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DTSTART;TZID=America/Chicago:20260430T160000
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DTSTAMP:20260421T204847
CREATED:20260311T134443Z
LAST-MODIFIED:20260421T173122Z
UID:10003981-1777564800-1777570200@uwm.edu
SUMMARY:Sosnovsky Lectureship Series - Guest Speaker Prof. Marc Greenberg from Johns Hopkins University
DESCRIPTION:Chemical Tools for DNA-Protein Cross-Link Formation and Study \nDNA-protein cross-links (DPCs) are highly toxic lesions formed via a variety of chemical pathways and as intermediates in enzyme transformations. DPCs are potent blocks of helicases\, as well as DNA and RNA polymerases. DPCs are associated with aging and diseases such as cancer. Recently\, DPCs were also shown to result in chronic inflammation. Despite their importance\, our understanding of DPCs has lagged that of other forms of DNA damage. For instance\, the first protease identified to repair DPCs in human cells (SPRTN) was only identified in the past decade. Our group is developing chemical tools for producing DPCs. These tools are useful for studying DPCs extra- and intracellularly and are potentially useful pharmacologically. Recent published and unpublished investigations will be presented.
URL:/chemistry/event/sosnovsky-lectureship-series-guest-speaker-prof-marc-greenberg-from-john-hopkins-university/
LOCATION:Chemistry Lecture Hall 108\, 2000 E. Kenwood Boulevard\, Milwaukee\, 53211\, United States
CATEGORIES:Special Events
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DTSTART;TZID=America/Chicago:20260501T113000
DTEND;TZID=America/Chicago:20260501T163000
DTSTAMP:20260421T204847
CREATED:20251210T215810Z
LAST-MODIFIED:20260206T220429Z
UID:10003968-1777635000-1777653000@uwm.edu
SUMMARY:Chemistry Awards Day and Research Symposium
DESCRIPTION:
URL:/chemistry/event/chemistry-awards-day-and-research-symposium/
LOCATION:Chemistry Lobby\, Milwaukee\, 53211\, United States
CATEGORIES:Special Events
X-TRIBE-STATUS:
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20260501T150000
DTEND;TZID=America/Chicago:20260501T155000
DTSTAMP:20260421T204847
CREATED:20260311T134558Z
LAST-MODIFIED:20260421T173050Z
UID:10003982-1777647600-1777650600@uwm.edu
SUMMARY:Sosnovsky Lectureship Series - Guest Speaker Prof. Marc Greenberg from John Hopkins University
DESCRIPTION:Sometimes DNA Damage is Only the Beginning \nDNA damage is detrimental to genome integrity and can be mutagenic and/or cytotoxic. The latter lie at the etiology of disease but is also the goal of many anti-cancer therapeutics. Consequently\, understanding this diverse and important group of processes is of paramount importance. \nFrequently\, scientists focus on the initially formed damage. To understand the consequences of DNA damage and its formation\, our group begins its investigations by using the reductionist approach of organic chemistry. Generating a single damage site (“lesion”) within DNA simplifies studies on DNA damage and facilitates a deeper understanding. Using this strategy\, our research group has discovered          that in some instances the formation of damaged DNA is only the beginning. \nFor instance\, some forms of damaged DNA inactivate repair enzymes. These discoveries provide insight into the chemical bases of drugs that kill cells by producing these forms of DNA damage and inspiration for designing inhibitors of such enzymes. Other DNA lesions react with the histone proteins within nucleosome core particles to produce more biologically deleterious forms of damage. Some of these processes that have been discovered in the test tube have been shown to occur in cells. \nOverall\, combining organic chemistry\, biochemistry and cell biology to study damaged DNA facilitates elucidating these biologically important and complex processes\, the discovery of previously unrecognized pathways\, and the inspiration for designing molecules with useful biological activity.
URL:/chemistry/event/sosnovsky-lectureship-series-guest-speaker-prof-marc-greenberg-from-john-hopkins-university-2/
LOCATION:Chemistry Lecture Hall 110\, 2000 E. Kenwood Boulevard\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Special Events
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20260508T150000
DTEND;TZID=America/Chicago:20260508T160000
DTSTAMP:20260421T204847
CREATED:20260202T171418Z
LAST-MODIFIED:20260202T171418Z
UID:10003978-1778252400-1778256000@uwm.edu
SUMMARY:Colloquium\, Mohammad Islam\, 51���� Chemistry
DESCRIPTION:
URL:/chemistry/event/colloquium-mohammad-islam-uwm-chemistry/
LOCATION:Chemistry Lecture Hall 110\, 2000 E. Kenwood Boulevard\, Milwaukee\, WI\, 53211\, United States
CATEGORIES:Colloquium
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DTSTART;VALUE=DATE:20260513
DTEND;VALUE=DATE:20260514
DTSTAMP:20260421T204847
CREATED:20221123T145634Z
LAST-MODIFIED:20250717T214136Z
UID:10003714-1778630400-1778716799@uwm.edu
SUMMARY:Last Day of Semester Classes
DESCRIPTION:
URL:/chemistry/event/last-day-of-semester-classes-4/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260514
DTEND;VALUE=DATE:20260515
DTSTAMP:20260421T204847
CREATED:20221123T145658Z
LAST-MODIFIED:20250717T213325Z
UID:10003829-1778716800-1778803199@uwm.edu
SUMMARY:Study Day
DESCRIPTION:
URL:/chemistry/event/study-day-5/
LOCATION:WI
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260515
DTEND;VALUE=DATE:20260523
DTSTAMP:20260421T204847
CREATED:20221123T145745Z
LAST-MODIFIED:20250717T213659Z
UID:10003830-1778803200-1779494399@uwm.edu
SUMMARY:Final Exams
DESCRIPTION:
URL:/chemistry/event/final-exams-9/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260517
DTEND;VALUE=DATE:20260518
DTSTAMP:20260421T204847
CREATED:20230627T160819Z
LAST-MODIFIED:20250717T213843Z
UID:10003878-1778976000-1779062399@uwm.edu
SUMMARY:Graduation
DESCRIPTION:
URL:/chemistry/event/graduation-4/
LOCATION:WI
X-TRIBE-STATUS:
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260822
DTEND;VALUE=DATE:20260823
DTSTAMP:20260421T204847
CREATED:20250515T194043Z
LAST-MODIFIED:20260203T200407Z
UID:10003951-1787356800-1787443199@uwm.edu
SUMMARY:Last Day of Summer Classes
DESCRIPTION:
URL:/chemistry/event/last-day-of-summer-classes/
LOCATION:WI
X-TRIBE-STATUS:
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260902
DTEND;VALUE=DATE:20260903
DTSTAMP:20260421T204847
CREATED:20230627T151735Z
LAST-MODIFIED:20260203T200523Z
UID:10003869-1788307200-1788393599@uwm.edu
SUMMARY:Instruction Begins
DESCRIPTION:
URL:/chemistry/event/instruction-begins-4/
LOCATION:WI
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20261125
DTEND;VALUE=DATE:20261130
DTSTAMP:20260421T204847
CREATED:20230627T160403Z
LAST-MODIFIED:20260203T201022Z
UID:10003873-1795564800-1795996799@uwm.edu
SUMMARY:Fall Recess
DESCRIPTION:
URL:/chemistry/event/fall-recess/
LOCATION:WI
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DTSTART;VALUE=DATE:20261214
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CREATED:20240726T161421Z
LAST-MODIFIED:20260203T201055Z
UID:10003928-1797206400-1797292799@uwm.edu
SUMMARY:Last Day of Semester Classes
DESCRIPTION:
URL:/chemistry/event/last-day-of-semester-classes-7/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261215
DTEND;VALUE=DATE:20261216
DTSTAMP:20260421T204847
CREATED:20240726T161454Z
LAST-MODIFIED:20260203T201129Z
UID:10003929-1797292800-1797379199@uwm.edu
SUMMARY:Study Day
DESCRIPTION:
URL:/chemistry/event/study-day-7/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261216
DTEND;VALUE=DATE:20261224
DTSTAMP:20260421T204847
CREATED:20240726T161539Z
LAST-MODIFIED:20260203T200948Z
UID:10003930-1797379200-1798070399@uwm.edu
SUMMARY:Final Exams
DESCRIPTION:
URL:/chemistry/event/final-exams-13/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261220
DTEND;VALUE=DATE:20261221
DTSTAMP:20260421T204847
CREATED:20240726T161618Z
LAST-MODIFIED:20260203T201209Z
UID:10003931-1797724800-1797811199@uwm.edu
SUMMARY:Graduation
DESCRIPTION:
URL:/chemistry/event/graduation-5/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20270125
DTEND;VALUE=DATE:20270126
DTSTAMP:20260421T204847
CREATED:20221123T145405Z
LAST-MODIFIED:20260203T201253Z
UID:10003705-1800835200-1800921599@uwm.edu
SUMMARY:Instruction Begins
DESCRIPTION:
URL:/chemistry/event/instruction-begins-3/
LOCATION:WI
X-TRIBE-STATUS:
END:VEVENT
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