. Cook, Aldrich Chimica Acta, 25, 43-54 (1992).
\n152.”Enantiospecific Total Synthesis of the Ajmaline Related Alkaloids (-)Suaveoline, (-)Raumacline and (-)Nb-Methylraumacline,” X. Fu and J.M. Cook, J. Am. Chem. Soc., 114, 6910-6912 (1992).
\n153.”Mechanism Driven Trans Stereospecificity in the Pictet Spengler Reaction. Stereospecific Formation of Trans-1,2,3-Trisubstituted-tetrahydro \u00df-Carbolines by Condensation of Nb-Diphenylmethyl-tryptophan Isopropyl Esters with Aldehydes,” K. Czerwinski, L. Deng and J.M. Cook, Tetrahedron Lett., 33, 4721-4724 (1992).
\n154.”Predictive Binding of \u00df-Carboline Inverse Agonists and Antagonists via the CoMFA\/ GLOPE Approach,” M.S. Allen, A. LaLoggia, L. Dorn, M.J. Martin, G. Costantino, T.J. Hagen, K. Koehler, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 4001-4010 (1992).
\n155.”Entry into 6-Methoxy-D(+)-Tryptophans. Stereospecific Synthesis of 1-Benzene-sulfonyl-6-methoxy-D(+)-tryptophan Ethyl Ester,” M. Allen, L. Hamaker, A. LaLoggia and J.M. Cook, Synthetic Comm., 22, (14) 2077-2102 (1992).
\n156.”The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective Anticonvulsant\/Anxiolytic,” H. Diaz-Arauzo, P. Skolnick and J.M. Cook, National Institute on Drug Abuse Research Monograph Series 119, Problems of Drug Dependence 1991: Proceedings of the 53rd Annual Scientific Meeting, p. 354 (1992).
\n157.”General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. XIV. Synthesis of Ellacene (1,10-Decanotriquinacene) and Studies of the Proposed Dimerization to a Substituted Dodecahedrane,” X. Fu and J.M. Cook, J. Org. Chem., 57, 5121-5128 (1992).
\n158.”Molecular Yardsticks. Rigid Planar Ligands to Define the Spatial Dimensions of the Benzodiazepine Receptor Binding Site,” M. Martin, M.L. Trudell, H. Diaz-Arauzo, M.S. Allen, A. LaLoggia, Li Deng,
\nC.A. Schultz, Y.-C. Tan, Y. Bi, K. Narayanan, L. Dorn, K. Koehler, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 4105-4117 (1992).
\n159.”High Pressure Raman Studies of Triquinacene and Dodecahedrane,” S.H. Bertz, G.A. Kourouklis, A. Jayaraman, G. Lannoye and J.M. Cook, Can. J. Chem., 71, 352-357 (1993).
\n160.”The Synthesis of Macroline Related Alkaloids,” Y. Bi, L. Hamaker and J.M. Cook, chapter of a book titled Studies in Natural Products Chemistry, Bioactive Natural Products, Part A, A.T. Rahman and F. Basha, eds., Elsevier, Amsterdam, Volume 13, pp. 383-432 (1993).
\n161.”General Approach for the Synthesis of Polyquinenes via the Weiss Reaction XV. Synthesis of the [5.5.5.5]Fenestrane System via the Aldol Approach and Studies Directed Toward the [5.5.6.6]Fenestranes,” X. Fu, G. Kubiak, W. Zhang, W. Han, A.K. Gupta and J.M. Cook, Tetrahedron, 49, 1511-1524 (1993).
\n162.”Novel Pyridodiindoles, Azadiindoles and Indolopyridoimidazoles via the Fischer- Indole Cyclization,” M. Martin, L.J. Dorn and J.M. Cook, Heterocycles, 36, 157-189 (1993).
\n163.”Synthetic and Computer-Assisted Analysis of the Structural Requirements for Selective, High-Affinity Ligand Binding to Diazepam-Insensitive Benzodiazepine Receptors,” G. Wong, K.F. Koehler, P. Skolnick, Z-Q. Gu, S. Ananthan, P. Sch\u00f6nholzer, W. Hunkeler, W. Zhang and J.M. Cook, J. Med. Chem., 36, 1820-1830 (1993).
\n164.”General Approach to the Synthesis of the Ajmaline-Related Alkaloids. Enantio-specific Total Synthesis of (-)Suaveoline, (-)Raumacline and (-)Nb- Raumacline,” X. Fu and J.M. Cook, J. Org. Chem., 58, 661-672 (1993).
\n165.”Novel Organic Reactions in the Search for Anxioselective Anxiolytics at the Benzodiazepine Receptor,” W. Zhang and J.M. Cook, in Drug Design for Neuroscience, Ed. by A. Kozikowski, Raven Press, New York, 87-117 (1993).
\n166.”Evaluation of Substituted \u00df-Carbolines as Noncompetitive Indoleamine 2,3-Dioxy-genase Inhibitors,” A.C. Peterson, A.J. La Loggia, L.K. Hamaker, R.A. Arend, P.L. Fisette, Y. Ozaki, J.A. Will, R.A. Brown and J.M. Cook, Med. Chem. Res, 3, 473-482, (1993).
\n167.”The Regiospecific Synthesis of Ortho Aminonaphthophenones via the Addition of Carbanions to Naphthoxazine-4-ones,” W. Zhang, R.Y. Liu and J.M. Cook, Heterocycles, 36, 2229-2236 (1993).
\n168.”General Approach for the Synthesis of Macroline\/Sarpagine Alkaloids. The Total Synthesis of (+)-Macroline,” Y. Bi and J.M. Cook, Tetrahedron Lett., 34, 4501-4504 (1993).
\n169.”Discriminative-stimulus Effects of Azaspirodecanedione Anxiolytics in Baboons Trained to Discriminate \u00df-Carboline-3-carboxylic Acid Ethyl Ester or Pentylene-tetrazole,” N.A. Ator, J.M. Cook, M.S. Allen and R.R. Griffiths, Behav. Pharmacol., 5, 176-188 (1994).
\n170.”Epoxide Metabolite of Quinine and Inhibition of the Multidrug Resistance Pump in Human Leukemic Lymphoblasts,” P. Wigler, K. Lyon, F. Patterson, A. LaLoggia, H. Diaz-Arauzo, M. Sreenivasa Reddy and J.M. Cook, Mol. Pharmacol., 46, 563-567 (1994).
\n171.”Synthesis of Benzo-Fused Benzodiazepines Employed as Probes to Study the Agonist Pharmacophore of the Benzodiazepine Receptor,” W. Zhang, P. Skolnick, K. Koehler, B. Harris and J.M. Cook, J. Med. Chem., 37, 745-757 (1994).
\n172.”Evaluation of Functionalized Tryptophan Derivatives and Related Compounds as Competitive Inhibitors of Indoleamine 2,3-Dioxygenase,” A.C. Peterson, M.T. Migawa, M.M. Martin, L.K. Hamaker, K.C. Czerwinski, Wei Zhang, R.A. Arend, P.L. Fisette, Y. Ozaki, J.A. Will, R.R. Brown and J.M. Cook, Med. Chem. Res., 4, 531-544 (1994).
\n173.”Studies on the Enantiospecific Synthesis of Oxindole Alkaloids,” A. Peterson and J.M. Cook, Tetrahedron Lett., 35, 2651-2654 (1994).
\n174.”The Enantiospecific Synthesis of (-)-Alstonerine, and (+)Macroline, as Well as a Partial Synthesis of (+)Villastonine,” Y. Bi, L.-H. Zhang, L. Hamaker and J.M. Cook, J. Am. Chem. Soc.,116, 9027-9041 (1994).
\n175.”Facile Formation of Dihydroacepentalene Dianions from Centro-Substituted Tribenzotriquinacenes with C-C Bond Cleavage,” R. Haag, D. Kuck, X. Fu, J.M. Cook and A. de Meijere, Synlett., 340-342 (1994).
\n176.”A Partial Synthesis of the Alstonia Bisindole Alkaloid Villalstonine,” Y. Bi, P. LeQuesne and J.M. Cook, Tetrahedron Lett., 35, 3877-3878 (1994).
\n177.”The Synthesis of Roeharmine and (-)-1,2,3,4-Tetrahydroroeharmine”, M.S. Reddy and J.M. Cook, Tetrahedron Lett., 35, 5413-5416 (1994).
\n178.”Weiss’s Endo- and Exo-Tetracyclo[5.5.1.02,6.010,13]tridecane-4,8,12-trione: Analysis of 1H-NMR Couplings in a System of Fused 5-Membered Rings,” S.H. Bertz, W. Zhang, J.M Cook, M.D. Bruch and L. Jelinski, Can. J. Chem., 72, 1926-1932 (1994).
\n179.”Development of a Comprehensive Pharmacophore Model for the Benzodiazepine Receptor,” W. Zhang, K. Koehler, P. Zhang and J.M. Cook, Drug Design and Discovery., 12, 193-248 (1995).
\n180.”The Synthesis of Macroline Related Sarpagine Alkaloids,” L.K. Hamaker and J.M. Cook, “Alkaloids: Chemical and Biological Perspectives,” Ed. by W. Pelletier, Elsevier Science, Oxford, Vol. 9, 23-84 (1995).
\n181.”Structure-Activity Relationships in Antagonist and Inverse Agonist Ligands for the Benzodiazepine Receptor,” P.W. Codding, A.W. Roszak, M.B. Szaradzinska, J.M. Cook, T.J. Hagen and M.S. Allen, Can. J. Chem., 73, 449-512 (1995).
\n182.”Dimethyl 1,3-acetonedicarboxylate,” M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 3, 1989-1992 (1995).
\n183.”Butane-2,3-dione,” M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 2, 817-819 (1995).
\n184.”Glyoxylic acid,” M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 4, 2620-2622 (1995).
\n185.”Glyoxal,” M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 4, 2616-2618 (1995).
\n186.”The Synthesis of 5-Thienyl and -Furyl Substituted Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors,” W. Zhang, R. Liu, Qi Huang, B. Harris, P. Skolnick and J.M. Cook, Eur. J. Med Chem., 30, 483-496 (1995).
\n187.”Synthesis and SAR Study of Novel Imidazobenzodiazepines at ‘Diazepam-insensitive’ Benzodiazepine Receptors,” P. Zhang, W. Zhang, R. Liu, B. Harris, P. Skolnick and J.M. Cook, J. Med. Chem., 38, 1679-1688 (1995).
\n188.”Studies Directed Toward the Enantiospecific Synthesis of Gardeneria, Voacanga, and Alstonia Oxindole Alkaloids,” A.C. Peterson and J.M. Cook, J. Org. Chem., 60, 191-193 (1995).
\n189.”Regiospecific Bromination of 3-Methylindoles with N-Bromosuccinimide,” P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 3103-3106 (1995).
\n190.”Enantiospecific Synthesis of 5-Methoxy-D(+)- or L(-) Tryptophan,” P. Zhang and J.M. Cook, Syn. Commun., 25, 3883-3900 (1995).
\n191.”The Pictet Spengler Condensation: New Directions for an Old Reaction,” E. Cox and J.M. Cook, Chem. Rev., 95, 1797-1842 (1995).
\n192.”Synthesis of Novel Imidazobenzodiazepines Selective for the \u03b15\u03b22\u03b32 (Bz5) GABAA\/ Benzodiazepine Receptor Subtype,” R. Liu, P. Zhang, R. McKernan, K. Wafford, and J.M. Cook, Med. Chem. Res., 5, 700-709 (1995).
\n193.”Studies of Novel Imidazobenzodiazepine Ligands at GABAA\/BzR Subtypes: Effect of C(3) Substituents on Receptor Site Selectivity,” P.W. Zhang, R. Liu, R. McKernan, K. Wafford and J.M. Cook, Med. Chem. Res., 5, 487-495 (1995).
\n194.”A Successful Acid Promoted Asymmetric Pictet-Spengler Reaction of Na-BOC Protected Tryptophans. Effect of the BOC Group on Reactivity and Stereoselectivity,” P.W. Zhang and J.M. Cook, Tetrahedron Lett., 36, 6999-7002 (1995).
\n195.”Bz1 Receptor Subtype Specific Ligands. Synthesis and Biological Properties of \u00dfCCt, A Bz1 Receptor Subtype Specific Antagonist,” E. Cox, T. Hagen, R. McKernan and J.M. Cook, Med. Chem. Res., 5, 710-718 (1995).
\n196.”An Enantiospecific Synthesis of L – and D -6-chloro-5-hydroxytryptophan: An Unusual Amino Acid Residue from the Cyclic Hexapeptide Keramamide A,” P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 7411-7414 (1995).
\n197.”A Concise Synthesis of Optically Active 2-Bromotryptophan Amino Acids Present in Konbamide and Jaspamide via a Regiospecific Bromination Procedure,” P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 9133-9136 (1995).
\n198.”Chemical and Computer-Assisted Development of An Inclusive Pharmacophore for the Benzodiazepine Receptor. The Inclusive Pharmacophore,” W. Zhang, K. Koehler, H. Diaz-Arauzo, M. Allen and J.M. Cook, in Studies in Medicinal Chemistry, Vol 2, Biological Inhibitors, M. Iqbal Choudhary, (Ed.), Harwood Academic Publishers, 303-373 (1996).
\n199.”Stereochemical Control of the Pictet-Spengler Reaction in the Synthesis of Natural Products,”K. Czerwinski and J.M. Cook, in Advances in Heterocyclic Natural Product Synthesis, W. Pearson (Ed.), JAI Press, Greenwich, Vol. 3, 217-277 (1996).
\n200.”Synthesis and Pharmacological Properties of Novel 8-Substituted Imidazobenzo-diazepines: High Affinity, Selective Probes for \u03b15 Containing GABAA Receptors,” R. Liu, R. Hu, P. Zhang, Phil Skolnick and J.M. Cook, J. Med. Chem., 39, 1928-1934 (1996).
\n201.”General Approach for the Synthesis of Macroline\/Sarpagine Related Indole Alkaloids via The Asymmetric Pictet-Spengler Reaction: The Enantiospecific Synthesis of (-)- Anhydromacrosalhine-methine,” T. Gan and J.M. Cook, Tetrahedron Lett., 37, 5033-5036 (1996).
\n202.”Partial Synthesis of The Antiamoebic Bisindole Alkaloid (-)-Macrocarpamine,” T. Gan and J.M. Cook, Tetrahedron Lett., 37, 5037-5038 (1996).
\n203.”Benzo-fused Benzodiazepines Employed as Topological Probes for the Study of Benzodiazepine Receptor Subtypes” Qi Huang, W. Zhang, R. Liu, R. McKernan and J.M. Cook, Med. Chem. Res., 6, 384-391 (1996).
\n204.\u201cGeneration of Four Five-membered Rings in a One Pot Process. Studies Directed Toward The Synthesis of Dicyclopenta[a,d]pentalene via The Tadem Pauson-Khand Reaction,\u201d S. Van Ornum and J.M. Cook, Tetrahedron Lett., 37, 7185-7188 (1996).
\n205.\u201cEvidence for C(1)-N(2) Bond Scission in the Isomerization of cis-Nb-Benzyl-1, 3-Disubstituted -1,2,3,4-Tetrahydro \u03b2-carbolines into Their Trans-Nb-Benzyl-1,3- Disubstituted Diastereomers Under Acidic Conditions,\u201d E.Cox, J. Li, L. Hamaker, P. Yu, and J.M. Cook, Chem. Commun., 2477-2478 (1996).
\n206.”Enantiospecific Formation of trans-1,3-Disubstituted Tetrahydro \u00df-Carbolines by the Pictet-Spengler Reaction and Conversion of cis Diastereomers into their Trans Counterparts by Scission of the C1\/N2 Bond,” E. Cox, L. Hamaker, J. Li, P. Yu, K. Czerwinski, L. Deng, D.W. Bennett, W. Watson, M. Krawiec and J.M. Cook, J. Org. Chem., 62, 44-61 (1997).
\n207.”Evidence for the Conservation of Conformational Topography at Five Major GABAA\/Benzodiazepine Receptor Subsites. Potent Affinities of The (S)-Enantiomers of Framework Constrained 4,5-Substituted Pyrroloimidazobenzodiazepines,” R. Liu, P. Zhang, T. Gan, R. McKernan and J.M. Cook, Med. Chem. Res., 7, 25-35 (1997).
\n208.\u201cEffect of \u03b2-Carboline-3-Carboxylate-t-Butyl Ester on Ventilatory Control,\u201d H. Greenberg, M. Scharf, W. Mendelson, J.M. Cook, E. Cox and S. Scharf, Life Sci., 60, 485-492 (1997).
\n209.\u201cEnantiospecific Total Synthesis of Tryprostatin A,\u201d T. Gan and J.M. Cook, Tetrahedron Lett., 38,
\n1301-1304 (1997).
\n210.\u201cUnexpected Stereoselectivity in The Weiss-Cook Condensation of Dimethyl 1,3-Acetonedcarboxylate with 2,3-Pentanedione\u201d, R. V. Williams, V. Gadgil, A. Vig, J. Cook, G. Kubiak and Q. Huang, Perkin Trans I., 1425-1428 (1997).
\n211.\u201cMode of Action of \u03b2-Carboline Convulants on the Insect Nervous System and Their Poetential as Insecticides.\u201d J. Bloomquist, H. Ferguson, E. Cox, M. Reddy, J.M. Cook. Pesticide Science, 51, 1-6 (1997).
\n212.\u201cSteric and Electronic Effects on The Weiss Reaction. Isolation of 1:1 Adducts,\u201d S. Van Ornum, G. Kubiak and J.M. Cook, Perkin Trans I., 3471-3478 (1997).
\n213.\u201cFormation of Six Carbon-Carbon Bonds in a One Pot Process. Generation of the Dicyclopenta[a,e]pentalene Ring system via The Tandem Pauson-Khand Reaction,\u201d S. G. Van Ornum and J. M. Cook, Tetrahedron Lett., 38, 3657-3658 (1997).
\n214.\u201c[3H]RY-080: A High Affinity, Selective Ligand for GABAA Receptors Containing \u03b15 Subunits,\u201d P. Skolnick, R. Hu, C. Cook, S. Hunt, J. Trometer, R. Liu, Qi Huang and J.M. Cook, J. Pharm. Exper. Thera., 283, 488-493 (1997).
\n215.\u201cSynthesis of GABAA Active Ligands by the Stille Process,\u201d T. Gan, S.G. Van Ornum and J.M. Cook, Tetrahedron Lett., 38, 8453-8456 (1997).
\n216.\u201cGeneral Approach for the Synthesis of Macroline\/Sarpagine Related Indole Alkaloids via the Asymmetric Pictet-Spengler Reaction: The Enantiospecific Synthesis of the Na-H, Azabicyclo[3.3.1]Nonane Template,\u201d P. Yu, T. Wang, F. Yu and J.M. Cook, Tetrahedron Lett., 38, 6819-6822 (1997).
\n217.\u201cRegiospecific Bromination 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides,\u201d R.Liu, P. Zhang, T. Gan and J.M. Cook, J. Org. Chem., 62, 7447-7456 (1997).
\n218.\u201cDiastereospecific Synthesis of Ketooxindoles. Potential Intermediates for the Synthesis of Alstonisine as well as for Voachalotine Related Oxindole Alkaloids,\u201d P. Yu and J. M. Cook, Tetrahedron Lett., 8799-8802 (1997).
\n219.\u201cConservation of Conformational Topography at Five GABAA\/Benzodiazepine Receptor Subtypes,\u201d X. He, T. Gan and J.M. Cook, NIDA Research Monograph Series, Number 178, Problems of Drug Dependence 1997: Proceedings of the 59th Annual Scientific Meeting, p. 72 (1998).
\n220.\u201cEnantiospecific Total Synthesis of (-)-Anhydromacrosalhine-methine and Partial Synthesis of the Antiamoebic Bisindole Alkaloid, (-)-Macrocarpamine,\u201d T. Gan and J.M. Cook, J. Org. Chem., 63, 1478-1483 (1998).
\n221.\u201cSynthesis and Evaluation of Analogues of the Partial Agonist 6-(Propyloxy)-4-(methoxymethyl)-\u03b2carboline-3-carboxylic Acid Ethyl Ester (6-PBC) & the Full Agonist 6-(Benzyloxy)-4-(methoxymethyl)-\u03b2carboline-3- carboxylic Acid Ethyl Ester (ZK-93423) at BzR sites\u201d Eric D. Cox, Hernando Diaz-Arauzo, Q. Huang, M. Reddy, B. Harris, R. McKernan, P. Skolnick, and J.M. Cook. J. Med. Chem., 41, 2537-2552 (1998).
\n222.\u201cGABAA – Benzodiazepine Receptors in the Striatum Are involved in the Sedation Produced by a Moderate, but Not an Intoxicating Ethanol Dose in Outbred Wistar Rats,\u201d H. June, S. H. Chen, G. Cheatem, R. Liu, T. Gan and J.M. Cook. Brain Research, 794, 103-118 (1998).
\n223.\u201cEnantiospecific Total Synthesis of (+)-Ajmaline and Alkaloid G via the Asymmetric Pictet-Spengler Reaction,\u201d J. Li and J.M. Cook, J. Org. Chem., 63, 4166-4167 (1998).
\n224.\u201cEnantiospecific Synthesis of Optically Active 6-Methoxytryptophan Derivatives and Total Synthesis of Tryprostatin A,\u201d T. Gan, R. Liu, P. Yu., S. Zhao and J.M. Cook, J. Org. Chem., 62, 9298-9304 (1998).
\n225.\u201cPredictive Models for GABAA\/Benzodiazepine Receptor Subtypes: Studies of Quantitative Structure-Activity Relationships (QSAR) for Imidazobenzodiazepines at Five Recombinant GABAA\/BzR Subtypes [\u03b1x\u03b23\u03b32(x=1-3,5,6] via CoMFA,\u201d Q. Huang, R. Liu, P. Zhang, R. McKernan, D. Bennett, T.
\nGan, X. He and J.M. Cook,\u201d J. Med. Chem., 41, 4130-4142 (1998).
\n226.\u201cThe Enantiospecific Total Synthesis of Norsuaveoline,\u201d T. Wang, P. Yu, J. Li and J.M. Cook, Tetrahedron Lett., 39, 8009-8012 (1998).
\n227.\u201cTotal Synthesis of Trypostatin A and B as Well as Their Enantiomers,\u201d S. Zhao, T. Gan, Peng Yu and J.M. Cook, Tetrahedron Lett., 39, 7009-7012 (1998).
\n228.\u201cThe Livinghouse Catalytic Approach to the Tandem Pauson-Khand Reaction. Entry into the Parent Ring Systems of Dicyclopenta[a,f]pentalene and Dicyclopenta[a,e]pentalene, S. Van Ornum, M. Bruendl and J.M. Cook, Tetrahedron Lett., 39, 6649-6650 (1998).
\n229.\u201cIdentification of Quinine Metabolites in Urine After Oral Dosing in Humans,\u201d P. Bannon, P. Yu, J. M. Cook, L. Roy and J-P. Villeneuveo, J. Chromatography B, Biomedical Science and Applications, 715, 387-393 (1998).
\n230.\u201cEnantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine. The Oxyanion Cope Approach.\u201d P. Yu and J.M. Cook, J. Org. Chem., 63, 9160-9161 (1999).
\n231.\u201cGeneral Approach for the Synthesis of Ajmaline\/ Sarpagine Indole Alkaloids. Enantiospecific Total Synthesis of (+) Ajmaline, Alkaloid G, and Novsuaveoline via the Asymmetric Pictet-Spengler Reaction,\u201d J. Li, T. Wang, P. Yu, A. Peterson, D. Soerens, R. Weber, D. Grubisha, D. Bennett, and J. M. Cook, J Am. Chem. Soc., 121, 6998-7010 (1999).
\n232.\u201cStudies of Molecular Pharmacophore\/Receptor Models for GABAA\/Benzodiazepine Receptor Subtypes: Binding Affinities of Substituted \u03b2-Carbolines at Recombinant \u03b1x\u03b23\u03b32 Subtypes and Quantitative Structure-Activity Relationship Studies via a Comparative Molecular Field Analysis,\u201d Q. Huang, E. Cox, T. Gan, C. Ma, D. Bennett, Ruth McKernan and James M. Cook, Drug Des. Disc., 16, 55-76, (1999).
\n233.\u201cConcise Synthesis of Optically Active Ring-A Substituted Tryptophans,\u201d C. Ma., X. Liu, S. Yu, S. Zhao and J.M. Cook, Tetrahedron Lett., 40, 657-660 (1999).
\n234.\u201cExploration of Regions L2 and LD1 of Pharmacophore\/Receptor Models for GABAA\/ BzR Subtypes, Problems of Drug Dependence, 1998: Proceedings of the 60th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc., ed. Louis Harris, NIDA Research Monograph, 179, 303 (1999).
\n235.\u201cExtension of the Tandem Pauson-Khand Reaction to [5.6.6.5]Tetracycles: A Unique Entry into cis-Fused Decalins,\u201d M. Bruendl, S. Van Ornum, Tze-Ming Chan and J.M. Cook, Tetrahedron Lett., 40, 1113-1116 (1999).
\n236.”Studies in the Search for \u03b15 Subtype Selective Agonists for GABAA\/BzR Sites,” S. Yu, C. Ma, X. He, R. McKernan, and J.M. Cook, Med. Chem. Res., 9, 71-88 (1999).
\n237.”Studies in Search of \u03b12 Selective Ligands for GABAA\/BzR Receptor Subtypes. Part 1. Evidence for the Conservation of Pharmacophoric Descriptors for DS Subtypes,” S. Yu, X. He, C. Ma, R. McKernan , and J.M. Cook, Med. Chem. Res., 9, 186-202, (1999).
\n238.”Studies of Molecular Pharmacophore\/Receptor Models for GABAA\/BzR Subtypes: Binding Affinities of Symmetrically Substituted Pyrazolo[4,3-c]quinolin-3-ones at Recombinant \u03b1x\u03b23\u03b32 Subtypes and Quantitative Structure-Activity Relationship Studies via Comparative Molecular Field Analysis,” X. He, Q. Huang, S.Yu, C. Ma, R. McKernan, and J.M. Cook, Drug Des. Disc., 16, 77-91, (1999).
\n239.”Effect of the Leaving Group on Alkylation Diastereoselectivity of the Sch\u00f6llkopf Chiral Auxillary,” C. Ma, X. He, X. Liu, S. Yu, S. Zhao, and J.M. Cook, Tetrahedron Lett., 40, 2917-2918 (1999).
\n240.\u201cPharmacophore\/Receptor Models for GABAA\/BzR Subtypes (\u03b11\u03b23\u03b32, \u03b15\u03b23\u03b32, and \u03b16\u03b23\u03b32) via a Comprehensive Ligand-Mapping Approach,\u201d Qi Huang, X. He, C. Ma, R. Liu, S. Yu, R. McKernan, G. Wenger, C. Dayer, and J. M.Cook, J. Med. Chem., 43, 71-95 (2000).
\n241.\u201cEfficient Asymmetric Synthesis of Important Tryptophan Analogues for Biological Research via the Sch\u00f6llkopf Chiral Auxillary,\u201d C. Ma, S. Yu, X. He, X. Liu, and J.M. Cook, Tetrahedron Lett., 41,2781-2785 (2000).
\n242.\u201cEnantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine, as well as the Improved Total Synthesis of Alstonerine and Anhydromacrosalhine-methine via the Asymmetric Pictet-Spengler Reaction,\u201d P. Yu, T. Wang, J. Li, and J.M. Cook, J. Org. Chem., 65, 3173-3191 (2000).
\n243.\u201cPharmacophore\/Receptor Models for GABA(A)\/BzR \u03b12\u03b23\u03b32, \u03b13\u03b23\u03b32, \u03b14\u03b23\u03b32 Recombinant Subtypes. Included Volume Analysis and Comparison to \u03b11\u03b23\u03b32, \u03b15\u03b23\u03b32 and \u03b16\u03b23\u03b32 Subtypes,\u201d X. He, Q. Huang, C. Ma, S. Yu, R. McKernan, and J.M. Cook, Drug Des. Disc., 17, 131-171 (2000).
\n244.\u201cGeneral Approach for the Synthesis of Sarpagine\/Ajmaline Indole Alkaloids. Stereospecific Total Synthesis of the Sarpagine Alkaloid (+)-Vellosimine,\u201d T. Wang and J.M. Cook, Org. Letters, 2, 2057-2059 (2000).
\n245.\u201cThe Molybdenum-Mediated Tandem Pauson-Khand Reaction. High Yield Entry into [5.5.5.5] Tetracyclic Systems,\u201d H. Cao, S.G. Van Ornum, and J.M. Cook, Tetrahedron Lett., 41, 5313-5316 (2000).
\n246.”Utility of the Tandem Pauson-Khand Reaction in the Construction of Tetracycles,\u201d S. Van Ornum, M. Bruendel, H. Cao, M. Reddy, D. Grubisha, D. Bennett, and J.M. Cook, J. Org. Chem., 65, 1957-1971 (2000).
\n247.\u201cGeneral Approach for the Synthesis of Indole Alkaloids via the Asymmetric Pictet- Spengler Reaction. First Enantiospectific Total Synthesis of (-)-Corynantheidine as well as the Enantiospecific Total Synthesis of (-)-Corynantheidol (-)-Geissoschizol, and (+)-Geissoschizine,\u201d S. Yu, M. Berner, and J.M. Cook, J. Am. Chem. Soc., 122, 7827-7828 (2000).
\n248.\u201cEnantiospecific Total Synthesis of the Enantiomer of the Indole Alkaloid Affinisine,\u201d X. Liu, T. Wang, Q. Xu, C. Ma, and J.M. Cook, Tetrahedron Lett., 41, 6299-6303 (2000).
\n249.\u201cDeterminants of Recognition of Ligands Binding to Benzodiazepine Receptor\/GABAA Receptors Initiating Sedation,\u201d D.L. Harris, T.M. DeLorey, X. He, J.M. Cook, and G.H. Loew, Eur. J. Pharmacol., 401, 271-287 (2000).
\n250.\u201cA Single Amino Acid Residue on the \u03b15 Subunit (Ile215) Is Essential for Ligand Selectivity at \u03b15\u03b23\u03b32 GABA(A) Receptors,\u201d M. Strakhova, S. Harvey, C. Cook, J.M. Cook, and P. Skolnick, Mol. Pharmacol, 58, 1434-1440 (2000).
\n251.\u201cSimultaneous Determination of Quinine and Four Metabolites in Plasma and Urine Using High Performance Liquid Chromatography,\u201d Rajaa Mirghani, Orjan Ericsson, J. Cook, P. Yu, and Lars Gustafsson, J. of Chromatography, B., 754(1), 57-64 (2001).
\n252.\u201cStereocontrolled Total Synthesis of Alkaloid G via the Oxy-anion Cope Rearrangement and Improved Total Synthesis of (+)-Ajmaline,\u201d T. Wang, Q. Xu, P. Yu, X. Liu, and J.M. Cook, Org. Lett., 3(3), 345-348 (2001).
\n253.\u201cStereocontrolled Conversion of Quinine into 10(R), 11 Dihydroxydihyroquinine via the Sharpless Osmylation Process,\u201d T. Zheng, Judy Flippen-Anderson, T. Wang, P. Yu, R. Mirghani, and J.M. Cook, J. Org. Chem., 66, 1509-1511 (2001).
\n254.\u201cEfficient Asymmetric Synthesis of Biologically Important Tryptophan Analogues via a Palladium Heteroannulation Reaction,\u201d C. Ma, X. Liu, X. Li, J. Flippen-Anderson, S.Yu, and J.M. Cook, J. Org. Chem., 66, 4525-4542 (2001).
\n255.\u201cModel of the BzR Binding Site: Correlation of Data From Site-Directed Mutagenesis and the Pharmacophore\/Receptor Model,\u201d X. He, C. Zhang, and J.M. Cook, Med. Chem. Res., 10, 269-308 (2001).
\n256.\u201cGABA(A)-Receptors Containing \u03b15 Subunits In the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry,\u201d H. June, P. Mc Kay, S. Harvey, K. Foster, M. Garcia, D. Mason, R.Cummings, C. Grey, S. Mc Cane, L. Williams, T. Johnson, X. He, S. Rock, and J.M. Cook, J. Neurosci., 21, 2166-2177 (2001).
\n257.\u201cZolpidem, Triazolam and Diazepam Decrease Distress Vocalizations in Mouse Pups: Differential
\nAntagonism by Flumazenil and \u03b2-Carboline-3-carboxylate-t-butyl Ester (\u03b2CCt),\u201d J. Rowlett, W. Tornatzky, J.M. Cook, C. Ma, and K. Miczek, J. Pharmacol. Exp. Ther., 297,247-253 (2001).
\n258.\u201cDifferent Types of GABAA Receptors May Mediate the Anticonflict and Response Rate-decreasing Effects of Zaleplon, Zolpidem and Midazolam in Squirrel Monkeys,\u201d C. Parnois, E. Cox, J.M. Cook, and J. Bergman, Psychopharmacology, 156, 461-468, (2001).
\n259.\u201cInfluence of Benzodiazepine Binding Site Ligands on Fear-Conditioned Contextual Memory,\u201d T. M. DeLorey, R. Lin, B. McBrady, X. He, J. M. Cook, J.Lameh, G. Loew, Eur. J. Pharmacol., 426, 45-54 (2001).
\n260.\u201cDifferential Sensitivity to Inverse Agonists of GABAA\/benzodiazepine Receptors in Rats with Genetic Absence-Epilepsy,\u201d M. Vergnes, A. Boehler, X. He, H. Greney, M. Dontenwill, J.M. Cook, and C. Marescauk, Epilepsy Res., 47, 43-53, (2001).
\n261.\u201cDifferential Role of GABAA\/Benzodiazepine Receptors Containing \u03b11 and \u03b15 Subunits in the Discriminative Stimulus Effects of Triazolam in Squirrel Monkeys,\u201d S. Lelas, J. Rowlett, R. Spealman, J. Cook, C. Ma, X. Li, and W. Yin, Psychopharmacology, 161, 180-188 (2002).
\n262.\u201cEnantiospecific, Stereospecific Total Synthesis of (+)-Majvinine, (+)-10-Methoxyaffinisine and (+)-Na-Methylsarpagine as well as the Total Synthesis of the Alstonia Bisindole Macralstonidine,\u201d S. Zhao, X. Liao, and J.M. Cook, Org. Lett., 4, 687-690 (2002).
\n263.\u201cSelective Antagonism of the Ataxic Effects of Zolpidem and Triazolam by the GABA(A)\/1-Preferring Antagonist \u03b2-CCt in Squirrel Monkeys,\u201d D. Platt, J. Rowlett, R. Spealman, J.M. Cook and Chunrong Ma, Psychopharmacology, 164, 151-159 (2002).
\n264.\u201cGeneral Approach for the Synthesis of Sarpagine\/Macroline Indole Alkaloids. Enantiospecific Total Synthesis of the Indole Alkaloid Trinervine,\u201d Xiaoxiang Liu and James M. Cook, Org. Lett., 3, 4023-4026 (2002).
\n265.\u201cEnantiospecific Total Synthesis of the Enantiomer of the Indole Alkaloid Intermediate Macroline,\u201d Xiaoxiang Liu, Chunchun Zhang, Xuebin Liao, and James M. Cook, Tetrahedron Letters, 43, 7373-7377 (2002).
\n266.\u201cDiscriminative Stimulus Effects of Benzodiazepine (BZ)1 Receptor-selective Ligands in Rhesus Monkeys,\u201d L.R. McMahon,L.R. Gerak, L. Carter, C. Ma, J.M. Cook, and C.P. France, J. Pharmacol. Exp. Ther., 300, 505-512, (2002).
\n267.\u201cBiological Activity of the Tryprostatins,\u201d S. Zhao, K. Smith, A. Deveau, C. Dieckhaus, M. Johnson, T.L. McDonald, and J.M. Cook, J. Med. Chem., 45, 1559-1562 (2002).
\n268.”The GABAA Receptor \u03b11 Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors,” S. Harvey,, K. Foster,P. McKay, M. Carroll, R. Seyoum, J.E. Woods II, C. Grey, C. Jones S. McCane, R. Cummings, D. Mason, C. Ma, J.M. Cook, and H. June J. Neuroscience, 22, 3765-3775 (2002).
\n269.\u201cEffects of Hippocampal Injections of a Novel Ligand Selective for the \u03b15\u03b22\u03b32 Subunits of the GABA\/Benzodiazepine Receptor on Pavlovian Conditioning,\u201d D.Bailey, J. Tetzlaff, J.M. Cook, X. He, and F. Helmstetter, Neurobiology of Learning and Memory, 58, 1-10 (2002).
\n270.\u201cEnzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway,\u201d R.A. Mirghani, U. Yasar, T. Zheng, J.M. Cook, L.L. Gustafsson, G. Tybring, and O. Ericsson, Drug Metab. Dispos., 30, 1368-1371 (2002).
\n271.\u201cThe Enantiospecific, Stereospecific Total Synthesis of the Oxindole Alkaloid Alstonisine,\u201d X.Z. Wearing and J.M. Cook, Org. Lett., 4, 4237-4240 (2002).
\n272.\u201cRegiospecific, Enantiospecific Total Synthesis of the Alkoxy-Substituted Indole Bases, 16-epi-Na-Methygardneral, 11-Methoxyaffinisine, and 11-Methoxymacroline as Well as the Indole Alkaloids Alstophylline and Macralstonine,\u201d Xiaoxiang Liu and James M. Cook, Org. Lett., 4, 3339-3342 (2002).
\n273.\u201cStereospecific Enantiospecific Total Synthesis of the Sarpagine Indole Alkaloids (E)16-Epiaffinisine, E(16)-Epinormacusine B and Dehydro-16-epiaffinisine,\u201d J.Yu, X. Liao, and J.M. Cook, Org. Letters, 4,
\n4681-4684 (2002).
\n274.\u201cGeneral Approach for the Total Synthesis of the Sarpagine-related Indole Alkaloids(+)-Na-Methyl-16-Epipericyclivine, (-)-Alkaloid Q3 and (-)-Panarine via the Asymmetric Pictet-Spengler Reaction,\u201d Jianming Yu, Xiangyu Wearing, and James M. Cook, Tetrahedron Lett., 44, 543-547 (2003).
\n275.\u201cDiscriminative Stimulus Effects of a High Dose of Zolpidem in Squirrel Monkeys: Evidence for a Primary Role of GABA(A)\/\u03b11 Receptors,\u201d J.K Rowlett, R. Spealman, S. Lelas, J.M. Cook, and W. Yin, Psychopharmacology, 165, 209-215 (2003).
\n276.\u201cThe Enantiospecific, Stereospecific Total Synthesis of the Ring-A Oxygenated Sarpagine Indole Alkaloids (+)-Majvinine, (+)-10-Methoxyaffinisine and (+)-Na\u2013Methylsarpagine as well as the First Total Synthesis of the Alstonia Bisindole Alkaloid Macralstonidine,\u201d S. Zhao, X. Liao, T. Wang, J. Flippen-Anderson , and J.M. Cook, J. Org. Chem., 68, 6279-6295 (2003).
\n277.\u201cThe Reinforcing Properties of Alcohol are Mediated By GABA(A1) Receptors in the Ventral Pallidum,\u201d H. June. K. Foster, P. McKay, M. Carroll, J. E. Woods II, Scott C. Harvey, Regat Seyoum, William J. H. Eiler II, Collette Grey, Shannon McCane, Cecily Jones, W. Yin, D. Mason, R. Cummings, M. Garcia, C. Ma, P.V.V.S. Sarma, James M. Cook, and P. Skolnick, Neuropsychopharmacology, 28, 2124-2137 (2003).
\n278.\u201cThe Synthesis of a Dicyclopenta[a,e]pentalene via a Molybdenum Hexacarbonyl-Mediated Tandem Allenic Pauson-Khand Reaction,\u201d H. Cao, J. Flippen-Anderson, and J.M. Cook, J. Am. Chem. Soc., 125, 3230-3231 (2003).
\n279.\u201cStudies on the Rh and Ir-Mediated Tandem Pauson-Khand Reaction. A New Entry into the Dicyclopenta [a,d] cyclooctene Ring System,\u201d H. Cao, S. R. Mundla, and J.M. Cook, Tetrahedron Lett., 44, 6165-6168 (2003).
\n280.\u201cGeneral Approach for the Synthesis of Sarpagine Indole Alkaloids. Enantiospecific Total Synthesis of (+)-Vellosimine, (+)-Normacusine B, (-)-Alkaloid Q3, (-)-Panarine, (+)-Na-Methylvellosimine, and (+)Na-Methyl-16-epipericyclivine, J. Yu, T. Wang, X. Liu, J. Deschamps, J. Flippen-Anderson, X. Liao, and J.M. Cook, J. Org. Chem., 68, 7565-7581 (2003).
\n281.\u201cStudies in Search of Diazepam-Insensitive Subtype Selective Agents for GABAA\/Bz Receptors,\u201d X. Li, C. Ma, X. He, J. Yu, D. Han, C. Zhang, J. Atack, and J.M. Cook, Med. Chem. Res., 9, 504-537 (2003).
\n282.\u201cThe First Enantiospecific Synthesis of (-)-Koumidine via the Intramolecular Palladium-catalyed Enolate Driven Cross Coupling Reaction. The Stereospecific Introduction of the 19-(Z) Ethylidene Side Chain,\u201d Hui Cao, Jianming Yu, Xiangyu Z. Wearing, Chunchun Zhang, Xiaoxiang Lui, Jeffery Deschamps, and James M. Cook, Tetrahedron Lett., 44, 8013-8017, (2003).
\n283.\u201cSynthesis, in Vitro Affinity, and Efficacy of a Bis 8-Ethynyl-4H-imidazo[1,5a]-[1,4]benzodiazepine Analogue, the First Bivalent \u03b15 Subtype Selective BzR\/GABAA Antagonist\u201d, Xiaoyan Li, Hui Cao, Chunchun Zhang, Roman Furtmueller, Karoline Fuchs, Sigismund Huck, Werner Sieghart, Jeffrey Deschamps, and James M. Cook, J. Med. Chem., 46, 5567-5570 (2003).
\n284.\u201cEnantiospecific Total Synthesis of (-)-(E)-Epiaffinisine, (+)-E(16)-Epinormacusine B, and (+)-Dehydro-16-epiaffinisine as well as the Stereocontrolled Total Synthesis of Alkaloid G,\u201d J. Yu, T. Wang, X. Wearing, J. Ma, and James M. Cook, J. Org. Chem., 68, 5852-5859 (2003).
\n285.\u201cRegiospecific, Enantiospecific Total Synthesis of the 12-Alkoxy-Substituted Indole Alkaloids, (+)-12-Methoxy-Na-methylvellosimine, (+)-12-Methoxyaffinisine, and (-)-Fuchsiaefoline\u201d, Hao Zhou, Xuebin Liao, and James M. Cook, Org. Lett., 6, 249-252, (2004).
\n286.\u201cGABAA and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors,\u201d K. Foster, P. McKay, R. Seyoum, D. Milbourne, W. Yin, P.V.V.S. Sarma, J.M. Cook, and H. June, Neuropsychopharmacology, 29, 269-284 (2004).
\n287.\u201cStereocontrolled Total Synthesis of (-)-Vincamajinine and (-)-11-Methoxy-17-epivin-camajine,\u201d Jianming Yu, Xiangyu Wearing, and J.M. Cook, J. Am. Chem. Soc., 126, 1358-1359 (2004).
\n288.\u201cRY 023: A Selective High Affinity Ligand for GABA(A)-Receptor Containing \u03b15 Subunit Attenuates
\nEthanol-Maintained Responding Following Systemic and Microinjection Into the CA1 and CA3 Hippocampal Fields,\u201d S. Harvey, K. Foster, P. Mc Kay, M. Garcia, D. Mason, R. Cummings, C. Grey, S. McCane, X. He, J.M. Cook, and H.L. June, submitted.
\n289.\u201cABCG2 Expression, Function, and Promoter Methylation in Human Multiple Myeloma,\u201d J. Turner, J. Gump, C. Shang, J.M. Cook, D. Marchion, L.Hazlehurst, P. Munster, M. Schell, W. Dalton, and D. Sullivan, Blood, 108, 3881-3889 (2006).
\n290.\u201cGABAA\/\u03b11 Receptor Agonists and Antagonists: Effects on Species-typical and Heightened Aggressive Behavior After Alcohol Self-Administration in Mice,\u201d R. Almeida, J.K. Rowlett, J.M. Cook, W. Yin, and K. Miczek, Psychopharmacology, 172, 255-263 (2004).
\n291.\u201cA High Affinity Ligand for GABA(A)-Receptor Containing \u03b15 Subunit Antagonizes Ethanols Neurobehavioral Effects in Long-Evans Rats,\u201d, P. McKay, K. Foster, D. Mason, R. Cummings, M. Garcia, L. Williams, C. Grey, S. McCane, X. He, J.M. Cook and H.L. June, Psychopharmacology, 172, 455-462 (2004).
\n292.\u201cBenzodiazepines and Heightened Aggressive Behavior in Rats: Reduction by GABAA\/\u03b11 Receptor Antagonists,\u201d S. Gourley, J.Debold, W. Yin, J. Cook, and K. Miczek, Psychopharmacology, 178, 232-240 (2005).
\n293.\u201cDetermination of the Stable Conformation of GABA(A)-Benzodiazepine Receptor Bivalent Ligands by Low Temperature NMR and X-ray Analysis,\u201d D. Han, F.H. F\u00f6rsterling, X. Li, J. Deschamps, H. Cao and J.M. Cook, Bioorg. Med. Chem. Lett., 14, 1465-1469 (2004).
\n294.\u201cThe First Enantiospecific Total Synthesis of a C-quaternary Voachalotine Alkaloid, (+)-Dehydrovoachatoline,\u201d J. Yu, A. Wearing, and J.M. Cook, Tetrahedron Lett., 45, 3937-3940 (2004).
\n295.\u201cBartoli Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 100-103 (2004).
\n296.\u201cBatcho-Leimgruber Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li; J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 104-109 (2004).
\n297.\u201cFischer Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 116-127 (2004).
\n298.\u201cGassman Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 128-131 (2004).
\n299.\u201cGraebe-Ullmann Carbazole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 132-134 (2004).
\n300.\u201cMadelung Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 140-144 (2004).
\n301.\u201cNenitzescu Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 144-153 (2004).
\n302.\u201cReissert Indole Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 154-158 (2004).
\n303.\u201cPinner Pyrimidine Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 534-537 (2004).
\n304.\u201cVon Richter Cinnoline Synthesis, in Name Reactions in Heterocyclic Chemistry\u201d J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 538-540 (2004).
\n305.”Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Elevated Plus Maze: Differential Antagonism by Flumazenil and BCCt,” M. Savi\u0107, D. Obradovi\u0107, N. Ugre\u0161i\u0107, J.M. Cook, W. Yin and D. Bokonji\u0107, Pharmacol. Biochem. Behav., 79, 279-290 (2004).
\n306.”Development of Selective Ligands for Benzodiazepine Receptor Subtypes by Manipulating the Substituents at Positions -3 and -7 of Optically Active BzR Ligands,” X. Li, J. Yu, J. Atack, and J.M. Cook, Med. Chem. Res, 13, 259-281 (2004)
\n307.”Synthesis of Optically Active Ring-A Substituted Tryptophans as IDO Inhibitors,” X. Li, W. Yin, P.V.V. S. Sarma, H. Zhao, J. Ma and J. M. Cook, Tetrahedron Lett., 45, 8569-8573 (2004).
\n308.”The Synthesis of Dicyclopenta[a,e]pentalenes via a Molybdenum Carbonyl-Mediated Tandem Allenic Pauson-Khand Reaction and the X-ray Crystal Structure of a Planar Dicyclopenta[a,e]pentalene,” H. Cao, S. Van Ornum, J. Deschamps, J. Flippen-Anderson, F. Laib, J.M. Cook, J. Am. Chem. Soc., 127, 933-943 (2005).
\n309.”Conformational Analysis in the Asymmetric Pictet-Spengler Reaction, Evidence for the C(1)-N(2) Scission Process in the Cis to Trans Isomerization” D. Han, F. H. F\u00f6rsterling, J. Deschamps, D. Parrish, X. Liu, S.Huang, W. Yin, and J.M. Cook, J. Nat. Prod., 70, 75-82 (2007).
\n310.”Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Passive Avoidance Task: Differential Antagonism by Flumazenil and BCCt,” M. Savic, D. Obradovic, N. Ugresic, J.M. Cook, W. Yin and D. Bokonjic, Behavioral Brain Res., 158, 293-300 (2005).
\n311.”A General Strategy for the Synthesis of Vincamajine-related Indole Alkaloids: Stereocontrolled Total Synthesis of (+)-Dehydrovoachalotine, (-)-Vincamajinine and (-)-11-Methoxy-17-epivincamajine, as well as the Related Alcohols, Quebrachidinediol, Vincamajinediol and Vincarinol,” J. Yu, A. Wearing and J. M. Cook, J. Org. Chem., 70, 3963-3979 (2005).
\n312.”Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Active Avoidance Acquisition and Retention: Differential Antagonism by Flumazenil and BCCt,” M. Savi\u0107, D. Obradovi\u0107, N. Ugre\u0161i\u0107, J.M. Cook, P.V.V.S. Sarma and D. Bokonji\u0107, Psychopharm., 180, 455-465 (2005).
\n313.\u201cBenzodiazepines and Heightened Aggressive Behavior in Rats: Reduction by GABA(A)\/alpha(1) Receptor Antagonists,\u201d S. L. Gourley, J. F. DeBold, W. Y. Yin, J. M. Cook, K. A. Miczek, Psychopharm., 178, 232-240 (2005).
\n314.”Contribution of \u03b1 1GABAA and \u03b1 5GABAA Receptor Subtypes to the Discriminative Stimulus Effects of Ethanol in Squirrel Monkeys” D. Platt, A. Duggan, R. Spealman, J.M. Cook, X. Li, W. Yin and J. K. Rowlett, J. Pharm. Exp. Therapeut., 313, 658-667 (2005).
\n315.\u201cContribution of GABAA Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]\u201d S. Licata, D. Platt, J.M. Cook, P.V.V.S. Sarma, G. Griebel and J. Rowlett, J. Pharm. Exp. Therapeut., 313, 1118-1125 (2005).
\n316.\u201cFirst Regiospecific, Enantiospecific Total Synthesis of Gardnerine and Gardnutine\u201d H. Zhou, P.V.V.S. Sarma, D. Han, J. Deschamps and J. M. Cook, Tetrahedron Lett., 46, 4219-4224 (2005).
\n317.\u201cConfirmation of the Structure of (3S)-3-Hydroxyquinine: Synthesis and X-ray Crystal Structure of Its 9-Aceto Analogue\u201d P.V.V.S. Sarma, D. Han, J. Deschamps and J. M. Cook, J. Nat. Prod., 68, 942-944 (2005).
\n318.\u201cSelective Antagonism of GABAA Receptor Subtypes: An In Vivo Approach to Exploring the Thereapeutic and Side Effects of Benzodiazepine-Type Drugs,\u201d J.K. Rowlett, J. M. Cook, A.N. Duke, D. M. Platt. CNS Spectr., 10, 40-48 (2005).
\n319.\u201cSynthesis of Bivalent Ligands of \u03b2-Carboline-3-Carboxylates Via a Palladium-Catalyzed Homocoupling Process\u201d W. Yin, P.V.V.S. Sarma, J. Ma, D. Han, J. L. Chen and J. M. Cook, Tetrahedron Lett., 46, 6363-6368 (2005).
\n320.\u201cThe First Regiospecific, Enantiospecific Total Synthesis of 6-Oxoalstophylline and and Improved Total Synthesis of Alstonerine and Alstophylline as Well as the Bisindole Alkaloid Macralstonine\u201d X. Liao, H. Zhou, X. Z. Wearing, J. Ma and J. M. Cook, Org. Lett., 7, 3501-3504 (2005).
\n321.\u201cSelective GABAA \u03b15 Benzodiazepine Inverse Agonist Antagonizes the Neurobehavioral Actions of Alcohol\u201d J. B. Cook, K. L. Foster, W. J. A. Eiler II, P. F. McKay, J. Woods II, S. C. Harvey, M. Garcia, C. Grey, S. McCane, D. Mason, R. Cummings, X. Li, J. M. Cook and H. June, Alcohol Clin. Exp. Res., 29, 1390-1401 (2005).
\n322.\u201cABCG2 Expression, Function and Promoter Methylation in Human Multiple Myeloma,\u201d J. G. Turner, J. L. Gump, C. C. Zhang, J. M. Cook, D. Marachion, L. Hazelhurst, P. Munster, M. J. Schell, W. S. Dalton and D. M. Sullivan, Blood, 108, 3881-3889 (2006).
\n323.\u201cAn Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on \u03b3 \u2013 Aminobutyric AcidA Receptors: Correlation with Comparative Models,\u201d T. Clayton, J. Chen, M. Ernst, L.Richter, B.A. Cromer, C.J. Morton, H.Ng, C. Cook \u2013 Kaczorowski, F.J. Helmstetter, R. Furtm\u00fceller, G. Ecker, M.W. Parker, W. Sieghart and J.M. Cook, Curr. Med. Chem., 14, 2755-2775 (2007).
\n324.\u201cGeneral Approach for the Synthesis of 12-Methoxy-substituted Sarpagine Indole Alkaloids Including (-)-12-Methoxy-Nb-methylvoachalotine, (+)-12-Methoxy-Na-methylvellosimine, (+)-12-Methoxyaffinisine and (-)-Fuchsiaefoline,\u201d H. Zhao, X. Liao, W. Yin, J. Ma and J. M. Cook, J. Org. Chem., 71, 251-259 (2006).
\n325.\u201cAn Improved Total Synthesis of (+)- Macroline and Alstonerine as Well as the Formal Total Synthesis of (-)- Talcarpine and (-)-Anhydromacrosalhine-methine,\u201d X. Liao, H. Zhou, J. Yu, and J. M. Cook, J. Org. Chem., 71, 8884-8890 (2006).
\n326.\u201cEnhanced Sucrose Pellet Consumption Induced by Benzodiazepine-Type Drugs in Squirrel Monkeys: Role of GABA(A) Receptor Subtypes,\u201d A. Duke, D. Platt, J. M. Cook, S. Huang, W. Yin, B. Mattingly, and J. K. Rowlett, Psychopharmacol. (Berlin), 187, 321-330 (2006).
\n327.\u201cEnantiospecific Synthesis of (+)-Na-Methyl-pericyclivine and (-)-Na-Methylakuammidine as well as the Ring-A Oxygenated Natural Products, (+)-10-Methoxy-Na-Methylpericyclivine and 10-Hydroxy-Na-Methylpericyclivine,\u201d Org. Lett., 8, 1017-1020 (2006).
\n328.\u201cBenzodiazepine Site Inverse Agonists and Locomotor Activity in Rats: Bimodal and Biphasic Influence,\u201d M. Savic, D. Obradovio, N. Ugresic, J. M. Cook, W. Yin, M. Van Linn and D. R. Bonkonjic, Pharmacol. Biochem. Behav., 84, 35-42 (2006).
\n329.\u201cConformational Analysis of the Cis and Trans Adducts of the Pictet-Spengler Reaction. Evidence for the Structural Basis for the C(1)-N(2) Scission Process in the Cis to Trans Isomerization,\u201d D. Han, F. Forsterling, J. Deschamps, D. Parrish, X. Liu, W. Yin, S. Huang and J. M. Cook, J. Nat. Prod. (Lloydia), 70, 75-82 (2007).
\n330.\u201cAre GABAA Receptors Containing \u03b15 Subunits Contributing to the Sedative Properties of \u03b15 Agonists?\u201d M. Savic, S. Huang, R. Furtmueller, T. Clayton, S. Huck, D. Obradovic, N. Ugresic, W. Sieghart, D. Bokonjic and J. M. Cook, Neuropsychopharmacology, 33, 332-339 (2008).
\n331.\u201cSynthesis and Structure Activity Relationships of Tryprostatin A: An Inhibitor of Breast Cancer Resistant Protein,\u201d H. Jain, C. Zhang, S. Zhao, H. Zhou, Amy Deveau, C. Dieckhaus, M. Johnson, K. Smith, T. MacDonald, H. Kakeya, H. Osada and J.M. Cook, Bioorg. and Med. Chem., 16, 4626-4651 (2008).
\n332.\u201cThe First Enantiospecific Total Synthesis of the Important Biogenetic Intermediates, (+)- Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-Epi-vellosimine and Macusine-A,\u201d W. Yin, J. Ma, F. Rivas and J. M. Cook, Org. Lett., 9, 295-298 (2007).
\n333.\u201cDopamine and Benzodiazepine-Dependent Mechanisms Regulate the EtOH-Enhanced Locomotor Stimulation in the GABAA \u03b11 Subunit Null Mutant Mice,\u201d H. L. June Sr., K. L. Foster, W. J.A. Eiler, J. Goergen, J. B. Cook, N. Johnson, B. Mensah-Zoe, J. O. Simmons, H. L. June Jr., W. Yin, J. M. Cook, and G. E. Homanics, Neuropsychopharmacology, 32, 137-152 (2007).
\n334.\u201cAn Efficient Palladium Catalyzed Negishi Cross-Coupling Reaction with Aryvinyl Iodides: Facile Regioselective Synthesis of E-Stilbenes and their Analogues,\u201d M. Shahjahan Kabir, A. Monte and J. M. Cook, Tetrahdron Lett., 48, 7269-7273 (2007).
\n335.\u201cTotal Synthesis of the Opioid Agonistic Indole Alkaloid, Mitragynine, as well as the First Total Synthesis of 9- Methoxygeissoschizol and 9-Methoxy-Nb-methyl-geissoschizol,\u201d Jun Ma, W. Yin, H. Zhou and J.M. Cook, Org. Lett., 9, 3491-3494 (2007).
\n336.\u201cCascade Approach toward the Core Structure of Neosarpagine,\u201d X. Liao, S. Huang, D. Parrish and J.M. Cook, Org. Lett., 9, 1469-1471 (2007).
\n337.\u201cPWZ-029, a Compound with Moderate Inverse Agonist Functional Selectivity at GABAA Receptors Containing Alpha 5 Subunits, Improves Passive, but not Active, Avoidance Learning in Rats,\u201d M. Savic, T. Clayton. R. Furtmueller, I. Gaurilovic, J. Samardzic, S. Savic, W.Sieghart and J.M. Cook, Brain Res., 1208, 150-159 (2008).
\n338.\u201cContribution of \u03b11 Subunit \u2013 containing \u03b3-Amino-butyric Acid (A) Receptors to Benzodiazepine \u2013 Induced Ataxia and Myorelaxation in Squirrel Monkeys,\u201d S.Licata, D. Platt, J. Cook, M. Van Linn, and J. Rowlett, Psychopharmacology, 203, 539-546 (2009).
\n339.\u201cSelective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABA(A) Receptors Containing the \u03b15 Subunit,\u201d D. Harris, T. Clayton, J. Cook, R.Halliwell, P. Sahbaie, W. Sieghart, R. Furtmueller, and T. DeLorey, J. Med. Chem., 51, 3788-3803 (2008).
\n340.\u201cThe Syntheisis of the Macroline Alkaloids: A Recent Review,\u201d C.S. Edwanker, R. Edwanker, S. Rallapalli, and J.M. Cook, Nat. Prod. Commun, 3, 1839-1870 (2008).
\n341.”Stereo- and Regiospecific Cu-Catalyzed Cross-Coupling Reaction of Vinyl Iodides and Thiols: A Very Mild and General Route for the Synthesis of Vinyl Sulfides,” M. Kabir, M.L. Van Linn, A. Monte, and J.M. Cook, Org. Lett., 10, 3363-336 (2008).
\n342.\u201cEnantiospecific Synthesis of (+)-Alstonisine via a Streospecific Osmylation Process,\u201d Y. Yang, A. Wearing, J. DeChamps, P. LeQuesne and J.M. Cook, J. Nat. Prod., 71, 1431-1440 (2008).
\n343.\u201cNew Classes of Gram-positive Selective Antibacterials: Inhibitors of MRSA and Surrogates of the Causative Agents of Anthrax and Tuberculosis,\u201d M. Shahjahan Kabir, Kathleen Engelbrecht, Rebecca Polanowski, Sara M. Krueger, Rachel Ignasiak, Marc Rott, William R. Schwan, Mary E. Stemper, Kurt D. Reed, David Sherman, James M. Cook, Aaron Monte, Bioorg. and Med. Chem., 18, 5745-5749 (2008).
\n344.\u201cA Study of the Structure-activity Relationship of GABAA-benzodiazepine Receptor Bivalent Ligands by Conformational Analysis with Low Temperature NMR and X-ray Analysis,\u201d Dongmei Han, F. Holger Forsterling, Xiaoyan Li, Jeffrey R. Deschamps, Damon Parrish, Hui Cao, Sundari Rallapalli, Terry Clayton, Yun Teng, Samarpan Majumder, Subramaniam Sankar, Bryan L. Roth, Werner Sieghart, Roman Furtmuller, James K. Rowlett, Michael R. Weed, James M. Cook, Bioorg. and Med. Chem., 16, 8853-8862 (2008).
\n345.\u201cGlutamatergic and GABAergic Modulations of Ultrasonic Vocalizations During Maternal Separation Distress in Mouse Pups,\u201d Takahashi, A.; Yap, J.J.; Bohager, D.Z.; Faccidomo, S.; Clayton, T.; Cook, J.M.; Miczek, K.A., Psychopharmacol. (Berlin, Ger.) , 204, 61-71 (2009).
\n346.\u201cGeneral Approach to the Total Synthesis of 9-Methoxy-Substituted Indole Alkaloids: Synthesis of Mitragynine, as well as 9-Methoxygeissoschizol and 9-Methoxy-Nb-Methylgeissoschizol,\u201d Jun Ma, Wenyuan Yin, Hao Zhou, Xuebin Liao, James M Cook, J. Org. Chem., 74, 264-273 (2009).
\n347.\u201cAntiseizure Activity of Novel \u03b3-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogs in Mice and Rat Models,\u201d F. Rivas, J. Stables, L. Murphree, R. Edwankar, C. Edwankar, S.Huang, H. Jain, H. Zhou, S. Majumder, B. Roth, S. Sanker, J. Ramerstorfer, R. Furtmuller, W.Sieghart, J. M. Cook, J. Med. Chem., 52, 1795-1798 (2009).
\n348.\u201cStudy of the Cis to Trans Isomerization of 1-Phenyl-2,3-Disubstituted Tetrahydro-Beta-Carbolines. Evidence for the Carbocation-Mediated Mechanism,\u201d H. Kumpaty, M. Van Linn, M. S. Kabir , F. Forsterling, J. Dechamps and J.M. Cook, J. Org. Chem, 74, 2771-2779 (2009).
\n349.\u201cThe Differential Role of \u03b11 and \u03b15 \u2013 Containing GABA(A) Receptors in Mediating Diazepam Effects on Spontaneous Locomotor Activity and Water-Maze Learning and Memory in Rats\u201d, M. Savic, M.
\nMilinkovic, S. Rallapalli, T. Clayton Sr., S. Joksimovic, M. Van Linn, J. M. Cook, Neuropsychopharmacology, 12, 1179-1193 (2009).
\n350.\u201cAn Improved Process for the Synthesis of 4H-Imidazo-[1,5 \u2013 a][1,4] benzodiazepines,\u201d J. Yang, Y. Teng, S. Ara, S. Rallapalli, James M. Cook, Synthesis, 6, 1036-1040 (2009).
\n351.\u201cDissociating Anxiolytic and Sedative Effects of GABA(A)ergic Drugs Using Temperature and Locomotor Responses to Acute Stress,\u201d C. Vinkers, M. Van Linn, Seth Hopkins and J.M. Cook, Psychopharmacology, 204, 299-311 (2009).
\n352.\u201cDiscriminative Stimulus Effects of L-838, 417: Role of GABA(A) Receptor Subtypes\u201d, S. Licata, J. Rowlett, D. Platt, M. Van Linn, J. M. Cook, Neuropharmacology, 58, 357-364 (2009).
\n353.\u201cEffects of Concurrent Administration of Nevirapine on the Disposition of Quinine in Healthy Volunteers,\u201d Soyinka JO, Onyeji CO, Omoruyi SI, Owolabi AR, Sarma PV, Cook JM, J Pharm Pharmacol. 61(4), 439-443 (2009).
\n354.\u201cRecent Progress in the Total Synthesis of Indole Alkaloids\u201d, C. Edwankar, R. Edwankar, O. Namjoshi, S. Rallapalli, J. Yang, J. M. Cook, Current Opinion in Drug Discovery and Development, 12, 752-771 (2009).
\n355.\u201cContribution of \u03b11 Subunit-Containing \u03b3-Aminobutyric Acid A (GABA A) Receptors to The Motor-Impairing Effects of Benzodiazepines in Squirrel Monkeys,\u201d S. Licata, D. Platt, J. Cook, M. Van Linn, J. Rowlett, Psychopharmacology, 203, 539-546 (2009).
\n356.\u201cThe \u03b11 Subunit of the GABA (A) Receptor Modulates Fear Learning and Plasticity in the Lateral Amygdala,\u201d B. Wiltgen, Godsil, Z. Peng, F. Saab, H. June, M. Van Linn, J. M. Cook, C. Houser, T. O’.Dell, G. Homanics, M. Fanselow, Frontiers in Behav. Neurosc. , 3, (article 37), pp 1-12 (2009).
\n357.\u201cNovel Positive Allosteric Modulators of GABA(A) Receptors: Do Subtle Differences in Activity at Alpha 1 Plus Alpha 5 Versus Alpha 2 Plus Alpha 3 Subunits Account for Dissimilarities in Behavioral Effects in Rats\u201d, M Savic, S. Majumder, S.Huang, R. Edwankar, R. Furtmuller, S. Joksimovic, T. Clayton, J. Ramerstovfer, M. Milinkovk, B. Roth, W. Sieghart, J. M. Cook, Progress in Neuro-Psychopharmacology and Behavioral Psychiatry, 34, 376-386 (2010).
\n358.\u201cPharmokinetic Interactions Between Ritonavir and Quinine in Healthy Volunteers Following Concurrent Administration\u201d, Cyp Onyesi, S. Pullela, J. M. Cook, Bri. J. Clin. Pharmacol, 69, 354-364 (2010).
\n359.\u201cFirst Application of an Efficient and Versatile Ligand for Copper-Catalyzed Reactions of Vinyl Halides with N-Heterocycles and Phenols,\u201d M. Kabir, M. Lorenz, O. Namjoshi, J.M. Cook, Org. Lett., 12, 464-467 (2010).
\n360.\u201cThe First Enantiospecific Total Synthesis of the 3-Oxygenated Sarpagine Indole Alkaloids Affinine and 16-Epiaffinine, as well as Vobasinediol and 16-Epivobasinediol\u201d, Jie Yang, Sundari K Rallapalli, James M Cook, Tetrahdron Lett., 51, 815-817 (2010).
\n361.\u201cA Two Step Synthesis of BzR\/GABAergic Active Flavones via a Wacker-related Oxidation,\u201d M. Lorenz, M. Kabir, J. M. Cook, Tetrahdron Lett., 51, 1095-1098 (2010).
\n362.\u201cSynthesis, Pharmacological Studies and Molecular Modeling of Some Tetracyclic 1,3 \u2013 Diazepinium Chlorides,\u201d J, -A. Grant, T. Bonnick, M. Gossell- Williams, T. Clayton, J. M. Cook, Yvette Jackson, Biorg. Med. Chem., 18, 909-921 (2010).
\n363.”Design, Synthesis and Subtype Selectivity Effects of 3,6-Disubstituted Beta Carbolines at Bz\/GABA(A)ergic Receptors. SAR and Studies Directed Toward Agents for Treatment of Alcohol Abuse,” Yin, W., Majumder, S., Clayton, T., Petrou, S., VanLinn, M., Ma, C., June, H.L., Cromer, B.A., Roth, B.L., Luddens, H., Cook, J.M. Bioorg and Med. Chem., 21, 7548-7564 (2010).
\n364.”Enantiospecific Total Synthesis of the Important Biogenetic Intermediates Along the Ajmaline Pathway, (+) Polyneuridine and (+) Polyneuridine Aldehyde, as well as 16-Epivellosimine and
\nMacusine A,” Yin, W., Kabir, S.M, Wang, Z., Rallapalli, S.K., Ma, J.,Cook, J.M., J. Org. Chem., 75, 3339-3349 (2010).
\n365.”The Asymmetric Pictet-Spengler Reaction,” Lorenz, M., VanLinn, M. L., Cook, J. M. Curr. Org. Syn., 7, 189-223 (2010).
\n366.”Mechanistic Studies on the Cis to Trans Epimerization of Trisubstituted 1, 2, 3, 4-Tetrahydro-\u03b2-carbolines,\u201d VanLinn, M. L., Cook, J.M., J. Org. Chem., 75, 3587-3599 (2010).
\n367.\u201cAnxiolytic-like Effects of 8-Acetylene Imidazobenzodiazepines in a Rhesus Monkey Conflict Procedure,\u201dFischer, B.; Licata, S.; Edwankar, R.; Wang, Z-J.; Huang, S.; He, X.; Yu, J. Zhou, H.; Johnson, Jr., E. M.; Cook, J.; Furtmuller, R.; Ramerstorfer, J.; Sieghart, W.; Roth, B.; Majumder, S.; Rowlett, J., , Neuropharmacology, 59, 612-618, (2010).
\n368.\u201cA Very Active Cu-Catalytic System for the Synthesis of Aryl, Heteroaryl, and Vinyl Sulfides,\u201d Kabir, S.M., Lorenz, M., Van Linn, M. L., Namjoshi, O. A., Ara, S., Cook, J.M. J. Org. Chem., 75, 3626-3643 (2010).
\n369.”A New Class of Potential Anti-Tuberculosis Agents: Synthesis and Preliminary Evaluation of Novel Acrylic Acid Ethyl Ester Derivatives,” Kabir, S. M., Namjoshi, O. A., Verma, R., Polanowski, R., Krueger, S. M., Sherman, D., Rott, M. A., Schwan, W. R., Monte, A., Cook, J. M. Bioorg and Med. Chem.., 18, 4178-4186 (2010).
\n370.\u201cDiscriminative Stimulus Effects of L-838,417 (7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): Role of GABA A Receptor Subtypes,\u201d Licata, S. C.; Platt, D. M.; R\u00fcedi-Bettschen, D.; Atack, J. R.; Dawson, G. R.; Van Linn, M. L.; Cook, J. M.; Rowlett, J. K., Neuropharmacology, 58, 357-364 (2010).
\n371.\u201cDevelopment of a Two-step Route to 3-PBC and \u03b2CCt, Two Agents Active Against Alcohol Self-Administration in Rodent and Primate Models,\u201d Namjoshi, O. A. ; Grzybkowska, A.; Fonseca, G. O.; Van Linn, M.; Wang, Z.; Deschamps. J. R.; Cook, J. M., J. Org. Chem., 76 (11), 4721\u20134727 (2011).
\n372.\u201cHZ-166, A Novel GABAA Receptor Subtype-Selective Benzodiazepine Site Ligand, Is Antihyperalgesic inMouse Models of Inflammatory and Neuropathic Pain,\u201d Di Lio, A.; Benke, D.;Besson,M.; Desmeules, J.; Daali, Y.; Wang, Z.J.; Edwankar, R.; Cook, J.M.; Zeilhofer., Neuropharmacology, 60, 626-632 (2011).
\n373.\u201c\u03b14-Containing GABA (A) Receptors are Required for Antagonism of Ethanol-Induced Motor in Coordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513,\u201d Iyer, S. V.; Benavides, R. A.; Chandra, D.; Rallapalli, S.; Cook, J.; June, H. L.; Homanics, G. E., Frontiers in Pharmacology, 2, 18, 1-7 (2011).
\n374.\u201cRegiospecific, Enantiospecific Total Synthesis of C-19 Methyl Substituted Sarpagine Alkaloids Dihydroperaksine-17-al and Dihydroperaksine,\u201d Edwankar, R. V.; Edwankar, C, R.; Deschamps, J.; Cook, J.M., Org Lett., 13, 5216-5219 (2011).
\n375.\u201cA Novel \u03b15 GABAAR-Positive Allosteric Modulator Revereses Hyperactivation of the Dopamine System in the MAM Modle of Schizophrenia,\u201d Gill, K.; Lodge, D.; Cook, J. M.; Ara, S.; Grace, A., Neuropsychopharmacology, 36, 1903-1911 (2011).
\n376.\u201cLifelong CRF Overproduction is Associated with Altered Gene Expression and Sensitivity of Discrete GABA (A) and mGlu Receptor Subtypes,\u201d Vinkers, C.; Hendriksen, H.; Oorshot, R.; Cook, J.; Rallapalli, S.; Huang, S.; Millian, M.; Oliver, B.; Groenink, L., Psychopharmacology, 219, 897-908 (2012).
\n377.\u201cThe Role of \u03b11 and \u03b15 Subunit-Containing GABAA Receptors in Motor Impairment Induced by Benzodiazepines in Rats\u201d, Milic, M.; Divljakovic, J.; Rallapalli, S.; Van Linn, M.L.; Timic, T.; Cook, J.
\nM.; Savic, M. M., Behav. Pharmacol., 23, 191-197 (2012).
\n378.\u201cModulation of the Reinforcing Effects of Ethanol in Rhesus Monkeys by \u03b15 GABA (A) Receptor-Selective Ligands,\u201d R\u00fcedi-Bettschen, D.; Rowlett, J. K.; Rallapalli, S.; Clayton, T.; Cook, J. M.; Platt, D. M., Alcoholism Clinical and Experimental Research, 37, 624-634 (2013).
\n379.\u201cGABAA Receptor \u03b1 Subunits Differentially Contribute to Diazepam Tolerance After Chronic Treatment,\u201d Vinkers, C.; Hansen, H.; Nielsen, E.; van Oorschot, R.; Cook, J. M.; Groenink, L.; Olivier, B.; Mirza, N., PLOS ONE, 7 (8) e43054, 1-11 (2012).
\n380.\u201cTargeting the Restricted \u03b14 Subunit Repertoire of Airway Smooth GABA (A) Receptors Augments Airway Smooth Muscle Relaxtion,\u201d Gallos, G.; Yim, P.; Chang, S.; Zhang, Y.; Xu, D.; Cook, J. M.; Gerthoffer, W.; Emala, Sr. C., Am. J. Physiol. Lung Cell Mol. Physiol., 302, 248-256 (2012).
\n381.\u201cBase-Mediated Stereospecific Synthesis of Aryloxy and Amino Substituted Ethyl Acrylates\u201d, Kabir*, M.S.; Namjoshi, O. A.;Verma, R.;Lorenz, M.; Tiruveedhula,V.V.N.P.; Monte, A.; Bertz, S. H.;Schwabacher*, A.; Cook*, J. M., J. Org. Chem., 77, 300-310 (2012).
\n382.\u201cBr\u00f8nsted Acid Mediated Cyclization of Enaminones. Rapid and Efficient Access to the Tetracyclic (ABCE) Framework of the Strychnos Alkaloids\u201d, Edwankar, R. V.; Edwankar, C. R.; Namjoshi, O. A.; Deschamps, J. R.; Cook*, J. M., J. Nat. Prod., 75, 181-188 (2012).
\n383.\u201cSynthesis and Minimum Inhibitory Concentrations of SK-03-92 against Staphylococcus aureus and other gram-positive bacteria\u201d, Schwan, W. R.; Kabir, M. S.; Kallaus, M.; Krueger, S.; Monte, A.; Cook, J. M., J. Infect. Chemother., 18, 124-126 (2012).
\n384.\u201cBenzodiazepine \u2013 Induced Spatial Learning Deficits in Rats are Regulated by the Degree of Modulation of \u03b11 GABA (A) Receptors,\u201d Joksimovic, S.; Divljakovic, J.; vanLinn, M.; Varagic, Z.; Brajkovic, G.; Milinkovic, M.; Yin, W.; Timic, T.; Sieghart, W.; Cook, J.; Savic, M. M., European J. Neuropsychopharmacology, 23, 390-399 (2013).
\n385.\u201cExposure to Cocaine Alters Fast Synaptic Transmission from the Ventral Tegmental Area to the Nucleus Accumbens,\u201d Ishikawa, M.; Otaka, M.; Neumann, P.; Wang, Z.; Cook, J. M.; Schluter, O.; Dong, Y.; Huang, Y., J. Physiol., 591 (Pt 19), 427-41 (2013).
\n386.\u201cComparison of Cell Expression Formats for the Characterization of the GABA Channels using Microfluidic Patch Clamp System,\u201d Chen, Q.; Yim, P.; Yuan, N.; Johnson, J.; Cook, J.; Smith, S.; Ionescu-Zanetti, C.; Wang, Z.; Arnold, A.;Emala, C., Assay and Drug Development Technologies, 10, 325-335 (2012).
\n387.\u201cNature-Inspired Stereospecific Total Synthesis of the (P)-Atropodiastereomer of (+)-Dispegatrine via a Non-Phenolic Intermolecular Biaryl Oxidative Coupling,\u201d Edwanker, C.; Edwankar, R.; Deschamps, J.; Cook, J., Angew. Chemie. Ind. Ed., 51, 11762-5 (2012).
\n388.\u201cRecent Adventures with the Pauson-Khand Reaction in Total Syntheis,\u201d Van Ornum, S.; Hoerner, S.; Cook, J.M., in The Pauson-Khand Reaction: Scope, Variations and Applications, First Edition. Edited by Ramon Rios Torres. John Wiley and Sons, Ltd., Chapter 8, 211-238 (2012).
\n389.\u201cThe Ability of Flumazenil to Reverse Diazepam Withdrawal-Induced Anxiety in Rats is Mediated by \u03b11 GABAA Receptors\u201d, J. Divljakovic, M. Milic, O. Namjoshi, Phani Babu, J. Cook, M. Savic, Brain Res. Bulletin, 91, 1-7 (2013).
\n390.\u201cSearch for \u03b13\u03b22\/3\u03b32 Subtype Selective Ligands that are Stable on Human Liver Microsomes and In Vitro and In Vivo Evaluation of Metabolically Stable Bioisosteric Analogs,\u201d Namjoshi, O.; Wang, Z.; Rallapalli, S.; Johnson, E. M.; Johnson, Yun-Teng; Ng, H.; Ramerstorger, J.; Sieghart, W.; Roth, B.;
\nRowlett, J.K.; Cook, J. M., Bioorg. and Med. Chem., 21, 93\u2013101 (2013).
\n391.\u201cRole of Gamma-aminobutyric Acid Type A Receptor Subtypes in Acute Benzodiazepine Physical Dependence: Evidence from Squirrel Monkeys Responding Under a Variable Schedule of Food Presentation,\u201d Fischer, B.l Teixeri, L.; Van Linn, M.; Namjoshi, O.; Cook, J.; Rowlett, J.K., Psychopharmacology, 227 (2), 347-54 (2013).
\n392.\u201cEnhancing the Function of Alpha 5-Containing GABA(A) Receptors Promotes Action Potential Firing of Neocortical Neurons During Upstates,\u201d Drexler, B.; Zinser, S.; Huang, S.; Poe, M. M.; Rudolph, U.; Cook, J. M.; Antkowiak, B. Eur. J. Neuropsychopharmacology, 18-24 (2013).
\n393.\u201cEffects of the Benzodiazepine GABA \u03b11 Selective Ligand 3-Propoxy-\u03b2-Carboline (3PBC) on Alcohol Seeking and Self-Administration in Baboons,\u201d Kaminski, B.; Van Linn, M.; Cook, J.; Yin, Wenyuan; Weerts, E., Psychoparmacology, 227, 127-136 (2013).
\n394.\u201c\u03b2CCT, an Antagonist Selective for \u03b1(1)GABA(A) Receptors, Reverses Diazepam Withdrawal-induced Anxiety in Rats.\u201d Divljakovi\u0107 ,J.; Mili\u0107, M.; Namjoshi, O. A.; Tiruveedhula, V. V.; Timi\u0107, T.; Cook, J. M.; Savi\u0107 ,M. M. Brain Res. Bull., 91:1-7 (2013).
\n395.\u201cCognition Impairing Effects of Benzodiazepine Type Drugs: Evaluation of the Role of GABAA Receptor Subtypes in Spatial Recognition Memory and Executive Function Tasks in Rhesus Monkeys\u201d, L. Makaron, C. Moran, O. Namjoshi, S. Rallapalli, J. Cook, J. Rowlett, Pharmacol.Biochem.Behav.,104, 62-68 (2013).
\n396.\u201cSubtype Selectivity of \u03b1+\u03b3 Site Ligands of GABAA Receptors-Identification of the First Highly Specific Positive Modulators at \u03b16\u03b2 (2\/3)\u03b32 Receptors\u201d, Z. Varagic, J. Ramerstorfer, S. Huang, S. Rallapalli, I.Sarto-Jackson, J. Cook, W.Sieghart, E. Margot., Bri. J. Pharmacol., 169, 384-399 (2013).
\n397.\u201cPWZ-029, An Inverse Agonist Selective for \u03b15 GABAA Receptors, Improves Object Recognition, But Not Water-Maze Memory in Normal And Scopolamine-Treated Rats,\u201d Milica,M.; Timica, T.; Joksimovica, S.; Biawat, P.; Rallapalli, S.; Divljakovica, J.; Radulovica, T.; Cook, J. M; Savic, M. M. Behav. Brain Res., 241, 206\u2013213 (2013).
\n398.\u201cInsights into Functional Pharmacologyal \u03b11 GABA (A) Receptors: How Much Does Partial Activation at the Benzodiazepine Site Matter,\u201d Joksimovic, S.; Divljakovic, J.; Varagic, Z.; Van Linn, M.; Milic, M.; Rallapalli, S.; Timic, T.; Sieghart, W.; Cook, J. M.; Savic, M., Psychopharmacology, 230, 113-23 (2013).
\n399.\u201cStereospecific Approach to the Synthesis of Ring-A Oxygenated Sarpagine Indole Alkaloids. Total Synthesis of the Dimeric Indole Alkaloid Dispegatrine and Six Other Monomeric Indole Alkaloids”, Edwankar, C.R.; Edwankar, R.V.; Namjoshi, O. A.; Deschamps, J.; Liao, X.; Cook, J. M. J. Org. Chem., 78, 6471\u20146487 (2013).
\n400.\u201cIdentification of Novel Positive Allolsteric Modulators and Null Modulators at the GABAA Receptor \u03b1+\u03b2 Interface\u201d, Varagic, Z.; Wimmer, L.; Schn\u00fcrch, M.; Mihovilovic, M .D.; Huang, S.; Rallapalli, S.; Cook, J. M.; Mirheydari, P.; Ecker, G.F.;Sieghart,W.;Ernst,M. Brit. J. of Pharmaco.169, 371-383 (2013).
\n401.\u201cTriple Monoamine Uptake Inhibitors Demonstrate a Pharmacologic Association Between Excessive Drinking and Impulsivity In High Alcohol-Preferring (HAP) Mice,\u201d O’Tousa, D. S.; Warnock, K. T.; Matson, L. M.; Namjoshi, O. A.; Van Linn, M. L.; Tiruveedhula, V.V.; Halcomb, M.E.; Cook, J. M.; Nicholas J. Grahame, N. J.; June,H. L., Addiction Biology, 20, 236-247 (2015). DOI: 10.1111\/adb.12100.
\n402.\u201cA Review: Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model\u201d,
\nClayton, T.; Poe, M.; Rallapalli, S.; Biawat, P.; Emala, C.; Gallos, G.; Kaczerowski,C.; Savic, M.; Rowlett, J.; Cook, J. M., submitted (2013).
\n403.\u201cDesign and Synthesis of Novel Antimicrobials with Activity Against Gram-Positive Bacteria and Mycro-bacterial Species, Including M. Tuberculosis\u201d, Tiruveedhula, V. V. N.; Witzigmann, C.; Verma, R.; Shahjahan, M.; Rott, M.; Schwan, W.; Monte, A.; Sherman, D.; Cook, J. M. Bioorg. and Med. Chem., 21, 7830-40 (2013).
\n404.\u201cAntihyperalgesia by Alpha 2 GABA (A) Receptors Occurs via a Genuine Spinal Action and Does not Involve Supraspinal Sites,\u201d Paul, J.; Yevenes, G.; Benke, D.; DiLio, A.; Ralvenius, W.; Witschi, R.; Scheuer, L.; Cook, J. M.; Rudolph, U.; Fritschy, J. M.; Zeilhofer, H. U., Neuropsychopharmacology, 39,(2), 477-487 (2014).
\n405.\u201cPrior Antipsychotic Drug Treatment Prevents Response to Noval Antipsychotic Agent in MAM Model of Schizophrenia,\u201d Gill, K.; Cook, J.; Poe, M.; Grace, A., Schizophrenia Bulletin, March, 40 (2), 341-50 (2014).
\n406.\u201cLittle Evidence of a Role for the \u03b11 GABAA Subunit \u2013 Containing Receptor in a Rhesus Monkey Model of Alcohol Drinking,\u201d Sawyer, E.; Moran, C.; Madelynn S.; Szafir, M.; Van Linn, M.; Namjoshi, O.; Tiruveedhula, P.B.; Cook, J.M.; Platt, D., Alcoholism Clinical and Experimental Research, 38 (4), 1108-1117 (2014).
\n407.\u201cEthanol Not Metabolized in Brain, Significantly Reduces Brain Metabolism, Probably via Action Specific GABA(A) Receptors and has Measurable Metabolic Effects at Very Low Concentrations,\u201d Rae, C; Davidson, J.; Maher, A.; Rowlands, B.; Kashem, M.; Nasrallah, F.; Rallapalli, S.; Cook, J.M.; Balcar, V., J. Neurosci., 21, 7830-7840 (2013) doi: 10.1111\/jnc.12634.
\n408.\u201cThe First Enantiospecific Total Synthesis of the Indole Alkaloid Ervincidine, Establishment of the C-6 Hydroxyl Stereochemistry,\u201d Rallapalli, S.; Deschamps, J.; Cook, J.M., J. Org. Chem., 79, 3776-3780 (2014).
\n409.\u201cDuration of Treatment and Activation of \u221d1-Containing GABA(A) Receptors Variably Affect the Level of Anxiety and Seizure Susceptibility After Spontaneous Diazepam Withdrawal in Rats,\u201d Kovacevic, J.; Timic, T.; Tiruveedhula, V.; Batinic, B.; Milic, M.; Joksimovic, S.; Cook, J.M.; Savic, M., Brain Res. Bull. 104, 1-6 (2014).
\n410.\u201cAllsoteric Modulation of GABA(A) Receptor Subtypes Effect on Visual Recognition and Visualspatial Working Memory in Rhesus Monkeys,\u201d Soto, P.; Ator, N.; Rallapalli, S.; Biawat, P.; Clayton, T.; Cook, M.; Weed, M., Neuropsychopharmacology, 38, 2315-2325, (2013).
\n411.\u201cExposure to Cocaine Regulates Inhibitory Syanpatic Transmission from the Ventral Tegmental Area of the Nucleus Accumbens,\u201d Ishikawa, M.; Otaka, M.; Neumann, P.A.; Wang, Z.; Cook, J.M.; Schluter, O.M.; Dong, Y.; Huang, Y.H., J. Physiol, 591 (Pt 19), 4827-41 (2013).
\n412.\u201c\u03b15-GABAA Receptors Negatively Regulate MYC-Amplified Medulloblastoma Growth,\u201d Sengupta, S.; Weeraratne, S.D.; Sun, H.; Phallen, J.; Rallapalli, S.K.; Tieder, N.; Kosaras, B.; Amani, V.; Pierre-Francois, J.; Tang, Y.; Nguyen, B.; Yu, F.; Schubert, S.; Balansay, B.; Mathios, D.; Lechpammer, M.; Archer, T.C.; Tran, P.; Reimer, R.J.; Cook, J.M.; Lim, M.; Jensen, F.E.; Pomeroy, S.L.; Cho, Y.J., Acta Neuropathol, 127 (4), 539-603 (2014).
\n413.\u201cZebrafish Heart Failure Models for the Evaluation of Chemical Probes and Drugs,\u201d Cheng, J.; Cook, J.M.; et. al., Assay Drug Dev. Technol. (9-10) 561-72 (2013).
\n414.\u201cVitamin D Receptor-Coactivator Inhibitors, \u201c Sidhu, P.; Nassif, N.; McCallum, M.; Teske, k.; Felke, BI; Yuan, N.; Nandhikondu, P.; Cook, J.; Singh R.; Bickle, D.; Arnold, A.; Med. Chem. Lett. 5, 199-204
\n(2014).
\n415.\u201cSH-I-048A, An In Vitro Nonselective Super Agonist at Benzodiazepine Site at GABA (A) Receptors; The Approximate Activation of Receptor Subtypes May Explain Behavioral Results,\u201d Savic, M.; Obradovic, A.; Joksimovic, S.; Huang, S.; Rammastorter, J.; Vargic, Z.; Namjoshi, O.; Batinic, B.; Radulovic, T.; Markovic, B.; Sieghart, J.; Cook, J., Brain Res., 1554, 36-48 (2014).
\n416.\u201cBehavioral Characterization of Four Endemic Staachys taxa,\u201d Savic, M.; Kukic\u2019, J.; Grayer, R.; Milinkovic\u2019, M.; Marin, P.; Divljakovic\u2019, J.; Van Linn, M.; Cook, J.M.; Petrovic\u2019, S.D.; Phytother.Res., 24, 1309-1316 (2010).
\n417.\u201cGlo 1 Inhibitors for Neuropsychiatric and Anti-epileptic Drug Dev.,\u201d McMurray, K.; Distler, M.; Sidhu, P.; Arnold, L.A.; Cook, J.M.; Palmer, A.; Plant, L., Biochem. Soc. Trans., 42, 461-467 (2014).
\n418.\u201cAnticancer Activity of VDR-Co-regulator Inhibitor PS121912,\u201d Sidhu, P.; A.; Sidhu, P.; Romano, N.; Hill, E.; Horan, T.; Nandhikonda, P.; Teske, K.; Feleki, B.; Yuan, N.; Guthrie, M.; Fernstrum, G.; Vyas, N.; Cook, J.; Han, L.; Silvaggi, N.; Bikle, D.; Moore, R.; Singh, R.; Arnold, L.A., Cancer Chemothera. Pharmacol, 74 (4) 787-798 (2014). doi 10.1007\/500280-014-2549-y (2014).
\n419.\u201cEffect of Dehusked Garcinia Kola Seed on the Overall Pharmokinetics of Quinine in Healthy Human Volunteers,\u201d Igbinoba, S.; Onyeji, C.; Akanmu, M.; Soyinka, J.; Owolabi, J.; Puellea, S.; Savina, V.V.; Cook, J.M., J.Clin.Pharmacol.,55, 348-354 (2015).
\n420.\u201cSelective Targeting of the \u03b15 Subunit of GABAA Receptors Relaxes Airway Smooth Muscle and Inhibits Cellular Calcium Handling,\u201d Gallos, G.; Yocum, G.; Siviski, M.; Yim, P.; Fu, X-W; Poe, M.; Cook, J.; Harrison, N.; Emala, C.; Am. J Physiol. Lung Cellular and Mol. Phosiol., 00, 0000-0000 (2015); doi:10.1152\/ajplung.00107.2014.
\n421.\u201cLink to Inpulsivity, Developmental Stress and Binge Drinking,\u201d Warnock, K.; Wang, H.; June, Jr., H.; Bell, K.; Rabe, H.;, Luddens, H.; Cook, J.; Babu, P.; Aurelians, L.; June Sr., H.L.,; Gondre-Lewis, M., Addiction Research, 00, 0000-0000 (2015).
\n422.\u201cAntagonism of Triazdam Self-Administration in Rhesus Monkeys Responding Under a Progressive-ratio Schedule: In vivo Apparent pA2 Analysis, Rowlett, J.\u2019 Rallapalli, S.; Cook, J.; et al submitted.
\n423.\u201cDifferential Effects of an \u03b15 GABAA Receptor-Negative Modulator on Spatial Social and Object Recognition Memory Impairment Induced by MK-801 in Rats, Timic-Stamenic, T.; Joksimovic, S.; Biawat, P.; Radulovie, T.; Markovic, B.; Cook, J.; Savic, M., Biological Pharmacol, Submitted (2014).
\n424.\u201cBehavorial Effects of the Benzodiazepine-Positive Modulator SH-053-2\u2019F-S-CH3 in an Immune-Mediated Neurodevelopmental Disruption Model,\u201d Richetto, J.; Labouesse, M.; Poe, M.M.; Cook, J.M.; Grace, A.; Riva, M.; Meyer, U., Int. J. of Neuropsychopharmacology, 1-11 (2015).
\n425.\u201cRegulating Anxiety with Extrasynaptic Inhibition,\u201d Botta, P.; Demmou, L.; Xu, C.; Lu, T.; Poe, M.M.; Xu, L.; Cook, J.M.; Rudolph, U.; Sah, P.; Luthi, A., Science Submitted (2014).
\n426.\u201cIdentification of VDR Antagonists Among Nuclear Receptor Ligands Using Virtual Screening,\u201d Teske, K,; Nandhidonda, P.; Bogart, J.; Feleke,; Sidhu, P.; Yuan, N.; Preston, J.; Goy, R.; Singh, R.; Bikle, D.; Cook, J.M.; Arnold, A., Nuclear Receptors Res., 1, 1-8 (2014).
\n427.\u201cFirst Staeospecific Total Synthesis of (-)-Affinisine Oxindole as well as Facile Entry Into the C (7) \u2013 Diastereomeric Chitosenine Stereochemistry, \u201cFonseca, G.; Wang, Z.; Namjoshi, O.; Deschamps, J.\u2019 Cook, J.; Tetrahedron Lett, 00,0000-0000 (2015); http:\/\/dx.doi.org\/10.1016\/j.tetlet.2014.11.036
\n428.\u201cGeneral Strategy for Synthesis of C-19 Methyl-Substituted Sarpagine\/Macroline\/Ajmaline Indole
\nAlkaloids including Total Synthesis of 19 (S), 20 (R) -Dihydroperaksine, 19 (S), 20 (R)- Dihydroperaksine-17-al and Peraksine, \u201cEdwankar, R.; Edwankar, C.; Deschamps, J.; Cook, J., J.Org.Chem, 79, 10030-10048 (2014).
\n429.\u201cExpression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and The GABA-A Receptor as Therapeutic Targets in Neuroblastoma,\u201d Hackett, C.; Quigley, D.; Wong, R.; Chen, J.; Cheng, C.; Song, C.; Wei, J.; Pawilkowska, L.; Bao, Y.; Goldenberg, D.; Nguyen, K.; Gustafson, W.; Rallapalli, S., Cho, Yoon-Jae; Cook, J.M.; Kozlov, S.; Mao, J.-H.; Dyke, T.; Kwok, P.-Y.; Khan, J.\u2019 Balmain, A.; Fan, Q.; Weiss; William; Cell Reports, 9, 1-13 (2014).
\n430.\u201cAnti-tumor activity of Vitamin D receptor-corregulator 31B in ovarian cancer,\u201d Han, A; Preetpal, S; Chen, E.; Hill, E.; Horan, T.; Premchendar, N.; Teske, K.; Yuan, N.; Gutherie, L.; Sidorko, M.; Kodali, R.; Cook, J.; Han, L.; Silvaggi, N.; Bikle, D.; Moore, R.; Singh, R.; Arnold, A.; Endocrine-Related Cancer, submitted (2015).
\n\u201cDelayed Behavioral Effects of SH-I-048A, A Novel Nonselective Positive Modulator of GABA (A) Receptors, After Peripheral Nerve Injury in Rats,\u201d OBradovic\u2019, L.; Joksimovic\u2019, S.; Poe, M.; Timic, T.; Cook, J.; Savic, M. Afta<\/p>\n","protected":false},"excerpt":{"rendered":"

A. Scholarly Publications 1. “Alstonerine, a New Indole Alkaloid from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, Chem. Commun., 1306-1307 (1969). 2. “The Structure of Alstonisidine: A Novel Dimeric Indole Alkaloid,” J.M. Cook and P.W. LeQuesne, J. Org. Chem., 36, …<\/p>\n","protected":false},"author":382,"featured_media":0,"parent":0,"menu_order":15,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","uwm_wg_additional_authors":[]},"class_list":["post-10347","page","type-page","status-publish","hentry"],"yoast_head":"\nChemistry & Biochemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uwm.edu\/chemistry\/cook-publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cook Publications\" \/>\n<meta property=\"og:description\" content=\"A. Scholarly Publications 1. “Alstonerine, a New Indole Alkaloid from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, Chem. 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Scholarly Publications 1. “Alstonerine, a New Indole Alkaloid from Alstonia muelleriana,” J.M. Cook and P.W. LeQuesne, Chem. Commun., 1306-1307 (1969). 2. “The Structure of Alstonisidine: A Novel Dimeric Indole Alkaloid,” J.M. Cook and P.W. LeQuesne, J. Org. 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